Details of the Target

General Information of Target

Target ID LDTP17046
Target Name RNA-binding motif, single-stranded-interacting protein 2 (RBMS2)
Gene Name RBMS2
Gene ID 5939
Synonyms
SCR3; RNA-binding motif, single-stranded-interacting protein 2; Suppressor of CDC2 with RNA-binding motif 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSASGPEAPGDIPALPPPPQPGSGPAPPAPAAAAQEAMDGRAELPAFPRAGAPPLAASDT
VPAAPEGAGAARPAAPLRPTSFSVLDILDPNKFNSRRRRCVLLGPVAPAACAPCASAPCA
PAPAASGRPPRAEELERRALAGAGGVGAAGAEPPNAGDPFKAGEAETNDTNGYSSGGGGH
SPSADSGDEVPDDEDDDEDEAPETEAARGAEEARGGGGGLGARGSGCQGAAETDASPGAT
VDEAAAPGPRENSPVAQGPPGGAAAPGGAGTTPQGTATAAKPKRKRTGSDSKSGKPRRAR
TAFTYEQLVALENKFKATRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQNPGADT
SAPTGGGGGPGPGAGPGTGLPGGLSPLSPSPPMGAPLGMHGPAGYPAHGPGGLVCAAQLP
FLSSPAVLSPFVLGSQTYGAPAFYAPHL
Target Bioclass
Other
Subcellular location
Nucleus
Uniprot ID
Q15434
Ensemble ID
ENST00000262031.10
HGNC ID
HGNC:9909

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C188(1.90)  LDD3312  [1]
BTD
 Probe Info  		C215(0.27)  LDD2106  [2]
HPAP
 Probe Info  		3.77  LDD0062  [3]
TFBX
 Probe Info  		N.A.  LDD0148  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C215(0.94)  LDD2112  [2]
 LDCM0215  AC10 PaTu 8988t C188(0.85)  LDD1094  [5]
 LDCM0216  AC100 PaTu 8988t C188(0.93)  LDD1095  [5]
 LDCM0217  AC101 PaTu 8988t C188(1.08)  LDD1096  [5]
 LDCM0218  AC102 PaTu 8988t C188(1.43)  LDD1097  [5]
 LDCM0219  AC103 PaTu 8988t C188(1.26)  LDD1098  [5]
 LDCM0220  AC104 PaTu 8988t C188(0.84)  LDD1099  [5]
 LDCM0221  AC105 PaTu 8988t C188(1.16)  LDD1100  [5]
 LDCM0222  AC106 PaTu 8988t C188(0.89)  LDD1101  [5]
 LDCM0223  AC107 PaTu 8988t C188(1.17)  LDD1102  [5]
 LDCM0224  AC108 PaTu 8988t C188(0.87)  LDD1103  [5]
 LDCM0225  AC109 PaTu 8988t C188(0.94)  LDD1104  [5]
 LDCM0226  AC11 PaTu 8988t C188(0.87)  LDD1105  [5]
 LDCM0227  AC110 PaTu 8988t C188(1.23)  LDD1106  [5]
 LDCM0228  AC111 PaTu 8988t C188(0.98)  LDD1107  [5]
 LDCM0229  AC112 PaTu 8988t C188(1.00)  LDD1108  [5]
 LDCM0237  AC12 PaTu 8988t C188(0.85)  LDD1116  [5]
 LDCM0259  AC14 PaTu 8988t C188(1.01)  LDD1138  [5]
 LDCM0270  AC15 PaTu 8988t C188(0.90)  LDD1149  [5]
 LDCM0276  AC17 PaTu 8988t C215(0.81)  LDD1155  [5]
 LDCM0277  AC18 PaTu 8988t C215(0.69)  LDD1156  [5]
 LDCM0278  AC19 PaTu 8988t C215(0.77)  LDD1157  [5]
 LDCM0280  AC20 PaTu 8988t C215(0.67)  LDD1159  [5]
 LDCM0281  AC21 PaTu 8988t C215(0.56)  LDD1160  [5]
 LDCM0282  AC22 PaTu 8988t C215(0.51)  LDD1161  [5]
 LDCM0283  AC23 PaTu 8988t C215(0.54)  LDD1162  [5]
 LDCM0284  AC24 PaTu 8988t C215(1.01)  LDD1163  [5]
 LDCM0289  AC29 HEK-293T C188(1.18)  LDD1528  [6]
 LDCM0298  AC37 HEK-293T C188(1.28)  LDD1537  [6]
 LDCM0307  AC45 HEK-293T C188(1.22)  LDD1546  [6]
 LDCM0308  AC46 PaTu 8988t C188(0.82)  LDD1187  [5]
 LDCM0309  AC47 PaTu 8988t C188(0.76)  LDD1188  [5]
 LDCM0310  AC48 PaTu 8988t C188(0.76)  LDD1189  [5]
 LDCM0311  AC49 PaTu 8988t C188(0.60)  LDD1190  [5]
 LDCM0312  AC5 HEK-293T C188(1.20)  LDD1551  [6]
 LDCM0313  AC50 PaTu 8988t C188(0.51)  LDD1192  [5]
 LDCM0314  AC51 PaTu 8988t C188(0.16)  LDD1193  [5]
 LDCM0315  AC52 PaTu 8988t C188(0.67)  LDD1194  [5]
 LDCM0316  AC53 PaTu 8988t C188(0.44)  LDD1195  [5]
 LDCM0317  AC54 PaTu 8988t C188(0.46)  LDD1196  [5]
 LDCM0318  AC55 PaTu 8988t C188(0.94)  LDD1197  [5]
 LDCM0319  AC56 PaTu 8988t C188(0.66)  LDD1198  [5]
 LDCM0323  AC6 PaTu 8988t C188(1.02)  LDD1202  [5]
 LDCM0325  AC61 HEK-293T C188(1.20)  LDD1564  [6]
 LDCM0334  AC7 PaTu 8988t C188(0.91)  LDD1213  [5]
 LDCM0345  AC8 PaTu 8988t C188(0.93)  LDD1224  [5]
 LDCM0365  AC98 PaTu 8988t C188(1.20)  LDD1244  [5]
 LDCM0366  AC99 PaTu 8988t C188(1.20)  LDD1245  [5]
 LDCM0248  AKOS034007472 PaTu 8988t C188(0.93)  LDD1127  [5]
 LDCM0356  AKOS034007680 PaTu 8988t C188(0.81)  LDD1235  [5]
 LDCM0275  AKOS034007705 PaTu 8988t C188(0.75)  LDD1154  [5]
 LDCM0367  CL1 PaTu 8988t C215(0.72)  LDD1246  [5]
 LDCM0368  CL10 PaTu 8988t C215(0.31)  LDD1247  [5]
 LDCM0370  CL101 PaTu 8988t C188(0.84)  LDD1249  [5]
 LDCM0371  CL102 PaTu 8988t C188(0.83)  LDD1250  [5]
 LDCM0372  CL103 PaTu 8988t C188(0.92)  LDD1251  [5]
 LDCM0373  CL104 PaTu 8988t C188(0.96)  LDD1252  [5]
 LDCM0374  CL105 PaTu 8988t C215(1.09)  LDD1253  [5]
 LDCM0375  CL106 PaTu 8988t C215(0.97)  LDD1254  [5]
 LDCM0376  CL107 PaTu 8988t C215(0.91)  LDD1255  [5]
 LDCM0377  CL108 PaTu 8988t C215(0.87)  LDD1256  [5]
 LDCM0378  CL109 PaTu 8988t C215(1.02)  LDD1257  [5]
 LDCM0379  CL11 PaTu 8988t C215(0.87)  LDD1258  [5]
 LDCM0380  CL110 PaTu 8988t C215(0.79)  LDD1259  [5]
 LDCM0381  CL111 PaTu 8988t C215(0.47)  LDD1260  [5]
 LDCM0383  CL113 HEK-293T C188(1.22)  LDD1587  [6]
 LDCM0387  CL117 HEK-293T C188(1.59)  LDD1591  [6]
 LDCM0390  CL12 PaTu 8988t C215(0.76)  LDD1269  [5]
 LDCM0392  CL121 PaTu 8988t C188(0.85)  LDD1271  [5]
 LDCM0393  CL122 PaTu 8988t C188(0.72)  LDD1272  [5]
 LDCM0394  CL123 PaTu 8988t C188(0.58)  LDD1273  [5]
 LDCM0395  CL124 PaTu 8988t C188(0.66)  LDD1274  [5]
 LDCM0396  CL125 HEK-293T C188(1.21)  LDD1600  [6]
 LDCM0400  CL13 PaTu 8988t C215(0.30)  LDD1279  [5]
 LDCM0401  CL14 PaTu 8988t C215(0.26)  LDD1280  [5]
 LDCM0402  CL15 PaTu 8988t C215(0.50)  LDD1281  [5]
 LDCM0403  CL16 PaTu 8988t C215(0.57)  LDD1282  [5]
 LDCM0404  CL17 PaTu 8988t C215(0.60)  LDD1283  [5]
 LDCM0405  CL18 PaTu 8988t C215(0.55)  LDD1284  [5]
 LDCM0406  CL19 PaTu 8988t C215(0.42)  LDD1285  [5]
 LDCM0407  CL2 PaTu 8988t C215(0.62)  LDD1286  [5]
 LDCM0408  CL20 PaTu 8988t C215(0.43)  LDD1287  [5]
 LDCM0409  CL21 PaTu 8988t C215(0.40)  LDD1288  [5]
 LDCM0410  CL22 PaTu 8988t C215(0.45)  LDD1289  [5]
 LDCM0411  CL23 PaTu 8988t C215(0.45)  LDD1290  [5]
 LDCM0412  CL24 PaTu 8988t C215(0.79)  LDD1291  [5]
 LDCM0413  CL25 PaTu 8988t C215(0.67)  LDD1292  [5]
 LDCM0414  CL26 PaTu 8988t C215(0.46)  LDD1293  [5]
 LDCM0415  CL27 PaTu 8988t C215(0.59)  LDD1294  [5]
 LDCM0416  CL28 PaTu 8988t C215(0.45)  LDD1295  [5]
 LDCM0417  CL29 PaTu 8988t C215(0.49)  LDD1296  [5]
 LDCM0418  CL3 PaTu 8988t C215(0.83)  LDD1297  [5]
 LDCM0419  CL30 PaTu 8988t C215(0.71)  LDD1298  [5]
 LDCM0420  CL31 PaTu 8988t C215(0.95)  LDD1299  [5]
 LDCM0421  CL32 PaTu 8988t C215(0.87)  LDD1300  [5]
 LDCM0422  CL33 PaTu 8988t C215(0.68)  LDD1301  [5]
 LDCM0423  CL34 PaTu 8988t C215(0.84)  LDD1302  [5]
 LDCM0424  CL35 PaTu 8988t C215(0.68)  LDD1303  [5]
 LDCM0425  CL36 PaTu 8988t C215(0.58)  LDD1304  [5]
 LDCM0426  CL37 PaTu 8988t C215(0.73)  LDD1305  [5]
 LDCM0428  CL39 PaTu 8988t C215(0.89)  LDD1307  [5]
 LDCM0429  CL4 PaTu 8988t C215(0.89)  LDD1308  [5]
 LDCM0430  CL40 PaTu 8988t C215(0.82)  LDD1309  [5]
 LDCM0431  CL41 PaTu 8988t C215(0.69)  LDD1310  [5]
 LDCM0432  CL42 PaTu 8988t C215(0.69)  LDD1311  [5]
 LDCM0433  CL43 PaTu 8988t C215(0.61)  LDD1312  [5]
 LDCM0434  CL44 PaTu 8988t C215(0.74)  LDD1313  [5]
 LDCM0435  CL45 PaTu 8988t C215(0.83)  LDD1314  [5]
 LDCM0439  CL49 HEK-293T C188(1.35)  LDD1643  [6]
 LDCM0440  CL5 PaTu 8988t C215(0.29)  LDD1319  [5]
 LDCM0448  CL57 HEK-293T C188(1.30)  LDD1651  [6]
 LDCM0451  CL6 PaTu 8988t C215(0.39)  LDD1330  [5]
 LDCM0453  CL61 PaTu 8988t C188(0.82)  LDD1332  [5]
 LDCM0454  CL62 PaTu 8988t C188(0.93)  LDD1333  [5]
 LDCM0455  CL63 PaTu 8988t C188(0.88)  LDD1334  [5]
 LDCM0456  CL64 PaTu 8988t C188(0.80)  LDD1335  [5]
 LDCM0457  CL65 PaTu 8988t C188(0.74)  LDD1336  [5]
 LDCM0458  CL66 PaTu 8988t C188(0.57)  LDD1337  [5]
 LDCM0459  CL67 PaTu 8988t C188(0.75)  LDD1338  [5]
 LDCM0460  CL68 PaTu 8988t C188(0.78)  LDD1339  [5]
 LDCM0461  CL69 PaTu 8988t C188(0.50)  LDD1340  [5]
 LDCM0462  CL7 PaTu 8988t C215(0.33)  LDD1341  [5]
 LDCM0463  CL70 PaTu 8988t C188(0.80)  LDD1342  [5]
 LDCM0464  CL71 PaTu 8988t C188(0.83)  LDD1343  [5]
 LDCM0465  CL72 PaTu 8988t C188(1.04)  LDD1344  [5]
 LDCM0466  CL73 PaTu 8988t C188(0.82)  LDD1345  [5]
 LDCM0467  CL74 PaTu 8988t C188(0.98)  LDD1346  [5]
 LDCM0473  CL8 PaTu 8988t C215(0.63)  LDD1352  [5]
 LDCM0475  CL81 HEK-293T C188(1.06)  LDD1678  [6]
 LDCM0479  CL85 HEK-293T C188(1.50)  LDD1682  [6]
 LDCM0484  CL9 PaTu 8988t C215(0.31)  LDD1363  [5]
 LDCM0488  CL93 HEK-293T C188(1.02)  LDD1691  [6]
 LDCM0492  CL97 HEK-293T C188(0.86)  LDD1695  [6]
 LDCM0468  Fragment33 PaTu 8988t C188(0.67)  LDD1347  [5]
 LDCM0427  Fragment51 PaTu 8988t C215(0.68)  LDD1306  [5]
 LDCM0022  KB02 786-O C188(1.63); C82(1.10)  LDD2247  [1]
 LDCM0023  KB03 786-O C188(2.11); C82(1.16)  LDD2664  [1]
 LDCM0024  KB05 HMCB C188(1.90)  LDD3312  [1]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C215(0.27)  LDD2106  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C96(1.30)  LDD2136  [2]
 LDCM0014  Panhematin HEK-293T 3.77  LDD0062  [3]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402