Details of the Target

General Information of Target

Target ID LDTP05097
Target Name Pituitary homeobox 1 (PITX1)
Gene Name PITX1
Gene ID 5307
Synonyms
BFT; PTX1; Pituitary homeobox 1; Hindlimb-expressed homeobox protein backfoot; Homeobox protein PITX1; Paired-like homeodomain transcription factor 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDAFKGGMSLERLPEGLRPPPPPPHDMGPAFHLARPADPREPLENSASESSDTELPEKER
GGEPKGPEDSGAGGTGCGGADDPAKKKKQRRQRTHFTSQQLQELEATFQRNRYPDMSMRE
EIAVWTNLTEPRVRVWFKNRRAKWRKRERNQQLDLCKGGYVPQFSGLVQPYEDVYAAGYS
YNNWAAKSLAPAPLSTKSFTFFNSMSPLSSQSMFSAPSSISSMTMPSSMGPGAVPGMPNS
GLNNINNLTGSSLNSAMSPGACPYGTPASPYSVYRDTCNSSLASLRLKSKQHSSFGYGGL
QGPASGLNACQYNS
Target Bioclass
Transcription factor
Family
Paired homeobox family, Bicoid subfamily
Subcellular location
Nucleus
Function
Sequence-specific transcription factor that binds gene promoters and activates their transcription. May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb.
Uniprot ID
P78337
Ensemble ID
ENST00000265340.12
HGNC ID
HGNC:9004

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HPAP
 Probe Info  		3.63  LDD0062  [1]
IA-alkyne
 Probe Info  		C278(0.94)  LDD2206  [2]
DBIA
 Probe Info  		C156(0.96)  LDD0078  [3]
IPM
 Probe Info  		C278(0.00); C77(0.00); C156(0.00)  LDD0025  [4]
Compound 10
 Probe Info  		N.A.  LDD2216  [5]
TFBX
 Probe Info  		N.A.  LDD0148  [4]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [6]
Acrolein
 Probe Info  		N.A.  LDD0217  [7]
Methacrolein
 Probe Info  		N.A.  LDD0218  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C77(1.17)  LDD0812  [3]
 LDCM0215  AC10 HCT 116 C77(1.23)  LDD0532  [3]
 LDCM0216  AC100 HEK-293T C77(1.73)  LDD0814  [3]
 LDCM0217  AC101 HEK-293T C77(2.13)  LDD0815  [3]
 LDCM0218  AC102 HEK-293T C77(2.10)  LDD0816  [3]
 LDCM0219  AC103 HEK-293T C77(2.06)  LDD0817  [3]
 LDCM0220  AC104 HEK-293T C77(2.60)  LDD0818  [3]
 LDCM0221  AC105 HEK-293T C77(1.46)  LDD0819  [3]
 LDCM0222  AC106 HEK-293T C77(0.98)  LDD0820  [3]
 LDCM0223  AC107 HEK-293T C77(1.31)  LDD0821  [3]
 LDCM0224  AC108 HEK-293T C77(1.03)  LDD0822  [3]
 LDCM0225  AC109 HEK-293T C77(2.02)  LDD0823  [3]
 LDCM0226  AC11 HCT 116 C77(1.23)  LDD0543  [3]
 LDCM0227  AC110 HEK-293T C77(3.29)  LDD0825  [3]
 LDCM0228  AC111 HEK-293T C77(3.06)  LDD0826  [3]
 LDCM0229  AC112 HEK-293T C77(1.56)  LDD0827  [3]
 LDCM0237  AC12 HCT 116 C77(1.09)  LDD0554  [3]
 LDCM0259  AC14 HCT 116 C77(1.34)  LDD0576  [3]
 LDCM0263  AC143 HEK-293T C77(0.89)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C77(1.18)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C77(0.91)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C77(1.36)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C77(1.12)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C77(0.82)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C77(0.90)  LDD0867  [3]
 LDCM0270  AC15 HCT 116 C77(1.26)  LDD0587  [3]
 LDCM0271  AC150 HEK-293T C77(0.70)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C77(1.66)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C77(1.01)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C77(0.99)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C77(0.92)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C77(1.06)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C77(1.02)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C77(1.66)  LDD2165  [3]
 LDCM0276  AC17 HCT 116 C77(1.19)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C77(1.35)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C77(1.01)  LDD0595  [3]
 LDCM0279  AC2 HEK-293T C77(1.57)  LDD0877  [3]
 LDCM0280  AC20 HCT 116 C77(1.05)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C77(1.10)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C77(0.97)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C77(1.04)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C77(0.89)  LDD0601  [3]
 LDCM0285  AC25 HEK-293T C77(2.37)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C77(1.06)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C77(2.22)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C77(4.70)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C77(1.83)  LDD0887  [3]
 LDCM0290  AC3 HEK-293T C77(1.14)  LDD0888  [3]
 LDCM0291  AC30 HEK-293T C77(2.21)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C77(2.60)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C77(2.22)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C77(1.36)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C77(2.18)  LDD0893  [3]
 LDCM0296  AC35 PaTu 8988t C77(1.11)  LDD1175  [3]
 LDCM0297  AC36 PaTu 8988t C77(1.07)  LDD1176  [3]
 LDCM0298  AC37 PaTu 8988t C77(1.41)  LDD1177  [3]
 LDCM0299  AC38 PaTu 8988t C77(1.22)  LDD1178  [3]
 LDCM0300  AC39 PaTu 8988t C77(1.65)  LDD1179  [3]
 LDCM0301  AC4 HEK-293T C77(1.15)  LDD0899  [3]
 LDCM0302  AC40 PaTu 8988t C77(1.73)  LDD1181  [3]
 LDCM0303  AC41 PaTu 8988t C77(1.49)  LDD1182  [3]
 LDCM0304  AC42 PaTu 8988t C77(1.72)  LDD1183  [3]
 LDCM0305  AC43 PaTu 8988t C77(1.22)  LDD1184  [3]
 LDCM0306  AC44 PaTu 8988t C77(2.47)  LDD1185  [3]
 LDCM0307  AC45 PaTu 8988t C77(1.66)  LDD1186  [3]
 LDCM0308  AC46 HCT 116 C77(1.13)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C77(1.03)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C77(1.38)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C77(1.51)  LDD0628  [3]
 LDCM0312  AC5 HEK-293T C77(2.38)  LDD0910  [3]
 LDCM0313  AC50 HCT 116 C77(1.55)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C77(0.93)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C77(1.11)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C77(1.33)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C77(1.35)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C77(2.30)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C77(4.47)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C156(1.13)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C156(0.93)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C156(1.07)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C77(1.11)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C156(1.13)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C156(0.96)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C156(1.15)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C156(1.27)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C156(1.25)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C156(1.14)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C156(0.98)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C156(1.38)  LDD0648  [3]
 LDCM0334  AC7 HCT 116 C77(0.84)  LDD0651  [3]
 LDCM0345  AC8 HCT 116 C77(1.07)  LDD0662  [3]
 LDCM0349  AC83 HCT 116 C156(1.59)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C156(1.17)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C156(1.05)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C156(1.35)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C156(1.00)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C156(1.28)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C156(1.21)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C156(0.79)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C156(1.40)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C156(1.48)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C156(0.80)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C156(0.89)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C156(0.79)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C156(1.35)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C156(1.16)  LDD0681  [3]
 LDCM0365  AC98 HEK-293T C77(1.18)  LDD0963  [3]
 LDCM0366  AC99 HEK-293T C77(1.79)  LDD0964  [3]
 LDCM0248  AKOS034007472 HCT 116 C77(1.20)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C77(1.05)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C77(1.82)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C156(0.96)  LDD0078  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [7]
 LDCM0367  CL1 HCT 116 C77(0.85)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C77(1.31)  LDD0685  [3]
 LDCM0369  CL100 HEK-293T C77(1.53)  LDD0967  [3]
 LDCM0370  CL101 HCT 116 C77(1.35)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C77(1.08)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C77(1.01)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C77(1.13)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C77(1.30)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C77(1.51)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C77(1.18)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C77(1.29)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C77(0.97)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C77(1.34)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C77(1.28)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C77(1.11)  LDD0698  [3]
 LDCM0382  CL112 HEK-293T C77(1.49)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C77(1.50)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C77(1.70)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C77(3.10)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C77(2.10)  LDD0984  [3]
 LDCM0387  CL117 PaTu 8988t C77(1.35)  LDD1266  [3]
 LDCM0388  CL118 PaTu 8988t C77(1.64)  LDD1267  [3]
 LDCM0389  CL119 PaTu 8988t C77(1.44)  LDD1268  [3]
 LDCM0390  CL12 HCT 116 C77(1.97)  LDD0707  [3]
 LDCM0391  CL120 PaTu 8988t C77(1.18)  LDD1270  [3]
 LDCM0392  CL121 HCT 116 C77(1.35)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C77(1.20)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C77(1.56)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C77(1.77)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C156(1.26)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C156(1.05)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C156(0.98)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C156(1.09)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C77(1.35)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C77(1.09)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C77(1.06)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C156(1.30)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C156(0.97)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C156(1.07)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C156(1.10)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C77(1.32)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C156(1.09)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C156(1.10)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C156(1.08)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C156(1.11)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C156(1.16)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C156(1.20)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C156(1.22)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C156(1.18)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C156(1.31)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C156(1.22)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C77(1.04)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C156(1.03)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C77(1.02)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C77(1.33)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C77(1.83)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C77(1.48)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C77(1.80)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C77(1.41)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C77(1.68)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C77(1.75)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C77(1.09)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C77(1.80)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C77(1.27)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C77(2.15)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C77(1.74)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C77(1.91)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C77(1.63)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C77(1.10); C156(1.03)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C77(1.48); C156(0.87)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C77(1.47); C156(0.97)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C77(0.89); C156(0.98)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C77(1.07)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C77(0.95); C156(0.89)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C77(1.45); C156(0.93)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C77(1.50); C156(1.13)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C77(0.96); C156(0.96)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C77(1.22); C156(1.08)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C77(1.14); C156(0.90)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C77(0.77); C156(0.81)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C77(1.13); C156(0.90)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C77(1.20); C156(1.09)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C77(1.05); C156(0.88)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C77(1.12)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C77(1.67); C156(0.87)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C156(0.77)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C156(0.82)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C156(0.88)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C156(0.90)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C156(0.64)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C156(0.72)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C156(0.88)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C156(0.65)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C156(0.75)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C77(1.21)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C156(0.75)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C156(0.68)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C156(0.85)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C156(0.71)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C156(0.76)  LDD0784  [3]
 LDCM0469  CL76 PaTu 8988t C77(1.17)  LDD1348  [3]
 LDCM0470  CL77 PaTu 8988t C77(0.95)  LDD1349  [3]
 LDCM0471  CL78 PaTu 8988t C77(1.42)  LDD1350  [3]
 LDCM0472  CL79 PaTu 8988t C77(1.33)  LDD1351  [3]
 LDCM0473  CL8 HCT 116 C77(1.23)  LDD0790  [3]
 LDCM0474  CL80 PaTu 8988t C77(1.36)  LDD1353  [3]
 LDCM0475  CL81 PaTu 8988t C77(1.38)  LDD1354  [3]
 LDCM0476  CL82 PaTu 8988t C77(1.54)  LDD1355  [3]
 LDCM0477  CL83 PaTu 8988t C77(1.48)  LDD1356  [3]
 LDCM0478  CL84 PaTu 8988t C77(1.39)  LDD1357  [3]
 LDCM0479  CL85 PaTu 8988t C77(1.18)  LDD1358  [3]
 LDCM0480  CL86 PaTu 8988t C77(1.35)  LDD1359  [3]
 LDCM0481  CL87 PaTu 8988t C77(1.72)  LDD1360  [3]
 LDCM0482  CL88 PaTu 8988t C77(1.53)  LDD1361  [3]
 LDCM0483  CL89 PaTu 8988t C77(1.52)  LDD1362  [3]
 LDCM0484  CL9 HCT 116 C77(1.11)  LDD0801  [3]
 LDCM0485  CL90 PaTu 8988t C77(1.56)  LDD1364  [3]
 LDCM0486  CL91 HEK-293T C77(1.31)  LDD1084  [3]
 LDCM0487  CL92 HEK-293T C77(1.65)  LDD1085  [3]
 LDCM0488  CL93 HEK-293T C77(0.95)  LDD1086  [3]
 LDCM0489  CL94 HEK-293T C77(1.50)  LDD1087  [3]
 LDCM0490  CL95 HEK-293T C77(1.58)  LDD1088  [3]
 LDCM0491  CL96 HEK-293T C77(2.42)  LDD1089  [3]
 LDCM0492  CL97 HEK-293T C77(2.24)  LDD1090  [3]
 LDCM0493  CL98 HEK-293T C77(1.23)  LDD1091  [3]
 LDCM0494  CL99 HEK-293T C77(0.79)  LDD1092  [3]
 LDCM0495  E2913 HEK-293T C156(1.09)  LDD1698  [8]
 LDCM0468  Fragment33 HCT 116 C156(0.76)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C77(2.32)  LDD0744  [3]
 LDCM0022  KB02 HCT 116 C77(1.70)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C77(1.27)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C77(1.36)  LDD0082  [3]
 LDCM0627  NUDT7-COV-1 HEK-293T C278(0.94)  LDD2206  [2]
 LDCM0014  Panhematin HEK-293T 3.63  LDD0062  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Inactive Ufm1-specific protease 1 (UFSP1) Peptidase C78 family Q6NVU6
Proteasome subunit beta type-11 (PSMB11) Peptidase T1B family A5LHX3
Group 10 secretory phospholipase A2 (PLA2G10) Phospholipase A2 family O15496
Putative serine/threonine-protein kinase SIK1B (SIK1B) CAMK Ser/Thr protein kinase family A0A0B4J2F2
Protein-tyrosine kinase 6 (PTK6) Tyr protein kinase family Q13882
Tyrosine-protein kinase transmembrane receptor ROR2 (ROR2) Tyr protein kinase family Q01974
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
E3 ubiquitin-protein ligase DZIP3 (DZIP3) . Q86Y13
Methyltransferase-like protein 27 (METTL27) . Q8N6F8
Secretion-regulating guanine nucleotide exchange factor (SERGEF) . Q9UGK8
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Importin-13 (IPO13) Importin beta family O94829
Solute carrier family 15 member 2 (SLC15A2) Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family Q16348
MyoD family inhibitor (MDFI) MDFI family Q99750
Phospholipid scramblase 3 (PLSCR3) Phospholipid scramblase family Q9NRY6
Transcription factor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Transcription factor AP-2-delta (TFAP2D) AP-2 family Q7Z6R9
Homeobox protein MSX-2 (MSX2) Msh homeobox family P35548
AT-rich interactive domain-containing protein 5A (ARID5A) . Q03989
T-box transcription factor TBX19 (TBX19) . O60806
T-box transcription factor TBX22 (TBX22) . Q9Y458
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) CEA family P40199
Other
Click To Hide/Show 32 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
A-kinase anchor protein 8-like (AKAP8L) AKAP95 family Q9ULX6
BPI fold-containing family A member 1 (BPIFA1) Plunc family Q9NP55
Cilia- and flagella-associated protein 68 (CFAP68) CFAP68 family Q9H5F2
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997
EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2) Fibulin family O95967
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin, type II cuticular Hb3 (KRT83) Intermediate filament family P78385
Keratin-associated protein 19-5 (KRTAP19-5) KRTAP type 19 family Q3LI72
Keratin-associated protein 19-7 (KRTAP19-7) KRTAP type 19 family Q3SYF9
Keratin-associated protein 3-3 (KRTAP3-3) KRTAP type 3 family Q9BYR6
Keratin-associated protein 6-1 (KRTAP6-1) KRTAP type 6 family Q3LI64
Keratin-associated protein 6-2 (KRTAP6-2) KRTAP type 6 family Q3LI66
Keratin-associated protein 7-1 (KRTAP7-1) KRTAP type 7 family Q8IUC3
Keratin-associated protein 8-1 (KRTAP8-1) KRTAP type 8 family Q8IUC2
Myozenin-3 (MYOZ3) Myozenin family Q8TDC0
Keratin-associated protein 13-2 (KRTAP13-2) PMG family Q52LG2
Keratin-associated protein 26-1 (KRTAP26-1) PMG family Q6PEX3
Prefoldin subunit 5 (PFDN5) Prefoldin subunit alpha family Q99471
Proline-rich protein 20D (PRR20D) PRR20 family P86480
Plasminogen activator inhibitor 1 (SERPINE1) Serpin family P05121
Tektin-5 (TEKT5) Tektin family Q96M29
Kelch-like protein 26 (KLHL26) . Q53HC5
Melanoma-associated antigen D1 (MAGED1) . Q9Y5V3
NHL-repeat-containing protein 4 (NHLRC4) . P0CG21
Pleckstrin homology domain-containing family B member 2 (PLEKHB2) . Q96CS7
RNA-binding protein with multiple splicing (RBPMS) . Q93062
Saitohin (STH) . Q8IWL8
TNF receptor-associated factor 1 (TRAF1) . Q13077
TP53-binding protein 1 (TP53BP1) . Q12888
Uncharacterized protein C10orf55 (C10orf55) . Q5SWW7

References

1 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
2 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402