Details of the Target

General Information of Target

Target ID LDTP01645
Target Name Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1)
Gene Name NFATC1
Gene ID 4772
Synonyms
NFAT2; NFATC; Nuclear factor of activated T-cells, cytoplasmic 1; NF-ATc1; NFATc1; NFAT transcription complex cytosolic component; NF-ATc; NFATc
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPSTSFPVPSKFPLGPAAAVFGRGETLGPAPRAGGTMKSAEEEHYGYASSNVSPALPLPT
AHSTLPAPCHNLQTSTPGIIPPADHPSGYGAALDGGPAGYFLSSGHTRPDGAPALESPRI
EITSCLGLYHNNNQFFHDVEVEDVLPSSKRSPSTATLSLPSLEAYRDPSCLSPASSLSSR
SCNSEASSYESNYSYPYASPQTSPWQSPCVSPKTTDPEEGFPRGLGACTLLGSPRHSPST
SPRASVTEESWLGARSSRPASPCNKRKYSLNGRQPPYSPHHSPTPSPHGSPRVSVTDDSW
LGNTTQYTSSAIVAAINALTTDSSLDLGDGVPVKSRKTTLEQPPSVALKVEPVGEDLGSP
PPPADFAPEDYSSFQHIRKGGFCDQYLAVPQHPYQWAKPKPLSPTSYMSPTLPALDWQLP
SHSGPYELRIEVQPKSHHRAHYETEGSRGAVKASAGGHPIVQLHGYLENEPLMLQLFIGT
ADDRLLRPHAFYQVHRITGKTVSTTSHEAILSNTKVLEIPLLPENSMRAVIDCAGILKLR
NSDIELRKGETDIGRKNTRVRLVFRVHVPQPSGRTLSLQVASNPIECSQRSAQELPLVEK
QSTDSYPVVGGKKMVLSGHNFLQDSKVIFVEKAPDGHHVWEMEAKTDRDLCKPNSLVVEI
PPFRNQRITSPVHVSFYVCNGKRKRSQYQRFTYLPANVPIIKTEPTDDYEPAPTCGPVSQ
GLSPLPRPYYSQQLAMPPDPSSCLVAGFPPCPQRSTLMPAAPGVSPKLHDLSPAAYTKGV
ASPGHCHLGLPQPAGEAPAVQDVPRPVATHPGSPGQPPPALLPQQVSAPPSSSCPPGLEH
SLCPSSPSPPLPPATQEPTCLQPCSPACPPATGRPQHLPSTVRRDESPTAGPRLLPEVHE
DGSPNLAPIPVTVKREPEELDQLYLDDVNEIIRNDLSSTSTHS
Target Bioclass
Transcription factor
Subcellular location
Cytoplasm
Function
Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells. Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function.
Uniprot ID
O95644
Ensemble ID
ENST00000253506.9
HGNC ID
HGNC:7775
ChEMBL ID
CHEMBL3876

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.Y45Ter .
A375 SNV: p.P287S .
CAL72 Substitution: p.G35D .
HCC827 SNV: p.S512F .
HCT15 SNV: p.P16S .
HT SNV: p.Q824R; p.S903G DBIA    Probe Info 
IGROV1 Deletion: p.E550DfsTer97 .
IPC298 SNV: p.S207F .
JHH4 SNV: p.S675G .
LS180 SNV: p.W417Ter .
NCIH1155 SNV: p.A314V .
NCIH2172 SNV: p.S831I .
NCIH2286 SNV: p.P413H DBIA    Probe Info 
NCIH358 SNV: p.P7T .
NCIH446 SNV: p.C751F .
NUGC3 SNV: p.A854T .
RKO SNV: p.Y407C .
RPMI7951 SNV: p.R555G; p.K556R DBIA    Probe Info 
SKES1 SNV: p.E599D DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		C383(0.91)  LDD2227  [1]
HPAP
 Probe Info  		3.56  LDD0062  [2]
IA-alkyne
 Probe Info  		C383(8.69); C228(15.89); C679(19.15); C263(9.36)  LDD1704  [3]
DBIA
 Probe Info  		C383(1.51)  LDD0531  [4]
IPM
 Probe Info  		C228(0.00); C263(0.00); C170(0.00); C715(0.00)  LDD2156  [5]
VSF
 Probe Info  		C228(0.00); C170(0.00)  LDD0007  [6]
AOyne
 Probe Info  		15.00  LDD0443  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C383(1.51)  LDD0531  [4]
 LDCM0215  AC10 HEK-293T C263(1.26); C383(0.86)  LDD1508  [8]
 LDCM0216  AC100 HCT 116 C383(1.04)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C383(1.36)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C383(1.37)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C383(1.34)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C383(1.38)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C383(1.49)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C383(1.36)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C383(1.46)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C383(1.22)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C383(1.17)  LDD0542  [4]
 LDCM0226  AC11 HEK-293T C263(1.14); C228(1.02)  LDD1509  [8]
 LDCM0227  AC110 HCT 116 C383(1.15)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C383(1.32)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C383(1.57)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C383(0.92)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C383(0.92)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C383(1.09)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C383(1.21)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C383(0.94)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C383(1.04)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C383(1.49)  LDD0553  [4]
 LDCM0237  AC12 HEK-293T C263(1.02); C228(0.97); C383(1.00); C587(1.01)  LDD1510  [8]
 LDCM0238  AC120 HCT 116 C383(1.06)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C383(0.77)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C383(1.04)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C383(1.01)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C383(1.25)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C383(0.93)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C383(0.99)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C383(1.06)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C383(1.12)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C383(1.27)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C383(1.31)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C383(0.96)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C383(1.01)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C383(1.54)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C383(1.32)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C383(1.70)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C383(1.15)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C383(1.27)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C383(1.50)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C383(1.03)  LDD0575  [4]
 LDCM0259  AC14 HEK-293T C263(1.08)  LDD1512  [8]
 LDCM0260  AC140 HCT 116 C383(1.40)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C383(1.20)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C383(1.10)  LDD0579  [4]
 LDCM0263  AC143 HEK-293T C383(1.15)  LDD0861  [4]
 LDCM0264  AC144 HEK-293T C383(1.45)  LDD0862  [4]
 LDCM0265  AC145 HEK-293T C383(1.26)  LDD0863  [4]
 LDCM0266  AC146 HEK-293T C383(1.34)  LDD0864  [4]
 LDCM0267  AC147 HEK-293T C383(1.73)  LDD0865  [4]
 LDCM0268  AC148 HEK-293T C383(1.34)  LDD0866  [4]
 LDCM0269  AC149 HEK-293T C383(1.00)  LDD0867  [4]
 LDCM0270  AC15 HEK-293T C263(1.08)  LDD1513  [8]
 LDCM0271  AC150 HEK-293T C383(1.19)  LDD0869  [4]
 LDCM0272  AC151 HEK-293T C383(1.40)  LDD0870  [4]
 LDCM0273  AC152 HEK-293T C383(1.26)  LDD0871  [4]
 LDCM0274  AC153 HEK-293T C383(1.14)  LDD0872  [4]
 LDCM0621  AC154 HEK-293T C383(1.10)  LDD2162  [4]
 LDCM0622  AC155 HEK-293T C383(1.33)  LDD2163  [4]
 LDCM0623  AC156 HEK-293T C383(1.48)  LDD2164  [4]
 LDCM0624  AC157 HEK-293T C383(1.95)  LDD2165  [4]
 LDCM0276  AC17 HCT 116 C383(1.21)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C383(2.63)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C383(1.57)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C383(0.98)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C383(1.86)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C383(1.46)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C383(1.75)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C383(1.77)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C383(1.21)  LDD0601  [4]
 LDCM0286  AC26 HEK-293T C263(1.26); C383(0.98)  LDD1525  [8]
 LDCM0287  AC27 HEK-293T C263(1.11); C228(1.02)  LDD1526  [8]
 LDCM0288  AC28 HEK-293T C263(1.11); C228(1.19); C383(1.13); C587(0.73)  LDD1527  [8]
 LDCM0289  AC29 HEK-293T C533(0.85)  LDD1528  [8]
 LDCM0290  AC3 HCT 116 C383(1.20)  LDD0607  [4]
 LDCM0291  AC30 HEK-293T C263(1.08)  LDD1530  [8]
 LDCM0292  AC31 HEK-293T C263(0.97)  LDD1531  [8]
 LDCM0293  AC32 HEK-293T C263(0.90)  LDD1532  [8]
 LDCM0295  AC34 HEK-293T C263(1.27); C383(1.15)  LDD1534  [8]
 LDCM0296  AC35 HCT 116 C383(0.81)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C383(0.82)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C383(0.96)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C383(1.12)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C383(1.05)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C383(1.65)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C383(0.82)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C383(1.14)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C383(1.11)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C383(0.91)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C383(1.07)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C383(0.81)  LDD0624  [4]
 LDCM0308  AC46 HEK-293T C383(1.02)  LDD0906  [4]
 LDCM0309  AC47 HEK-293T C383(1.08)  LDD0907  [4]
 LDCM0310  AC48 HEK-293T C383(1.07)  LDD0908  [4]
 LDCM0311  AC49 HEK-293T C383(1.07)  LDD0909  [4]
 LDCM0312  AC5 HCT 116 C383(1.62)  LDD0629  [4]
 LDCM0313  AC50 HEK-293T C383(0.88)  LDD0911  [4]
 LDCM0314  AC51 HEK-293T C383(1.20)  LDD0912  [4]
 LDCM0315  AC52 HEK-293T C383(1.04)  LDD0913  [4]
 LDCM0316  AC53 HEK-293T C383(0.89)  LDD0914  [4]
 LDCM0317  AC54 HEK-293T C383(1.00)  LDD0915  [4]
 LDCM0318  AC55 HEK-293T C383(1.09)  LDD0916  [4]
 LDCM0319  AC56 HEK-293T C383(1.07)  LDD0917  [4]
 LDCM0320  AC57 HEK-293T C383(1.23)  LDD0918  [4]
 LDCM0321  AC58 HEK-293T C383(1.21)  LDD0919  [4]
 LDCM0322  AC59 HEK-293T C383(1.01)  LDD0920  [4]
 LDCM0323  AC6 HEK-293T C263(0.99)  LDD1562  [8]
 LDCM0324  AC60 HEK-293T C383(1.11)  LDD0922  [4]
 LDCM0325  AC61 HEK-293T C383(1.37)  LDD0923  [4]
 LDCM0326  AC62 HEK-293T C383(1.05)  LDD0924  [4]
 LDCM0327  AC63 HEK-293T C383(1.11)  LDD0925  [4]
 LDCM0328  AC64 HEK-293T C383(1.01)  LDD0926  [4]
 LDCM0329  AC65 HEK-293T C383(1.19)  LDD0927  [4]
 LDCM0330  AC66 HEK-293T C383(1.09)  LDD0928  [4]
 LDCM0331  AC67 HEK-293T C383(1.29)  LDD0929  [4]
 LDCM0334  AC7 HEK-293T C263(1.04)  LDD1568  [8]
 LDCM0345  AC8 HEK-293T C263(0.70)  LDD1569  [8]
 LDCM0365  AC98 HCT 116 C383(1.25)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C383(2.12)  LDD0683  [4]
 LDCM0248  AKOS034007472 HEK-293T C533(0.91)  LDD1511  [8]
 LDCM0275  AKOS034007705 HEK-293T C263(0.85)  LDD1514  [8]
 LDCM0020  ARS-1620 HCC44 C182(1.09); C209(1.09)  LDD2171  [4]
 LDCM0632  CL-Sc Hep-G2 C383(0.91)  LDD2227  [1]
 LDCM0368  CL10 HEK-293T C263(0.88)  LDD1572  [8]
 LDCM0369  CL100 HCT 116 C383(1.07)  LDD0686  [4]
 LDCM0372  CL103 HEK-293T C263(0.94)  LDD1576  [8]
 LDCM0374  CL105 HCT 116 C383(1.72)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C383(1.57)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C383(2.11)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C383(2.14)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C383(1.64)  LDD0695  [4]
 LDCM0379  CL11 HEK-293T C263(0.72)  LDD1583  [8]
 LDCM0380  CL110 HCT 116 C383(1.68)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C383(1.43)  LDD0698  [4]
 LDCM0385  CL115 HEK-293T C263(0.95)  LDD1589  [8]
 LDCM0387  CL117 HCT 116 C383(1.02)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C383(0.98)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C383(0.87)  LDD0706  [4]
 LDCM0390  CL12 HEK-293T C263(0.62)  LDD1594  [8]
 LDCM0391  CL120 HCT 116 C383(0.96)  LDD0708  [4]
 LDCM0392  CL121 HEK-293T C383(1.19)  LDD0990  [4]
 LDCM0393  CL122 HEK-293T C383(1.04)  LDD0991  [4]
 LDCM0394  CL123 HEK-293T C383(0.86)  LDD0992  [4]
 LDCM0395  CL124 HEK-293T C383(1.07)  LDD0993  [4]
 LDCM0396  CL125 HEK-293T C383(1.09)  LDD0994  [4]
 LDCM0397  CL126 HEK-293T C383(1.02)  LDD0995  [4]
 LDCM0398  CL127 HEK-293T C383(1.07)  LDD0996  [4]
 LDCM0399  CL128 HEK-293T C383(1.04)  LDD0997  [4]
 LDCM0402  CL15 HEK-293T C263(0.93)  LDD1606  [8]
 LDCM0404  CL17 HCT 116 C383(1.06)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C383(0.68)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C383(1.26)  LDD0723  [4]
 LDCM0408  CL20 HCT 116 C383(1.17)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C383(1.24)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C383(1.09)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C383(1.33)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C383(1.12)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C383(0.79)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C383(1.19)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C383(1.04)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C383(0.98)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C383(1.32)  LDD0734  [4]
 LDCM0418  CL3 HEK-293T C263(0.91)  LDD1622  [8]
 LDCM0419  CL30 HCT 116 C383(1.38)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C383(1.01)  LDD0737  [4]
 LDCM0421  CL32 HEK-293T C263(0.84); C228(1.44); C383(0.95); C587(0.88)  LDD1625  [8]
 LDCM0422  CL33 HEK-293T C533(0.90)  LDD1626  [8]
 LDCM0423  CL34 HEK-293T C263(0.65)  LDD1627  [8]
 LDCM0424  CL35 HEK-293T C263(0.68)  LDD1628  [8]
 LDCM0425  CL36 HEK-293T C263(0.73)  LDD1629  [8]
 LDCM0428  CL39 HEK-293T C263(1.23)  LDD1632  [8]
 LDCM0432  CL42 HEK-293T C263(1.12); C383(0.96)  LDD1636  [8]
 LDCM0433  CL43 HEK-293T C263(1.03); C228(1.15)  LDD1637  [8]
 LDCM0434  CL44 HEK-293T C263(0.95); C228(0.85); C383(1.03); C587(0.76)  LDD1638  [8]
 LDCM0435  CL45 HEK-293T C533(0.99)  LDD1639  [8]
 LDCM0436  CL46 HEK-293T C263(0.83)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C263(0.73)  LDD1641  [8]
 LDCM0438  CL48 HEK-293T C263(0.75)  LDD1642  [8]
 LDCM0445  CL54 HEK-293T C263(1.17); C383(1.00)  LDD1648  [8]
 LDCM0446  CL55 HEK-293T C263(1.01); C228(1.09)  LDD1649  [8]
 LDCM0447  CL56 HEK-293T C263(0.86); C228(1.07); C383(1.01); C587(0.98)  LDD1650  [8]
 LDCM0448  CL57 HEK-293T C533(0.97)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C263(0.88)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C263(0.79)  LDD1653  [8]
 LDCM0451  CL6 HEK-293T C263(1.26); C383(1.23)  LDD1654  [8]
 LDCM0452  CL60 HEK-293T C263(0.80)  LDD1655  [8]
 LDCM0455  CL63 HEK-293T C263(1.04)  LDD1658  [8]
 LDCM0458  CL66 HEK-293T C263(1.20); C383(1.09)  LDD1661  [8]
 LDCM0459  CL67 HEK-293T C263(1.02); C228(1.12)  LDD1662  [8]
 LDCM0460  CL68 HEK-293T C263(0.86); C228(1.10); C383(0.94); C587(0.92)  LDD1663  [8]
 LDCM0461  CL69 HEK-293T C533(0.92)  LDD1664  [8]
 LDCM0462  CL7 HEK-293T C263(1.06); C228(1.22)  LDD1665  [8]
 LDCM0463  CL70 HEK-293T C263(0.82)  LDD1666  [8]
 LDCM0464  CL71 HEK-293T C263(0.78)  LDD1667  [8]
 LDCM0465  CL72 HEK-293T C263(0.83)  LDD1668  [8]
 LDCM0469  CL76 HCT 116 C383(0.88)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C383(0.88)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C383(1.33)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C383(0.91)  LDD0789  [4]
 LDCM0473  CL8 HEK-293T C263(0.86); C228(1.17); C383(1.13); C587(0.83)  LDD1676  [8]
 LDCM0474  CL80 HCT 116 C383(0.82)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C383(1.23)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C383(1.20)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C383(0.84)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C383(0.88)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C383(0.76)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C383(0.77)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C383(0.68)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C383(0.72)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C383(0.81)  LDD0800  [4]
 LDCM0484  CL9 HEK-293T C533(1.07)  LDD1687  [8]
 LDCM0485  CL90 HCT 116 C383(1.03)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C383(1.20)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C383(1.42)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C383(1.43)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C383(1.25)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C383(1.84)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C383(1.10)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C383(1.62)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C383(1.32)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C383(1.28)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C263(1.17)  LDD1698  [8]
 LDCM0625  F8 Ramos C228(1.07)  LDD2187  [9]
 LDCM0573  Fragment11 Ramos C228(1.94)  LDD2190  [9]
 LDCM0574  Fragment12 Ramos C228(1.12)  LDD2191  [9]
 LDCM0576  Fragment14 Ramos C228(0.98)  LDD2193  [9]
 LDCM0580  Fragment21 Ramos C228(0.97)  LDD2195  [9]
 LDCM0586  Fragment28 Ramos C228(1.10)  LDD2198  [9]
 LDCM0588  Fragment30 Ramos C228(1.11)  LDD2199  [9]
 LDCM0468  Fragment33 HEK-293T C263(1.10)  LDD1671  [8]
 LDCM0596  Fragment38 Ramos C228(0.77)  LDD2203  [9]
 LDCM0022  KB02 T cell-activated C383(8.69); C228(15.89); C679(19.15); C263(9.36)  LDD1704  [3]
 LDCM0023  KB03 Ramos C228(1.43)  LDD2183  [9]
 LDCM0024  KB05 MKN-1 C61(2.74)  LDD3331  [10]
 LDCM0014  Panhematin HEK-293T 3.56  LDD0062  [2]
 LDCM0021  THZ1 HCT 116 C182(1.09); C209(1.09)  LDD2173  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT) Glycosyltransferase 41 family O15294
Transcription factor
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-C13 (HOXC13) Abd-B homeobox family P31276
Cyclic AMP-responsive element-binding protein 1 (CREB1) BZIP family P16220
Cyclic AMP-dependent transcription factor ATF-1 (ATF1) BZIP family P18846
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) BZIP family P18847
Transcription factor Jun (JUN) BZIP family P05412
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-dependent transcription factor ATF-2 (ATF2) BZIP family P15336

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pseudoephedrine Small molecular drug DB00852

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
2 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
3 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
10 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840