Details of the Target

General Information of Target

Target ID LDTP11258
Target Name TNF receptor-associated factor 4 (TRAF4)
Gene Name TRAF4
Gene ID 9618
Synonyms
CART1; MLN62; RNF83; TNF receptor-associated factor 4; EC 2.3.2.27; Cysteine-rich domain associated with RING and Traf domains protein 1; Metastatic lymph node gene 62 protein; MLN 62; RING finger protein 83
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAADLSHGHYLSGDPVCLHEEKTPAGRIVADCLTDCYQDSVTFDDVAVDFTQEEWTLLD
STQRSLYSDVMLENYKNLATVGGQIIKPSLISWLEQEESRTVQGGVLQGWEMRLETQWSI
LQQDFLRGQTSIGIQLEGKHNGRELCDCEQCGEVFSEHSCLKTHVRTQSTGNTHDCNQYG
KDFLTLCEKTSTGEKLSEFNQSEKIFSLTPNIVYQRTSTQEKSFECSHCGKSFINESYLQ
AHMRTHNGEKLYEWRNYGPGFIDSTSLSVLIETLNAKKPYKCKECGKGYRYPAYLSIHMR
THTGEKPYECKECGKAFNYSNSFQIHGRTHTGEKPYVCKECGKAFTQYSGLSMHVRSHSG
DKPYECKECGKSFLTSSRLIQHIRTHTGEKPFVCVECGKAFAVSSNLSGHLRTHTEEKAC
ECKICGKVFGYPSCLNNHMRTHSAQKPYTCKECGKAFNYSTHLKIHMRIHTGEKPYECKQ
CGKAFSHSSSFQIHERTHTGEKPYECKECGKAFTCSSSFRIHEKTHTEEKPYKCQQCGKA
YSHPRSLRRHEQIH
Target Bioclass
Enzyme
Family
TNF receptor-associated factor family, B subfamily
Subcellular location
Cytoplasm
Function
Adapter protein with E3 ligase activity that is involved in many diverse biological processes including cell proliferation, migration, differentiation, DNA repair, platelet activation or apoptosis. Promotes EGFR-mediated signaling by facilitating the dimerization of EGFR and downstream AKT activation thereby promoting cell proliferation. Ubiquitinates SMURF2 through 'Lys-48'-linked ubiquitin chain leading to SMURF2 degradation through the proteasome and subsequently osteogenic differentiation. Promotes 'Lys-63'-mediated ubiquitination of CHK1 which in turn activates cell cycle arrest and activation of DNA repair. In addition, promotes an atypical 'Lys-29'-linked ubiquitination at the C-terminal end of IRS1 which is crucial for insulin-like growth factor (IGF) signal transduction. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract. Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions. Inhibits adipogenic differentiation by activating pyruvate kinase PKM activity and subsequently the beta-catenin signaling pathway.
Uniprot ID
Q9BUZ4
Ensemble ID
ENST00000262395.10
HGNC ID
HGNC:12034

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.R137W; p.S273N DBIA    Probe Info 
AN3CA SNV: p.R137W .
DU145 Insertion: p.C39LfsTer11 .
HS936T SNV: p.H98Y .
HT115 SNV: p.Q75H .
MKN1 SNV: p.W414G DBIA    Probe Info 
MOLT4 SNV: p.L249H .
U937 SNV: p.E88Ter .
VCAP SNV: p.R448Q DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C83(0.00); C90(0.00)  LDD0241  [1]
HPAP
 Probe Info  		3.03  LDD0063  [2]
DBIA
 Probe Info  		C83(1.52); C90(1.52)  LDD0080  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [4]
NAIA_5
 Probe Info  		N.A.  LDD2223  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0230  AC113 HEK-293T C243(1.62); C90(1.62)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C243(1.27); C90(1.27)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C243(0.91); C90(0.91)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C243(0.83); C90(0.83)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C243(0.89); C90(0.89)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C243(0.65); C90(0.65)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C243(0.88); C90(0.88)  LDD0834  [3]
 LDCM0238  AC120 HEK-293T C243(0.75); C90(0.75)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C243(0.78); C90(0.78)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C243(0.53); C90(0.53)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C243(0.84); C90(0.84)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C243(0.72); C90(0.72)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C243(0.73); C90(0.73)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C243(0.71); C90(0.71)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C243(0.70); C90(0.70)  LDD0843  [3]
 LDCM0263  AC143 HEK-293T C243(1.32); C90(1.32)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C243(0.70); C90(0.70)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C243(0.76); C90(0.76)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C243(0.74); C90(0.74)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C243(0.93); C90(0.93)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C243(0.99); C90(0.99)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C243(1.08); C90(1.08)  LDD0867  [3]
 LDCM0271  AC150 HEK-293T C243(0.77); C90(0.77)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C243(0.94); C90(0.94)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C243(0.77); C90(0.77)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C243(0.80); C90(0.80)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C243(0.97); C90(0.97)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C243(0.81); C90(0.81)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C243(0.81); C90(0.81)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C243(0.89); C90(0.89)  LDD2165  [3]
 LDCM0276  AC17 HCT 116 C83(0.86); C90(0.86)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C83(1.43); C90(1.43)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C83(1.17); C90(1.17)  LDD0595  [3]
 LDCM0280  AC20 HCT 116 C83(1.01); C90(1.01)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C83(1.04); C90(1.04)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C83(1.16); C90(1.16)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C83(0.74); C90(0.74)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C83(0.80); C90(0.80)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C243(0.88); C250(0.88)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C243(0.93); C250(0.93)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C243(0.90); C250(0.90)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C243(0.90); C250(0.90)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C243(1.17); C250(1.17)  LDD0606  [3]
 LDCM0291  AC30 HCT 116 C243(1.05); C250(1.05)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C243(1.11); C250(1.11)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C243(0.91); C250(0.91)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C243(1.03); C250(1.03)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C243(0.85); C250(0.85)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C83(0.78); C90(0.78)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C83(1.03); C90(1.03)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C83(1.01); C90(1.01)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C83(0.93); C90(0.93)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C83(0.89); C90(0.89)  LDD0617  [3]
 LDCM0302  AC40 HCT 116 C83(1.23); C90(1.23)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C83(0.96); C90(0.96)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C83(0.82); C90(0.82)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C83(1.09); C90(1.09)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C83(1.18); C90(1.18)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C83(1.07); C90(1.07)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C83(0.91); C90(0.91)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C83(0.94); C90(0.94)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C83(0.94); C90(0.94)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C83(1.33); C90(1.33)  LDD0628  [3]
 LDCM0313  AC50 HCT 116 C83(1.31); C90(1.31)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C83(0.82); C90(0.82)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C83(1.01); C90(1.01)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C83(1.06); C90(1.06)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C83(1.13); C90(1.13)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C83(1.37); C90(1.37)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C83(1.62); C90(1.62)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C243(0.71); C250(0.71); C83(1.25); C90(1.25)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C243(0.74); C250(0.74); C83(1.11); C90(1.11)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C243(0.71); C250(0.71); C83(1.29); C90(1.29)  LDD0639  [3]
 LDCM0324  AC60 HCT 116 C243(0.84); C250(0.84); C83(1.14); C90(1.14)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C243(0.91); C250(0.91); C83(1.00); C90(1.00)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C243(0.58); C250(0.58); C83(1.05); C90(1.05)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C243(0.73); C250(0.73); C83(1.18); C90(1.18)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C243(0.64); C250(0.64); C83(1.26); C90(1.26)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C243(0.90); C250(0.90); C83(1.02); C90(1.02)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C243(0.88); C250(0.88); C83(1.06); C90(1.06)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C243(0.50); C250(0.50); C83(1.10); C90(1.10)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C83(1.04); C90(1.04)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C83(1.14); C90(1.14)  LDD0650  [3]
 LDCM0335  AC70 HCT 116 C83(1.05); C90(1.05)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C83(0.88); C90(0.88)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C83(0.95); C90(0.95)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C83(1.47); C90(1.47)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C83(1.16); C90(1.16)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C83(1.41); C90(1.41)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C83(1.03); C90(1.03)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C83(1.16); C90(1.16)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C83(0.80); C90(0.80)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C83(0.84); C90(0.84)  LDD0661  [3]
 LDCM0346  AC80 HCT 116 C83(0.93); C90(0.93)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C83(0.85); C90(0.85)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C83(1.08); C90(1.08)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C83(1.50); C90(1.50)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C83(1.43); C90(1.43)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C83(1.12); C90(1.12)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C83(1.17); C90(1.17)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C83(1.05); C90(1.05)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C83(1.21); C90(1.21)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C83(1.52); C90(1.52)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C83(1.39); C90(1.39)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C83(1.62); C90(1.62)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C83(1.54); C90(1.54)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C83(1.25); C90(1.25)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C83(1.17); C90(1.17)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C83(1.10); C90(1.10)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C83(1.25); C90(1.25)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C83(1.41); C90(1.41)  LDD0681  [3]
 LDCM0020  ARS-1620 HCC44 C83(1.35); C90(1.35); C243(1.66); C250(1.66)  LDD2171  [3]
 LDCM0374  CL105 HCT 116 C83(1.11); C90(1.11)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C83(1.19); C90(1.19)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C83(1.00); C90(1.00)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C83(1.60); C90(1.60)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C83(1.13); C90(1.13)  LDD0695  [3]
 LDCM0380  CL110 HCT 116 C83(1.07); C90(1.07)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C83(0.91); C90(0.91)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C243(0.85); C250(0.85)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C243(0.88); C250(0.88)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C243(0.77); C250(0.77)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C243(1.12); C250(1.12)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C243(0.94); C250(0.94)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C83(1.48); C90(1.48)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C83(1.07); C90(1.07)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C83(1.06); C90(1.06)  LDD0706  [3]
 LDCM0391  CL120 HCT 116 C83(1.23); C90(1.23)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C83(1.39); C90(1.39)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C83(0.94); C90(0.94)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C83(0.94); C90(0.94)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C83(1.05); C90(1.05)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C243(0.89); C250(0.89); C83(0.98); C90(0.98)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C243(0.56); C250(0.56); C83(0.91); C90(0.91)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C243(0.83); C250(0.83); C83(0.92); C90(0.92)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C243(0.81); C250(0.81); C83(1.47); C90(1.47)  LDD0716  [3]
 LDCM0403  CL16 HCT 116 C83(1.21); C90(1.21)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C83(0.92); C90(0.92)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C83(1.01); C90(1.01)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C83(0.95); C90(0.95)  LDD0723  [3]
 LDCM0408  CL20 HCT 116 C83(1.10); C90(1.10)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C83(1.03); C90(1.03)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C83(0.99); C90(0.99)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C83(0.98); C90(0.98)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C83(1.14); C90(1.14)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C83(1.02); C90(1.02)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C83(1.06); C90(1.06)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C83(1.17); C90(1.17)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C83(1.33); C90(1.33)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C83(1.18); C90(1.18)  LDD0734  [3]
 LDCM0419  CL30 HCT 116 C83(1.21); C90(1.21)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C83(1.09); C90(1.09)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C83(0.93); C90(0.93)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C83(0.79); C90(0.79)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C83(1.02); C90(1.02)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C83(1.21); C90(1.21)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C83(1.08); C90(1.08)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C83(1.19); C90(1.19)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C83(1.00); C90(1.00)  LDD0745  [3]
 LDCM0430  CL40 HCT 116 C83(1.11); C90(1.11)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C83(0.88); C90(0.88)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C83(0.85); C90(0.85)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C83(0.96); C90(0.96)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C83(1.42); C90(1.42)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C83(1.13); C90(1.13)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C243(0.92); C250(0.92); C83(0.98); C90(0.98)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C243(1.02); C250(1.02); C83(1.01); C90(1.01)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C243(1.01); C250(1.01); C83(0.87); C90(0.87)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C243(1.05); C250(1.05); C83(0.96); C90(0.96)  LDD0756  [3]
 LDCM0441  CL50 HCT 116 C243(0.94); C250(0.94); C83(0.89); C90(0.89)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C243(1.11); C250(1.11); C83(0.95); C90(0.95)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C243(1.16); C250(1.16); C83(0.78); C90(0.78)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C243(0.92); C250(0.92); C83(0.82); C90(0.82)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C243(1.00); C250(1.00); C83(0.95); C90(0.95)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C243(1.10); C250(1.10); C83(0.90); C90(0.90)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C243(1.07); C250(1.07); C83(1.06); C90(1.06)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C243(0.97); C250(0.97); C83(0.87); C90(0.87)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C243(1.02); C250(1.02); C83(1.08); C90(1.08)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C243(1.06); C250(1.06); C83(0.93); C90(0.93)  LDD0767  [3]
 LDCM0452  CL60 HCT 116 C243(1.04); C250(1.04); C83(1.01); C90(1.01)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C243(1.05); C250(1.05); C83(1.18); C90(1.18)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C243(0.94); C250(0.94); C83(1.26); C90(1.26)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C243(0.96); C250(0.96); C83(1.06); C90(1.06)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C243(0.74); C250(0.74); C83(1.61); C90(1.61)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C243(0.92); C250(0.92); C83(1.15); C90(1.15)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C243(0.85); C250(0.85); C83(1.01); C90(1.01)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C243(0.86); C250(0.86); C83(0.96); C90(0.96)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C243(0.97); C250(0.97); C83(1.05); C90(1.05)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C243(1.40); C250(1.40); C83(1.36); C90(1.36)  LDD0778  [3]
 LDCM0463  CL70 HCT 116 C243(1.02); C250(1.02); C83(1.11); C90(1.11)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C243(0.95); C250(0.95); C83(0.94); C90(0.94)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C243(1.11); C250(1.11); C83(0.88); C90(0.88)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C243(0.75); C250(0.75); C83(1.04); C90(1.04)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C243(0.69); C250(0.69); C83(0.94); C90(0.94)  LDD0784  [3]
 LDCM0469  CL76 HEK-293T C243(1.01); C90(1.01)  LDD1067  [3]
 LDCM0470  CL77 HEK-293T C243(0.80); C90(0.80)  LDD1068  [3]
 LDCM0471  CL78 HEK-293T C243(0.71); C90(0.71)  LDD1069  [3]
 LDCM0472  CL79 HEK-293T C243(0.93); C90(0.93)  LDD1070  [3]
 LDCM0474  CL80 HEK-293T C243(1.23); C90(1.23)  LDD1072  [3]
 LDCM0475  CL81 HEK-293T C243(0.91); C90(0.91)  LDD1073  [3]
 LDCM0476  CL82 HEK-293T C243(1.07); C90(1.07)  LDD1074  [3]
 LDCM0477  CL83 HEK-293T C243(1.79); C90(1.79)  LDD1075  [3]
 LDCM0478  CL84 HEK-293T C243(0.88); C90(0.88)  LDD1076  [3]
 LDCM0479  CL85 HEK-293T C243(0.87); C90(0.87)  LDD1077  [3]
 LDCM0480  CL86 HEK-293T C243(0.90); C90(0.90)  LDD1078  [3]
 LDCM0481  CL87 HEK-293T C243(1.54); C90(1.54)  LDD1079  [3]
 LDCM0482  CL88 HEK-293T C243(0.96); C90(0.96)  LDD1080  [3]
 LDCM0483  CL89 HEK-293T C243(0.92); C90(0.92)  LDD1081  [3]
 LDCM0485  CL90 HEK-293T C243(1.10); C90(1.10)  LDD1083  [3]
 LDCM0468  Fragment33 HCT 116 C243(0.84); C250(0.84); C83(1.07); C90(1.07)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C83(0.83); C90(0.83)  LDD0744  [3]
 LDCM0022  KB02 HCT 116 C83(1.52); C90(1.52)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C83(1.51); C90(1.51)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C83(1.37); C90(1.37)  LDD0082  [3]
 LDCM0014  Panhematin K562 3.03  LDD0063  [2]
 LDCM0021  THZ1 HCT 116 C83(1.35); C90(1.35); C243(1.66); C250(1.66)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 23 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
26S proteasome regulatory subunit 6A (PSMC3) AAA ATPase family P17980
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 (ALKBH4) AlkB family Q9NXW9
DNA-directed RNA polymerase II subunit RPB11-a (POLR2J) Archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family P52435
DNA-directed RNA polymerase II subunit RPB11-b2 (POLR2J3) Archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family Q9H1A7
Glutamine--tRNA ligase (QARS1) Class-I aminoacyl-tRNA synthetase family P47897
Probable E3 ubiquitin-protein ligase DTX3 (DTX3) Deltex family Q8N9I9
Lysine-specific histone demethylase 1A (KDM1A) Flavin monoamine oxidase family O60341
Inositol-3-phosphate synthase 1 (ISYNA1) Myo-inositol 1-phosphate synthase family Q9NPH2
Tudor-interacting repair regulator protein (NUDT16L1) Nudix hydrolase family Q9BRJ7
Ubiquitin thioesterase ZRANB1 (ZRANB1) Peptidase C64 family Q9UGI0
Non-receptor tyrosine-protein kinase TYK2 (TYK2) Tyr protein kinase family P29597
Putative exonuclease GOR (REXO1L1P) REXO1/REXO3 family Q8IX06
Helicase ARIP4 (RAD54L2) SNF2/RAD54 helicase family Q9Y4B4
TNF receptor-associated factor 4 (TRAF4) TNF receptor-associated factor family Q9BUZ4
Dynamin-2 (DNM2) Dynamin/Fzo/YdjA family P50570
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Ubiquitin-like modifier-activating enzyme 1 (UBA1) Ubiquitin-activating E1 family P22314
Probable ribonuclease ZC3H12C (ZC3H12C) ZC3H12 family Q9C0D7
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
E3 ubiquitin-protein ligase RNF4 (RNF4) . P78317
NEDD4-like E3 ubiquitin-protein ligase WWP1 (WWP1) . Q9H0M0
NEDD4-like E3 ubiquitin-protein ligase WWP2 (WWP2) . O00308
Tripeptidyl-peptidase 1 (TPP1) . O14773
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hairy/enhancer-of-split related with YRPW motif protein 2 (HEY2) HEY family Q9UBP5
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF2) . Q15599
Transcription factor
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-B5 (HOXB5) Antp homeobox family P09067
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Transcription regulator protein BACH2 (BACH2) BZIP family Q9BYV9
Zinc finger and BTB domain-containing protein 16 (ZBTB16) Krueppel C2H2-type zinc-finger protein family Q05516
Zinc finger protein 275 (ZNF275) Krueppel C2H2-type zinc-finger protein family Q9NSD4
Zinc finger protein 3 (ZNF3) Krueppel C2H2-type zinc-finger protein family P17036
Zinc finger protein 620 (ZNF620) Krueppel C2H2-type zinc-finger protein family Q6ZNG0
Zinc finger protein 784 (ZNF784) Krueppel C2H2-type zinc-finger protein family Q8NCA9
Zinc finger protein 835 (ZNF835) Krueppel C2H2-type zinc-finger protein family Q9Y2P0
Zinc finger protein PLAGL2 (PLAGL2) Krueppel C2H2-type zinc-finger protein family Q9UPG8
Calcium-responsive transcription factor (CARF) . Q8N187
High mobility group protein 20A (HMG20A) . Q9NP66
Transcription factor AP-4 (TFAP4) . Q01664
Zinc finger and BTB domain-containing protein 26 (ZBTB26) . Q9HCK0
Zinc finger protein 581 (ZNF581) . Q9P0T4
Other
Click To Hide/Show 37 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ABI gene family member 3 (ABI3) ABI family Q9P2A4
Atos homolog protein B (ATOSB) ATOS family Q7L5A3
Large ribosomal subunit protein bL28m (MRPL28) Bacterial ribosomal protein bL28 family Q13084
Protein BANP (BANP) BANP/SMAR1 family Q8N9N5
Bystin (BYSL) Bystin family Q13895
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Golgin subfamily A member 6A (GOLGA6A) GOLGA6 family Q9NYA3
Golgi reassembly-stacking protein 1 (GORASP1) GORASP family Q9BQQ3
Golgi reassembly-stacking protein 2 (GORASP2) GORASP family Q9H8Y8
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Nuclear pore complex-interacting protein family member A7 (NPIPA7) NPIP family E9PJI5
Transforming growth factor beta-1-induced transcript 1 protein (TGFB1I1) Paxillin family O43294
Splicing factor 3B subunit 4 (SF3B4) SF3B4 family Q15427
Protein Spindly (SPDL1) Spindly family Q96EA4
Small ubiquitin-related modifier 1 (SUMO1) Ubiquitin family P63165
Vacuolar protein sorting-associated protein 52 homolog (VPS52) VPS52 family Q8N1B4
Brain-enriched guanylate kinase-associated protein (BEGAIN) . Q9BUH8
Bromo adjacent homology domain-containing 1 protein (BAHD1) . Q8TBE0
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (NOS1AP) . O75052
DPEP2 neighbor protein (DPEP2NB) . A0A0U1RQF7
EZH inhibitory protein (EZHIP) . Q86X51
Fibroblast growth factor receptor substrate 3 (FRS3) . O43559
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964
KAT8 regulatory NSL complex subunit 1 (KANSL1) . Q7Z3B3
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
Leukocyte receptor cluster member 8 (LENG8) . Q96PV6
Neutrophil cytosol factor 1 (NCF1) . P14598
PRKCA-binding protein (PICK1) . Q9NRD5
Tax1-binding protein 1 (TAX1BP1) . Q86VP1
TBC1 domain family member 7 (TBC1D7) . Q9P0N9
Testis-specific protein 10-interacting protein (TSGA10IP) . Q3SY00
Ubiquilin-2 (UBQLN2) . Q9UHD9
Ubiquitin-like protein 4A (UBL4A) . P11441
Ubiquitin-like protein 4B (UBL4B) . Q8N7F7
WW domain-binding protein 11 (WBP11) . Q9Y2W2

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264