Details of the Target

General Information of Target

Target ID LDTP10295
Target Name Zinc finger protein 503 (ZNF503)
Gene Name ZNF503
Gene ID 84858
Synonyms
NOLZ1; Zinc finger protein 503
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELS
PQRNLRPNRPLAKMAEMARRLHPPSPVPQGVCPAHREPLAAFCGDELRLLCAACERSGEH
WAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQKMVESQRQNVLG
EFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAELEGRCQLPA
LGLLQDIKDALRRVQDVKLQPPEVVPMELRTVCRVPGLVETLRRFRGDVTLDPDTANPEL
ILSEDRRSVQRGDLRQALPDSPERFDPGPCVLGQERFTSGRHYWEVEVGDRTSWALGVCR
ENVNRKEKGELSAGNGFWILVFLGSYYNSSERALAPLRDPPRRVGIFLDYEAGHLSFYSA
TDGSLLFIFPEIPFSGTLRPLFSPLSSSPTPMTICRPKGGSGDTLAPQ
Target Bioclass
Other
Family
Elbow/Noc family
Subcellular location
Nucleus
Function May function as a transcriptional repressor.
Uniprot ID
Q96F45
Ensemble ID
ENST00000372524.5
HGNC ID
HGNC:23589

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
8505C SNV: p.L441M .
AN3CA Deletion: p.T348CfsTer9
SNV: p.K406E		 .
HEC1 SNV: p.S553L .
Ishikawa (Heraklio) 02 ER Deletion: p.G204del .
KYSE510 Substitution: p.E534D .
MFE319 SNV: p.A306P .
NALM6 SNV: p.A355V .
NCIH196 Deletion: p.P97LfsTer66 .
OAW42 SNV: p.Y431N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH214
 Probe Info  		Y602(20.00)  LDD0258  [1]
HPAP
 Probe Info  		8.68  LDD0062  [2]
HHS-465
 Probe Info  		Y178(10.00); Y602(10.00)  LDD2237  [3]
Acrolein
 Probe Info  		N.A.  LDD0223  [4]
DBIA
 Probe Info  		C219(0.93)  LDD0531  [5]
IA-alkyne
 Probe Info  		C286(0.00); C219(0.00)  LDD0165  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
TFBX
 Probe Info  		N.A.  LDD0027  [8]
ENE
 Probe Info  		N.A.  LDD0006  [9]
IPM
 Probe Info  		C286(0.00); C120(0.00); C219(0.00)  LDD0005  [9]
VSF
 Probe Info  		C286(0.00); C120(0.00); C236(0.00)  LDD0007  [9]
Phosphinate-6
 Probe Info  		C286(0.00); C219(0.00); C120(0.00)  LDD0018  [10]
AOyne
 Probe Info  		15.00  LDD0443  [11]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		17.26  LDD0475  [12]
FFF probe2
 Probe Info  		20.00  LDD0463  [12]
FFF probe6
 Probe Info  		20.00  LDD0467  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C219(0.93)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C219(0.88)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C219(1.21)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C219(0.91)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C219(1.01)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C219(1.72)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C219(1.14)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C219(1.72)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C219(1.52)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C219(1.29)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C219(0.99)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C219(0.99)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C219(1.15)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C219(1.20)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C219(0.96)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C219(1.76)  LDD0546  [5]
 LDCM0230  AC113 HEK-293T C219(0.96); C286(0.78)  LDD0828  [5]
 LDCM0231  AC114 HEK-293T C219(0.87); C286(1.03)  LDD0829  [5]
 LDCM0232  AC115 HEK-293T C219(1.05); C286(0.84)  LDD0830  [5]
 LDCM0233  AC116 HEK-293T C219(0.67); C286(0.80)  LDD0831  [5]
 LDCM0234  AC117 HEK-293T C219(0.78); C286(0.91)  LDD0832  [5]
 LDCM0235  AC118 HEK-293T C219(0.82); C286(0.95)  LDD0833  [5]
 LDCM0236  AC119 HEK-293T C219(1.00); C286(0.87)  LDD0834  [5]
 LDCM0237  AC12 HCT 116 C219(0.96)  LDD0554  [5]
 LDCM0238  AC120 HEK-293T C219(1.28); C286(1.03)  LDD0836  [5]
 LDCM0239  AC121 HEK-293T C219(1.11); C286(1.10)  LDD0837  [5]
 LDCM0240  AC122 HEK-293T C219(1.31); C286(1.06)  LDD0838  [5]
 LDCM0241  AC123 HEK-293T C219(1.07); C286(0.99)  LDD0839  [5]
 LDCM0242  AC124 HEK-293T C219(1.49); C286(1.09)  LDD0840  [5]
 LDCM0243  AC125 HEK-293T C219(1.35); C286(1.26)  LDD0841  [5]
 LDCM0244  AC126 HEK-293T C219(1.77); C286(1.21)  LDD0842  [5]
 LDCM0245  AC127 HEK-293T C219(1.58); C286(1.01)  LDD0843  [5]
 LDCM0246  AC128 HEK-293T C286(1.25)  LDD0844  [5]
 LDCM0247  AC129 HEK-293T C286(1.42)  LDD0845  [5]
 LDCM0249  AC130 HEK-293T C286(1.07)  LDD0847  [5]
 LDCM0250  AC131 HEK-293T C286(1.35)  LDD0848  [5]
 LDCM0251  AC132 HEK-293T C286(1.62)  LDD0849  [5]
 LDCM0252  AC133 HEK-293T C286(1.14)  LDD0850  [5]
 LDCM0253  AC134 HEK-293T C286(1.26)  LDD0851  [5]
 LDCM0254  AC135 HEK-293T C286(1.44)  LDD0852  [5]
 LDCM0255  AC136 HEK-293T C286(2.23)  LDD0853  [5]
 LDCM0256  AC137 HEK-293T C286(1.55)  LDD0854  [5]
 LDCM0257  AC138 HEK-293T C286(1.15)  LDD0855  [5]
 LDCM0258  AC139 HEK-293T C286(1.54)  LDD0856  [5]
 LDCM0259  AC14 HCT 116 C219(1.05)  LDD0576  [5]
 LDCM0260  AC140 HEK-293T C286(1.17)  LDD0858  [5]
 LDCM0261  AC141 HEK-293T C286(1.26)  LDD0859  [5]
 LDCM0262  AC142 HEK-293T C286(1.44)  LDD0860  [5]
 LDCM0263  AC143 HCT 116 C219(1.82)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C219(1.68)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C219(1.37)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C219(1.92)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C219(1.92)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C219(2.28)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C219(1.71)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C219(0.74)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C219(1.35)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C219(1.30)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C219(2.06)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C219(3.39)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C219(2.88)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C219(1.80)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C219(1.37)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C219(1.74)  LDD2161  [5]
 LDCM0276  AC17 HEK-293T C286(0.95)  LDD0874  [5]
 LDCM0277  AC18 HEK-293T C286(1.13)  LDD0875  [5]
 LDCM0278  AC19 HEK-293T C286(1.11)  LDD0876  [5]
 LDCM0279  AC2 HCT 116 C219(0.95)  LDD0596  [5]
 LDCM0280  AC20 HEK-293T C286(0.74)  LDD0878  [5]
 LDCM0281  AC21 HEK-293T C286(0.80)  LDD0879  [5]
 LDCM0282  AC22 HEK-293T C286(0.94)  LDD0880  [5]
 LDCM0283  AC23 HEK-293T C286(0.95)  LDD0881  [5]
 LDCM0284  AC24 HEK-293T C286(1.01)  LDD0882  [5]
 LDCM0285  AC25 HCT 116 C219(1.57)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C219(1.10)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C219(1.43)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C219(1.64)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C219(1.27)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C219(0.88)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C219(0.88)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C219(1.72)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C219(1.85)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C219(2.23)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C219(2.02)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C219(0.55)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C219(0.83)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C219(0.72)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C219(0.93)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C219(0.88)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C219(0.81)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C219(1.20)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C219(0.82)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C219(1.13)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C219(1.02)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C219(0.95)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C219(1.09)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C219(1.30)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C219(1.26)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C219(1.24)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C219(1.32)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C219(0.84)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C219(1.61)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C219(1.20)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C219(1.30)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C219(1.51)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C219(1.45)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C219(1.70)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C219(2.40)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C219(0.86)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C219(1.51)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C219(1.40)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C219(1.01)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C219(1.15)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C219(0.90)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C219(2.27)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C219(1.48)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C219(0.86)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C219(0.53)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C219(0.58)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C219(0.80)  LDD0648  [5]
 LDCM0332  AC68 HEK-293T C219(1.10)  LDD0930  [5]
 LDCM0333  AC69 HEK-293T C219(0.99)  LDD0931  [5]
 LDCM0334  AC7 HCT 116 C219(0.95)  LDD0651  [5]
 LDCM0335  AC70 HEK-293T C219(1.14)  LDD0933  [5]
 LDCM0336  AC71 HEK-293T C219(1.18)  LDD0934  [5]
 LDCM0337  AC72 HEK-293T C219(1.31)  LDD0935  [5]
 LDCM0338  AC73 HEK-293T C219(1.21)  LDD0936  [5]
 LDCM0339  AC74 HEK-293T C219(1.82)  LDD0937  [5]
 LDCM0340  AC75 HEK-293T C219(1.38)  LDD0938  [5]
 LDCM0341  AC76 HEK-293T C219(1.48)  LDD0939  [5]
 LDCM0342  AC77 HEK-293T C219(1.11)  LDD0940  [5]
 LDCM0343  AC78 HEK-293T C219(1.14)  LDD0941  [5]
 LDCM0344  AC79 HEK-293T C219(1.18)  LDD0942  [5]
 LDCM0345  AC8 HCT 116 C219(0.87)  LDD0662  [5]
 LDCM0346  AC80 HEK-293T C219(1.35)  LDD0944  [5]
 LDCM0347  AC81 HEK-293T C219(1.24)  LDD0945  [5]
 LDCM0348  AC82 HEK-293T C219(1.60)  LDD0946  [5]
 LDCM0349  AC83 HEK-293T C219(0.50); C286(0.99)  LDD0947  [5]
 LDCM0350  AC84 HEK-293T C219(0.73); C286(1.12)  LDD0948  [5]
 LDCM0351  AC85 HEK-293T C219(0.70); C286(0.97)  LDD0949  [5]
 LDCM0352  AC86 HEK-293T C219(0.68); C286(1.16)  LDD0950  [5]
 LDCM0353  AC87 HEK-293T C219(0.54); C286(1.33)  LDD0951  [5]
 LDCM0354  AC88 HEK-293T C219(0.86); C286(1.18)  LDD0952  [5]
 LDCM0355  AC89 HEK-293T C219(0.70); C286(1.12)  LDD0953  [5]
 LDCM0357  AC90 HEK-293T C219(0.63); C286(0.94)  LDD0955  [5]
 LDCM0358  AC91 HEK-293T C219(0.80); C286(1.17)  LDD0956  [5]
 LDCM0359  AC92 HEK-293T C219(0.73); C286(1.04)  LDD0957  [5]
 LDCM0360  AC93 HEK-293T C219(0.87); C286(0.96)  LDD0958  [5]
 LDCM0361  AC94 HEK-293T C219(0.61); C286(1.12)  LDD0959  [5]
 LDCM0362  AC95 HEK-293T C219(0.86); C286(0.88)  LDD0960  [5]
 LDCM0363  AC96 HEK-293T C219(1.48); C286(1.22)  LDD0961  [5]
 LDCM0364  AC97 HEK-293T C219(1.15); C286(1.07)  LDD0962  [5]
 LDCM0365  AC98 HCT 116 C219(2.17)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C219(1.02)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C219(1.02)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C219(0.98)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C219(0.94)  LDD0592  [5]
 LDCM0367  CL1 HCT 116 C219(1.18)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C219(1.48)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C219(0.90)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C219(0.76)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C219(1.10)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C219(0.81)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C219(0.94)  LDD0690  [5]
 LDCM0374  CL105 HEK-293T C286(0.99)  LDD0972  [5]
 LDCM0375  CL106 HEK-293T C286(1.31)  LDD0973  [5]
 LDCM0376  CL107 HEK-293T C286(0.99)  LDD0974  [5]
 LDCM0377  CL108 HEK-293T C286(1.29)  LDD0975  [5]
 LDCM0378  CL109 HEK-293T C286(0.75)  LDD0976  [5]
 LDCM0379  CL11 HCT 116 C219(1.81)  LDD0696  [5]
 LDCM0380  CL110 HEK-293T C286(0.96)  LDD0978  [5]
 LDCM0381  CL111 HEK-293T C286(1.32)  LDD0979  [5]
 LDCM0382  CL112 HCT 116 C219(2.19)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C219(1.74)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C219(1.21)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C219(1.91)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C219(1.22)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C219(1.16)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C219(1.02)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C219(0.87)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C219(1.50)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C219(0.85)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C219(1.25)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C219(1.22)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C219(1.53)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C219(1.78)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C219(0.62)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C219(0.98)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C219(1.45)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C219(2.49)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C219(0.99)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C219(1.30)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C219(1.00)  LDD0719  [5]
 LDCM0403  CL16 HEK-293T C286(0.69)  LDD1001  [5]
 LDCM0404  CL17 HEK-293T C286(0.78)  LDD1002  [5]
 LDCM0405  CL18 HEK-293T C286(0.85)  LDD1003  [5]
 LDCM0406  CL19 HEK-293T C286(0.74)  LDD1004  [5]
 LDCM0407  CL2 HCT 116 C219(1.07)  LDD0724  [5]
 LDCM0408  CL20 HEK-293T C286(0.81)  LDD1006  [5]
 LDCM0409  CL21 HEK-293T C286(0.96)  LDD1007  [5]
 LDCM0410  CL22 HEK-293T C286(1.01)  LDD1008  [5]
 LDCM0411  CL23 HEK-293T C286(0.70)  LDD1009  [5]
 LDCM0412  CL24 HEK-293T C286(0.87)  LDD1010  [5]
 LDCM0413  CL25 HEK-293T C286(0.72)  LDD1011  [5]
 LDCM0414  CL26 HEK-293T C286(0.67)  LDD1012  [5]
 LDCM0415  CL27 HEK-293T C286(0.61)  LDD1013  [5]
 LDCM0416  CL28 HEK-293T C286(0.85)  LDD1014  [5]
 LDCM0417  CL29 HEK-293T C286(0.79)  LDD1015  [5]
 LDCM0418  CL3 HCT 116 C219(1.14)  LDD0735  [5]
 LDCM0419  CL30 HEK-293T C286(0.86)  LDD1017  [5]
 LDCM0420  CL31 HEK-293T C286(1.06); C219(0.95); C120(1.05); C404(1.51)  LDD1624  [13]
 LDCM0421  CL32 HEK-293T C286(1.11); C219(1.07); C120(1.23); C404(1.41)  LDD1625  [13]
 LDCM0422  CL33 HEK-293T C286(0.63); C219(0.97); C120(1.03); C404(2.38)  LDD1626  [13]
 LDCM0423  CL34 HEK-293T C286(0.97); C219(1.00); C120(1.09); C404(2.05)  LDD1627  [13]
 LDCM0424  CL35 HEK-293T C286(1.12); C219(1.19); C120(1.17); C404(3.19)  LDD1628  [13]
 LDCM0425  CL36 HEK-293T C286(0.86); C219(1.10); C120(1.44); C404(2.38)  LDD1629  [13]
 LDCM0426  CL37 HEK-293T C286(1.45); C219(1.25); C120(1.36); C404(1.08)  LDD1630  [13]
 LDCM0428  CL39 HEK-293T C286(1.39); C219(1.32); C120(1.82); C404(1.29)  LDD1632  [13]
 LDCM0429  CL4 HCT 116 C219(1.16)  LDD0746  [5]
 LDCM0430  CL40 HEK-293T C286(1.54); C219(1.30); C120(1.24); C404(1.11)  LDD1634  [13]
 LDCM0431  CL41 HEK-293T C286(1.09); C219(1.24); C120(1.13); C404(1.03)  LDD1635  [13]
 LDCM0432  CL42 HEK-293T C286(1.03); C219(0.95); C120(1.06); C404(1.27)  LDD1636  [13]
 LDCM0433  CL43 HEK-293T C286(1.09); C219(1.07); C120(1.01); C404(1.56)  LDD1637  [13]
 LDCM0434  CL44 HEK-293T C286(1.02); C219(1.14); C120(1.21); C404(1.22)  LDD1638  [13]
 LDCM0435  CL45 HEK-293T C286(0.79); C219(1.15); C120(1.26); C404(2.05)  LDD1639  [13]
 LDCM0436  CL46 HEK-293T C219(1.18); C286(0.91)  LDD1034  [5]
 LDCM0437  CL47 HEK-293T C219(1.02); C286(1.59)  LDD1035  [5]
 LDCM0438  CL48 HEK-293T C219(1.09); C286(0.85)  LDD1036  [5]
 LDCM0439  CL49 HEK-293T C219(1.12); C286(0.82)  LDD1037  [5]
 LDCM0440  CL5 HCT 116 C219(1.05)  LDD0757  [5]
 LDCM0441  CL50 HEK-293T C219(1.55); C286(0.93)  LDD1039  [5]
 LDCM0442  CL51 HEK-293T C219(1.42); C286(1.04)  LDD1040  [5]
 LDCM0443  CL52 HEK-293T C219(0.94); C286(1.28)  LDD1041  [5]
 LDCM0444  CL53 HEK-293T C219(1.26); C286(1.83)  LDD1042  [5]
 LDCM0445  CL54 HEK-293T C219(1.40); C286(1.07)  LDD1043  [5]
 LDCM0446  CL55 HEK-293T C219(1.03); C286(0.79)  LDD1044  [5]
 LDCM0447  CL56 HEK-293T C219(1.05); C286(1.05)  LDD1045  [5]
 LDCM0448  CL57 HEK-293T C219(1.42); C286(1.08)  LDD1046  [5]
 LDCM0449  CL58 HEK-293T C219(1.02); C286(1.01)  LDD1047  [5]
 LDCM0450  CL59 HEK-293T C219(1.21); C286(1.02)  LDD1048  [5]
 LDCM0451  CL6 HCT 116 C219(1.31)  LDD0768  [5]
 LDCM0452  CL60 HEK-293T C219(1.43); C286(1.00)  LDD1050  [5]
 LDCM0453  CL61 HEK-293T C219(0.93); C286(1.27)  LDD1051  [5]
 LDCM0454  CL62 HEK-293T C219(0.94); C286(1.34)  LDD1052  [5]
 LDCM0455  CL63 HEK-293T C219(1.21); C286(0.80)  LDD1053  [5]
 LDCM0456  CL64 HEK-293T C219(1.40); C286(1.46)  LDD1054  [5]
 LDCM0457  CL65 HEK-293T C219(1.23); C286(1.67)  LDD1055  [5]
 LDCM0458  CL66 HEK-293T C219(1.27); C286(0.89)  LDD1056  [5]
 LDCM0459  CL67 HEK-293T C219(1.09); C286(1.13)  LDD1057  [5]
 LDCM0460  CL68 HEK-293T C219(1.34); C286(0.88)  LDD1058  [5]
 LDCM0461  CL69 HEK-293T C219(1.09); C286(2.02)  LDD1059  [5]
 LDCM0462  CL7 HCT 116 C219(1.12)  LDD0779  [5]
 LDCM0463  CL70 HEK-293T C219(0.94); C286(1.41)  LDD1061  [5]
 LDCM0464  CL71 HEK-293T C219(0.90); C286(0.85)  LDD1062  [5]
 LDCM0465  CL72 HEK-293T C219(1.03); C286(1.15)  LDD1063  [5]
 LDCM0466  CL73 HEK-293T C219(1.68); C286(1.49)  LDD1064  [5]
 LDCM0467  CL74 HEK-293T C219(1.42); C286(0.94)  LDD1065  [5]
 LDCM0469  CL76 HEK-293T C219(1.16); C286(1.32)  LDD1067  [5]
 LDCM0470  CL77 HEK-293T C219(1.28); C286(0.95)  LDD1068  [5]
 LDCM0471  CL78 HEK-293T C219(1.03); C286(1.61)  LDD1069  [5]
 LDCM0472  CL79 HEK-293T C219(0.89); C286(1.98)  LDD1070  [5]
 LDCM0473  CL8 HCT 116 C219(1.49)  LDD0790  [5]
 LDCM0474  CL80 HEK-293T C219(1.27); C286(1.53)  LDD1072  [5]
 LDCM0475  CL81 HEK-293T C219(0.94); C286(0.89)  LDD1073  [5]
 LDCM0476  CL82 HEK-293T C219(0.76); C286(1.49)  LDD1074  [5]
 LDCM0477  CL83 HEK-293T C219(0.85); C286(1.36)  LDD1075  [5]
 LDCM0478  CL84 HEK-293T C219(1.21); C286(2.24)  LDD1076  [5]
 LDCM0479  CL85 HEK-293T C219(0.98); C286(1.35)  LDD1077  [5]
 LDCM0480  CL86 HEK-293T C219(0.87); C286(1.03)  LDD1078  [5]
 LDCM0481  CL87 HEK-293T C219(0.99); C286(1.39)  LDD1079  [5]
 LDCM0482  CL88 HEK-293T C219(1.34); C286(1.44)  LDD1080  [5]
 LDCM0483  CL89 HEK-293T C219(0.78); C286(1.09)  LDD1081  [5]
 LDCM0484  CL9 HCT 116 C219(1.15)  LDD0801  [5]
 LDCM0485  CL90 HEK-293T C219(1.22); C286(1.41)  LDD1083  [5]
 LDCM0486  CL91 HCT 116 C219(0.65)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C219(0.84)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C219(0.94)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C219(0.91)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C219(1.01)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C219(0.96)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C219(0.89)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C219(0.84)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C219(0.91)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C286(1.44); C219(1.29); C120(1.84); C404(1.14)  LDD1698  [13]
 LDCM0468  Fragment33 HEK-293T C219(1.41); C286(1.20)  LDD1066  [5]
 LDCM0427  Fragment51 HEK-293T C286(1.18); C219(1.27); C120(1.28); C404(1.23)  LDD1631  [13]
 LDCM0022  KB02 HEK-293T C286(0.95); C219(0.96); C427(1.17); C120(0.99)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C286(1.00); C219(1.04); C427(1.09); C120(1.07)  LDD1497  [13]
 LDCM0024  KB05 NCI-N87 C219(1.74)  LDD3364  [14]
 LDCM0109  NEM HeLa N.A.  LDD0223  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C286(0.39)  LDD2206  [15]
 LDCM0014  Panhematin HEK-293T 8.68  LDD0062  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable E3 ubiquitin-protein ligase DTX2 (DTX2) Deltex family Q86UW9
Terminal nucleotidyltransferase 5B (TENT5B) TENT family Q96A09
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein prophet of Pit-1 (PROP1) Paired homeobox family O75360
AT-rich interactive domain-containing protein 5A (ARID5A) . Q03989
Forkhead box protein H1 (FOXH1) . O75593
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin-associated protein 19-1 (KRTAP19-1) KRTAP type 19 family Q8IUB9
Keratin-associated protein 3-3 (KRTAP3-3) KRTAP type 3 family Q9BYR6
Keratin-associated protein 6-2 (KRTAP6-2) KRTAP type 6 family Q3LI66

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
3 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
15 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.