Details of the Target

General Information of Target

Target ID LDTP00249
Target Name Cell division cycle 7-related protein kinase (CDC7)
Gene Name CDC7
Gene ID 8317
Synonyms
CDC7L1; Cell division cycle 7-related protein kinase; CDC7-related kinase; HsCdc7; huCdc7; EC 2.7.11.1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEASLGIQMDEPMAFSPQRDRFQAEGSLKKNEQNFKLAGVKKDIEKLYEAVPQLSNVFKI
EDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGV
KYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKP
SNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIPLSG
PVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISH
ESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATDKVC
SICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDD
LTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQ
GHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVPD
EAYDLLDKLLDLNPASRITAEEALLHPFFKDMSL
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Protein kinase superfamily, Ser/Thr protein kinase family, CDC7 subfamily
Subcellular location
Nucleus
Function Kinase involved in initiation of DNA replication. Phosphorylates critical substrates that regulate the G1/S phase transition and initiation of DNA replication, such as MCM proteins and CLASPIN.
TTD ID
T81358
Uniprot ID
O00311
DrugMap ID
TTSMTDI
Ensemble ID
ENST00000234626.11
HGNC ID
HGNC:1745
ChEMBL ID
CHEMBL5443

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
LS180 Deletion: p.L143WfsTer4 .
MCC13 SNV: p.A400S .
MCC26 SNV: p.E25K; p.G202E; p.K514Ter .
MFE319 SNV: p.Q248R .
NCIH2286 SNV: p.D551H .
NCIH358 Deletion: p.H482MfsTer51 .
RKO SNV: p.S239R .
SG231 SNV: p.I395F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HPAP
 Probe Info  		3.11  LDD0062  [1]
IA-alkyne
 Probe Info  		C499(2.07)  LDD0372  [2]
DBIA
 Probe Info  		C345(14.03); C353(14.03)  LDD0080  [3]
ATP probe
 Probe Info  		N.A.  LDD0199  [4]
IPM
 Probe Info  		C345(0.00); C499(0.00); C353(0.00)  LDD2156  [5]
AOyne
 Probe Info  		15.00  LDD0443  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C499(2.07)  LDD0372  [2]
 LDCM0214  AC1 HCT 116 C499(1.01)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C360(0.79); C363(0.79); C499(0.86)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C345(0.96); C351(0.96); C353(0.96); C499(1.09)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C345(0.71); C351(0.71); C353(0.71); C499(1.03)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C345(0.82); C351(0.82); C353(0.82); C499(1.05)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C345(0.87); C351(0.87); C353(0.87); C499(1.04)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C345(0.77); C351(0.77); C353(0.77); C499(0.93)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C345(0.81); C351(0.81); C353(0.81); C499(1.29)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C345(0.78); C351(0.78); C353(0.78); C499(1.10)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C345(0.88); C351(0.88); C353(0.88); C499(1.12)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C345(0.74); C351(0.74); C353(0.74); C499(1.00)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C345(0.78); C351(0.78); C353(0.78); C499(0.83)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C360(0.71); C363(0.71); C499(0.86)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C345(1.07); C351(1.07); C353(1.07); C499(1.00)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C345(0.81); C351(0.81); C353(0.81); C499(0.95)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C345(0.81); C351(0.81); C353(0.81); C499(0.99)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C345(1.06); C351(1.06); C353(1.06); C499(0.86)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C345(1.12); C351(1.07); C353(1.07); C499(0.88)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C345(1.11); C351(1.09); C353(1.09); C499(0.68)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C345(1.40); C351(1.42); C353(1.42); C499(1.03)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C345(1.21); C351(1.16); C353(1.16); C499(0.97)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C345(1.07); C351(0.99); C353(0.99); C499(0.84)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C345(1.14); C351(1.13); C353(1.13); C499(0.95)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C360(0.67); C363(0.67); C499(0.98)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C345(1.20); C351(1.11); C353(1.11); C499(0.87)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C345(0.98); C351(0.92); C353(0.92); C499(0.66)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C345(1.13); C351(1.01); C353(1.01); C499(0.77)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C345(1.17); C351(1.19); C353(1.19); C499(0.69)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C345(1.29); C351(1.24); C353(1.24); C499(0.78)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C345(1.15); C351(1.16); C353(1.16); C499(0.89)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C345(1.28); C351(1.21); C353(1.21); C499(0.71)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C345(1.03); C351(1.03); C353(1.03); C499(0.72)  LDD0562  [3]
 LDCM0246  AC128 HEK-293T C345(0.88); C351(0.78); C353(0.88); C499(0.77)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C345(1.03); C351(0.88); C353(1.03); C499(0.84)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C345(0.93); C351(0.91); C353(0.93); C499(1.07)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C345(0.79); C351(1.14); C353(0.79); C499(1.06)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C345(1.11); C351(0.89); C353(1.11); C499(1.20)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C345(0.74); C351(0.89); C353(0.74); C499(1.26)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C345(1.14); C351(1.16); C353(1.14); C499(1.20)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C345(0.93); C351(0.78); C353(0.93); C499(1.62)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C345(0.94); C351(0.71); C353(0.94); C499(1.01)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C345(1.06); C351(0.75); C353(1.06); C499(0.88)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C345(0.94); C351(0.60); C353(0.94); C499(0.81)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C345(0.72); C351(0.81); C353(0.72); C499(0.88)  LDD0856  [3]
 LDCM0259  AC14 HCT 116 C360(0.79); C363(0.79); C499(0.86)  LDD0576  [3]
 LDCM0260  AC140 HEK-293T C345(1.06); C351(0.79); C353(1.06); C499(0.86)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C345(1.06); C351(0.81); C353(1.06); C499(0.86)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C345(1.15); C351(0.98); C353(1.15); C499(0.97)  LDD0860  [3]
 LDCM0263  AC143 HCT 116 C345(0.86); C351(0.86); C353(0.86)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C345(1.09); C351(1.09); C353(1.09)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C345(1.03); C351(1.03); C353(1.03)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C345(1.12); C351(1.12); C353(1.12)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C345(1.01); C351(1.01); C353(1.01)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C345(1.43); C351(1.43); C353(1.43)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C345(1.19); C351(1.19); C353(1.19)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C360(0.79); C363(0.79); C499(0.82)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C345(0.90); C351(0.90); C353(0.90)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C345(0.96); C351(0.96); C353(0.96)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C345(1.12); C351(1.12); C353(1.12)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C345(1.46); C351(1.46); C353(1.46)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C345(1.21); C351(1.21); C353(1.21)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C345(1.30); C351(1.30); C353(1.30)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C345(1.21); C351(1.21); C353(1.21)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C345(1.39); C351(1.39); C353(1.39)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C360(0.78); C363(0.78); C499(0.89)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C360(0.78); C363(0.78); C499(0.91)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C360(0.77); C363(0.77); C499(0.95)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C499(0.95)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C360(0.58); C363(0.58); C499(0.92)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C360(0.57); C363(0.57); C499(0.92)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C360(0.59); C363(0.59); C499(0.96)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C360(0.52); C363(0.52); C499(0.94)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C360(0.61); C363(0.61); C499(0.93)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C499(0.84)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C499(1.00)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C499(1.03)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C499(0.91)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C499(1.13)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C499(1.01)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C499(1.31)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C499(0.97)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C499(1.43)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C499(0.89)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C499(1.09)  LDD0612  [3]
 LDCM0296  AC35 HEK-293T C360(1.01); C363(1.01); C499(1.01)  LDD0894  [3]
 LDCM0297  AC36 HEK-293T C360(1.42); C363(1.42); C499(1.42)  LDD0895  [3]
 LDCM0298  AC37 HEK-293T C360(1.25); C363(1.25); C499(0.90)  LDD0896  [3]
 LDCM0299  AC38 HEK-293T C360(1.28); C363(1.28); C499(1.08)  LDD0897  [3]
 LDCM0300  AC39 HEK-293T C360(1.18); C363(1.18); C499(1.24)  LDD0898  [3]
 LDCM0301  AC4 HCT 116 C499(0.90)  LDD0618  [3]
 LDCM0302  AC40 HEK-293T C360(1.22); C363(1.22); C499(1.07)  LDD0900  [3]
 LDCM0303  AC41 HEK-293T C360(0.98); C363(0.98); C499(1.02)  LDD0901  [3]
 LDCM0304  AC42 HEK-293T C360(0.95); C363(0.95); C499(0.98)  LDD0902  [3]
 LDCM0305  AC43 HEK-293T C360(1.30); C363(1.30); C499(1.09)  LDD0903  [3]
 LDCM0306  AC44 HEK-293T C360(1.06); C363(1.06); C499(0.98)  LDD0904  [3]
 LDCM0307  AC45 HEK-293T C360(1.05); C363(1.05); C499(1.15)  LDD0905  [3]
 LDCM0308  AC46 HEK-293T C345(1.15); C351(1.15); C353(0.97); C360(1.13)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C345(0.85); C351(0.85); C353(1.15); C360(0.96)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C345(0.90); C351(0.90); C353(0.82); C360(0.90)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C345(0.90); C351(0.90); C353(0.86); C360(0.93)  LDD0909  [3]
 LDCM0312  AC5 HCT 116 C499(0.88)  LDD0629  [3]
 LDCM0313  AC50 HEK-293T C345(1.13); C351(1.13); C353(0.98); C360(1.11)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C345(1.08); C351(1.08); C353(0.92); C360(0.94)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C345(1.08); C351(1.08); C353(1.22); C360(1.23)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C345(1.19); C351(1.19); C353(1.01); C360(0.99)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C345(0.92); C351(0.92); C353(0.92); C360(0.96)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C345(1.10); C351(1.10); C353(1.01); C360(1.39)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C345(1.17); C351(1.17); C353(0.95); C360(1.17)  LDD0917  [3]
 LDCM0320  AC57 HCT 116 C345(0.82); C351(0.82); C353(0.82)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C345(0.86); C351(0.86); C353(0.86)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C345(0.72); C351(0.72); C353(0.72)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C360(0.88); C363(0.88); C499(1.01)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C345(0.64); C351(0.64); C353(0.64)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C345(0.74); C351(0.74); C353(0.74)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C345(0.69); C351(0.69); C353(0.69)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C345(0.62); C351(0.62); C353(0.62)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C345(0.68); C351(0.68); C353(0.68)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C345(0.37); C351(0.37); C353(0.37)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C345(0.41); C351(0.41); C353(0.41)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C345(0.35); C351(0.35); C353(0.35)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C345(0.75); C351(0.75); C353(0.75); C360(0.87)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C345(0.82); C351(0.82); C353(0.82); C360(1.03)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C360(0.75); C363(0.75); C499(0.90)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C360(1.37); C363(1.37); C345(1.67); C351(1.67)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C345(0.58); C351(0.58); C353(0.58); C360(0.85)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C345(0.84); C351(0.84); C353(0.84); C360(1.05)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C345(0.94); C351(0.94); C353(0.94); C360(1.29)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C345(0.89); C351(0.89); C353(0.89); C360(1.08)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C345(0.86); C351(0.86); C353(0.86); C360(1.17)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C345(0.74); C351(0.74); C353(0.74); C360(0.89)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C345(0.78); C351(0.78); C353(0.78); C360(0.97)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C345(0.67); C351(0.67); C353(0.67); C360(0.97)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C345(0.85); C351(0.85); C353(0.85); C360(0.88)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C360(0.68); C363(0.68); C499(0.95)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C345(0.86); C351(0.86); C353(0.86); C360(1.07)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C360(1.07); C363(1.07); C345(1.22); C351(1.22)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C345(0.79); C351(0.79); C353(0.79); C360(0.98)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C499(1.01); C345(1.30); C353(1.30)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C499(1.09); C345(1.13); C353(1.13)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C345(0.93); C353(0.93); C499(1.15)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C345(0.87); C353(0.87); C499(1.13)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C345(0.90); C353(0.90); C499(1.09)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C345(0.97); C353(0.97); C499(1.07)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C345(0.86); C353(0.86); C499(1.16)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C345(0.90); C353(0.90); C499(1.17)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C345(0.98); C353(0.98); C499(1.00)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C499(0.97); C345(1.29); C353(1.29)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C345(0.94); C353(0.94); C499(1.14)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C345(0.63); C353(0.63); C499(1.04)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C499(1.02); C345(1.17); C353(1.17)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C345(0.86); C353(0.86); C499(1.08)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C345(0.88); C353(0.88); C499(1.21)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C345(0.82); C351(0.82); C353(0.82); C499(1.06)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C345(0.79); C351(0.79); C353(0.79); C499(1.00)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C360(0.73); C363(0.73); C499(0.98)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C499(0.72); C360(0.75); C363(0.75)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C360(0.79); C363(0.79); C499(0.95)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C345(1.05); C353(1.05); C360(1.04); C363(1.04)  LDD2171  [3]
 LDCM0367  CL1 HCT 116 C499(1.09); C363(1.28)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C499(1.03); C363(2.04)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C499(1.13)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C360(0.73); C363(0.73); C499(0.91)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C360(0.77); C363(0.77); C499(0.85)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C499(0.82); C360(0.93); C363(0.93)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C360(0.75); C363(0.75); C499(0.87)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C360(0.50); C363(0.50); C499(0.94)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C360(0.51); C363(0.51); C499(0.87)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C360(0.82); C363(0.82); C499(0.89)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C360(0.68); C363(0.68); C499(0.86)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C360(0.72); C363(0.72); C499(0.93)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C363(1.18); C499(1.22)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C360(0.50); C363(0.50); C499(0.92)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C360(0.64); C363(0.64); C499(0.90)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C499(1.00)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C499(1.20)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C499(1.22)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C499(1.25)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C499(1.16)  LDD0703  [3]
 LDCM0387  CL117 HEK-293T C360(1.32); C363(1.32); C499(0.84)  LDD0985  [3]
 LDCM0388  CL118 HEK-293T C360(1.12); C363(1.12); C499(0.86)  LDD0986  [3]
 LDCM0389  CL119 HEK-293T C360(1.10); C363(1.10); C499(0.73)  LDD0987  [3]
 LDCM0390  CL12 HCT 116 C499(1.08); C363(1.84)  LDD0707  [3]
 LDCM0391  CL120 HEK-293T C360(1.05); C363(1.05); C499(0.79)  LDD0989  [3]
 LDCM0392  CL121 HEK-293T C345(1.15); C351(1.15); C353(1.02); C360(1.25)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C345(1.25); C351(1.25); C353(1.15); C360(1.37)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C345(1.28); C351(1.28); C353(1.32); C360(1.30)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C345(1.07); C351(1.07); C353(1.14); C360(1.07)  LDD0993  [3]
 LDCM0396  CL125 HCT 116 C345(0.76); C351(0.76); C353(0.76)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C345(0.65); C351(0.65); C353(0.65)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C345(0.85); C351(0.85); C353(0.85)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C345(0.75); C351(0.75); C353(0.75)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C499(0.94); C363(1.08)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C499(1.05); C363(1.10)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C363(0.85); C499(0.98)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C499(0.77)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C499(0.99)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C499(1.00)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C499(0.98)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C363(0.97); C499(0.97)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C499(1.26)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C499(1.26)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C499(0.99)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C499(1.06)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C499(0.95)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C499(1.04)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C499(1.12)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C499(1.07)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C499(1.01)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C499(1.05)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C363(1.14); C499(0.97)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C499(0.81)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C499(1.13)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C499(0.98)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C499(1.10)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C499(1.09)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C499(1.20)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C499(1.17)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C499(1.34)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C499(1.28)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C363(2.07); C499(1.09)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C499(1.16)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C499(1.16)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C499(1.50)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C499(1.34)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C499(1.32)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C499(1.35)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C360(0.99); C363(0.99); C499(1.08)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C360(0.74); C363(0.74); C499(0.85)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C360(0.71); C363(0.71); C499(0.92)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C360(0.99); C363(0.99); C499(1.01)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C363(1.18); C499(0.95)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C360(0.74); C363(0.74); C499(0.92)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C360(0.84); C363(0.84); C499(0.99)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C360(1.05); C363(1.05); C499(1.25)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C360(0.84); C363(0.84); C499(1.13)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C360(0.78); C363(0.78); C499(0.93)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C360(0.74); C363(0.74); C499(1.00)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C360(0.76); C363(0.76); C499(0.93)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C360(0.82); C363(0.82); C499(0.97)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C360(1.14); C363(1.14); C499(0.94)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C360(0.96); C363(0.96); C499(0.94)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C363(1.10); C499(0.91)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C360(0.83); C363(0.83); C499(0.98)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C345(1.71); C353(1.71); C360(1.28); C363(1.28)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C345(1.43); C353(1.43); C360(0.91); C363(0.91)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C345(1.69); C353(1.69); C360(0.86); C363(0.86)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C345(1.02); C353(1.02); C360(0.88); C363(0.88)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C345(1.99); C353(1.99); C360(1.06); C363(1.06)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C345(1.28); C353(1.28); C360(1.09); C363(1.09)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C345(1.77); C353(1.77); C360(0.99); C363(0.99)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C345(1.56); C353(1.56); C360(0.92); C363(0.92)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C345(3.12); C353(3.12); C360(0.94); C363(0.94)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C363(1.61); C499(0.87)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C345(1.44); C353(1.44); C360(1.10); C363(1.10)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C345(1.54); C353(1.54); C360(1.00); C363(1.00)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C345(2.21); C353(2.21); C360(1.08); C363(1.08)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C345(1.01); C353(1.01); C360(0.95); C363(0.95)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C345(2.61); C353(2.61); C360(0.83); C363(0.83)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C499(0.96)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C499(1.05)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C499(0.98)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C499(1.31)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C363(0.67); C499(1.50)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C499(0.97)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C499(1.08)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C499(1.25)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C499(1.14)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C499(1.16)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C499(0.98)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C499(0.91)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C499(1.05)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C499(1.13)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C499(1.28)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C363(1.51); C499(1.10)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C499(1.07)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C499(1.00)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C499(0.96)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C499(0.87)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C499(0.95)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C499(1.28)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C499(0.92)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C499(0.98)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C499(1.12)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C499(0.97)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C499(1.04); C360(1.01)  LDD1698  [7]
 LDCM0468  Fragment33 HCT 116 C345(1.78); C353(1.78); C360(0.94); C363(0.94)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C499(1.60)  LDD0744  [3]
 LDCM0022  KB02 HCT 116 C345(14.03); C353(14.03)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C345(8.73); C353(8.73)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C345(8.77); C353(8.77)  LDD0082  [3]
 LDCM0014  Panhematin HEK-293T 3.11  LDD0062  [1]
 LDCM0021  THZ1 HCT 116 C345(1.05); C353(1.05); C360(1.04); C363(1.04)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase TRIM37 (TRIM37) TRIM/RBCC family O94972
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bax inhibitor 1 (TMBIM6) BI1 family P55061
Huntingtin (HTT) Huntingtin family P42858
Leucine zipper putative tumor suppressor 1 (LZTS1) LZTS family Q9Y250
Transcription factor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein Aiolos (IKZF3) Ikaros C2H2-type zinc-finger protein family Q9UKT9
Zinc finger protein Eos (IKZF4) Ikaros C2H2-type zinc-finger protein family Q9H2S9
Glucocorticoid modulatory element-binding protein 2 (GMEB2) . Q9UKD1
Homeobox-containing protein 1 (HMBOX1) . Q6NT76
Zinc finger and BTB domain-containing protein 26 (ZBTB26) . Q9HCK0
Zinc finger and BTB domain-containing protein 8B (ZBTB8B) . Q8NAP8
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Golgin subfamily A member 6A (GOLGA6A) GOLGA6 family Q9NYA3
Mini-chromosome maintenance complex-binding protein (MCMBP) MCMBP family Q9BTE3
Testis-specific Y-encoded protein 10 (TSPY10) Nucleosome assembly protein (NAP) family P0CW01
Signal transducing adapter molecule 2 (STAM2) STAM family O75886
Protein DBF4 homolog A (DBF4) . Q9UBU7
SERTA domain-containing protein 2 (SERTAD2) . Q14140
Translin-associated factor X-interacting protein 1 (TSNAXIP1) . Q2TAA8

The Drug(s) Related To This Target

Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Bms-863233 Small molecular drug D03ISJ
Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Tak-931 . D0LL4Y
Investigative
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pha-767491 Small molecular drug D03DZO
Pmid19115845c89s Small molecular drug D0T8NU
Pmid20873740c18 Small molecular drug D08HFG
Pmid24793884c74 Small molecular drug D0RJ8J
Pmid24793884c77 Small molecular drug D0N3LC
Patented
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pmid26161698-compound-44 Small molecular drug D0G6QW

References

1 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402