Details of the Target

General Information of Target

Target ID LDTP04890
Target Name Signal recognition particle subunit SRP54 (SRP54)
Gene Name SRP54
Gene ID 6729
Synonyms
Signal recognition particle subunit SRP54; EC 3.6.5.4; Signal recognition particle 54 kDa protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVLADLGRKITSALRSLSNATIINEEVLNAMLKEVCTALLEADVNIKLVKQLRENVKSAI
DLEEMASGLNKRKMIQHAVFKELVKLVDPGVKAWTPTKGKQNVIMFVGLQGSGKTTTCSK
LAYYYQRKGWKTCLICADTFRAGAFDQLKQNATKARIPFYGSYTEMDPVIIASEGVEKFK
NENFEIIIVDTSGRHKQEDSLFEEMLQVANAIQPDNIVYVMDASIGQACEAQAKAFKDKV
DVASVIVTKLDGHAKGGGALSAVAATKSPIIFIGTGEHIDDFEPFKTQPFISKLLGMGDI
EGLIDKVNELKLDDNEALIEKLKHGQFTLRDMYEQFQNIMKMGPFSQILGMIPGFGTDFM
SKGNEQESMARLKKLMTIMDSMNDQELDSTDGAKVFSKQPGRIQRVARGSGVSTRDVQEL
LTQYTKFAQMVKKMGGIKGLFKGGDMSKNVSQSQMAKLNQQMAKMMDPRVLHHMGGMAGL
QSMMRQFQQGAAGNMKGMMGFNNM
Target Bioclass
Enzyme
Family
GTP-binding SRP family, SRP54 subfamily
Subcellular location
Nucleus speckle
Function
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane. Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes. Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA. SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER. Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA. Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development.
Uniprot ID
P61011
Ensemble ID
ENST00000216774.11
HGNC ID
HGNC:11301
ChEMBL ID
CHEMBL4295786

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AU565 SNV: p.D190H DBIA    Probe Info 
EFO27 SNV: p.Q423Ter DBIA    Probe Info 
G415 SNV: p.D199H DBIA    Probe Info 
HCT116 SNV: p.V247A DBIA    Probe Info 
HT115 SNV: p.D445N .
JURKAT SNV: p.V307I .
NCIH23 SNV: p.G444S DBIA    Probe Info 
TE1 SNV: p.I104L DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 23 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.39  LDD0402  [1]
TH211
 Probe Info  		Y163(11.67)  LDD0260  [2]
TH216
 Probe Info  		Y424(20.00)  LDD0259  [2]
STPyne
 Probe Info  		K149(10.00); K154(6.63); K286(0.83); K323(6.28)  LDD0277  [3]
Probe 1
 Probe Info  		Y123(10.40); Y125(19.44)  LDD3495  [4]
BTD
 Probe Info  		C118(1.11)  LDD1700  [5]
HPAP
 Probe Info  		3.13  LDD0063  [6]
DBIA
 Probe Info  		C136(1.26)  LDD0080  [7]
ATP probe
 Probe Info  		K81(0.00); K438(0.00); K398(0.00); K321(0.00)  LDD0199  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C36(0.00); C229(0.00); C133(0.00); C136(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C229(0.00); C133(0.00); C136(0.00)  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		C36(0.00); C229(0.00); C133(0.00); C136(0.00)  LDD0037  [9]
ATP probe
 Probe Info  		N.A.  LDD0035  [10]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [11]
IPM
 Probe Info  		N.A.  LDD0147  [11]
NHS
 Probe Info  		N.A.  LDD0010  [12]
SF
 Probe Info  		N.A.  LDD0028  [13]
TFBX
 Probe Info  		C118(0.00); C36(0.00)  LDD0148  [11]
1c-yne
 Probe Info  		K457(0.00); K448(0.00)  LDD0228  [14]
Acrolein
 Probe Info  		N.A.  LDD0217  [15]
AOyne
 Probe Info  		4.90  LDD0443  [16]
NAIA_5
 Probe Info  		C229(0.00); C36(0.00); C136(0.00); C133(0.00)  LDD2223  [17]
HHS-482
 Probe Info  		Y124(1.06)  LDD2239  [18]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C278
 Probe Info  		52.71  LDD1948  [19]
FFF probe11
 Probe Info  		6.97  LDD0472  [20]
FFF probe2
 Probe Info  		12.54  LDD0463  [20]
FFF probe3
 Probe Info  		7.25  LDD0465  [20]
STS-1
 Probe Info  		N.A.  LDD0137  [21]
STS-2
 Probe Info  		N.A.  LDD0139  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C118(0.63)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C118(1.26)  LDD2152  [5]
 LDCM0214  AC1 HCT 116 C133(1.27); C136(1.26)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C133(1.27); C136(1.31)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C133(0.89); C136(0.86)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C133(0.94); C136(0.84)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C133(0.97); C136(0.91)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C133(0.86); C136(0.83)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C133(1.10); C136(0.98)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C133(0.97); C136(0.88)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C133(0.86); C136(0.87)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C133(0.93); C136(0.90)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C133(0.94); C136(0.96)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C133(1.10); C136(0.93)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C133(1.30); C136(1.29)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C133(0.90); C136(0.79)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C133(1.02); C136(0.88)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C133(0.93); C136(0.84)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C133(0.91); C136(0.91)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C133(0.98); C136(0.89)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C133(0.97); C136(0.84)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C133(1.01); C136(0.98)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C133(0.95); C136(0.82)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C133(1.05); C136(0.87)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C133(0.93); C136(0.92)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C133(1.17); C136(1.19)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C133(1.08); C136(0.85)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C133(1.09); C136(0.90)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C133(0.88); C136(0.85)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C133(0.82); C136(0.69)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C133(0.82); C136(0.84)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C133(0.95); C136(0.90)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C133(1.00); C136(0.88)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C133(1.05); C136(0.89)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C133(1.12); C136(1.12)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C133(1.04); C136(1.04)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C133(1.03); C136(1.03)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C133(1.34); C136(1.34)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C133(0.98); C136(0.98)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C133(1.10); C136(1.10)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C133(0.97); C136(0.97)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C133(0.98); C136(0.98)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C133(0.73); C136(0.73)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C133(0.92); C136(0.92)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C133(0.93); C136(0.93)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C133(0.75); C136(0.75)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C133(1.18); C136(1.17)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C133(0.74); C136(0.74)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C133(0.95); C136(0.95)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C133(0.91); C136(0.91)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C136(1.11); C133(1.12)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C136(0.95); C133(1.12)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C133(1.02); C136(1.52)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C133(1.14); C136(1.25)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C133(1.01); C136(1.24)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C136(1.10); C133(1.49)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C133(1.18); C136(1.52)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C136(1.27); C133(1.31)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C133(1.32); C136(1.65)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C136(1.13); C133(1.31)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C133(1.30); C136(1.65)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C133(1.14); C136(1.45)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C133(1.04); C136(1.53)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C133(1.25); C136(1.50)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C133(0.93); C136(1.46)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C133(1.23); C136(1.85)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C133(1.09); C136(1.18)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C133(0.82); C136(0.93)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C133(0.83); C136(1.02)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C133(1.17); C136(1.26)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C133(1.03); C136(1.17)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C133(0.99); C136(1.02)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C133(0.97); C136(1.11)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C133(0.83); C136(0.92)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C133(1.24); C136(1.34)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C133(0.99); C136(1.16)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C133(0.89); C136(1.06)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C133(0.98); C136(1.05)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C133(0.97); C136(0.97)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C133(0.83); C136(1.05)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C133(1.20); C136(1.31)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C133(0.91); C136(1.11)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C133(1.02); C136(1.20)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C133(0.75); C136(1.07)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C133(0.78); C136(0.99)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C133(0.72); C136(0.90)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C133(1.04); C136(1.25)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C133(0.87); C136(0.96)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C133(1.18); C136(1.67)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C133(0.93); C136(0.93)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C136(0.95); C133(0.97)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C133(1.32); C136(1.43)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C133(0.84); C136(0.92)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C133(0.93); C136(1.02)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C136(1.04); C133(1.07)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C133(0.91); C136(1.01)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C133(1.00); C136(1.27)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C133(1.13); C136(1.50)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C133(1.18); C136(1.18)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C133(1.08); C136(1.08)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C133(0.86); C136(0.86)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C133(0.80); C136(0.80)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C133(1.38); C136(1.47)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C133(0.79); C136(0.79)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C133(1.40); C136(1.40)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C133(1.05); C136(1.05)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C133(0.86); C136(0.86)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C133(0.83); C136(0.83)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C133(0.86); C136(0.86)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C133(0.90); C136(0.90)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C136(0.84); C133(0.90)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C136(0.93); C133(1.16)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C136(1.03); C133(1.19)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C133(1.15); C136(1.20)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C136(0.77); C133(0.94)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C136(0.84); C133(0.88)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C133(0.85); C136(0.88)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C133(0.73); C136(0.78)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C133(0.69); C136(0.79)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C136(0.89); C133(1.06)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C136(0.85); C133(0.98)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C133(0.77); C136(0.80)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C136(0.92); C133(0.93)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C136(0.75); C133(0.87)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C133(1.04); C136(1.06)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C136(0.77); C133(0.85)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C136(0.78); C133(1.46)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C133(0.88); C136(0.92)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C133(0.72); C136(0.91)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C136(0.79); C133(1.00)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C136(0.92); C133(1.12)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C136(0.86); C133(0.95)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C133(0.74); C136(0.87)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C133(0.83); C136(0.96)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C136(0.92); C133(1.33)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C136(1.11); C133(1.15)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C136(0.80); C133(1.01)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C136(0.84); C133(1.05)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C133(0.83); C136(0.96)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C136(1.12); C133(1.12)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C133(1.06); C136(1.18)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C133(0.63); C136(1.13)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C133(0.91); C136(1.00)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C133(1.09); C136(1.16)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C133(1.11); C136(1.14)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C133(0.93); C136(1.06)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C136(0.99); C133(1.13)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C133(0.76); C136(1.09)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C133(0.95); C136(1.15)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C133(0.89); C136(1.31)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C133(0.74); C136(0.90)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C133(0.74); C136(1.04)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C133(0.69); C136(1.14)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C133(0.66); C136(1.07)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C136(0.92); C133(1.08)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C136(0.92); C133(0.92)  LDD0683  [7]
 LDCM0545  Acetamide MDA-MB-231 C118(0.30)  LDD2138  [5]
 LDCM0520  AKOS000195272 MDA-MB-231 C118(0.88)  LDD2113  [5]
 LDCM0248  AKOS034007472 HCT 116 C133(1.31); C136(1.32)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C136(1.03); C133(1.07)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C136(1.12); C133(1.18)  LDD0592  [7]
 LDCM0156  Aniline NCI-H1299 11.45  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C136(1.08)  LDD2171  [7]
 LDCM0102  BDHI 8 Jurkat C36(19.78)  LDD0204  [22]
 LDCM0498  BS-3668 MDA-MB-231 C118(0.34)  LDD2091  [5]
 LDCM0108  Chloroacetamide HeLa H278(0.00); C136(0.00)  LDD0222  [15]
 LDCM0632  CL-Sc Hep-G2 C133(1.63)  LDD2227  [17]
 LDCM0367  CL1 HCT 116 C133(0.79); C136(0.81)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C136(0.82); C133(1.14)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C133(1.10); C136(1.12)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C133(1.14); C136(1.23)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C136(0.78); C133(0.84)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C136(1.22); C133(1.24)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C136(0.88); C133(0.93)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C136(1.00); C133(1.01)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C136(0.58); C133(0.64)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C133(0.64); C136(0.73)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C136(0.79); C133(0.81)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C133(0.91); C136(1.07)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C133(0.96); C136(1.09)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C133(0.75); C136(0.89)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C133(0.83); C136(0.89)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C133(1.06); C136(1.17)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C133(0.75); C136(1.05)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C133(0.84); C136(1.06)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C133(0.83); C136(1.16)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C133(0.87); C136(1.08)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C133(0.91); C136(0.94)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C136(0.92); C133(1.01)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C133(0.93); C136(1.02)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C133(1.13); C136(1.38)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C133(0.88); C136(0.96)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C133(1.33); C136(1.33)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C133(0.98); C136(0.98)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C133(0.83); C136(0.83)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C133(0.89); C136(0.89)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C133(0.74); C136(0.83)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C136(0.79); C133(0.90)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C136(0.97); C133(1.11)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C136(0.74); C133(0.87)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C136(0.97); C133(1.13)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C136(0.99); C133(1.15)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C136(1.04); C133(1.14)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C133(0.85); C136(1.01)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C133(0.85); C136(0.90)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C133(0.94); C136(0.96)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C136(0.85); C133(1.02)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C136(0.84); C133(1.03)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C136(1.07); C133(1.12)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C136(0.82); C133(0.87)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C136(1.00); C133(1.42)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C133(0.69); C136(0.81)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C133(1.02); C136(0.82)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C133(1.00); C136(0.89)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C133(1.02); C136(1.11)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C133(0.99); C136(0.90)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C133(1.02); C136(1.02)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C133(0.85); C136(0.92)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C133(1.15); C136(0.98)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C133(0.88); C136(0.90)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C133(0.98); C136(0.93)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C133(0.92); C136(0.89)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C133(0.80); C136(0.99)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C133(0.96); C136(0.86)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C133(0.78); C136(1.02)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C133(0.98); C136(0.89)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C133(0.89); C136(0.95)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C133(0.79); C136(0.92)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C133(0.92); C136(0.84)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C133(0.80); C136(0.89)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C133(1.05); C136(0.96)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C133(0.80); C136(0.86)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C133(0.92); C136(1.10)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C133(0.98); C136(1.02)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C133(1.11); C136(1.01)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C133(1.24); C136(0.92)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C133(1.38); C136(1.02)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C133(1.36); C136(1.13)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C133(1.25); C136(1.02)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C133(1.08); C136(1.07)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C133(1.40); C136(1.15)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C133(1.26); C136(1.07)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C133(1.38); C136(1.24)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C133(1.64); C136(0.93)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C133(1.56); C136(1.03)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C133(1.55); C136(0.99)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C133(1.52); C136(0.98)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C133(1.35); C136(1.11)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C133(1.32); C136(1.11)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C133(1.35); C136(1.05)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C133(1.16); C136(0.94)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C133(1.71); C136(0.98)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C133(0.65); C136(0.93)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C133(0.92); C136(0.82)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C133(0.75); C136(0.74)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C133(0.80); C136(0.70)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C133(0.82); C136(0.92)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C133(0.95); C136(0.77)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C133(0.82); C136(0.69)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C133(0.67); C136(0.77)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C133(0.69); C136(0.75)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C133(1.25); C136(1.08)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C133(0.85); C136(0.78)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C133(0.75); C136(0.89)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C133(0.64); C136(0.78)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C133(0.62); C136(0.63)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C133(0.81); C136(0.83)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C133(0.94); C136(0.87)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C133(0.90); C136(0.94)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C133(0.86); C136(1.00)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C133(0.94); C136(1.31)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C133(1.06); C136(1.12)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C133(1.02); C136(1.41)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C133(1.02); C136(1.03)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C133(1.02); C136(1.22)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C133(0.92); C136(1.19)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C133(0.90); C136(1.12)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C133(0.88); C136(1.02)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C133(0.90); C136(1.50)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C133(1.02); C136(1.28)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C133(0.99); C136(1.15)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C133(1.02); C136(1.29)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C133(1.06); C136(0.99)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C133(0.87); C136(1.07)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C133(0.96); C136(0.95)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C133(1.00); C136(0.99)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C133(1.21); C136(1.20)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C133(1.12); C136(1.18)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C133(1.10); C136(1.17)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C133(1.12); C136(1.24)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C133(1.01); C136(1.19)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C133(0.99); C136(0.99)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C133(1.16); C136(1.12)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C36(1.09); C229(0.93); C136(0.95); C133(0.79)  LDD1698  [23]
 LDCM0468  Fragment33 HCT 116 C133(0.80); C136(0.88)  LDD0785  [7]
 LDCM0427  Fragment51 HCT 116 C133(0.85); C136(0.90)  LDD0744  [7]
 LDCM0107  IAA HeLa N.A.  LDD0221  [15]
 LDCM0022  KB02 HCT 116 C136(1.26)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C136(2.33)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C136(1.54)  LDD0082  [7]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C118(0.97)  LDD2102  [5]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C118(0.50)  LDD2121  [5]
 LDCM0109  NEM HeLa N.A.  LDD0223  [15]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C118(0.35)  LDD2089  [5]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C118(1.02)  LDD2090  [5]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C118(0.73)  LDD2093  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C118(0.69)  LDD2099  [5]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C118(0.56)  LDD2100  [5]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C118(1.02)  LDD2101  [5]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C118(0.82)  LDD2106  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C118(0.81)  LDD2107  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C118(0.52)  LDD2109  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C118(0.67)  LDD2111  [5]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C118(0.63)  LDD2115  [5]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C118(1.00)  LDD2118  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C118(0.50)  LDD2123  [5]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C118(0.83)  LDD2124  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C118(0.56)  LDD2125  [5]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C118(0.87)  LDD2128  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C118(0.79)  LDD2129  [5]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C118(0.93)  LDD2133  [5]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C118(0.63)  LDD2134  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C118(0.63)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C118(0.82)  LDD2137  [5]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C118(1.11)  LDD1700  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C118(0.45)  LDD2140  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C118(0.47)  LDD2141  [5]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C118(1.63)  LDD2143  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C118(0.91)  LDD2146  [5]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C118(0.67)  LDD2148  [5]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C118(1.40)  LDD2153  [5]
 LDCM0014  Panhematin K562 3.13  LDD0063  [6]
 LDCM0021  THZ1 HCT 116 C136(1.08)  LDD2173  [7]

References

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Mass spectrometry data entry: PXD028270
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Mass spectrometry data entry: PXD039908 , PXD029761
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Mass spectrometry data entry: PXD034651
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Mass spectrometry data entry: PXD028853
10 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
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Mass spectrometry data entry: PXD029255
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD039931
14 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
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Mass spectrometry data entry: PXD041264
18 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
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Mass spectrometry data entry: PXD041587
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Mass spectrometry data entry: PXD044402