Details of the Target

General Information of Target

Target ID LDTP11716
Target Name Serine/threonine-protein kinase SIK2 (SIK2)
Gene Name SIK2
Gene ID 23235
Synonyms
KIAA0781; QIK; SNF1LK2; Serine/threonine-protein kinase SIK2; EC 2.7.11.1; Qin-induced kinase; Salt-inducible kinase 2; SIK-2; Serine/threonine-protein kinase SNF1-like kinase 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAQAGVVGEVTQVLCAAGGALELPELRRRLRMGLSADALERLLRQRGRFVVAVRAGGAAA
APERVVLAASPLRLCRAHQGSKPGCVGLCAQLHLCRFMVYGACKFLRAGKNCRNSHSLTT
EHNLSVLRTHGVDHLSYNELCQLLFQNDPWLLPEICQHYNKGDGPHGSCAFQKQCIKLHI
CQYFLQGECKFGTSCKRSHDFSNSENLEKLEKLGMSSDLVSRLPTIYRNAHDIKNKSSAP
SRVPPLFVPQGTSERKDSSGSVSPNTLSQEEGDQICLYHIRKSCSFQDKCHRVHFHLPYR
WQFLDRGKWEDLDNMELIEEAYCNPKIERILCSESASTFHSHCLNFNAMTYGATQARRLS
TASSVTKPPHFILTTDWIWYWSDEFGSWQEYGRQGTVHPVTTVSSSDVEKAYLAYCTPGS
DGQAATLKFQAGKHNYELDFKAFVQKNLVYGTTKKVCRRPKYVSPQDVTTMQTCNTKFPG
PKSIPDYWDSSALPDPGFQKITLSSSSEEYQKVWNLFNRTLPFYFVQKIERVQNLALWEV
YQWQKGQMQKQNGGKAVDERQLFHGTSAIFVDAICQQNFDWRVCGVHGTSYGKGSYFARD
AAYSHHYSKSDTQTHTMFLARVLVGEFVRGNASFVRPPAKEGWSNAFYDSCVNSVSDPSI
FVIFEKHQVYPEYVIQYTTSSKPSVTPSILLALGSLFSSRQ
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily
Subcellular location
Cytoplasm
Function
Serine/threonine-protein kinase that plays a role in many biological processes such as fatty acid oxidation, autophagy, immune response or glucose metabolism. Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators. Phosphorylates EP300 and thus inhibits its histone acetyltransferase activity. In turn, regulates the DNA-binding ability of several transcription factors such as PPARA or MLXIPL. Also plays a role in thymic T-cell development.
TTD ID
T30495
Uniprot ID
Q9H0K1
DrugMap ID
TTCUGZR
Ensemble ID
ENST00000304987.4
HGNC ID
HGNC:21680
ChEMBL ID
CHEMBL5699

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HPAP
 Probe Info  		4.39  LDD0062  [1]
IA-alkyne
 Probe Info  		C701(9.97)  LDD1704  [2]
DBIA
 Probe Info  		C697(1.13); C701(1.13); C133(0.90)  LDD0078  [3]
IPM
 Probe Info  		C697(0.00); C426(0.00); C244(0.00)  LDD2156  [4]
AOyne
 Probe Info  		13.90  LDD0443  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C697(0.70)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C697(1.00); C701(1.00)  LDD0532  [3]
 LDCM0216  AC100 PaTu 8988t C697(0.86); C701(0.86)  LDD1095  [3]
 LDCM0217  AC101 PaTu 8988t C697(1.03); C701(1.03)  LDD1096  [3]
 LDCM0218  AC102 PaTu 8988t C697(0.89); C701(0.89)  LDD1097  [3]
 LDCM0219  AC103 PaTu 8988t C697(1.23); C701(1.23)  LDD1098  [3]
 LDCM0220  AC104 PaTu 8988t C697(0.75); C701(0.75)  LDD1099  [3]
 LDCM0221  AC105 PaTu 8988t C697(1.01); C701(1.01)  LDD1100  [3]
 LDCM0222  AC106 PaTu 8988t C697(0.86); C701(0.86)  LDD1101  [3]
 LDCM0223  AC107 PaTu 8988t C697(0.68); C701(0.68)  LDD1102  [3]
 LDCM0224  AC108 PaTu 8988t C697(0.78); C701(0.78)  LDD1103  [3]
 LDCM0225  AC109 PaTu 8988t C697(0.88); C701(0.88)  LDD1104  [3]
 LDCM0226  AC11 HCT 116 C697(1.15); C701(1.15)  LDD0543  [3]
 LDCM0227  AC110 PaTu 8988t C697(1.13); C701(1.13)  LDD1106  [3]
 LDCM0228  AC111 PaTu 8988t C697(1.38); C701(1.38)  LDD1107  [3]
 LDCM0229  AC112 PaTu 8988t C697(1.06); C701(1.06)  LDD1108  [3]
 LDCM0230  AC113 HCT 116 C697(0.64); C701(0.64)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C697(1.07); C701(1.07)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C697(1.19); C701(1.19)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C697(1.05); C701(1.05)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C697(1.03); C701(1.03)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C697(0.91); C701(0.91)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C697(1.17); C701(1.17)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C697(0.80); C701(0.80)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C697(1.08); C701(1.08)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C697(1.17); C701(1.17)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C697(1.27); C701(1.27)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C697(0.85); C701(0.85)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C697(1.06); C701(1.06)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C697(1.21); C701(1.21)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C697(0.93); C701(0.93)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C697(0.87); C701(0.87)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C697(0.53); C701(0.53)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C697(0.38); C701(0.38)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C697(0.44); C701(0.44)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C697(0.51); C701(0.51)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C697(0.42); C701(0.42)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C697(0.48); C701(0.48)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C697(0.53); C701(0.53)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C697(0.50); C701(0.50)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C697(0.54); C701(0.54)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C697(0.49); C701(0.49)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C697(0.53); C701(0.53)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C697(0.50); C701(0.50)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C697(1.15); C701(1.15)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C697(0.52); C701(0.52)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C697(0.53); C701(0.53)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C697(0.46); C701(0.46)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C697(0.96); C701(0.96)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C697(0.76); C701(0.76)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C697(0.72); C701(0.72)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C697(0.79); C701(0.79)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C697(0.92); C701(0.92)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C697(1.05); C701(1.05)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C697(1.11); C701(1.11)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C697(0.71); C701(0.71)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C697(0.70); C701(0.70)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C697(0.66); C701(0.66)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C697(0.86); C701(0.86)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C697(0.80); C701(0.80)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C697(0.66); C701(0.66)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C697(0.69); C701(0.69)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C697(0.69); C701(0.69)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C697(0.68); C701(0.68)  LDD2161  [3]
 LDCM0276  AC17 HEK-293T C697(1.93); C701(2.36)  LDD0874  [3]
 LDCM0277  AC18 HEK-293T C697(1.57); C701(1.92)  LDD0875  [3]
 LDCM0278  AC19 HEK-293T C697(1.62); C701(2.21)  LDD0876  [3]
 LDCM0279  AC2 HCT 116 C697(0.57)  LDD0596  [3]
 LDCM0280  AC20 HEK-293T C697(1.20); C701(1.45)  LDD0878  [3]
 LDCM0281  AC21 HEK-293T C697(1.11); C701(1.33)  LDD0879  [3]
 LDCM0282  AC22 HEK-293T C697(1.15); C701(1.41)  LDD0880  [3]
 LDCM0283  AC23 HEK-293T C697(1.21); C701(1.49)  LDD0881  [3]
 LDCM0284  AC24 HEK-293T C697(1.38); C701(1.69)  LDD0882  [3]
 LDCM0285  AC25 PaTu 8988t C697(0.85); C701(0.85)  LDD1164  [3]
 LDCM0286  AC26 PaTu 8988t C697(0.93); C701(0.93)  LDD1165  [3]
 LDCM0287  AC27 PaTu 8988t C697(0.87); C701(0.87)  LDD1166  [3]
 LDCM0288  AC28 PaTu 8988t C697(0.94); C701(0.94)  LDD1167  [3]
 LDCM0289  AC29 PaTu 8988t C697(0.88); C701(0.88)  LDD1168  [3]
 LDCM0290  AC3 HCT 116 C697(0.57)  LDD0607  [3]
 LDCM0291  AC30 PaTu 8988t C697(0.86); C701(0.86)  LDD1170  [3]
 LDCM0292  AC31 PaTu 8988t C697(0.93); C701(0.93)  LDD1171  [3]
 LDCM0293  AC32 PaTu 8988t C697(1.07); C701(1.07)  LDD1172  [3]
 LDCM0294  AC33 PaTu 8988t C697(1.21); C701(1.21)  LDD1173  [3]
 LDCM0295  AC34 PaTu 8988t C697(0.96); C701(0.96)  LDD1174  [3]
 LDCM0296  AC35 HEK-293T C697(0.98); C701(1.05)  LDD0894  [3]
 LDCM0297  AC36 HEK-293T C697(0.74); C701(0.75)  LDD0895  [3]
 LDCM0298  AC37 HEK-293T C697(1.08); C701(1.10)  LDD0896  [3]
 LDCM0299  AC38 HEK-293T C697(1.26); C701(1.43)  LDD0897  [3]
 LDCM0300  AC39 HEK-293T C697(1.06); C701(1.11)  LDD0898  [3]
 LDCM0301  AC4 HCT 116 C697(0.57)  LDD0618  [3]
 LDCM0302  AC40 HEK-293T C697(1.22); C701(1.31)  LDD0900  [3]
 LDCM0303  AC41 HEK-293T C697(0.85); C701(0.72)  LDD0901  [3]
 LDCM0304  AC42 HEK-293T C697(0.98); C701(0.92)  LDD0902  [3]
 LDCM0305  AC43 HEK-293T C697(1.09); C701(1.22)  LDD0903  [3]
 LDCM0306  AC44 HEK-293T C697(0.93); C701(0.91)  LDD0904  [3]
 LDCM0307  AC45 HEK-293T C697(1.10); C701(1.11)  LDD0905  [3]
 LDCM0308  AC46 HEK-293T C697(0.97); C701(0.97)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C697(0.80); C701(0.80)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C697(0.86); C701(0.86)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C697(0.89); C701(0.89)  LDD0909  [3]
 LDCM0312  AC5 HCT 116 C697(0.49)  LDD0629  [3]
 LDCM0313  AC50 HEK-293T C697(1.04); C701(1.04)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C697(0.93); C701(0.93)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C697(1.07); C701(1.07)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C697(1.71); C701(1.71)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C697(1.19); C701(1.19)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C697(1.30); C701(1.30)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C697(0.84); C701(0.84)  LDD0917  [3]
 LDCM0320  AC57 PaTu 8988t C697(1.54); C701(1.54)  LDD1199  [3]
 LDCM0321  AC58 PaTu 8988t C697(1.33); C701(1.33)  LDD1200  [3]
 LDCM0322  AC59 PaTu 8988t C697(1.42); C701(1.42)  LDD1201  [3]
 LDCM0323  AC6 HCT 116 C697(1.12); C701(1.12)  LDD0640  [3]
 LDCM0324  AC60 PaTu 8988t C697(1.28); C701(1.28)  LDD1203  [3]
 LDCM0325  AC61 PaTu 8988t C697(1.11); C701(1.11)  LDD1204  [3]
 LDCM0326  AC62 PaTu 8988t C697(0.83); C701(0.83)  LDD1205  [3]
 LDCM0327  AC63 PaTu 8988t C697(0.95); C701(0.95)  LDD1206  [3]
 LDCM0328  AC64 PaTu 8988t C697(0.94); C701(0.94)  LDD1207  [3]
 LDCM0329  AC65 PaTu 8988t C697(0.87); C701(0.87)  LDD1208  [3]
 LDCM0330  AC66 PaTu 8988t C697(1.07); C701(1.07)  LDD1209  [3]
 LDCM0331  AC67 PaTu 8988t C697(0.90); C701(0.90)  LDD1210  [3]
 LDCM0332  AC68 HEK-293T C697(0.65)  LDD0930  [3]
 LDCM0333  AC69 HEK-293T C697(0.62)  LDD0931  [3]
 LDCM0334  AC7 HCT 116 C697(1.15); C701(1.15)  LDD0651  [3]
 LDCM0335  AC70 HEK-293T C697(0.48)  LDD0933  [3]
 LDCM0336  AC71 HEK-293T C697(0.75)  LDD0934  [3]
 LDCM0337  AC72 HEK-293T C697(0.89)  LDD0935  [3]
 LDCM0338  AC73 HEK-293T C697(0.88)  LDD0936  [3]
 LDCM0339  AC74 HEK-293T C697(0.51)  LDD0937  [3]
 LDCM0340  AC75 HEK-293T C697(1.03)  LDD0938  [3]
 LDCM0341  AC76 HEK-293T C697(0.88)  LDD0939  [3]
 LDCM0342  AC77 HEK-293T C697(0.74)  LDD0940  [3]
 LDCM0343  AC78 HEK-293T C697(0.79)  LDD0941  [3]
 LDCM0344  AC79 HEK-293T C697(0.87)  LDD0942  [3]
 LDCM0345  AC8 HCT 116 C697(0.91); C701(0.91)  LDD0662  [3]
 LDCM0346  AC80 HEK-293T C697(0.86)  LDD0944  [3]
 LDCM0347  AC81 HEK-293T C697(1.03)  LDD0945  [3]
 LDCM0348  AC82 HEK-293T C697(0.82)  LDD0946  [3]
 LDCM0349  AC83 PaTu 8988t C697(0.78); C701(0.78)  LDD1228  [3]
 LDCM0350  AC84 PaTu 8988t C697(0.91); C701(0.91)  LDD1229  [3]
 LDCM0351  AC85 PaTu 8988t C697(0.75); C701(0.75)  LDD1230  [3]
 LDCM0352  AC86 PaTu 8988t C697(0.83); C701(0.83)  LDD1231  [3]
 LDCM0353  AC87 PaTu 8988t C697(0.58); C701(0.58)  LDD1232  [3]
 LDCM0354  AC88 PaTu 8988t C697(0.70); C701(0.70)  LDD1233  [3]
 LDCM0355  AC89 PaTu 8988t C697(0.84); C701(0.84)  LDD1234  [3]
 LDCM0357  AC90 PaTu 8988t C697(0.91); C701(0.91)  LDD1236  [3]
 LDCM0358  AC91 PaTu 8988t C697(0.88); C701(0.88)  LDD1237  [3]
 LDCM0359  AC92 PaTu 8988t C697(0.68); C701(0.68)  LDD1238  [3]
 LDCM0360  AC93 PaTu 8988t C697(0.72); C701(0.72)  LDD1239  [3]
 LDCM0361  AC94 PaTu 8988t C697(0.80); C701(0.80)  LDD1240  [3]
 LDCM0362  AC95 PaTu 8988t C697(0.93); C701(0.93)  LDD1241  [3]
 LDCM0363  AC96 PaTu 8988t C697(0.63); C701(0.63)  LDD1242  [3]
 LDCM0364  AC97 PaTu 8988t C697(0.92); C701(0.92)  LDD1243  [3]
 LDCM0365  AC98 PaTu 8988t C697(0.87); C701(0.87)  LDD1244  [3]
 LDCM0366  AC99 PaTu 8988t C697(0.71); C701(0.71)  LDD1245  [3]
 LDCM0248  AKOS034007472 HCT 116 C697(1.02); C701(1.02)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C697(1.20); C701(1.20)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C697(0.80); C701(0.80)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C697(1.13); C701(1.13); C133(0.90)  LDD0078  [3]
 LDCM0367  CL1 HEK-293T C697(1.52); C701(1.52)  LDD0965  [3]
 LDCM0368  CL10 HEK-293T C697(2.04); C701(2.04)  LDD0966  [3]
 LDCM0369  CL100 HCT 116 C697(0.56)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C697(1.41); C701(1.41)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C697(1.68); C701(1.68)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C697(1.07); C701(1.07)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C697(1.13); C701(1.13)  LDD0690  [3]
 LDCM0374  CL105 HEK-293T C697(1.14); C701(1.49)  LDD0972  [3]
 LDCM0375  CL106 HEK-293T C697(1.82); C701(2.59)  LDD0973  [3]
 LDCM0376  CL107 HEK-293T C697(1.56); C701(2.05)  LDD0974  [3]
 LDCM0377  CL108 HEK-293T C697(1.44); C701(1.78)  LDD0975  [3]
 LDCM0378  CL109 HEK-293T C697(1.55); C701(1.83)  LDD0976  [3]
 LDCM0379  CL11 HEK-293T C697(1.00); C701(1.00)  LDD0977  [3]
 LDCM0380  CL110 HEK-293T C697(2.31); C701(3.27)  LDD0978  [3]
 LDCM0381  CL111 HEK-293T C697(2.01); C701(2.64)  LDD0979  [3]
 LDCM0382  CL112 PaTu 8988t C697(0.83); C701(0.83)  LDD1261  [3]
 LDCM0383  CL113 PaTu 8988t C697(0.86); C701(0.86)  LDD1262  [3]
 LDCM0384  CL114 PaTu 8988t C697(1.11); C701(1.11)  LDD1263  [3]
 LDCM0385  CL115 PaTu 8988t C697(0.97); C701(0.97)  LDD1264  [3]
 LDCM0386  CL116 PaTu 8988t C697(1.09); C701(1.09)  LDD1265  [3]
 LDCM0387  CL117 HEK-293T C697(1.13); C701(1.27)  LDD0985  [3]
 LDCM0388  CL118 HEK-293T C697(0.82); C701(0.70)  LDD0986  [3]
 LDCM0389  CL119 HEK-293T C697(0.88); C701(0.89)  LDD0987  [3]
 LDCM0390  CL12 HEK-293T C697(1.13); C701(1.13)  LDD0988  [3]
 LDCM0391  CL120 HEK-293T C697(0.88); C701(0.83)  LDD0989  [3]
 LDCM0392  CL121 HEK-293T C697(1.19); C701(1.19)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C697(1.12); C701(1.12)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C697(1.83); C701(1.83)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C697(1.17); C701(1.17)  LDD0993  [3]
 LDCM0396  CL125 PaTu 8988t C697(1.19); C701(1.19)  LDD1275  [3]
 LDCM0397  CL126 PaTu 8988t C697(1.21); C701(1.21)  LDD1276  [3]
 LDCM0398  CL127 PaTu 8988t C697(1.23); C701(1.23)  LDD1277  [3]
 LDCM0399  CL128 PaTu 8988t C697(1.50); C701(1.50)  LDD1278  [3]
 LDCM0400  CL13 HEK-293T C697(1.06); C701(1.06)  LDD0998  [3]
 LDCM0401  CL14 HEK-293T C697(1.15); C701(1.15)  LDD0999  [3]
 LDCM0402  CL15 HEK-293T C697(2.70); C701(2.70)  LDD1000  [3]
 LDCM0403  CL16 HCT 116 C697(0.88); C701(0.88)  LDD0720  [3]
 LDCM0405  CL18 HEK-293T C244(0.90); C426(0.88)  LDD1609  [6]
 LDCM0407  CL2 HEK-293T C697(1.03); C701(1.03)  LDD1005  [3]
 LDCM0411  CL23 HEK-293T C244(0.87)  LDD1615  [6]
 LDCM0416  CL28 HEK-293T C244(0.93)  LDD1620  [6]
 LDCM0418  CL3 HEK-293T C697(0.81); C701(0.81)  LDD1016  [3]
 LDCM0419  CL30 HEK-293T C244(1.03); C426(1.00)  LDD1623  [6]
 LDCM0420  CL31 HEK-293T C697(0.95); C701(0.95)  LDD1018  [3]
 LDCM0421  CL32 HCT 116 C697(0.79); C701(0.79)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C697(1.53); C701(1.53)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C697(0.79); C701(0.79)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C697(0.73); C701(0.73)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C697(0.85); C701(0.85)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C697(0.63); C701(0.63)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C697(0.77); C701(0.77)  LDD0745  [3]
 LDCM0429  CL4 HEK-293T C697(1.17); C701(1.17)  LDD1027  [3]
 LDCM0430  CL40 HCT 116 C697(0.99); C701(0.99)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C697(1.14); C701(1.14)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C697(0.73); C701(0.73)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C697(0.89); C701(0.89)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C697(0.60); C701(0.60)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C697(0.65); C701(0.65)  LDD0752  [3]
 LDCM0436  CL46 HEK-293T C697(0.94); C701(0.94)  LDD1034  [3]
 LDCM0437  CL47 HEK-293T C697(0.98); C701(0.98)  LDD1035  [3]
 LDCM0438  CL48 HEK-293T C697(1.09); C701(1.09)  LDD1036  [3]
 LDCM0439  CL49 HEK-293T C697(0.93); C701(0.93)  LDD1037  [3]
 LDCM0440  CL5 HEK-293T C697(0.96); C701(0.96)  LDD1038  [3]
 LDCM0441  CL50 HEK-293T C697(1.68); C701(1.68)  LDD1039  [3]
 LDCM0442  CL51 HEK-293T C697(1.58); C701(1.58)  LDD1040  [3]
 LDCM0443  CL52 HEK-293T C697(1.28); C701(1.28)  LDD1041  [3]
 LDCM0444  CL53 HEK-293T C697(2.16); C701(2.16)  LDD1042  [3]
 LDCM0445  CL54 HEK-293T C697(1.43); C701(1.43)  LDD1043  [3]
 LDCM0446  CL55 HEK-293T C697(0.79); C701(0.79)  LDD1044  [3]
 LDCM0447  CL56 HEK-293T C697(0.83); C701(0.83)  LDD1045  [3]
 LDCM0448  CL57 HEK-293T C697(1.55); C701(1.55)  LDD1046  [3]
 LDCM0449  CL58 HEK-293T C697(1.24); C701(1.24)  LDD1047  [3]
 LDCM0450  CL59 HEK-293T C697(1.26); C701(1.26)  LDD1048  [3]
 LDCM0451  CL6 HEK-293T C697(1.25); C701(1.25)  LDD1049  [3]
 LDCM0452  CL60 HEK-293T C697(0.99); C701(0.99)  LDD1050  [3]
 LDCM0453  CL61 HCT 116 C697(0.99); C701(0.99)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C697(1.13); C701(1.13)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C697(0.96); C701(0.96)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C697(0.95); C701(0.95)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C697(0.92); C701(0.92)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C697(0.77); C701(0.77)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C697(0.74); C701(0.74)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C697(0.73); C701(0.73)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C697(0.97); C701(0.97)  LDD0778  [3]
 LDCM0462  CL7 HEK-293T C697(0.80); C701(0.80)  LDD1060  [3]
 LDCM0463  CL70 HCT 116 C697(1.09); C701(1.09)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C697(0.87); C701(0.87)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C697(1.18); C701(1.18)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C697(0.86); C701(0.86)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C697(0.99); C701(0.99)  LDD0784  [3]
 LDCM0469  CL76 HEK-293T C697(0.99); C701(0.99)  LDD1067  [3]
 LDCM0470  CL77 HEK-293T C697(1.57); C701(1.57)  LDD1068  [3]
 LDCM0471  CL78 HEK-293T C697(0.84); C701(0.84)  LDD1069  [3]
 LDCM0472  CL79 HEK-293T C697(1.01); C701(1.01)  LDD1070  [3]
 LDCM0473  CL8 HEK-293T C697(0.93); C701(0.93)  LDD1071  [3]
 LDCM0474  CL80 HEK-293T C697(0.97); C701(0.97)  LDD1072  [3]
 LDCM0475  CL81 HEK-293T C697(0.91); C701(0.91)  LDD1073  [3]
 LDCM0476  CL82 HEK-293T C697(0.86); C701(0.86)  LDD1074  [3]
 LDCM0477  CL83 HEK-293T C697(0.87); C701(0.87)  LDD1075  [3]
 LDCM0478  CL84 HEK-293T C697(1.10); C701(1.10)  LDD1076  [3]
 LDCM0479  CL85 HEK-293T C697(1.09); C701(1.09)  LDD1077  [3]
 LDCM0480  CL86 HEK-293T C697(0.88); C701(0.88)  LDD1078  [3]
 LDCM0481  CL87 HEK-293T C697(1.00); C701(1.00)  LDD1079  [3]
 LDCM0482  CL88 HEK-293T C697(1.29); C701(1.29)  LDD1080  [3]
 LDCM0483  CL89 HEK-293T C697(0.82); C701(0.82)  LDD1081  [3]
 LDCM0484  CL9 HEK-293T C697(1.30); C701(0.99)  LDD1082  [3]
 LDCM0485  CL90 HEK-293T C697(2.62); C701(2.62)  LDD1083  [3]
 LDCM0486  CL91 HCT 116 C697(0.85)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C697(1.06)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C697(0.74)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C697(0.90)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C697(1.08)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C697(0.76)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C697(0.78)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C697(0.67)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C697(0.71)  LDD0811  [3]
 LDCM0468  Fragment33 HCT 116 C697(0.93); C701(0.93)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C697(0.83); C701(0.83)  LDD0744  [3]
 LDCM0022  KB02 HEK-293T C697(0.89)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C697(1.01)  LDD1497  [6]
 LDCM0024  KB05 HEK-293T C697(0.99)  LDD1502  [6]
 LDCM0014  Panhematin HEK-293T 4.39  LDD0062  [1]
 LDCM0021  THZ1 HCT 116 C697(1.03); C701(1.03)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transitional endoplasmic reticulum ATPase (VCP) AAA ATPase family P55072
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gamma-aminobutyric acid receptor-associated protein-like 2 (GABARAPL2) ATG8 family P60520
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) PI3K p85 subunit family P27986
Centrosome-associated protein CEP250 (CEP250) . Q9BV73

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fostamatinib Small molecular drug DB12010
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Hg-9-91-01 Small molecular drug D03YVB

References

1 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
2 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402