Details of the Target

General Information of Target

Target ID LDTP04370
Target Name ETS domain-containing transcription factor ERF (ERF)
Gene Name ERF
Gene ID 2077
Synonyms
ETS domain-containing transcription factor ERF; Ets2 repressor factor; PE-2
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MKTPADTGFAFPDWAYKPESSPGSRQIQLWHFILELLRKEEYQGVIAWQGDYGEFVIKDP
DEVARLWGVRKCKPQMNYDKLSRALRYYYNKRILHKTKGKRFTYKFNFNKLVLVNYPFID
VGLAGGAVPQSAPPVPSGGSHFRFPPSTPSEVLSPTEDPRSPPACSSSSSSLFSAVVARR
LGRGSVSDCSDGTSELEEPLGEDPRARPPGPPDLGAFRGPPLARLPHDPGVFRVYPRPRG
GPEPLSPFPVSPLAGPGSLLPPQLSPALPMTPTHLAYTPSPTLSPMYPSGGGGPSGSGGG
SHFSFSPEDMKRYLQAHTQSVYNYHLSPRAFLHYPGLVVPQPQRPDKCPLPPMAPETPPV
PSSASSSSSSSSSPFKFKLQPPPLGRRQRAAGEKAVAGADKSGGSAGGLAEGAGALAPPP
PPPQIKVEPISEGESEEVEVTDISDEDEEDGEVFKTPRAPPAPPKPEPGEAPGASQCMPL
KLRFKRRWSEDCRLEGGGGPAGGFEDEGEDKKVRGEGPGEAGGPLTPRRVSSDLQHATAQ
LSLEHRDS
Target Type
Literature-reported
Target Bioclass
Transcription factor
Family
ETS family
Subcellular location
Nucleus
Function
Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment. May be important for regulating trophoblast stem cell differentiation.
TTD ID
T11561
Uniprot ID
P50548
DrugMap ID
TTGXULC
Ensemble ID
ENST00000222329.9
HGNC ID
HGNC:3444

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL148 SNV: p.E411Ter .
CHL1 SNV: p.P261S DBIA    Probe Info 
DU145 SNV: p.A132S .
EOL1 SNV: p.V234I DBIA    Probe Info 
G415 SNV: p.P4A .
JURKAT Deletion: p.R205AfsTer66 .
KASUMI1 SNV: p.H302P .
MKN1 Insertion: p.E437DfsTer3; p.E437GfsTer2 .
MOLT4 SNV: p.A47V; p.R92C .
OVISE Insertion: p.R179HfsTer22 .
OVK18 Deletion: p.L525SfsTer6 .
SNGM Deletion: p.G299EfsTer12 .
SNU1 Deletion: p.G299EfsTer12 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y322(10.73)  LDD0257  [2]
HPAP
 Probe Info  		3.20  LDD0062  [3]
DBIA
 Probe Info  		C72(0.80)  LDD0532  [4]
IPM
 Probe Info  		N.A.  LDD0025  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
WYneN
 Probe Info  		N.A.  LDD0021  [7]
WYneO
 Probe Info  		N.A.  LDD0022  [7]
VSF
 Probe Info  		N.A.  LDD0007  [7]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [8]
W1
 Probe Info  		N.A.  LDD0236  [9]
NAIA_5
 Probe Info  		N.A.  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C477(1.04); C165(1.19); C348(0.89)  LDD1507  [10]
 LDCM0215  AC10 HCT 116 C72(0.80)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C72(0.89)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C72(1.20)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C72(1.01)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C72(1.07)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C72(0.98)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C72(0.97)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C72(0.97)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C72(1.03)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C72(0.97)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C72(1.03)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C72(0.90)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C72(1.19)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C72(1.12)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C72(1.16)  LDD0546  [4]
 LDCM0237  AC12 HCT 116 C72(0.83)  LDD0554  [4]
 LDCM0259  AC14 HCT 116 C72(0.87)  LDD0576  [4]
 LDCM0270  AC15 HCT 116 C72(0.75)  LDD0587  [4]
 LDCM0276  AC17 HEK-293T C477(1.08); C165(1.12); C348(1.19)  LDD1515  [10]
 LDCM0277  AC18 HEK-293T C477(0.98); C165(0.92); C348(1.05); C72(1.07)  LDD1516  [10]
 LDCM0278  AC19 HEK-293T C477(2.19); C165(1.05); C348(1.09)  LDD1517  [10]
 LDCM0279  AC2 HEK-293T C477(1.00); C165(0.99); C348(1.11); C72(1.09)  LDD1518  [10]
 LDCM0280  AC20 HEK-293T C477(1.11); C165(0.98); C348(0.92)  LDD1519  [10]
 LDCM0281  AC21 HEK-293T C477(0.99); C165(0.86); C348(0.84); C72(1.05)  LDD1520  [10]
 LDCM0282  AC22 HEK-293T C477(1.14); C165(0.98); C348(1.10)  LDD1521  [10]
 LDCM0283  AC23 HEK-293T C477(0.99); C165(1.07); C348(1.18)  LDD1522  [10]
 LDCM0284  AC24 HEK-293T C477(0.99); C165(0.89)  LDD1523  [10]
 LDCM0285  AC25 HEK-293T C477(1.08); C165(1.06); C348(1.12)  LDD1524  [10]
 LDCM0286  AC26 HEK-293T C477(1.04); C165(0.92); C348(1.09); C72(1.03)  LDD1525  [10]
 LDCM0287  AC27 HEK-293T C477(0.95); C165(0.95); C348(1.06)  LDD1526  [10]
 LDCM0288  AC28 HEK-293T C477(1.04); C165(0.95); C348(0.87)  LDD1527  [10]
 LDCM0289  AC29 HEK-293T C477(1.04); C165(0.92); C348(0.92); C72(0.98)  LDD1528  [10]
 LDCM0290  AC3 HEK-293T C477(1.03); C165(0.98); C348(0.91)  LDD1529  [10]
 LDCM0291  AC30 HEK-293T C477(0.98); C165(1.06); C348(0.92)  LDD1530  [10]
 LDCM0292  AC31 HEK-293T C477(0.96); C165(0.90); C348(1.06)  LDD1531  [10]
 LDCM0293  AC32 HEK-293T C477(1.01); C165(1.02)  LDD1532  [10]
 LDCM0294  AC33 HEK-293T C477(1.10); C165(1.27); C348(1.11)  LDD1533  [10]
 LDCM0295  AC34 HEK-293T C477(1.03); C165(0.91); C348(1.26); C72(1.00)  LDD1534  [10]
 LDCM0296  AC35 HEK-293T C477(1.11); C165(1.03); C348(1.13)  LDD1535  [10]
 LDCM0297  AC36 HEK-293T C477(1.08); C165(1.08); C348(0.96)  LDD1536  [10]
 LDCM0298  AC37 HEK-293T C477(0.97); C165(0.94); C348(1.00); C72(1.15)  LDD1537  [10]
 LDCM0299  AC38 HEK-293T C477(1.05); C165(0.80); C348(0.97)  LDD1538  [10]
 LDCM0300  AC39 HEK-293T C477(1.02); C165(1.09); C348(1.30)  LDD1539  [10]
 LDCM0301  AC4 HEK-293T C477(1.01); C165(1.10); C348(1.06)  LDD1540  [10]
 LDCM0302  AC40 HEK-293T C477(1.05); C165(0.99)  LDD1541  [10]
 LDCM0303  AC41 HEK-293T C477(1.16); C165(1.17); C348(0.87)  LDD1542  [10]
 LDCM0304  AC42 HEK-293T C477(0.99); C165(1.08); C348(0.97); C72(1.02)  LDD1543  [10]
 LDCM0305  AC43 HEK-293T C477(1.17); C165(0.95); C348(1.11)  LDD1544  [10]
 LDCM0306  AC44 HEK-293T C477(1.08); C165(1.03); C348(0.74)  LDD1545  [10]
 LDCM0307  AC45 HEK-293T C477(1.07); C165(1.03); C348(1.03); C72(1.17)  LDD1546  [10]
 LDCM0308  AC46 HEK-293T C477(1.07); C165(1.03); C348(0.96)  LDD1547  [10]
 LDCM0309  AC47 HEK-293T C477(0.98); C165(0.99); C348(1.11)  LDD1548  [10]
 LDCM0310  AC48 HEK-293T C477(1.03); C165(0.78)  LDD1549  [10]
 LDCM0311  AC49 HEK-293T C477(1.11); C165(0.93); C348(1.13)  LDD1550  [10]
 LDCM0312  AC5 HEK-293T C477(0.96); C165(0.89); C348(0.84); C72(1.07)  LDD1551  [10]
 LDCM0313  AC50 HEK-293T C477(1.01); C165(1.00); C348(0.97); C72(1.05)  LDD1552  [10]
 LDCM0314  AC51 HEK-293T C477(0.93); C165(1.07); C348(1.01)  LDD1553  [10]
 LDCM0315  AC52 HEK-293T C477(1.08); C165(0.93); C348(1.04)  LDD1554  [10]
 LDCM0316  AC53 HEK-293T C477(1.09); C165(0.93); C348(0.90); C72(1.13)  LDD1555  [10]
 LDCM0317  AC54 HEK-293T C477(1.04); C165(1.03); C348(1.07)  LDD1556  [10]
 LDCM0318  AC55 HEK-293T C477(0.96); C165(1.10); C348(1.10)  LDD1557  [10]
 LDCM0319  AC56 HEK-293T C477(0.99); C165(1.04)  LDD1558  [10]
 LDCM0320  AC57 HCT 116 C72(1.13)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C72(1.29)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C72(1.23)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C72(0.94)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C72(1.17)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C72(1.25)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C72(1.18)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C72(1.13)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C72(1.22)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C72(1.25)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C72(1.08)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C72(1.31)  LDD0648  [4]
 LDCM0334  AC7 HCT 116 C72(0.83)  LDD0651  [4]
 LDCM0345  AC8 HCT 116 C72(0.85)  LDD0662  [4]
 LDCM0365  AC98 HCT 116 C72(1.15)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C72(1.07)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C72(0.84)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C72(1.07)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C72(0.84)  LDD0592  [4]
 LDCM0156  Aniline NCI-H1299 11.45  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C72(0.57)  LDD2227  [6]
 LDCM0367  CL1 HEK-293T C477(0.85); C165(1.26); C348(0.92); C72(1.13)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C477(1.11); C165(1.04); C348(1.07)  LDD1572  [10]
 LDCM0369  CL100 HEK-293T C477(1.08); C165(0.86); C348(1.11); C72(1.18)  LDD1573  [10]
 LDCM0370  CL101 HCT 116 C72(0.78)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C72(0.86)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C72(0.91)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C72(0.77)  LDD0690  [4]
 LDCM0374  CL105 HEK-293T C477(0.91); C165(0.98); C348(0.85); C72(1.03)  LDD1578  [10]
 LDCM0375  CL106 HEK-293T C165(1.04); C348(1.11)  LDD1579  [10]
 LDCM0376  CL107 HEK-293T C477(0.99); C165(0.94); C348(0.97); C72(1.07)  LDD1580  [10]
 LDCM0377  CL108 HEK-293T C477(0.91); C165(0.90); C348(1.06); C72(1.07)  LDD1581  [10]
 LDCM0378  CL109 HEK-293T C477(0.96); C165(1.05); C348(0.82); C72(1.07)  LDD1582  [10]
 LDCM0379  CL11 HEK-293T C477(0.89); C165(1.11); C348(1.29)  LDD1583  [10]
 LDCM0380  CL110 HEK-293T C165(0.89); C348(1.10)  LDD1584  [10]
 LDCM0381  CL111 HEK-293T C477(0.98); C165(0.99); C348(1.02); C72(1.18)  LDD1585  [10]
 LDCM0382  CL112 HEK-293T C477(0.87); C165(1.01); C348(1.14); C72(1.04)  LDD1586  [10]
 LDCM0383  CL113 HEK-293T C477(0.98); C165(1.13); C348(0.86); C72(1.12)  LDD1587  [10]
 LDCM0384  CL114 HEK-293T C165(1.21); C348(1.15)  LDD1588  [10]
 LDCM0385  CL115 HEK-293T C477(1.07); C165(0.93); C348(0.95); C72(1.17)  LDD1589  [10]
 LDCM0386  CL116 HEK-293T C477(0.87); C165(0.82); C348(1.06); C72(1.01)  LDD1590  [10]
 LDCM0387  CL117 HEK-293T C477(1.04); C165(1.15); C348(0.80); C72(1.19)  LDD1591  [10]
 LDCM0388  CL118 HEK-293T C165(0.92); C348(1.10)  LDD1592  [10]
 LDCM0389  CL119 HEK-293T C477(1.14); C165(1.11); C348(0.86); C72(1.15)  LDD1593  [10]
 LDCM0390  CL12 HEK-293T C477(1.09); C165(1.16)  LDD1594  [10]
 LDCM0391  CL120 HEK-293T C477(0.93); C165(0.98); C348(1.06); C72(1.12)  LDD1595  [10]
 LDCM0392  CL121 HEK-293T C477(1.00); C165(0.95); C348(0.87); C72(1.06)  LDD1596  [10]
 LDCM0393  CL122 HEK-293T C165(1.04); C348(0.94)  LDD1597  [10]
 LDCM0394  CL123 HEK-293T C477(1.42); C165(0.87); C348(0.95); C72(1.19)  LDD1598  [10]
 LDCM0395  CL124 HEK-293T C477(0.96); C165(0.87); C348(1.00); C72(1.38)  LDD1599  [10]
 LDCM0396  CL125 HCT 116 C72(1.16)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C72(0.94)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C72(1.18)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C72(1.01)  LDD0716  [4]
 LDCM0400  CL13 HEK-293T C477(1.53); C165(1.19); C348(0.94); C72(1.27)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C165(1.02); C348(1.02)  LDD1605  [10]
 LDCM0402  CL15 HEK-293T C477(1.56); C165(0.92); C348(1.16); C72(1.53)  LDD1606  [10]
 LDCM0403  CL16 HCT 116 C72(0.93)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C72(0.96)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C72(0.96)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C72(0.99)  LDD0723  [4]
 LDCM0407  CL2 HEK-293T C165(1.38); C348(1.11)  LDD1611  [10]
 LDCM0408  CL20 HCT 116 C72(1.03)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C72(1.02)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C72(0.94)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C72(1.15)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C72(0.94)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C72(1.01)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C72(1.01)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C72(0.98)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C72(1.01)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C72(1.00)  LDD0734  [4]
 LDCM0418  CL3 HEK-293T C477(1.18); C165(1.14); C348(1.25); C72(1.22)  LDD1622  [10]
 LDCM0419  CL30 HCT 116 C72(1.06)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C72(0.97)  LDD0737  [4]
 LDCM0421  CL32 HEK-293T C477(1.04); C165(1.03); C348(1.04)  LDD1625  [10]
 LDCM0422  CL33 HEK-293T C477(1.04); C165(1.15); C348(1.04); C72(1.37)  LDD1626  [10]
 LDCM0423  CL34 HEK-293T C477(1.02); C165(0.94); C348(0.97)  LDD1627  [10]
 LDCM0424  CL35 HEK-293T C477(0.96); C165(1.01); C348(1.29)  LDD1628  [10]
 LDCM0425  CL36 HEK-293T C477(0.96); C165(1.01)  LDD1629  [10]
 LDCM0426  CL37 HEK-293T C477(0.98); C165(1.03); C348(1.08); C72(1.05)  LDD1630  [10]
 LDCM0428  CL39 HEK-293T C477(0.91); C165(1.14); C348(1.35); C72(1.12)  LDD1632  [10]
 LDCM0429  CL4 HEK-293T C477(0.93); C165(0.86); C348(1.11); C72(1.13)  LDD1633  [10]
 LDCM0430  CL40 HEK-293T C477(1.00); C165(0.79); C348(1.08); C72(0.94)  LDD1634  [10]
 LDCM0431  CL41 HEK-293T C477(1.00); C165(0.98); C348(1.03)  LDD1635  [10]
 LDCM0432  CL42 HEK-293T C477(1.01); C165(1.00); C348(1.05); C72(1.01)  LDD1636  [10]
 LDCM0433  CL43 HEK-293T C477(0.98); C165(1.01); C348(1.04)  LDD1637  [10]
 LDCM0434  CL44 HEK-293T C477(1.10); C165(0.84); C348(1.10)  LDD1638  [10]
 LDCM0435  CL45 HEK-293T C477(1.04); C165(1.02); C348(0.97); C72(1.14)  LDD1639  [10]
 LDCM0436  CL46 HCT 116 C72(0.98)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C72(0.92)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C72(1.02)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C72(1.07)  LDD0756  [4]
 LDCM0440  CL5 HEK-293T C477(1.03); C165(1.19); C348(0.98)  LDD1644  [10]
 LDCM0441  CL50 HCT 116 C72(0.91)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C72(0.88)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C72(0.89)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C72(1.01)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C72(0.82)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C72(0.84)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C72(0.86)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C72(0.95)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C72(0.84)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C72(0.90)  LDD0767  [4]
 LDCM0451  CL6 HEK-293T C477(1.05); C165(1.26); C348(1.05); C72(1.09)  LDD1654  [10]
 LDCM0452  CL60 HCT 116 C72(0.99)  LDD0769  [4]
 LDCM0453  CL61 HEK-293T C477(0.88); C165(1.16); C348(0.73); C72(1.12)  LDD1656  [10]
 LDCM0454  CL62 HEK-293T C165(1.18); C348(1.09)  LDD1657  [10]
 LDCM0455  CL63 HEK-293T C477(1.08); C165(0.94); C348(0.85); C72(1.20)  LDD1658  [10]
 LDCM0456  CL64 HEK-293T C477(0.79); C165(0.72); C348(1.04); C72(1.19)  LDD1659  [10]
 LDCM0457  CL65 HEK-293T C477(1.17); C165(1.05); C348(1.06)  LDD1660  [10]
 LDCM0458  CL66 HEK-293T C477(1.05); C165(0.96); C348(1.16); C72(0.95)  LDD1661  [10]
 LDCM0459  CL67 HEK-293T C477(0.93); C165(0.98); C348(1.06)  LDD1662  [10]
 LDCM0460  CL68 HEK-293T C477(1.11); C165(1.28); C348(0.92)  LDD1663  [10]
 LDCM0461  CL69 HEK-293T C477(1.06); C165(0.86); C348(0.98); C72(1.21)  LDD1664  [10]
 LDCM0462  CL7 HEK-293T C477(1.17); C165(0.96); C348(1.09)  LDD1665  [10]
 LDCM0463  CL70 HEK-293T C477(1.02); C165(1.01); C348(1.05)  LDD1666  [10]
 LDCM0464  CL71 HEK-293T C477(1.02); C165(0.98); C348(1.17)  LDD1667  [10]
 LDCM0465  CL72 HEK-293T C477(1.22); C165(0.95)  LDD1668  [10]
 LDCM0466  CL73 HEK-293T C477(1.08); C165(1.10); C348(0.82); C72(1.11)  LDD1669  [10]
 LDCM0467  CL74 HEK-293T C165(1.14); C348(0.98)  LDD1670  [10]
 LDCM0469  CL76 HEK-293T C477(0.89); C165(0.88); C348(1.03); C72(1.20)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C477(0.97); C165(1.16); C348(1.25)  LDD1673  [10]
 LDCM0471  CL78 HEK-293T C477(0.99); C165(1.04); C348(1.10); C72(0.97)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C477(0.96); C165(1.08); C348(0.91)  LDD1675  [10]
 LDCM0473  CL8 HEK-293T C477(1.08); C165(1.05); C348(1.25)  LDD1676  [10]
 LDCM0474  CL80 HEK-293T C477(1.01); C165(1.19); C348(0.98)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C477(1.05); C165(0.88); C348(1.07); C72(1.15)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C477(1.04); C165(0.97); C348(0.92)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C477(0.96); C165(1.17); C348(1.11)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C477(1.11); C165(0.83)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C477(1.05); C165(1.16); C348(0.83); C72(1.14)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C165(1.22); C348(1.13)  LDD1683  [10]
 LDCM0481  CL87 HEK-293T C477(1.02); C165(1.05); C348(0.96); C72(1.16)  LDD1684  [10]
 LDCM0482  CL88 HEK-293T C477(0.91); C165(0.88); C348(1.09); C72(1.16)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C477(1.25); C165(1.09); C348(1.03)  LDD1686  [10]
 LDCM0484  CL9 HEK-293T C477(1.01); C165(0.98); C348(1.11); C72(1.24)  LDD1687  [10]
 LDCM0485  CL90 HEK-293T C477(1.03); C165(0.87); C348(1.47); C72(1.34)  LDD1688  [10]
 LDCM0486  CL91 HEK-293T C477(0.89); C165(1.04); C348(1.02)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C477(1.13); C165(1.02); C348(0.98)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C477(1.13); C165(0.99); C348(1.00); C72(1.24)  LDD1691  [10]
 LDCM0489  CL94 HEK-293T C477(1.08); C165(0.96); C348(1.15)  LDD1692  [10]
 LDCM0490  CL95 HEK-293T C477(1.12); C165(0.93); C348(1.22)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C477(1.03); C165(0.92)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C477(0.98); C165(1.00); C348(0.93); C72(1.09)  LDD1695  [10]
 LDCM0493  CL98 HEK-293T C165(1.01); C348(1.12)  LDD1696  [10]
 LDCM0494  CL99 HEK-293T C477(1.03); C165(0.96); C348(1.05); C72(1.13)  LDD1697  [10]
 LDCM0495  E2913 HEK-293T C477(1.00); C165(0.98); C348(1.35); C72(1.15)  LDD1698  [10]
 LDCM0468  Fragment33 HEK-293T C477(1.04); C165(1.13); C348(1.06); C72(1.17)  LDD1671  [10]
 LDCM0427  Fragment51 HEK-293T C165(1.16); C348(1.16)  LDD1631  [10]
 LDCM0022  KB02 HEK-293T C72(0.89); C477(1.03)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C72(0.93); C477(1.06)  LDD1497  [10]
 LDCM0024  KB05 ONS-76 C477(1.99)  LDD3376  [11]
 LDCM0014  Panhematin HEK-293T 3.20  LDD0062  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin thioesterase ZRANB1 (ZRANB1) Peptidase C64 family Q9UGI0
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Microspherule protein 1 (MCRS1) . Q96EZ8

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
9 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840