Details of the Target

General Information of Target

Target ID LDTP04806
Target Name Sestrin-2 (SESN2)
Gene Name SESN2
Gene ID 83667
Synonyms
Hi95; SEST2; Sestrin-2; EC 1.11.1.-; Hypoxia-induced gene
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MIVADSECRAELKDYLRFAPGGVGDSGPGEEQRESRARRGPRGPSAFIPVEEVLREGAES
LEQHLGLEALMSSGRVDNLAVVMGLHPDYFTSFWRLHYLLLHTDGPLASSWRHYIAIMAA
ARHQCSYLVGSHMAEFLQTGGDPEWLLGLHRAPEKLRKLSEINKLLAHRPWLITKEHIQA
LLKTGEHTWSLAELIQALVLLTHCHSLSSFVFGCGILPEGDADGSPAPQAPTPPSEQSSP
PSRDPLNNSGGFESARDVEALMERMQQLQESLLRDEGTSQEEMESRFELEKSESLLVTPS
ADILEPSPHPDMLCFVEDPTFGYEDFTRRGAQAPPTFRAQDYTWEDHGYSLIQRLYPEGG
QLLDEKFQAAYSLTYNTIAMHSGVDTSVLRRAIWNYIHCVFGIRYDDYDYGEVNQLLERN
LKVYIKTVACYPEKTTRRMYNLFWRHFRHSEKVHVNLLLLEARMQAALLYALRAITRYMT
Target Bioclass
Enzyme
Family
Sestrin family
Subcellular location
Cytoplasm
Function
Functions as an intracellular leucine sensor that negatively regulates the mTORC1 signaling pathway through the GATOR complex . In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents mTORC1 signaling . Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway. This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. May negatively regulate protein translation in response to endoplasmic reticulum stress, via mTORC1. May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1. May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress. Moreover, may prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein. Was originally reported to contribute to oxidative stress resistance by reducing PRDX1. However, this could not be confirmed.
Uniprot ID
P58004
Ensemble ID
ENST00000253063.4
HGNC ID
HGNC:20746

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.32  LDD0402  [1]
TH211
 Probe Info  		Y349(20.00)  LDD0257  [2]
TH216
 Probe Info  		Y342(5.18)  LDD0259  [2]
DBIA
 Probe Info  		C430(2.06)  LDD3323  [3]
HPAP
 Probe Info  		3.52  LDD0063  [4]
IA-alkyne
 Probe Info  		C8(0.93)  LDD2206  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
NAIA_5
 Probe Info  		N.A.  LDD2224  [7]
IPM
 Probe Info  		C314(0.00); C399(0.00); C430(0.00)  LDD2156  [8]
VSF
 Probe Info  		N.A.  LDD0007  [9]
AOyne
 Probe Info  		15.00  LDD0443  [10]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		14.73  LDD0475  [11]
FFF probe2
 Probe Info  		20.00  LDD0463  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C430(0.96); C314(0.97)  LDD1507  [12]
 LDCM0215  AC10 HEK-293T C430(1.02); C399(1.11); C314(1.00)  LDD1508  [12]
 LDCM0226  AC11 HEK-293T C430(0.95); C314(0.91)  LDD1509  [12]
 LDCM0237  AC12 HEK-293T C430(0.96); C399(0.87); C314(1.13)  LDD1510  [12]
 LDCM0259  AC14 HEK-293T C430(0.95); C399(0.90); C314(0.99)  LDD1512  [12]
 LDCM0270  AC15 HEK-293T C430(0.91); C399(0.88); C314(0.84)  LDD1513  [12]
 LDCM0276  AC17 HEK-293T C430(0.98); C314(1.00)  LDD1515  [12]
 LDCM0277  AC18 HEK-293T C430(1.00); C399(1.14); C314(0.83)  LDD1516  [12]
 LDCM0278  AC19 HEK-293T C430(0.99); C314(0.98)  LDD1517  [12]
 LDCM0279  AC2 HEK-293T C430(1.00); C399(1.02); C314(1.04)  LDD1518  [12]
 LDCM0280  AC20 HEK-293T C430(0.93); C399(0.81); C314(0.85)  LDD1519  [12]
 LDCM0281  AC21 HEK-293T C430(1.04); C314(1.07); C125(0.95)  LDD1520  [12]
 LDCM0282  AC22 HEK-293T C430(0.95); C399(0.80); C314(1.25)  LDD1521  [12]
 LDCM0283  AC23 HEK-293T C430(1.03); C399(1.45); C314(0.75)  LDD1522  [12]
 LDCM0284  AC24 HEK-293T C430(0.93); C399(1.38); C314(0.90); C125(0.92)  LDD1523  [12]
 LDCM0285  AC25 HEK-293T C430(0.92); C314(1.16)  LDD1524  [12]
 LDCM0286  AC26 HEK-293T C430(1.04); C399(0.85); C314(0.92)  LDD1525  [12]
 LDCM0287  AC27 HEK-293T C430(0.95); C314(1.10)  LDD1526  [12]
 LDCM0288  AC28 HEK-293T C430(0.98); C399(0.90); C314(1.02)  LDD1527  [12]
 LDCM0289  AC29 HEK-293T C430(1.02); C314(0.97); C125(1.03)  LDD1528  [12]
 LDCM0290  AC3 HEK-293T C430(0.99); C314(1.06)  LDD1529  [12]
 LDCM0291  AC30 HEK-293T C430(0.98); C399(0.82); C314(0.93)  LDD1530  [12]
 LDCM0292  AC31 HEK-293T C430(0.92); C399(1.10); C314(0.84)  LDD1531  [12]
 LDCM0293  AC32 HEK-293T C430(0.94); C399(1.09); C314(0.96); C125(0.97)  LDD1532  [12]
 LDCM0294  AC33 HEK-293T C430(0.93); C314(0.86)  LDD1533  [12]
 LDCM0295  AC34 HEK-293T C430(1.02); C399(1.12); C314(0.89)  LDD1534  [12]
 LDCM0296  AC35 HEK-293T C430(0.95); C314(1.02)  LDD1535  [12]
 LDCM0297  AC36 HEK-293T C430(0.98); C399(0.93); C314(1.10)  LDD1536  [12]
 LDCM0298  AC37 HEK-293T C430(1.00); C314(0.99); C125(1.16)  LDD1537  [12]
 LDCM0299  AC38 HEK-293T C430(0.92); C399(1.05); C314(1.04)  LDD1538  [12]
 LDCM0300  AC39 HEK-293T C430(0.88); C399(0.87); C314(0.99)  LDD1539  [12]
 LDCM0301  AC4 HEK-293T C430(0.99); C399(0.74); C314(1.17)  LDD1540  [12]
 LDCM0302  AC40 HEK-293T C430(0.95); C399(1.29); C314(0.92); C125(1.03)  LDD1541  [12]
 LDCM0303  AC41 HEK-293T C430(0.89); C314(1.26)  LDD1542  [12]
 LDCM0304  AC42 HEK-293T C430(0.98); C399(1.18); C314(1.04)  LDD1543  [12]
 LDCM0305  AC43 HEK-293T C430(0.93); C314(0.99)  LDD1544  [12]
 LDCM0306  AC44 HEK-293T C430(0.91); C399(1.04); C314(0.94)  LDD1545  [12]
 LDCM0307  AC45 HEK-293T C430(1.00); C314(1.00); C125(1.02)  LDD1546  [12]
 LDCM0308  AC46 HEK-293T C430(0.93); C399(0.76); C314(1.18)  LDD1547  [12]
 LDCM0309  AC47 HEK-293T C430(1.00); C399(0.83); C314(0.66)  LDD1548  [12]
 LDCM0310  AC48 HEK-293T C430(1.04); C399(1.28); C314(1.20); C125(0.94)  LDD1549  [12]
 LDCM0311  AC49 HEK-293T C430(0.82); C314(1.15)  LDD1550  [12]
 LDCM0312  AC5 HEK-293T C430(1.01); C314(1.07); C125(1.05)  LDD1551  [12]
 LDCM0313  AC50 HEK-293T C430(0.98); C399(1.35); C314(1.02)  LDD1552  [12]
 LDCM0314  AC51 HEK-293T C430(0.91); C314(0.93)  LDD1553  [12]
 LDCM0315  AC52 HEK-293T C430(0.94); C399(0.78); C314(1.04)  LDD1554  [12]
 LDCM0316  AC53 HEK-293T C430(0.96); C314(0.96); C125(0.99)  LDD1555  [12]
 LDCM0317  AC54 HEK-293T C430(0.90); C399(0.84); C314(1.07)  LDD1556  [12]
 LDCM0318  AC55 HEK-293T C430(0.99); C399(0.96); C314(0.84)  LDD1557  [12]
 LDCM0319  AC56 HEK-293T C430(1.02); C399(1.06); C314(0.89); C125(0.94)  LDD1558  [12]
 LDCM0320  AC57 HEK-293T C430(0.95); C314(1.15)  LDD1559  [12]
 LDCM0321  AC58 HEK-293T C430(1.03); C399(0.97); C314(1.02)  LDD1560  [12]
 LDCM0322  AC59 HEK-293T C430(0.91); C314(1.00)  LDD1561  [12]
 LDCM0323  AC6 HEK-293T C430(1.02); C399(0.97); C314(1.01)  LDD1562  [12]
 LDCM0324  AC60 HEK-293T C430(1.00); C399(0.89); C314(0.85)  LDD1563  [12]
 LDCM0325  AC61 HEK-293T C430(1.05); C314(1.04); C125(0.94)  LDD1564  [12]
 LDCM0326  AC62 HEK-293T C430(0.96); C399(0.80); C314(1.14)  LDD1565  [12]
 LDCM0327  AC63 HEK-293T C430(0.98); C399(1.00); C314(0.86)  LDD1566  [12]
 LDCM0328  AC64 HEK-293T C430(0.97); C399(0.79); C314(1.02); C125(1.12)  LDD1567  [12]
 LDCM0334  AC7 HEK-293T C430(0.99); C399(1.44); C314(1.30)  LDD1568  [12]
 LDCM0345  AC8 HEK-293T C430(1.01); C399(1.06); C314(0.95); C125(0.91)  LDD1569  [12]
 LDCM0248  AKOS034007472 HEK-293T C430(1.02); C314(0.95); C125(1.08)  LDD1511  [12]
 LDCM0356  AKOS034007680 HEK-293T C430(0.91); C314(1.28)  LDD1570  [12]
 LDCM0275  AKOS034007705 HEK-293T C430(1.00); C399(1.16); C314(0.89); C125(1.06)  LDD1514  [12]
 LDCM0156  Aniline NCI-H1299 11.39  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C430(1.11); C314(1.22); C125(1.13)  LDD1571  [12]
 LDCM0368  CL10 HEK-293T C430(1.44); C399(1.00); C314(1.25)  LDD1572  [12]
 LDCM0369  CL100 HEK-293T C430(0.98); C399(1.06); C314(1.17)  LDD1573  [12]
 LDCM0370  CL101 HEK-293T C430(0.96); C314(1.09); C125(1.16)  LDD1574  [12]
 LDCM0371  CL102 HEK-293T C430(0.90); C314(0.85)  LDD1575  [12]
 LDCM0372  CL103 HEK-293T C430(0.93); C314(1.07)  LDD1576  [12]
 LDCM0373  CL104 HEK-293T C430(0.95); C399(0.99); C314(0.80)  LDD1577  [12]
 LDCM0374  CL105 HEK-293T C430(0.97); C314(1.10); C125(1.11)  LDD1578  [12]
 LDCM0375  CL106 HEK-293T C430(0.87); C314(0.89)  LDD1579  [12]
 LDCM0376  CL107 HEK-293T C430(0.87); C314(1.00)  LDD1580  [12]
 LDCM0377  CL108 HEK-293T C430(0.97); C399(1.36); C314(0.95)  LDD1581  [12]
 LDCM0378  CL109 HEK-293T C430(0.93); C314(0.86); C125(1.08)  LDD1582  [12]
 LDCM0379  CL11 HEK-293T C430(1.20); C399(1.05); C314(0.90)  LDD1583  [12]
 LDCM0380  CL110 HEK-293T C430(0.97); C314(0.92)  LDD1584  [12]
 LDCM0381  CL111 HEK-293T C430(0.97); C314(1.19)  LDD1585  [12]
 LDCM0382  CL112 HEK-293T C430(0.93); C399(1.60); C314(0.98)  LDD1586  [12]
 LDCM0383  CL113 HEK-293T C430(0.97); C314(1.00); C125(1.22)  LDD1587  [12]
 LDCM0384  CL114 HEK-293T C430(0.95); C314(0.88)  LDD1588  [12]
 LDCM0385  CL115 HEK-293T C430(0.90); C314(1.03)  LDD1589  [12]
 LDCM0386  CL116 HEK-293T C430(0.94); C399(1.07); C314(0.84)  LDD1590  [12]
 LDCM0387  CL117 HEK-293T C430(0.91); C314(0.97); C125(1.10)  LDD1591  [12]
 LDCM0388  CL118 HEK-293T C430(0.89); C314(0.85)  LDD1592  [12]
 LDCM0389  CL119 HEK-293T C430(0.90); C314(0.97)  LDD1593  [12]
 LDCM0390  CL12 HEK-293T C430(1.07); C399(1.04); C314(0.95); C125(1.00)  LDD1594  [12]
 LDCM0391  CL120 HEK-293T C430(0.97); C399(0.82); C314(0.87)  LDD1595  [12]
 LDCM0392  CL121 HEK-293T C430(0.94); C314(0.88); C125(1.13)  LDD1596  [12]
 LDCM0393  CL122 HEK-293T C430(0.84); C314(0.88)  LDD1597  [12]
 LDCM0394  CL123 HEK-293T C430(0.97); C314(1.00)  LDD1598  [12]
 LDCM0395  CL124 HEK-293T C430(0.97); C399(1.14); C314(0.84)  LDD1599  [12]
 LDCM0396  CL125 HEK-293T C430(0.94); C314(1.03); C125(1.21)  LDD1600  [12]
 LDCM0397  CL126 HEK-293T C430(0.97); C314(0.91)  LDD1601  [12]
 LDCM0398  CL127 HEK-293T C430(0.91); C314(1.01)  LDD1602  [12]
 LDCM0399  CL128 HEK-293T C430(0.90); C399(1.38); C314(0.83)  LDD1603  [12]
 LDCM0400  CL13 HEK-293T C430(1.05); C314(1.15); C125(0.97)  LDD1604  [12]
 LDCM0401  CL14 HEK-293T C430(0.86); C314(0.89)  LDD1605  [12]
 LDCM0402  CL15 HEK-293T C430(1.08); C314(1.07)  LDD1606  [12]
 LDCM0403  CL16 HEK-293T C430(0.93); C399(0.90); C314(0.96)  LDD1607  [12]
 LDCM0404  CL17 HEK-293T C430(1.03); C314(1.00)  LDD1608  [12]
 LDCM0405  CL18 HEK-293T C430(1.06); C399(0.92); C314(1.06)  LDD1609  [12]
 LDCM0406  CL19 HEK-293T C430(0.92); C314(0.97)  LDD1610  [12]
 LDCM0407  CL2 HEK-293T C430(0.90); C314(0.86)  LDD1611  [12]
 LDCM0408  CL20 HEK-293T C430(1.03); C399(1.07); C314(1.09)  LDD1612  [12]
 LDCM0409  CL21 HEK-293T C430(1.09); C314(1.07); C125(0.88)  LDD1613  [12]
 LDCM0410  CL22 HEK-293T C430(1.02); C399(0.97); C314(1.02)  LDD1614  [12]
 LDCM0411  CL23 HEK-293T C430(1.08); C399(1.26); C314(0.86)  LDD1615  [12]
 LDCM0412  CL24 HEK-293T C430(1.15); C399(1.37); C314(1.03); C125(0.94)  LDD1616  [12]
 LDCM0413  CL25 HEK-293T C430(1.20); C314(0.90); C125(0.98)  LDD1617  [12]
 LDCM0414  CL26 HEK-293T C430(0.91); C314(0.92)  LDD1618  [12]
 LDCM0415  CL27 HEK-293T C430(0.88); C314(1.06)  LDD1619  [12]
 LDCM0416  CL28 HEK-293T C430(0.90); C399(1.10); C314(0.74)  LDD1620  [12]
 LDCM0417  CL29 HEK-293T C430(0.95); C314(1.56)  LDD1621  [12]
 LDCM0418  CL3 HEK-293T C430(1.08); C314(0.99)  LDD1622  [12]
 LDCM0419  CL30 HEK-293T C430(1.06); C399(1.16); C314(0.95)  LDD1623  [12]
 LDCM0420  CL31 HEK-293T C430(0.94); C314(1.11)  LDD1624  [12]
 LDCM0421  CL32 HEK-293T C430(0.97); C399(1.01); C314(1.06)  LDD1625  [12]
 LDCM0422  CL33 HEK-293T C430(1.64); C314(0.91); C125(0.97)  LDD1626  [12]
 LDCM0423  CL34 HEK-293T C430(1.03); C399(0.89); C314(1.51)  LDD1627  [12]
 LDCM0424  CL35 HEK-293T C430(1.05); C399(0.85); C314(0.90)  LDD1628  [12]
 LDCM0425  CL36 HEK-293T C430(1.16); C399(1.41); C314(1.16); C125(0.95)  LDD1629  [12]
 LDCM0426  CL37 HEK-293T C430(1.01); C314(1.05); C125(1.00)  LDD1630  [12]
 LDCM0428  CL39 HEK-293T C430(0.89); C314(0.99)  LDD1632  [12]
 LDCM0429  CL4 HEK-293T C430(0.98); C399(1.17); C314(0.97)  LDD1633  [12]
 LDCM0430  CL40 HEK-293T C430(1.03); C399(1.46); C314(1.11)  LDD1634  [12]
 LDCM0431  CL41 HEK-293T C430(0.99); C314(1.00)  LDD1635  [12]
 LDCM0432  CL42 HEK-293T C430(1.09); C399(1.17); C314(0.88)  LDD1636  [12]
 LDCM0433  CL43 HEK-293T C430(0.95); C314(1.00)  LDD1637  [12]
 LDCM0434  CL44 HEK-293T C430(1.11); C399(0.95); C314(1.01)  LDD1638  [12]
 LDCM0435  CL45 HEK-293T C430(1.19); C314(1.05); C125(0.97)  LDD1639  [12]
 LDCM0436  CL46 HEK-293T C430(1.13); C399(0.60); C314(1.15)  LDD1640  [12]
 LDCM0437  CL47 HEK-293T C430(1.16); C399(1.04); C314(0.88)  LDD1641  [12]
 LDCM0438  CL48 HEK-293T C430(1.13); C399(1.16); C314(1.07); C125(0.97)  LDD1642  [12]
 LDCM0439  CL49 HEK-293T C430(1.03); C314(1.14); C125(0.97)  LDD1643  [12]
 LDCM0440  CL5 HEK-293T C430(1.02); C314(0.89)  LDD1644  [12]
 LDCM0441  CL50 HEK-293T C430(0.87); C314(0.76)  LDD1645  [12]
 LDCM0443  CL52 HEK-293T C430(1.02); C399(0.93); C314(1.31)  LDD1646  [12]
 LDCM0444  CL53 HEK-293T C430(1.05); C314(1.09)  LDD1647  [12]
 LDCM0445  CL54 HEK-293T C430(1.22); C399(1.22); C314(0.98)  LDD1648  [12]
 LDCM0446  CL55 HEK-293T C430(0.94); C314(0.97)  LDD1649  [12]
 LDCM0447  CL56 HEK-293T C430(1.05); C399(0.74); C314(0.83)  LDD1650  [12]
 LDCM0448  CL57 HEK-293T C430(1.18); C314(1.00); C125(1.02)  LDD1651  [12]
 LDCM0449  CL58 HEK-293T C430(0.99); C399(0.86); C314(1.08)  LDD1652  [12]
 LDCM0450  CL59 HEK-293T C430(1.01); C399(0.81); C314(1.02)  LDD1653  [12]
 LDCM0451  CL6 HEK-293T C430(1.14); C399(1.35); C314(0.89)  LDD1654  [12]
 LDCM0452  CL60 HEK-293T C430(1.18); C399(1.04); C314(0.91); C125(1.05)  LDD1655  [12]
 LDCM0453  CL61 HEK-293T C430(0.98); C314(1.15); C125(1.19)  LDD1656  [12]
 LDCM0454  CL62 HEK-293T C430(0.87); C314(0.84)  LDD1657  [12]
 LDCM0455  CL63 HEK-293T C430(0.89); C314(0.94)  LDD1658  [12]
 LDCM0456  CL64 HEK-293T C430(1.01); C399(0.63); C314(1.05)  LDD1659  [12]
 LDCM0457  CL65 HEK-293T C430(0.94); C314(1.17)  LDD1660  [12]
 LDCM0458  CL66 HEK-293T C430(1.01); C399(1.05); C314(1.20)  LDD1661  [12]
 LDCM0459  CL67 HEK-293T C430(0.96); C314(1.03)  LDD1662  [12]
 LDCM0460  CL68 HEK-293T C430(1.02); C399(0.85); C314(0.83)  LDD1663  [12]
 LDCM0461  CL69 HEK-293T C430(1.24); C314(1.03); C125(0.96)  LDD1664  [12]
 LDCM0462  CL7 HEK-293T C430(1.05); C314(0.86)  LDD1665  [12]
 LDCM0463  CL70 HEK-293T C430(1.02); C399(1.04); C314(1.24)  LDD1666  [12]
 LDCM0464  CL71 HEK-293T C430(1.07); C399(1.00); C314(0.68)  LDD1667  [12]
 LDCM0465  CL72 HEK-293T C430(1.06); C399(1.39); C314(0.92); C125(0.91)  LDD1668  [12]
 LDCM0466  CL73 HEK-293T C430(1.01); C314(1.03); C125(1.21)  LDD1669  [12]
 LDCM0467  CL74 HEK-293T C430(0.88); C314(1.07)  LDD1670  [12]
 LDCM0469  CL76 HEK-293T C430(0.96); C399(1.02); C314(1.01)  LDD1672  [12]
 LDCM0470  CL77 HEK-293T C430(0.94); C314(1.22)  LDD1673  [12]
 LDCM0471  CL78 HEK-293T C430(1.05); C399(1.23); C314(0.83)  LDD1674  [12]
 LDCM0472  CL79 HEK-293T C430(0.92); C314(0.95)  LDD1675  [12]
 LDCM0473  CL8 HEK-293T C430(1.63); C399(0.85); C314(1.08)  LDD1676  [12]
 LDCM0474  CL80 HEK-293T C430(1.02); C399(0.95); C314(0.96)  LDD1677  [12]
 LDCM0475  CL81 HEK-293T C430(1.11); C314(1.10); C125(1.05)  LDD1678  [12]
 LDCM0476  CL82 HEK-293T C430(1.00); C399(0.92); C314(1.15)  LDD1679  [12]
 LDCM0477  CL83 HEK-293T C430(1.09); C399(0.90); C314(0.78)  LDD1680  [12]
 LDCM0478  CL84 HEK-293T C430(1.08); C399(1.29); C314(1.17); C125(1.00)  LDD1681  [12]
 LDCM0479  CL85 HEK-293T C430(1.04); C314(0.94); C125(1.02)  LDD1682  [12]
 LDCM0480  CL86 HEK-293T C430(0.97); C314(0.98)  LDD1683  [12]
 LDCM0481  CL87 HEK-293T C430(0.92); C314(0.89)  LDD1684  [12]
 LDCM0482  CL88 HEK-293T C430(0.96); C399(0.98); C314(0.85)  LDD1685  [12]
 LDCM0483  CL89 HEK-293T C430(0.98); C314(1.24)  LDD1686  [12]
 LDCM0484  CL9 HEK-293T C430(1.15); C314(1.02); C125(1.12)  LDD1687  [12]
 LDCM0485  CL90 HEK-293T C430(1.94); C399(1.04); C314(0.83)  LDD1688  [12]
 LDCM0486  CL91 HEK-293T C430(0.95); C314(0.90)  LDD1689  [12]
 LDCM0487  CL92 HEK-293T C430(1.07); C399(0.92); C314(1.00)  LDD1690  [12]
 LDCM0488  CL93 HEK-293T C430(1.16); C314(1.04); C125(1.05)  LDD1691  [12]
 LDCM0489  CL94 HEK-293T C430(1.06); C399(0.92); C314(1.19)  LDD1692  [12]
 LDCM0490  CL95 HEK-293T C430(1.43); C399(1.03); C314(1.21)  LDD1693  [12]
 LDCM0491  CL96 HEK-293T C430(1.20); C399(1.42); C314(0.85); C125(1.03)  LDD1694  [12]
 LDCM0492  CL97 HEK-293T C430(1.10); C314(1.03); C125(1.00)  LDD1695  [12]
 LDCM0493  CL98 HEK-293T C430(0.94); C314(0.99)  LDD1696  [12]
 LDCM0494  CL99 HEK-293T C430(0.89); C314(1.01)  LDD1697  [12]
 LDCM0495  E2913 HEK-293T C430(0.85); C314(1.16)  LDD1698  [12]
 LDCM0468  Fragment33 HEK-293T C430(0.86); C314(1.03)  LDD1671  [12]
 LDCM0427  Fragment51 HEK-293T C430(0.93); C314(0.96)  LDD1631  [12]
 LDCM0022  KB02 HEK-293T C430(0.91); C399(1.21); C314(0.95)  LDD1492  [12]
 LDCM0023  KB03 HEK-293T C430(1.04); C399(1.03); C314(0.99)  LDD1497  [12]
 LDCM0024  KB05 SKMEL24 C430(2.06)  LDD3323  [3]
 LDCM0627  NUDT7-COV-1 HEK-293T C8(0.93)  LDD2206  [5]
 LDCM0628  OTUB2-COV-1 HEK-293T C8(1.47)  LDD2207  [5]
 LDCM0014  Panhematin K562 3.52  LDD0063  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase RBX1 (RBX1) RING-box family P62877
GATOR2 complex protein WDR24 (WDR24) WD repeat WDR24 family Q96S15
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Kelch-like ECH-associated protein 1 (KEAP1) KEAP1 family Q14145
GATOR2 complex protein MIOS (MIOS) WD repeat mio family Q9NXC5
Sequestosome-1 (SQSTM1) . Q13501

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
5 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402