Details of the Target

General Information of Target

Target ID LDTP04346
Target Name Motor neuron and pancreas homeobox protein 1 (MNX1)
Gene Name MNX1
Gene ID 3110
Synonyms
HLXB9; Motor neuron and pancreas homeobox protein 1; Homeobox protein HB9
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEKSKNFRIDALLAVDPPRAASAQSAPLALVTSLAAAASGTGGGGGGGGASGGTSGSCSP
ASSEPPAAPADRLRAESPSPPRLLAAHCALLPKPGFLGAGGGGGGTGGGHGGPHHHAHPG
AAAAAAAAAAAAAAGGLALGLHPGGAQGGAGLPAQAALYGHPVYGYSAAAAAAALAGQHP
ALSYSYPQVQGAHPAHPADPIKLGAGTFQLDQWLRASTAGMILPKMPDFNSQAQSNLLGK
CRRPRTAFTSQQLLELEHQFKLNKYLSRPKRFEVATSLMLTETQVKIWFQNRRMKWKRSK
KAKEQAAQEAEKQKGGGGGAGKGGAEEPGAEELLGPPAPGDKGSGRRLRDLRDSDPEEDE
DEDDEDHFPYSNGASVHAASSDCSSEDDSPPPRPSHQPAPQ
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function
Transcription factor. Recognizes and binds to the regulatory elements of target genes, such as visual system homeobox CHX10, negatively modulating transcription. Plays a role in establishing motor neuron identity, in concert with LIM domain transcription factor LMO4. Involved in negatively modulating transcription of interneuron genes in motor neurons, acting, at least in part, by blocking regulatory sequence interactions of the ISL1-LHX3 complex. Involved in pancreas development and function; may play a role in pancreatic cell fate specification.
Uniprot ID
P50219
Ensemble ID
ENST00000252971.11
HGNC ID
HGNC:4979

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CALU1 SNV: p.S63T .
DEL SNV: p.G102V .
HEC1 SNV: p.A320V .
HT SNV: p.Q305R .
IGROV1 SNV: p.A374T .
NCIH2286 Deletion: p.W213CfsTer9
SNV: p.A399E		 .
OVKATE SNV: p.P153Q .
RKO SNV: p.E331D .
SW1271 SNV: p.P65L .
WM115 SNV: p.R72L; p.E76D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HPAP
 Probe Info  		3.51  LDD0062  [1]
DBIA
 Probe Info  		C88(0.96)  LDD1492  [2]
NAIA_5
 Probe Info  		N.A.  LDD2225  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]
AOyne
 Probe Info  		11.70  LDD0443  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C88(1.31)  LDD1507  [2]
 LDCM0215  AC10 HEK-293T C88(1.01)  LDD1508  [2]
 LDCM0226  AC11 HEK-293T C88(1.03)  LDD1509  [2]
 LDCM0237  AC12 HEK-293T C88(0.97)  LDD1510  [2]
 LDCM0259  AC14 HEK-293T C88(0.97)  LDD1512  [2]
 LDCM0270  AC15 HEK-293T C88(0.98)  LDD1513  [2]
 LDCM0276  AC17 HEK-293T C88(1.09)  LDD1515  [2]
 LDCM0277  AC18 HEK-293T C88(1.13)  LDD1516  [2]
 LDCM0278  AC19 HEK-293T C88(1.28)  LDD1517  [2]
 LDCM0279  AC2 HEK-293T C88(1.05)  LDD1518  [2]
 LDCM0280  AC20 HEK-293T C88(0.94)  LDD1519  [2]
 LDCM0281  AC21 HEK-293T C88(1.13)  LDD1520  [2]
 LDCM0282  AC22 HEK-293T C88(0.95)  LDD1521  [2]
 LDCM0283  AC23 HEK-293T C88(0.98)  LDD1522  [2]
 LDCM0284  AC24 HEK-293T C88(0.94)  LDD1523  [2]
 LDCM0285  AC25 HEK-293T C88(1.09)  LDD1524  [2]
 LDCM0286  AC26 HEK-293T C88(1.05)  LDD1525  [2]
 LDCM0287  AC27 HEK-293T C88(0.98)  LDD1526  [2]
 LDCM0288  AC28 HEK-293T C88(1.03)  LDD1527  [2]
 LDCM0289  AC29 HEK-293T C88(1.04)  LDD1528  [2]
 LDCM0290  AC3 HEK-293T C88(1.09)  LDD1529  [2]
 LDCM0291  AC30 HEK-293T C88(1.03)  LDD1530  [2]
 LDCM0292  AC31 HEK-293T C88(0.97)  LDD1531  [2]
 LDCM0293  AC32 HEK-293T C88(0.99)  LDD1532  [2]
 LDCM0294  AC33 HEK-293T C88(1.13)  LDD1533  [2]
 LDCM0295  AC34 HEK-293T C88(0.99)  LDD1534  [2]
 LDCM0296  AC35 HEK-293T C88(0.94)  LDD1535  [2]
 LDCM0297  AC36 HEK-293T C88(0.98)  LDD1536  [2]
 LDCM0298  AC37 HEK-293T C88(1.06)  LDD1537  [2]
 LDCM0299  AC38 HEK-293T C88(0.98)  LDD1538  [2]
 LDCM0300  AC39 HEK-293T C88(0.99)  LDD1539  [2]
 LDCM0301  AC4 HEK-293T C88(1.06)  LDD1540  [2]
 LDCM0302  AC40 HEK-293T C88(1.06)  LDD1541  [2]
 LDCM0303  AC41 HEK-293T C88(1.18)  LDD1542  [2]
 LDCM0304  AC42 HEK-293T C88(1.11)  LDD1543  [2]
 LDCM0305  AC43 HEK-293T C88(0.98)  LDD1544  [2]
 LDCM0306  AC44 HEK-293T C88(1.01)  LDD1545  [2]
 LDCM0307  AC45 HEK-293T C88(1.14)  LDD1546  [2]
 LDCM0308  AC46 HEK-293T C88(1.06)  LDD1547  [2]
 LDCM0309  AC47 HEK-293T C88(1.07)  LDD1548  [2]
 LDCM0310  AC48 HEK-293T C88(1.05)  LDD1549  [2]
 LDCM0311  AC49 HEK-293T C88(1.25)  LDD1550  [2]
 LDCM0312  AC5 HEK-293T C88(1.16)  LDD1551  [2]
 LDCM0313  AC50 HEK-293T C88(1.08)  LDD1552  [2]
 LDCM0314  AC51 HEK-293T C88(0.98)  LDD1553  [2]
 LDCM0315  AC52 HEK-293T C88(1.02)  LDD1554  [2]
 LDCM0316  AC53 HEK-293T C88(1.10)  LDD1555  [2]
 LDCM0317  AC54 HEK-293T C88(1.07)  LDD1556  [2]
 LDCM0318  AC55 HEK-293T C88(1.06)  LDD1557  [2]
 LDCM0319  AC56 HEK-293T C88(1.11)  LDD1558  [2]
 LDCM0320  AC57 HEK-293T C88(1.28)  LDD1559  [2]
 LDCM0321  AC58 HEK-293T C88(1.07)  LDD1560  [2]
 LDCM0322  AC59 HEK-293T C88(1.10)  LDD1561  [2]
 LDCM0323  AC6 HEK-293T C88(1.11)  LDD1562  [2]
 LDCM0324  AC60 HEK-293T C88(1.04)  LDD1563  [2]
 LDCM0325  AC61 HEK-293T C88(1.16)  LDD1564  [2]
 LDCM0326  AC62 HEK-293T C88(1.12)  LDD1565  [2]
 LDCM0327  AC63 HEK-293T C88(0.98)  LDD1566  [2]
 LDCM0328  AC64 HEK-293T C88(1.22)  LDD1567  [2]
 LDCM0334  AC7 HEK-293T C88(1.06)  LDD1568  [2]
 LDCM0345  AC8 HEK-293T C88(1.05)  LDD1569  [2]
 LDCM0248  AKOS034007472 HEK-293T C88(1.18)  LDD1511  [2]
 LDCM0356  AKOS034007680 HEK-293T C88(1.35)  LDD1570  [2]
 LDCM0275  AKOS034007705 HEK-293T C88(1.06)  LDD1514  [2]
 LDCM0632  CL-Sc Hep-G2 C58(20.00)  LDD2227  [3]
 LDCM0368  CL10 HEK-293T C88(0.88)  LDD1572  [2]
 LDCM0369  CL100 HEK-293T C88(1.06)  LDD1573  [2]
 LDCM0371  CL102 HEK-293T C88(1.09)  LDD1575  [2]
 LDCM0373  CL104 HEK-293T C88(1.08)  LDD1577  [2]
 LDCM0375  CL106 HEK-293T C88(0.99)  LDD1579  [2]
 LDCM0377  CL108 HEK-293T C88(1.09)  LDD1581  [2]
 LDCM0379  CL11 HEK-293T C88(0.82)  LDD1583  [2]
 LDCM0380  CL110 HEK-293T C88(0.84)  LDD1584  [2]
 LDCM0382  CL112 HEK-293T C88(1.08)  LDD1586  [2]
 LDCM0384  CL114 HEK-293T C88(0.88)  LDD1588  [2]
 LDCM0386  CL116 HEK-293T C88(1.07)  LDD1590  [2]
 LDCM0388  CL118 HEK-293T C88(1.12)  LDD1592  [2]
 LDCM0390  CL12 HEK-293T C88(0.81)  LDD1594  [2]
 LDCM0391  CL120 HEK-293T C88(1.01)  LDD1595  [2]
 LDCM0393  CL122 HEK-293T C88(1.05)  LDD1597  [2]
 LDCM0395  CL124 HEK-293T C88(1.12)  LDD1599  [2]
 LDCM0397  CL126 HEK-293T C88(1.16)  LDD1601  [2]
 LDCM0399  CL128 HEK-293T C88(1.19)  LDD1603  [2]
 LDCM0401  CL14 HEK-293T C88(1.08)  LDD1605  [2]
 LDCM0403  CL16 HEK-293T C88(0.96)  LDD1607  [2]
 LDCM0404  CL17 HEK-293T C88(1.12)  LDD1608  [2]
 LDCM0405  CL18 HEK-293T C88(0.85)  LDD1609  [2]
 LDCM0406  CL19 HEK-293T C88(0.77)  LDD1610  [2]
 LDCM0407  CL2 HEK-293T C88(1.04)  LDD1611  [2]
 LDCM0408  CL20 HEK-293T C88(0.83)  LDD1612  [2]
 LDCM0409  CL21 HEK-293T C88(0.94)  LDD1613  [2]
 LDCM0410  CL22 HEK-293T C88(0.85)  LDD1614  [2]
 LDCM0411  CL23 HEK-293T C88(0.80)  LDD1615  [2]
 LDCM0412  CL24 HEK-293T C88(0.76)  LDD1616  [2]
 LDCM0414  CL26 HEK-293T C88(1.01)  LDD1618  [2]
 LDCM0416  CL28 HEK-293T C88(0.98)  LDD1620  [2]
 LDCM0417  CL29 HEK-293T C88(0.93)  LDD1621  [2]
 LDCM0419  CL30 HEK-293T C88(0.82)  LDD1623  [2]
 LDCM0420  CL31 HEK-293T C88(0.85)  LDD1624  [2]
 LDCM0421  CL32 HEK-293T C88(0.76)  LDD1625  [2]
 LDCM0422  CL33 HEK-293T C88(1.03)  LDD1626  [2]
 LDCM0423  CL34 HEK-293T C88(0.81)  LDD1627  [2]
 LDCM0424  CL35 HEK-293T C88(0.86)  LDD1628  [2]
 LDCM0425  CL36 HEK-293T C88(0.77)  LDD1629  [2]
 LDCM0429  CL4 HEK-293T C88(0.99)  LDD1633  [2]
 LDCM0430  CL40 HEK-293T C88(0.88)  LDD1634  [2]
 LDCM0431  CL41 HEK-293T C88(1.08)  LDD1635  [2]
 LDCM0432  CL42 HEK-293T C88(0.92)  LDD1636  [2]
 LDCM0433  CL43 HEK-293T C88(0.75)  LDD1637  [2]
 LDCM0434  CL44 HEK-293T C88(0.79)  LDD1638  [2]
 LDCM0435  CL45 HEK-293T C88(0.89)  LDD1639  [2]
 LDCM0436  CL46 HEK-293T C88(0.79)  LDD1640  [2]
 LDCM0437  CL47 HEK-293T C88(0.80)  LDD1641  [2]
 LDCM0438  CL48 HEK-293T C88(0.83)  LDD1642  [2]
 LDCM0440  CL5 HEK-293T C88(1.21)  LDD1644  [2]
 LDCM0441  CL50 HEK-293T C88(0.97)  LDD1645  [2]
 LDCM0443  CL52 HEK-293T C88(0.88)  LDD1646  [2]
 LDCM0444  CL53 HEK-293T C88(1.19)  LDD1647  [2]
 LDCM0445  CL54 HEK-293T C88(0.82)  LDD1648  [2]
 LDCM0446  CL55 HEK-293T C88(0.79)  LDD1649  [2]
 LDCM0447  CL56 HEK-293T C88(0.89)  LDD1650  [2]
 LDCM0448  CL57 HEK-293T C88(1.04)  LDD1651  [2]
 LDCM0449  CL58 HEK-293T C88(0.81)  LDD1652  [2]
 LDCM0450  CL59 HEK-293T C88(0.84)  LDD1653  [2]
 LDCM0451  CL6 HEK-293T C88(0.96)  LDD1654  [2]
 LDCM0452  CL60 HEK-293T C88(0.83)  LDD1655  [2]
 LDCM0454  CL62 HEK-293T C88(1.15)  LDD1657  [2]
 LDCM0456  CL64 HEK-293T C88(0.97)  LDD1659  [2]
 LDCM0457  CL65 HEK-293T C88(1.16)  LDD1660  [2]
 LDCM0458  CL66 HEK-293T C88(0.88)  LDD1661  [2]
 LDCM0459  CL67 HEK-293T C88(0.82)  LDD1662  [2]
 LDCM0460  CL68 HEK-293T C88(0.81)  LDD1663  [2]
 LDCM0461  CL69 HEK-293T C88(1.01)  LDD1664  [2]
 LDCM0462  CL7 HEK-293T C88(0.83)  LDD1665  [2]
 LDCM0463  CL70 HEK-293T C88(0.88)  LDD1666  [2]
 LDCM0464  CL71 HEK-293T C88(0.80)  LDD1667  [2]
 LDCM0465  CL72 HEK-293T C88(0.76)  LDD1668  [2]
 LDCM0467  CL74 HEK-293T C88(1.13)  LDD1670  [2]
 LDCM0469  CL76 HEK-293T C88(1.03)  LDD1672  [2]
 LDCM0470  CL77 HEK-293T C88(1.13)  LDD1673  [2]
 LDCM0471  CL78 HEK-293T C88(0.93)  LDD1674  [2]
 LDCM0472  CL79 HEK-293T C88(0.80)  LDD1675  [2]
 LDCM0473  CL8 HEK-293T C88(1.23)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C88(0.89)  LDD1677  [2]
 LDCM0475  CL81 HEK-293T C88(1.01)  LDD1678  [2]
 LDCM0476  CL82 HEK-293T C88(0.89)  LDD1679  [2]
 LDCM0477  CL83 HEK-293T C88(0.84)  LDD1680  [2]
 LDCM0478  CL84 HEK-293T C88(0.84)  LDD1681  [2]
 LDCM0480  CL86 HEK-293T C88(1.25)  LDD1683  [2]
 LDCM0482  CL88 HEK-293T C88(1.16)  LDD1685  [2]
 LDCM0483  CL89 HEK-293T C88(1.28)  LDD1686  [2]
 LDCM0484  CL9 HEK-293T C88(0.93)  LDD1687  [2]
 LDCM0485  CL90 HEK-293T C88(1.03)  LDD1688  [2]
 LDCM0486  CL91 HEK-293T C88(0.92)  LDD1689  [2]
 LDCM0487  CL92 HEK-293T C88(1.01)  LDD1690  [2]
 LDCM0488  CL93 HEK-293T C88(1.09)  LDD1691  [2]
 LDCM0489  CL94 HEK-293T C88(0.95)  LDD1692  [2]
 LDCM0490  CL95 HEK-293T C88(0.93)  LDD1693  [2]
 LDCM0491  CL96 HEK-293T C88(1.08)  LDD1694  [2]
 LDCM0493  CL98 HEK-293T C88(1.02)  LDD1696  [2]
 LDCM0427  Fragment51 HEK-293T C88(1.00)  LDD1631  [2]
 LDCM0022  KB02 HEK-293T C88(0.96)  LDD1492  [2]
 LDCM0023  KB03 HEK-293T C88(1.00)  LDD1497  [2]
 LDCM0024  KB05 HEK-293T C88(1.00)  LDD1502  [2]
 LDCM0014  Panhematin HEK-293T 3.51  LDD0062  [1]

References

1 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.