Details of the Target

General Information of Target

Target ID LDTP08264
Target Name Protein FAM83A (FAM83A)
Gene Name FAM83A
Gene ID 84985
Synonyms
TSGP; Protein FAM83A; Tumor antigen BJ-TSA-9; Tumor-specific gene expressed in prostate protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSRSRHLGKIRKRLEDVKSQWVRPARADFSDNESARLATDALLDGGSEAYWRVLSQEGEV
DFLSSVEAQYIQAQAREPPCPPDTLGGAEAGPKGLDSSSLQSGTYFPVASEGSEPALLHS
WASAEKPYLKEKSSATVYFQTVKHNNIRDLVRRCITRTSQVLVILMDVFTDVEIFCDILE
AANKRGVFVCVLLDQGGVKLFQEMCDKVQISDSHLKNISIRSVEGEIYCAKSGRKFAGQI
REKFIISDWRFVLSGSYSFTWLCGHVHRNILSKFTGQAVELFDEEFRHLYASSKPVMGLK
SPRLVAPVPPGAAPANGRLSSSSGSASDRTSSNPFSGRSAGSHPGTRSVSASSGPCSPAA
PHPPPPPRFQPHQGPWGAPSPQAHLSPRPHDGPPAAVYSNLGAYRPTRLQLEQLGLVPRL
TPTWRPFLQASPHF
Target Bioclass
Other
Family
FAM83 family
Subcellular location
Cytoplasm
Function
Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both RAS/MAPK and PI3K/AKT/TOR signaling cascades downstream of EGFR. Required for the RAS/MAPK signaling cascade activation upon EGFR stimulation, it also activates both signaling cascades independently of EGFR activation.
Uniprot ID
Q86UY5
Ensemble ID
ENST00000276699.10
HGNC ID
HGNC:28210

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.S159N .
COLO800 SNV: p.Q140Ter .
DU145 SNV: p.S134R DBIA    Probe Info 
LS123 SNV: p.S213T .
NCIH1155 SNV: p.G415V .
RL SNV: p.V60G .
SISO SNV: p.N183S DBIA    Probe Info 
SKMEL2 SNV: p.Y50C; p.Q382H .
TOV21G SNV: p.R287L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C205(1.95)  LDD3312  [1]
HPAP
 Probe Info  		3.23  LDD0063  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 8305C C80(1.68)  LDD2248  [1]
 LDCM0023  KB03 8505C C80(1.38)  LDD2666  [1]
 LDCM0024  KB05 HMCB C205(1.95)  LDD3312  [1]
 LDCM0014  Panhematin K562 3.23  LDD0063  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone-lysine N-methyltransferase SMYD1 (SMYD1) Class V-like SAM-binding methyltransferase superfamily Q8NB12
PR domain zinc finger protein 14 (PRDM14) Class V-like SAM-binding methyltransferase superfamily Q9GZV8
Glutamine--tRNA ligase (QARS1) Class-I aminoacyl-tRNA synthetase family P47897
Proteasome subunit alpha type-3 (PSMA3) Peptidase T1A family P25788
Casein kinase I isoform epsilon (CSNK1E) CK1 Ser/Thr protein kinase family P49674
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein PLAGL2 (PLAGL2) Krueppel C2H2-type zinc-finger protein family Q9UPG8
Class E basic helix-loop-helix protein 40 (BHLHE40) . O14503
Forkhead box protein H1 (FOXH1) . O75593
Other
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Protein FAM83A (FAM83A) FAM83 family Q86UY5
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin-associated protein 6-2 (KRTAP6-2) KRTAP type 6 family Q3LI66
Keratin-associated protein 8-1 (KRTAP8-1) KRTAP type 8 family Q8IUC2
Gelsolin (GSN) Villin/gelsolin family P06396
Cytoplasmic protein NCK2 (NCK2) . O43639
DAZ-associated protein 2 (DAZAP2) . Q15038
GRIP and coiled-coil domain-containing protein 1 (GCC1) . Q96CN9
Melanoma-associated antigen D1 (MAGED1) . Q9Y5V3
Protein phosphatase 1 regulatory inhibitor subunit 16B (PPP1R16B) . Q96T49
Ubiquilin-1 (UBQLN1) . Q9UMX0

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060