Details of the Target

General Information of Target

Target ID LDTP08582
Target Name Zinc finger protein ZFPM1 (ZFPM1)
Gene Name ZFPM1
Gene ID 161882
Synonyms
FOG1; ZFN89A; Zinc finger protein ZFPM1; Friend of GATA protein 1; FOG-1; Friend of GATA 1; Zinc finger protein 89A; Zinc finger protein multitype 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSRRKQSNPRQIKRSLGDMEAREEVQLVGASHMEQKATAPEAPSPPSADVNSPPPLPPPT
SPGGPKELEGQEPEPRPTEEEPGSPWSGPDELEPVVQDGQRRIRARLSLATGLSWGPFHG
SVQTRASSPRQAEPSPALTLLLVDEACWLRTLPQALTEAEANTEIHRKDDALWCRVTKPV
PAGGLLSVLLTAEPHSTPGHPVKKEPAEPTCPAPAHDLQLLPQQAGMASILATAVINKDV
FPCKDCGIWYRSERNLQAHLLYYCASRQGTGSPAAAATDEKPKETYPNERVCPFPQCRKS
CPSASSLEIHMRSHSGERPFVCLICLSAFTTKANCERHLKVHTDTLSGVCHSCGFISTTR
DILYSHLVTNHMVCQPGSKGEIYSPGAGHPATKLPPDSLGSFQQQHTALQGPLASADLGL
APTPSPGLDRKALAEATNGEARAEPLAQNGGSSEPPAAPRSIKVEAVEEPEAAPILGPGE
PGPQAPSRTPSPRSPAPARVKAELSSPTPGSSPVPGELGLAGALFLPQYVFGPDAAPPAS
EILAKMSELVHSRLQQGAGAGAGGAQTGLFPGAPKGATCFECEITFSNVNNYYVHKRLYC
SGRRAPEDAPAARRPKAPPGPARAPPGQPAEPDAPRSSPGPGAREEGAGGAATPEDGAGG
RGSEGSQSPGSSVDDAEDDPSRTLCEACNIRFSRHETYTVHKRYYCASRHDPPPRRPAAP
PGPPGPAAPPAPSPAAPVRTRRRRKLYELHAAGAPPPPPPGHAPAPESPRPGSGSGSGPG
LAPARSPGPAADGPIDLSKKPRRPLPGAPAPALADYHECTACRVSFHSLEAYLAHKKYSC
PAAPPPGALGLPAAACPYCPPNGPVRGDLLEHFRLAHGLLLGAPLAGPGVEARTPADRGP
SPAPAPAASPQPGSRGPRDGLGPEPQEPPPGPPPSPAAAPEAVPPPPAPPSYSDKGVQTP
SKGTPAPLPNGNHRYCRLCNIKFSSLSTFIAHKKYYCSSHAAEHVK
Target Bioclass
Transcription factor
Family
FOG (Friend of GATA) family
Subcellular location
Nucleus
Function
Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2.
Uniprot ID
Q8IX07
Ensemble ID
ENST00000319555.8
HGNC ID
HGNC:19762

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C264(1.39)  LDD3334  [1]
NAIA_5
 Probe Info  		C997(1.15)  LDD2227  [2]
HPAP
 Probe Info  		3.09  LDD0063  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0237  AC12 HEK-293T C147(1.10)  LDD1510  [4]
 LDCM0280  AC20 HEK-293T C147(1.00)  LDD1519  [4]
 LDCM0288  AC28 HEK-293T C147(0.80)  LDD1527  [4]
 LDCM0297  AC36 HEK-293T C147(1.08)  LDD1536  [4]
 LDCM0301  AC4 HEK-293T C147(0.97)  LDD1540  [4]
 LDCM0306  AC44 HEK-293T C147(0.91)  LDD1545  [4]
 LDCM0315  AC52 HEK-293T C147(0.84)  LDD1554  [4]
 LDCM0324  AC60 HEK-293T C147(0.96)  LDD1563  [4]
 LDCM0632  CL-Sc Hep-G2 C997(1.15)  LDD2227  [2]
 LDCM0408  CL20 HEK-293T C147(1.09)  LDD1612  [4]
 LDCM0421  CL32 HEK-293T C147(0.79)  LDD1625  [4]
 LDCM0434  CL44 HEK-293T C147(1.09)  LDD1638  [4]
 LDCM0447  CL56 HEK-293T C147(1.21)  LDD1650  [4]
 LDCM0460  CL68 HEK-293T C147(1.18)  LDD1663  [4]
 LDCM0473  CL8 HEK-293T C147(0.89)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C147(0.89)  LDD1677  [4]
 LDCM0487  CL92 HEK-293T C147(0.96)  LDD1690  [4]
 LDCM0022  KB02 A2780 C264(1.53)  LDD2254  [1]
 LDCM0023  KB03 CMK C264(1.53)  LDD2719  [1]
 LDCM0024  KB05 MOLM-16 C264(1.39)  LDD3334  [1]
 LDCM0014  Panhematin K562 3.09  LDD0063  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glycogen synthase kinase-3 beta (GSK3B) CMGC Ser/Thr protein kinase family P49841
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Erythroid transcription factor (GATA1) . P15976
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone-binding protein RBBP4 (RBBP4) WD repeat RBAP46/RBAP48/MSI1 family Q09028

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402