Details of the Target

General Information of Target

Target ID LDTP03495
Target Name RNA-binding motif, single-stranded-interacting protein 1 (RBMS1)
Gene Name RBMS1
Gene ID 5937
Synonyms
C2orf12; MSSP; MSSP1; SCR2; RNA-binding motif, single-stranded-interacting protein 1; Single-stranded DNA-binding protein MSSP-1; Suppressor of CDC2 with RNA-binding motif 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGKVWKQQMYPQYATYYYPQYLQAKQSLVPAHPMAPPSPSTTSSNNNSSSSSNSGWDQLS
KTNLYIRGLPPHTTDQDLVKLCQPYGKIVSTKAILDKTTNKCKGYGFVDFDSPAAAQKAV
SALKASGVQAQMAKQQEQDPTNLYISNLPLSMDEQELENMLKPFGQVISTRILRDSSGTS
RGVGFARMESTEKCEAVIGHFNGKFIKTPPGVSAPTEPLLCKFADGGQKKRQNPNKYIPN
GRPWHREGEVRLAGMTLTYDPTTAAIQNGFYPSPYSIATNRMITQTSITPYIASPVSAYQ
VQSPSWMQPQPYILQHPGAVLTPSMEHTMSLQPASMISPLAQQMSHLSLGSTGTYMPATS
AMQGAYLPQYAHMQTTAVPVEEASGQQQVAVETSNDHSPYTFQPNK
Target Bioclass
Other
Subcellular location
Nucleus
Function Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds specifically to the DNA sequence motif 5'-[AT]CT[AT][AT]T-3'. Probably has a role in DNA replication.
Uniprot ID
P29558
Ensemble ID
ENST00000348849.8
HGNC ID
HGNC:9907

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.E154G .
BT549 SNV: p.E381K .
CORL23 SNV: p.S345G .
SKMEL30 SNV: p.N159D DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K204(6.05)  LDD0277  [2]
DBIA
 Probe Info  		C194(1.85)  LDD3312  [3]
BTD
 Probe Info  		C102(2.62)  LDD1700  [4]
HPAP
 Probe Info  		3.76  LDD0062  [5]
5E-2FA
 Probe Info  		H200(0.00); H72(0.00)  LDD2235  [6]
ATP probe
 Probe Info  		K103(0.00); K92(0.00)  LDD0199  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [8]
PF-06672131
 Probe Info  		N.A.  LDD0152  [9]
PPMS
 Probe Info  		N.A.  LDD0008  [10]
Acrolein
 Probe Info  		N.A.  LDD0217  [11]
Methacrolein
 Probe Info  		N.A.  LDD0218  [11]
W1
 Probe Info  		N.A.  LDD0236  [12]
AOyne
 Probe Info  		6.90  LDD0443  [13]
NAIA_5
 Probe Info  		C194(0.00); C221(0.00)  LDD2223  [14]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		16.29  LDD0471  [15]
FFF probe2
 Probe Info  		20.00  LDD0463  [15]
JN0003
 Probe Info  		20.00  LDD0469  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C82(0.36)  LDD2142  [4]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C82(0.51)  LDD2095  [4]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C82(0.70)  LDD2130  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C82(0.93); C102(0.84); C221(0.78)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C82(0.98); C102(1.25)  LDD2152  [4]
 LDCM0214  AC1 HEK-293T C221(0.89)  LDD1507  [16]
 LDCM0215  AC10 HEK-293T C194(1.01); C221(0.90)  LDD1508  [16]
 LDCM0226  AC11 HEK-293T C221(0.90)  LDD1509  [16]
 LDCM0237  AC12 HEK-293T C221(0.92)  LDD1510  [16]
 LDCM0259  AC14 HEK-293T C194(0.94); C221(0.94)  LDD1512  [16]
 LDCM0270  AC15 HEK-293T C194(0.94); C221(1.03)  LDD1513  [16]
 LDCM0276  AC17 HEK-293T C221(0.97)  LDD1515  [16]
 LDCM0277  AC18 HEK-293T C194(0.96); C221(0.95)  LDD1516  [16]
 LDCM0278  AC19 HEK-293T C221(0.71)  LDD1517  [16]
 LDCM0279  AC2 HEK-293T C194(0.93); C221(0.98)  LDD1518  [16]
 LDCM0280  AC20 HEK-293T C221(1.00)  LDD1519  [16]
 LDCM0281  AC21 HEK-293T C194(1.26); C221(1.02)  LDD1520  [16]
 LDCM0282  AC22 HEK-293T C194(0.99); C221(1.02)  LDD1521  [16]
 LDCM0283  AC23 HEK-293T C194(0.97); C221(1.00)  LDD1522  [16]
 LDCM0284  AC24 HEK-293T C221(0.94)  LDD1523  [16]
 LDCM0285  AC25 HEK-293T C221(0.96)  LDD1524  [16]
 LDCM0286  AC26 HEK-293T C194(1.00); C221(0.96)  LDD1525  [16]
 LDCM0287  AC27 HEK-293T C221(0.85)  LDD1526  [16]
 LDCM0288  AC28 HEK-293T C221(0.95)  LDD1527  [16]
 LDCM0289  AC29 HEK-293T C194(1.24); C221(1.03)  LDD1528  [16]
 LDCM0290  AC3 HEK-293T C221(0.97)  LDD1529  [16]
 LDCM0291  AC30 HEK-293T C194(0.99); C221(1.10)  LDD1530  [16]
 LDCM0292  AC31 HEK-293T C194(0.99); C221(1.01)  LDD1531  [16]
 LDCM0293  AC32 HEK-293T C221(0.94)  LDD1532  [16]
 LDCM0294  AC33 HEK-293T C221(0.89)  LDD1533  [16]
 LDCM0295  AC34 HEK-293T C194(1.10); C221(0.98)  LDD1534  [16]
 LDCM0296  AC35 HEK-293T C221(0.85)  LDD1535  [16]
 LDCM0297  AC36 HEK-293T C221(0.87)  LDD1536  [16]
 LDCM0298  AC37 HEK-293T C194(1.19); C221(1.19)  LDD1537  [16]
 LDCM0299  AC38 HEK-293T C194(0.88); C221(0.93)  LDD1538  [16]
 LDCM0300  AC39 HEK-293T C194(1.02); C221(0.98)  LDD1539  [16]
 LDCM0301  AC4 HEK-293T C221(0.96)  LDD1540  [16]
 LDCM0302  AC40 HEK-293T C221(0.93)  LDD1541  [16]
 LDCM0303  AC41 HEK-293T C221(0.91)  LDD1542  [16]
 LDCM0304  AC42 HEK-293T C194(1.08); C221(0.93)  LDD1543  [16]
 LDCM0305  AC43 HEK-293T C221(0.90)  LDD1544  [16]
 LDCM0306  AC44 HEK-293T C221(0.93)  LDD1545  [16]
 LDCM0307  AC45 HEK-293T C194(1.12); C221(0.99)  LDD1546  [16]
 LDCM0308  AC46 HEK-293T C194(0.76); C221(1.40)  LDD1547  [16]
 LDCM0309  AC47 HEK-293T C194(1.02); C221(1.01)  LDD1548  [16]
 LDCM0310  AC48 HEK-293T C221(1.15)  LDD1549  [16]
 LDCM0311  AC49 HEK-293T C221(0.91)  LDD1550  [16]
 LDCM0312  AC5 HEK-293T C194(1.01); C221(1.05)  LDD1551  [16]
 LDCM0313  AC50 HEK-293T C194(1.08); C221(1.00)  LDD1552  [16]
 LDCM0314  AC51 HEK-293T C221(0.86)  LDD1553  [16]
 LDCM0315  AC52 HEK-293T C221(0.97)  LDD1554  [16]
 LDCM0316  AC53 HEK-293T C194(1.00); C221(0.98)  LDD1555  [16]
 LDCM0317  AC54 HEK-293T C194(0.95); C221(1.01)  LDD1556  [16]
 LDCM0318  AC55 HEK-293T C194(0.97); C221(0.96)  LDD1557  [16]
 LDCM0319  AC56 HEK-293T C221(1.06)  LDD1558  [16]
 LDCM0320  AC57 HEK-293T C221(0.87)  LDD1559  [16]
 LDCM0321  AC58 HEK-293T C194(0.96); C221(0.92)  LDD1560  [16]
 LDCM0322  AC59 HEK-293T C221(0.83)  LDD1561  [16]
 LDCM0323  AC6 HEK-293T C194(0.84); C221(0.96)  LDD1562  [16]
 LDCM0324  AC60 HEK-293T C221(0.87)  LDD1563  [16]
 LDCM0325  AC61 HEK-293T C194(0.84); C221(0.95)  LDD1564  [16]
 LDCM0326  AC62 HEK-293T C194(0.91); C221(0.92)  LDD1565  [16]
 LDCM0327  AC63 HEK-293T C194(0.94); C221(0.91)  LDD1566  [16]
 LDCM0328  AC64 HEK-293T C221(1.05)  LDD1567  [16]
 LDCM0334  AC7 HEK-293T C194(0.86); C221(0.98)  LDD1568  [16]
 LDCM0345  AC8 HEK-293T C221(0.96)  LDD1569  [16]
 LDCM0545  Acetamide MDA-MB-231 C102(0.27)  LDD2138  [4]
 LDCM0520  AKOS000195272 MDA-MB-231 C82(0.75); C102(0.68)  LDD2113  [4]
 LDCM0248  AKOS034007472 HEK-293T C194(1.16); C221(1.08)  LDD1511  [16]
 LDCM0356  AKOS034007680 HEK-293T C221(0.93)  LDD1570  [16]
 LDCM0275  AKOS034007705 HEK-293T C221(1.03)  LDD1514  [16]
 LDCM0156  Aniline NCI-H1299 13.46  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C82(0.82); C102(0.35)  LDD2091  [4]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [11]
 LDCM0367  CL1 HEK-293T C194(0.76); C221(0.79)  LDD1571  [16]
 LDCM0368  CL10 HEK-293T C194(0.71); C221(0.77)  LDD1572  [16]
 LDCM0369  CL100 HEK-293T C194(1.13); C221(0.72)  LDD1573  [16]
 LDCM0370  CL101 HEK-293T C194(0.78); C221(0.90)  LDD1574  [16]
 LDCM0371  CL102 HEK-293T C194(0.88); C221(1.04)  LDD1575  [16]
 LDCM0372  CL103 HEK-293T C194(0.95); C221(1.01)  LDD1576  [16]
 LDCM0373  CL104 HEK-293T C194(1.39); C221(0.84)  LDD1577  [16]
 LDCM0374  CL105 HEK-293T C194(0.95); C221(0.90)  LDD1578  [16]
 LDCM0375  CL106 HEK-293T C194(1.05); C221(1.04)  LDD1579  [16]
 LDCM0376  CL107 HEK-293T C194(1.36); C221(1.09)  LDD1580  [16]
 LDCM0377  CL108 HEK-293T C194(1.08); C221(1.04)  LDD1581  [16]
 LDCM0378  CL109 HEK-293T C194(1.24); C221(1.09)  LDD1582  [16]
 LDCM0379  CL11 HEK-293T C194(1.00); C221(1.02)  LDD1583  [16]
 LDCM0380  CL110 HEK-293T C194(0.86); C221(0.86)  LDD1584  [16]
 LDCM0381  CL111 HEK-293T C194(1.43); C221(0.99)  LDD1585  [16]
 LDCM0382  CL112 HEK-293T C194(0.95); C221(1.05)  LDD1586  [16]
 LDCM0383  CL113 HEK-293T C194(1.11); C221(0.95)  LDD1587  [16]
 LDCM0384  CL114 HEK-293T C194(0.82); C221(0.92)  LDD1588  [16]
 LDCM0385  CL115 HEK-293T C194(0.98); C221(1.01)  LDD1589  [16]
 LDCM0386  CL116 HEK-293T C194(1.25); C221(1.10)  LDD1590  [16]
 LDCM0387  CL117 HEK-293T C194(0.92); C221(0.92)  LDD1591  [16]
 LDCM0388  CL118 HEK-293T C194(1.15); C221(1.03)  LDD1592  [16]
 LDCM0389  CL119 HEK-293T C194(1.17); C221(1.06)  LDD1593  [16]
 LDCM0390  CL12 HEK-293T C221(0.86)  LDD1594  [16]
 LDCM0391  CL120 HEK-293T C194(1.25); C221(0.92)  LDD1595  [16]
 LDCM0392  CL121 HEK-293T C194(1.07); C221(0.72)  LDD1596  [16]
 LDCM0393  CL122 HEK-293T C194(1.09); C221(0.98)  LDD1597  [16]
 LDCM0394  CL123 HEK-293T C194(1.29); C221(0.90)  LDD1598  [16]
 LDCM0395  CL124 HEK-293T C194(1.05); C221(1.00)  LDD1599  [16]
 LDCM0396  CL125 HEK-293T C194(1.12); C221(0.86)  LDD1600  [16]
 LDCM0397  CL126 HEK-293T C194(0.85); C221(0.97)  LDD1601  [16]
 LDCM0398  CL127 HEK-293T C194(1.07); C221(0.93)  LDD1602  [16]
 LDCM0399  CL128 HEK-293T C194(1.21); C221(0.86)  LDD1603  [16]
 LDCM0400  CL13 HEK-293T C194(0.98); C221(0.62)  LDD1604  [16]
 LDCM0401  CL14 HEK-293T C194(0.81); C221(1.00)  LDD1605  [16]
 LDCM0402  CL15 HEK-293T C194(0.94); C221(0.86)  LDD1606  [16]
 LDCM0403  CL16 HEK-293T C194(0.84); C221(0.86)  LDD1607  [16]
 LDCM0404  CL17 HEK-293T C221(0.80)  LDD1608  [16]
 LDCM0405  CL18 HEK-293T C194(1.11); C221(0.95)  LDD1609  [16]
 LDCM0406  CL19 HEK-293T C221(0.91)  LDD1610  [16]
 LDCM0407  CL2 HEK-293T C194(0.92); C221(1.27)  LDD1611  [16]
 LDCM0408  CL20 HEK-293T C221(0.86)  LDD1612  [16]
 LDCM0409  CL21 HEK-293T C194(0.95); C221(0.81)  LDD1613  [16]
 LDCM0410  CL22 HEK-293T C194(1.01); C221(0.98)  LDD1614  [16]
 LDCM0411  CL23 HEK-293T C194(1.04); C221(0.98)  LDD1615  [16]
 LDCM0412  CL24 HEK-293T C221(1.01)  LDD1616  [16]
 LDCM0413  CL25 HEK-293T C194(1.01); C221(0.74)  LDD1617  [16]
 LDCM0414  CL26 HEK-293T C194(1.07); C221(0.98)  LDD1618  [16]
 LDCM0415  CL27 HEK-293T C194(1.25); C221(1.06)  LDD1619  [16]
 LDCM0416  CL28 HEK-293T C194(1.05); C221(0.92)  LDD1620  [16]
 LDCM0417  CL29 HEK-293T C221(1.01)  LDD1621  [16]
 LDCM0418  CL3 HEK-293T C194(1.04); C221(1.02)  LDD1622  [16]
 LDCM0419  CL30 HEK-293T C194(1.09); C221(1.11)  LDD1623  [16]
 LDCM0420  CL31 HEK-293T C221(0.83)  LDD1624  [16]
 LDCM0421  CL32 HEK-293T C221(0.93)  LDD1625  [16]
 LDCM0422  CL33 HEK-293T C194(0.89); C221(0.87)  LDD1626  [16]
 LDCM0423  CL34 HEK-293T C194(1.01); C221(1.11)  LDD1627  [16]
 LDCM0424  CL35 HEK-293T C194(0.96); C221(1.02)  LDD1628  [16]
 LDCM0425  CL36 HEK-293T C221(0.98)  LDD1629  [16]
 LDCM0426  CL37 HEK-293T C194(1.25); C221(0.92)  LDD1630  [16]
 LDCM0428  CL39 HEK-293T C194(0.85); C221(1.08)  LDD1632  [16]
 LDCM0429  CL4 HEK-293T C194(0.64); C221(0.92)  LDD1633  [16]
 LDCM0430  CL40 HEK-293T C194(1.13); C221(0.94)  LDD1634  [16]
 LDCM0431  CL41 HEK-293T C221(0.88)  LDD1635  [16]
 LDCM0432  CL42 HEK-293T C194(1.01); C221(1.01)  LDD1636  [16]
 LDCM0433  CL43 HEK-293T C221(1.17)  LDD1637  [16]
 LDCM0434  CL44 HEK-293T C221(0.95)  LDD1638  [16]
 LDCM0435  CL45 HEK-293T C194(1.11); C221(0.95)  LDD1639  [16]
 LDCM0436  CL46 HEK-293T C194(0.97); C221(1.04)  LDD1640  [16]
 LDCM0437  CL47 HEK-293T C194(0.92); C221(1.06)  LDD1641  [16]
 LDCM0438  CL48 HEK-293T C221(0.96)  LDD1642  [16]
 LDCM0439  CL49 HEK-293T C194(1.20); C221(0.95)  LDD1643  [16]
 LDCM0440  CL5 HEK-293T C221(0.99)  LDD1644  [16]
 LDCM0441  CL50 HEK-293T C194(0.94); C221(0.94)  LDD1645  [16]
 LDCM0443  CL52 HEK-293T C194(1.00); C221(0.92)  LDD1646  [16]
 LDCM0444  CL53 HEK-293T C221(0.84)  LDD1647  [16]
 LDCM0445  CL54 HEK-293T C194(1.01); C221(0.94)  LDD1648  [16]
 LDCM0446  CL55 HEK-293T C221(1.00)  LDD1649  [16]
 LDCM0447  CL56 HEK-293T C221(1.08)  LDD1650  [16]
 LDCM0448  CL57 HEK-293T C194(0.93); C221(0.98)  LDD1651  [16]
 LDCM0449  CL58 HEK-293T C194(0.94); C221(1.05)  LDD1652  [16]
 LDCM0450  CL59 HEK-293T C194(0.96); C221(1.00)  LDD1653  [16]
 LDCM0451  CL6 HEK-293T C194(1.16); C221(0.85)  LDD1654  [16]
 LDCM0452  CL60 HEK-293T C221(1.07)  LDD1655  [16]
 LDCM0453  CL61 HEK-293T C194(0.94); C221(1.05)  LDD1656  [16]
 LDCM0454  CL62 HEK-293T C194(1.11); C221(1.10)  LDD1657  [16]
 LDCM0455  CL63 HEK-293T C194(1.06); C221(0.99)  LDD1658  [16]
 LDCM0456  CL64 HEK-293T C194(0.97); C221(0.96)  LDD1659  [16]
 LDCM0457  CL65 HEK-293T C221(0.91)  LDD1660  [16]
 LDCM0458  CL66 HEK-293T C194(1.00); C221(0.98)  LDD1661  [16]
 LDCM0459  CL67 HEK-293T C221(0.90)  LDD1662  [16]
 LDCM0460  CL68 HEK-293T C221(0.90)  LDD1663  [16]
 LDCM0461  CL69 HEK-293T C194(1.09); C221(1.15)  LDD1664  [16]
 LDCM0462  CL7 HEK-293T C221(1.01)  LDD1665  [16]
 LDCM0463  CL70 HEK-293T C194(0.79); C221(1.02)  LDD1666  [16]
 LDCM0464  CL71 HEK-293T C194(0.98); C221(1.08)  LDD1667  [16]
 LDCM0465  CL72 HEK-293T C221(0.97)  LDD1668  [16]
 LDCM0466  CL73 HEK-293T C194(1.02); C221(0.99)  LDD1669  [16]
 LDCM0467  CL74 HEK-293T C194(0.87); C221(1.05)  LDD1670  [16]
 LDCM0469  CL76 HEK-293T C194(1.09); C221(0.79)  LDD1672  [16]
 LDCM0470  CL77 HEK-293T C221(0.92)  LDD1673  [16]
 LDCM0471  CL78 HEK-293T C194(1.00); C221(1.08)  LDD1674  [16]
 LDCM0472  CL79 HEK-293T C221(1.17)  LDD1675  [16]
 LDCM0473  CL8 HEK-293T C221(0.63)  LDD1676  [16]
 LDCM0474  CL80 HEK-293T C221(1.06)  LDD1677  [16]
 LDCM0475  CL81 HEK-293T C194(1.10); C221(1.06)  LDD1678  [16]
 LDCM0476  CL82 HEK-293T C194(0.82); C221(1.17)  LDD1679  [16]
 LDCM0477  CL83 HEK-293T C194(1.04); C221(1.01)  LDD1680  [16]
 LDCM0478  CL84 HEK-293T C221(0.90)  LDD1681  [16]
 LDCM0479  CL85 HEK-293T C194(0.93); C221(0.77)  LDD1682  [16]
 LDCM0480  CL86 HEK-293T C194(0.63); C221(1.09)  LDD1683  [16]
 LDCM0481  CL87 HEK-293T C194(0.94); C221(0.96)  LDD1684  [16]
 LDCM0482  CL88 HEK-293T C194(0.88); C221(0.97)  LDD1685  [16]
 LDCM0483  CL89 HEK-293T C221(0.99)  LDD1686  [16]
 LDCM0484  CL9 HEK-293T C194(0.75); C221(0.97)  LDD1687  [16]
 LDCM0485  CL90 HEK-293T C194(0.92); C221(0.77)  LDD1688  [16]
 LDCM0486  CL91 HEK-293T C221(1.08)  LDD1689  [16]
 LDCM0487  CL92 HEK-293T C221(0.77)  LDD1690  [16]
 LDCM0488  CL93 HEK-293T C194(0.84); C221(1.02)  LDD1691  [16]
 LDCM0489  CL94 HEK-293T C194(0.96); C221(1.20)  LDD1692  [16]
 LDCM0490  CL95 HEK-293T C194(0.81); C221(0.83)  LDD1693  [16]
 LDCM0491  CL96 HEK-293T C221(0.91)  LDD1694  [16]
 LDCM0492  CL97 HEK-293T C194(0.80); C221(0.75)  LDD1695  [16]
 LDCM0493  CL98 HEK-293T C194(0.83); C221(1.02)  LDD1696  [16]
 LDCM0494  CL99 HEK-293T C194(0.94); C221(0.99)  LDD1697  [16]
 LDCM0495  E2913 HEK-293T C194(0.93); C221(0.98)  LDD1698  [16]
 LDCM0468  Fragment33 HEK-293T C194(0.76); C221(1.04)  LDD1671  [16]
 LDCM0427  Fragment51 HEK-293T C194(1.08); C221(1.11)  LDD1631  [16]
 LDCM0022  KB02 HEK-293T C221(0.91)  LDD1492  [16]
 LDCM0023  KB03 HEK-293T C221(0.92)  LDD1497  [16]
 LDCM0024  KB05 HMCB C194(1.85)  LDD3312  [3]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C82(0.99); C102(0.44)  LDD2121  [4]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C82(0.90); C102(0.33)  LDD2089  [4]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C102(0.35)  LDD2096  [4]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C82(0.93); C102(0.64); C194(0.88)  LDD2097  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C102(0.37)  LDD2098  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C82(1.25); C102(0.97)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C82(0.34); C102(0.27)  LDD2100  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C82(0.93); C221(0.72)  LDD2101  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C102(0.96)  LDD2104  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C82(0.91); C102(0.87); C221(0.85)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C82(0.75); C102(0.85)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C102(0.95)  LDD2111  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C82(0.44); C102(0.47)  LDD2115  [4]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C102(0.86)  LDD2116  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C102(0.70)  LDD2118  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C82(1.87)  LDD2119  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C82(0.91); C102(0.86)  LDD2120  [4]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C102(0.56)  LDD2122  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C82(0.89); C102(1.13)  LDD2123  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C102(0.51)  LDD2124  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C82(0.82); C102(0.73)  LDD2125  [4]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C102(0.62)  LDD2126  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C82(1.12)  LDD2127  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C102(1.01)  LDD2128  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C82(0.95); C102(1.30)  LDD2129  [4]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C82(0.59)  LDD2133  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C82(0.55); C102(0.48); C194(0.64); C221(0.46)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C82(1.63); C102(1.10)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C82(0.91); C102(1.28); C221(0.81)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C82(0.99); C102(1.48); C221(1.27)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C102(2.62)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C82(0.86); C102(0.67); C221(1.12)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C82(0.60)  LDD2141  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C102(1.27)  LDD2143  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C82(2.54); C102(3.81)  LDD2144  [4]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C82(0.99)  LDD2145  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C102(0.91)  LDD2146  [4]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C102(5.37)  LDD2147  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C82(0.42); C194(0.53)  LDD2148  [4]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C102(0.62)  LDD2149  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C82(0.80); C102(0.26)  LDD2150  [4]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C102(0.47)  LDD2151  [4]
 LDCM0014  Panhematin HEK-293T 3.76  LDD0062  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-globin transcription factor CP2 (TFCP2) Grh/CP2 family Q12800

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
6 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
7 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402