Details of the Target

General Information of Target

Target ID LDTP13398
Target Name Forkhead box protein D3 (FOXD3)
Gene Name FOXD3
Gene ID 27022
Synonyms
HFH2; Forkhead box protein D3; HNF3/FH transcription factor genesis
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPQLSGGGGGGGGDPELCATDEMIPFKDEGDPQKEKIFAEISHPEEEGDLADIKSSLVNE
SEIIPASNGHEVARQAQTSQEPYHDKAREHPDDGKHPDGGLYNKGPSYSSYSGYIMMPNM
NNDPYMSNGSLSPPIPRTSNKVPVVQPSHAVHPLTPLITYSDEHFSPGSHPSHIPSDVNS
KQGMSRHPPAPDIPTFYPLSPGGVGQITPPLGWQGQPVYPITGGFRQPYPSSLSVDTSMS
RFSHHMIPGPPGPHTTGIPHPAIVTPQVKQEHPHTDSDLMHVKPQHEQRKEQEPKRPHIK
KPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHM
QLYPGWSARDNYGKKKKRKREKLQESASGTGPRMTAAYI
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function
Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Negatively regulates transcription of transcriptional repressor RHIT/ZNF205. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis.
Uniprot ID
Q9UJU5
Ensemble ID
ENST00000371116.4
HGNC ID
HGNC:3804

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HPAP
 Probe Info  		3.24  LDD0062  [1]
DBIA
 Probe Info  		C104(1.01)  LDD1492  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0259  AC14 HEK-293T C104(1.03)  LDD1512  [2]
 LDCM0282  AC22 HEK-293T C104(1.02)  LDD1521  [2]
 LDCM0291  AC30 HEK-293T C104(1.16)  LDD1530  [2]
 LDCM0299  AC38 HEK-293T C104(0.88)  LDD1538  [2]
 LDCM0308  AC46 HEK-293T C104(1.04)  LDD1547  [2]
 LDCM0317  AC54 HEK-293T C104(1.28)  LDD1556  [2]
 LDCM0323  AC6 HEK-293T C104(0.97)  LDD1562  [2]
 LDCM0326  AC62 HEK-293T C104(1.02)  LDD1565  [2]
 LDCM0368  CL10 HEK-293T C104(0.88)  LDD1572  [2]
 LDCM0410  CL22 HEK-293T C104(1.18)  LDD1614  [2]
 LDCM0423  CL34 HEK-293T C104(1.18)  LDD1627  [2]
 LDCM0436  CL46 HEK-293T C104(1.58)  LDD1640  [2]
 LDCM0449  CL58 HEK-293T C104(1.47)  LDD1652  [2]
 LDCM0463  CL70 HEK-293T C104(1.12)  LDD1666  [2]
 LDCM0476  CL82 HEK-293T C104(1.13)  LDD1679  [2]
 LDCM0489  CL94 HEK-293T C104(1.12)  LDD1692  [2]
 LDCM0022  KB02 HEK-293T C104(1.01)  LDD1492  [2]
 LDCM0023  KB03 HEK-293T C104(1.03)  LDD1497  [2]
 LDCM0024  KB05 HEK-293T C104(0.99)  LDD1502  [2]
 LDCM0014  Panhematin HEK-293T 3.24  LDD0062  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
POU domain, class 5, transcription factor 1 (POU5F1) POU transcription factor family Q01860

References

1 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402