Details of the Target

General Information of Target

Target ID LDTP16129
Target Name DDB1- and CUL4-associated factor 16 (DCAF16)
Gene Name DCAF16
Gene ID 54876
Synonyms
C4orf30; DDB1- and CUL4-associated factor 16
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTKKRKRQHDFQKVKLKVGKKKPKLQNATPTNFKTKTIHLPEQLKEDGTLPTNNRKLNIK
DLLSQMHHYNAGVKQSALLGLKDLLSQYPFIIDAHLSNILSEVTAVFTDKDANVRLAAVQ
LLQFLAPKIRAEQISPFFPLVSAHLSSAMTHITEGIQEDSLKVLDILLEQYPALITGRSS
ILLKNFVELISHQQLSKGLINRDRSQSWILSVNPNRRLTSQQWRLKVLVRLSKFLQALAD
GSSRLRESEGLQEQKENPHATSNSIFINWKEHANDQQHIQVYENGGSQPNVSSQFRLRYL
VGGLSGVDEGLSSTENLKGFIEIIIPLLIECWVEAVPPQLATPVGNGIEREPLQVMQQVL
NIISLLWKLSKQQDETHKLESWLRKNYLIDFKHHFMSRFPYVLKEITKHKRKEPNKSIKH
CTVLSNNIDHLLLNLTLSDIMVSLANASTLQKDCSWIEMIRKFVTETLEDGSRLNSKQLN
RLLGVSWRLMQIQPNREDTETLIKAVYTLYQQRGLILPVRTLLLKFFSKIYQTEELRSCR
FRYRSKVLSRWLAGLPLQLAHLGSRNPELSTQLIDIIHTAAARANKELLKSLQATALRIY
DPQEGAVVVLPADSQQRLVQLVYFLPSLPADLLSRLSRCCIMGRLSSSLAAMLIGILHMR
SSFSGWKYSAKDWLMSDVDYFSFLFSTLTGFSKEELTWLQSLRGVPHVIQTQLSPVLLYL
TDLDQFLHHWDVTEAVFHSLLVIPARSQNFDILQSAISKHLVGLTVIPDSTAGCVFGVIC
KLLDHTCVVSETLLPFLASCCYSLLYFLLTIEKGEAEHLRKRDKLWGVCVSILALLPRVL
RLMLQSLRVNRVGPEELPVVGQLLRLLLQHAPLRTHMLTNAILVQQIIKNITTLKSGSVQ
EQWLTDLHYCFNVYITGHPQGPSALATVY
Target Bioclass
Other
Subcellular location
Nucleus
Function Functions as a substrate recognition component for CUL4-DDB1 E3 ubiquitin-protein ligase complex, which mediates ubiquitination and proteasome-dependent degradation of nuclear proteins.
Uniprot ID
Q9NXF7
Ensemble ID
ENST00000382247.6
HGNC ID
HGNC:25987

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.03  LDD0402  [1]
TH211
 Probe Info  		Y165(20.00); Y199(5.51)  LDD0257  [2]
NAIA_5
 Probe Info  		C119(1.48)  LDD2227  [3]
HPAP
 Probe Info  		3.17  LDD0062  [4]
IPM
 Probe Info  		C100(1.86)  LDD1701  [5]
Acrolein
 Probe Info  		N.A.  LDD0223  [6]
DBIA
 Probe Info  		C173(1.42); C178(1.26)  LDD0531  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [8]
NAIA_4
 Probe Info  		N.A.  LDD2226  [3]
SF
 Probe Info  		N.A.  LDD0028  [9]
AOyne
 Probe Info  		15.00  LDD0443  [10]
HHS-465
 Probe Info  		K167(0.00); Y165(0.00)  LDD2240  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C173(1.42); C178(1.26)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C173(1.37); C178(1.35)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C173(1.07); C179(1.41); C178(1.01)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C173(1.21); C179(1.20); C178(1.15)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C173(1.10); C179(1.22); C178(1.05)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C173(1.39); C179(1.53); C178(1.38)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C173(1.25); C179(1.81); C178(1.21)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C173(1.26); C179(1.31); C178(1.28)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C173(1.21); C179(1.52); C178(1.20)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C173(1.17); C179(1.86); C178(0.91)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C173(1.04); C179(0.86); C178(0.94)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C173(1.01); C179(1.32); C178(0.92)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C173(1.55); C178(1.52)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C173(1.08); C179(1.22); C178(1.03)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C173(1.12); C179(1.13); C178(1.04)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C173(1.35); C179(1.54); C178(1.12)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C173(0.99); C179(1.15); C178(0.94); C177(0.80)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C173(1.16); C179(1.30); C178(1.00); C177(0.72)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C173(1.37); C179(1.59); C178(1.34); C177(1.18)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C173(1.38); C179(1.45); C178(1.15); C177(1.02)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C173(1.23); C179(1.18); C178(1.16); C177(1.34)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C173(1.08); C179(1.17); C178(1.04); C177(0.96)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C173(1.17); C179(1.41); C178(1.12); C177(0.94)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C173(1.01); C178(1.01)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C173(1.31); C179(1.38); C178(1.26); C177(0.93)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C173(1.06); C179(1.14); C178(0.92); C177(1.17)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C173(1.10); C179(1.16); C178(1.01); C177(0.86)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C173(1.09); C179(1.11); C178(1.12); C177(0.81)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C173(0.99); C179(0.94); C178(0.97); C177(1.05)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C173(1.06); C179(1.07); C178(1.04); C177(0.84)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C173(1.22); C179(1.40); C178(1.01); C177(0.94)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C173(1.18); C179(1.18); C178(1.09); C177(0.73)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C173(1.29); C178(0.64)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C173(0.94); C178(0.77)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C173(1.22); C178(0.77)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C173(0.89); C178(0.82)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C173(0.92); C178(0.92)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C173(0.99); C178(0.87)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C173(1.21); C178(1.07)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C173(1.15); C178(0.80)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C173(1.20); C178(0.93)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C173(1.02); C178(0.86)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C173(1.39); C178(1.48)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C173(1.27); C178(1.43)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C173(1.34); C178(1.42)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C173(1.42); C178(1.47)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C173(1.31); C178(1.75)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C173(0.99); C178(1.08)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C173(1.31); C179(1.84); C178(1.23); C177(1.11)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C177(0.96); C178(1.18); C173(1.36); C179(2.18)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C173(1.13); C178(1.19); C177(1.43); C179(1.67)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C177(0.99); C178(1.23); C173(1.36); C179(2.35)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C177(1.07); C178(1.29); C173(1.44); C179(2.10)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C177(1.37); C178(1.93); C173(2.29); C179(4.29)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C177(1.36); C178(1.60); C173(1.74); C179(2.84)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C178(1.19); C173(1.26)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C177(1.14); C173(1.14); C178(1.15); C179(1.47)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C177(1.08); C178(1.15); C173(1.17); C179(1.48)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C177(0.87); C178(1.35); C173(1.54); C179(2.04)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C177(1.18); C178(2.38); C173(2.98); C179(4.47)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C173(1.42); C179(2.19); C178(1.39); C177(1.30)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C173(1.18); C179(1.76); C178(1.16); C177(1.07)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C173(1.00); C179(1.30); C178(0.99); C177(0.92)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C173(0.99); C179(1.07); C178(0.98); C177(0.90)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C178(1.05); C173(1.08); C177(1.12)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C177(1.40); C178(1.66); C173(1.68)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C177(0.94); C173(1.13); C178(1.23)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C178(1.33); C173(1.42)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C177(1.06); C178(1.13); C173(1.14)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C177(1.09); C178(1.19); C173(1.20)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C177(0.99); C173(1.09); C178(1.11)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C177(1.06); C173(1.33); C178(1.43)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C173(1.06); C177(1.07); C178(1.11)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C173(1.04); C178(1.10); C177(1.19)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C173(1.28); C178(1.36); C177(1.45)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C173(1.11); C178(1.20); C177(1.21)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C173(1.24); C178(1.27); C177(1.36)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C177(1.24); C173(1.24); C178(1.29)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C178(1.12); C173(1.30)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C173(1.45); C177(1.51); C178(1.54)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C173(1.30); C177(1.41); C178(1.44)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C173(1.56); C177(1.66); C178(1.68)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C173(1.48); C178(1.50); C177(1.51)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C178(1.60); C173(1.64); C177(1.84)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C178(0.93); C173(0.95); C179(1.22)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C178(0.91); C173(0.94); C179(0.96)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C178(0.86); C173(0.90); C179(1.01)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C178(0.88); C173(0.90); C179(0.97)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C178(0.97); C173(0.98); C179(1.23)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C178(1.18); C173(1.55)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C178(1.15); C173(1.20); C179(1.58)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C178(0.98); C179(0.99); C173(1.02)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C178(1.17); C173(1.22); C179(1.30)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C179(1.06); C173(1.10); C178(1.11)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C173(1.09); C178(1.09); C179(1.10)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C178(1.25); C173(1.27); C179(1.48)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C178(0.93); C173(1.07)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C178(0.98); C173(1.02)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C178(0.85); C173(0.93)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C178(1.66); C173(1.77)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C178(1.27); C173(1.73)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C178(1.36); C173(1.56)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C178(0.76); C173(0.91)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C178(1.01); C173(1.04)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C173(1.50); C178(1.63)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C178(1.33); C173(1.41)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C173(1.70); C178(1.80)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C173(3.65); C178(3.66)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C178(1.34); C173(1.49)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C178(1.47); C173(1.65)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C178(1.54); C173(1.66)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C178(1.32); C173(1.35)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C178(1.46); C173(1.63)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C178(1.41); C173(1.56)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C178(1.74); C173(1.78)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C178(1.41); C173(1.52)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C178(1.73); C173(1.89)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C178(1.77); C173(1.95)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C178(1.51); C173(1.68)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C178(2.75); C173(2.96)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C173(1.25); C178(1.27)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C173(1.31); C178(1.32)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C178(1.14); C173(1.15)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C178(1.41); C173(1.43)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C173(0.89); C178(0.90)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C178(1.28); C173(1.30)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C178(2.14); C173(2.16)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C178(2.33); C173(2.34)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C173(2.72); C178(2.73)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C178(1.36); C173(1.38)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C178(1.39); C173(1.39)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C173(1.12); C178(1.13)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C173(1.05); C178(1.07)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C178(1.19); C173(1.22)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C173(1.26); C178(1.27)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C173(1.40); C178(1.44)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C173(3.93); C178(3.94)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C178(2.05); C179(2.13); C173(2.25)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C178(1.69); C173(1.97); C179(2.10)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C179(1.13); C178(1.40); C173(1.44)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C173(1.21); C178(1.23); C179(1.24)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C178(1.06); C173(1.08); C179(1.20)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C179(1.07); C178(1.17); C173(1.21)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C178(1.35); C179(1.36); C173(1.42)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C179(0.64); C178(0.89); C173(0.90)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C178(1.84); C173(2.02); C179(2.24)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C179(1.26); C178(1.41); C173(1.44)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C179(0.87); C178(1.05); C173(1.10)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C178(1.21); C179(1.33); C173(1.34)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C178(1.22); C173(1.23); C179(1.35)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C179(1.35); C178(1.39); C173(1.51)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C178(1.66); C173(1.75); C179(2.56)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C178(1.89); C173(2.79); C179(3.24)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C178(1.01); C173(1.08); C179(1.17)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C173(1.16); C178(1.19)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C178(1.33); C173(1.37)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C178(1.78); C173(1.87)  LDD0592  [7]
 LDCM0020  ARS-1620 HCC44 C173(1.27); C179(1.27)  LDD2171  [7]
 LDCM0632  CL-Sc Hep-G2 C119(1.48)  LDD2227  [3]
 LDCM0367  CL1 HCT 116 C173(1.01); C178(1.04)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C178(1.79); C173(2.22)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C178(1.28); C173(1.52)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C178(1.50); C173(1.50)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C173(1.45); C178(1.64)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C173(1.21); C178(1.28)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C178(1.36); C173(1.37)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C177(1.20); C173(1.44); C178(1.76)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C177(1.68); C173(1.83); C178(1.91)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C177(1.34); C178(1.40); C173(1.48)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C177(1.45); C178(1.62); C173(1.66)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C177(1.34); C173(1.61); C178(1.74)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C173(1.62); C178(1.68)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C177(1.72); C173(1.88); C178(2.07)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C177(1.25); C173(1.54); C178(1.69)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C173(1.17); C178(1.24); C177(1.34)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C173(1.54); C177(1.59); C178(1.65)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C177(1.40); C173(1.50); C178(1.68)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C178(1.43); C173(1.43); C177(1.50)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C178(1.25); C173(1.27); C177(1.31)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C173(2.11); C178(2.20); C179(2.93)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C178(1.03); C173(1.07); C179(1.13)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C173(1.10); C178(1.13); C179(1.25)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C178(1.24); C173(1.48)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C178(0.97); C173(0.99); C179(1.04)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C173(1.64); C178(1.72)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C178(1.28); C173(1.28)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C178(1.76); C173(1.82)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C173(1.80); C178(1.87)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C178(1.09); C173(1.09)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C173(1.44); C178(1.53)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C178(1.21); C173(1.21)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C178(1.32); C173(1.44)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C173(1.21); C178(1.26)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C173(1.11); C178(1.13)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C173(1.49); C178(1.84)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C177(1.03); C173(1.22); C178(1.24)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C178(1.35); C173(1.38)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C178(1.36); C173(1.42)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C178(1.31); C173(1.34)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C173(0.91); C178(1.13)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C178(1.44); C173(1.51)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C178(2.15); C173(2.24)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C178(3.30); C173(3.60)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C178(1.18); C173(1.18)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C178(1.76); C173(1.83)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C173(2.06); C178(2.04)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C173(1.35); C178(1.31)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C173(1.15); C178(1.16)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C173(1.67); C178(1.65)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C173(1.56); C178(1.52)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C173(0.89); C178(0.98)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C173(1.24); C178(1.22)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C173(1.27); C178(1.25)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C173(1.52); C178(1.52); C177(1.45)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C173(2.15); C178(2.26); C177(2.06)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C173(1.99); C178(2.00); C177(1.41)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C173(1.98); C178(2.02); C177(1.00)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C173(1.53); C178(1.47); C177(1.13)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C173(2.00); C178(1.96); C177(0.89)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C173(2.06); C178(2.03); C177(1.17)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C173(1.13); C178(1.10)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C173(1.79); C178(1.72); C177(1.35)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C173(1.56); C178(1.45); C177(1.33)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C173(5.50); C178(5.17); C177(1.08)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C173(2.38); C178(2.30); C177(1.04)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C173(2.01); C178(1.96); C177(0.92)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C173(2.41); C178(2.42); C177(0.91)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C173(0.97); C178(1.03)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C173(0.92); C178(0.96)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C173(0.97); C178(0.98)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C173(0.98); C178(1.02)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C173(0.92); C178(0.91)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C173(0.89); C178(0.86)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C173(0.94); C178(0.95)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C173(1.01); C178(1.04)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C173(1.12); C178(1.08)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C173(1.01); C178(1.05)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C173(0.86); C178(0.87)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C173(1.03); C178(1.09)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C173(0.94); C178(0.99)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C173(0.92); C178(0.99)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C173(0.94); C178(0.91)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C173(1.24); C178(1.33)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C173(0.99); C178(0.98)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C173(1.00); C178(0.87)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C173(0.93); C178(0.85)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C173(1.23); C178(1.11)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C173(1.58); C178(1.38)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C173(1.09); C178(0.98)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C173(1.50); C178(1.55)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C173(1.33); C178(1.28)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C173(1.21); C178(1.25)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C173(1.15); C178(1.11)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C173(1.25); C178(1.24)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C173(1.11); C178(1.05)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C173(1.21); C178(1.19)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C173(1.02); C178(0.94)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C173(1.21); C178(1.18)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C173(1.28); C178(1.08)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C173(1.26); C178(1.27)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C173(1.32); C178(1.37)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C173(1.29); C178(1.33)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C173(1.61); C178(1.47)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C173(2.48); C178(2.73)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C173(1.20); C178(1.19)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C173(1.32); C178(1.22)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C173(2.40); C178(2.10)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C173(2.02); C178(1.78)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C173(3.03); C178(2.58)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C173(1.29); C178(1.30)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C173(1.23); C178(1.25)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C173(1.38); C178(1.39)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C173(1.77); C178(1.71)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C173(4.16); C178(3.41)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C173(1.15); C178(1.23)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C173(1.69); C178(1.63)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C173(1.37); C178(1.31)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C173(1.43); C178(1.15)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C173(1.24); C178(0.91)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C173(1.75); C178(1.55)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C173(1.80); C178(1.71)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C173(1.33); C178(1.22)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C173(1.65); C178(1.53)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C173(1.73); C178(1.40)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C173(1.44); C178(1.45)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C119(0.96); C103(0.96)  LDD1698  [12]
 LDCM0625  F8 Ramos C119(1.14)  LDD2187  [13]
 LDCM0572  Fragment10 Ramos C119(1.13)  LDD2189  [13]
 LDCM0573  Fragment11 Ramos C119(0.11); 20.00  LDD2190  [13]
 LDCM0574  Fragment12 Ramos C119(0.90)  LDD2191  [13]
 LDCM0575  Fragment13 Ramos C119(0.81)  LDD2192  [13]
 LDCM0576  Fragment14 Ramos C119(1.63); 1.09  LDD2193  [13]
 LDCM0579  Fragment20 Ramos C119(1.56)  LDD2194  [13]
 LDCM0580  Fragment21 Ramos C119(0.64)  LDD2195  [13]
 LDCM0582  Fragment23 Ramos C119(0.86)  LDD2196  [13]
 LDCM0578  Fragment27 Ramos C119(0.74)  LDD2197  [13]
 LDCM0586  Fragment28 Ramos C119(0.41); 0.89  LDD2198  [13]
 LDCM0588  Fragment30 Ramos C119(1.08)  LDD2199  [13]
 LDCM0589  Fragment31 Ramos C119(1.05)  LDD2200  [13]
 LDCM0590  Fragment32 Ramos C119(1.06)  LDD2201  [13]
 LDCM0468  Fragment33 HCT 116 C173(1.35); C178(1.38)  LDD0785  [7]
 LDCM0596  Fragment38 Ramos C119(1.18)  LDD2203  [13]
 LDCM0566  Fragment4 Ramos C119(1.37)  LDD2184  [13]
 LDCM0427  Fragment51 HCT 116 C173(3.44); C178(3.39); C177(0.90)  LDD0744  [7]
 LDCM0610  Fragment52 Ramos C119(1.21)  LDD2204  [13]
 LDCM0614  Fragment56 Ramos C119(1.12)  LDD2205  [13]
 LDCM0569  Fragment7 Ramos C119(1.50); 1.53  LDD2186  [13]
 LDCM0571  Fragment9 Ramos C119(1.53)  LDD2188  [13]
 LDCM0022  KB02 HEK-293T C119(1.07); C100(0.94)  LDD1492  [12]
 LDCM0023  KB03 HEK-293T C119(1.01); C100(0.89)  LDD1497  [12]
 LDCM0024  KB05 HEK-293T C119(1.06); C100(0.95)  LDD1502  [12]
 LDCM0109  NEM HeLa N.A.  LDD0223  [6]
 LDCM0627  NUDT7-COV-1 HEK-293T C119(0.74)  LDD2206  [14]
 LDCM0628  OTUB2-COV-1 HEK-293T C119(1.04)  LDD2207  [14]
 LDCM0014  Panhematin HEK-293T 3.17  LDD0062  [4]
 LDCM0021  THZ1 HCT 116 C173(1.27); C179(1.27)  LDD2173  [7]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
14 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.