Details of the Target

General Information of Target

Target ID LDTP09142
Target Name SUMO-interacting motif-containing protein 1 (SIMC1)
Gene Name SIMC1
Gene ID 375484
Synonyms
C5orf25; PLEIAD; SUMO-interacting motif-containing protein 1; Platform element for inhibition of autolytic degradation
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPASASGEDLRKLPTMAEVNGEQDFIDLTRETRPRTKDRSGLYVIDLTRAEGENRPIAT
LDLTLEPVTPSQKEPTSLQTCASLSGKAVMEGHVDRSSQPTARRIINSDPVDLDLVEENT
FVGPPPATSISGGSVYPTEPNCSSATFTGNLSFLASLQLSSDVSSLSPTSNNSRSSSSSS
NQKAPLPCPQQDVSRPPQALPCPLRPLPCPPRASPCPPRASSCPPRALSCPSQTMQCQLP
ALTHPPQEVPCPRQNIPGPPQDSLGLPQDVPGLPQSILHPQDVAYLQDMPRSPGDVPQSP
SDVSPSPDAPQSPGGMPHLPGDVLHSPGDMPHSSGDVTHSPRDIPHLPGDRPDFTQNDVQ
NRDMPMDISALSSPSCSPSPQSETPLEKVPWLSVMETPARKEISLSEPAKPGSAHVQSRT
PQGGLYNRPCLHRLKYFLRPPVHHLFFQTLIPDKDTRENKGQKLEPIPHRRLRMVTNTIE
ENFPLGTVQFLMDFVSPQHYPPREIVAHIIQKILLSGSETVDVLKEAYMLLMKIQQLHPA
NAKTVEWDWKLLTYVMEEEGQTLPGRVLFLRYVVQTLEDDFQQTLRRQRQHLQQSIANMV
LSCDKQPHNVRDVIKWLVKAVTEDGLTQPPNGNQTSSGTGILKASSSHPSSQPNLTKNTN
QLIVCQLQRMLSIAVEVDRTPTCSSNKIAEMMFGFVLDIPERSQREMFFTTMESHLLRCK
VLEIIFLHSCETPTRLPLSLAQALYFLNNSTSLLKCQSDKSQWQTWDELVEHLQFLLSSY
QHVLREHLRSSVIDRKDLIIKRIKPKPQQGDDITVVDVEKQIEAFRSRLIQMLGEPLVPQ
LQDKVHLLKLLLFYAADLNPDAEPFQKGWSGS
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Plays a role in SMC5-SMC6 complex recruitment for viral restriction. Forms a complex with SLF2 and this complex is required to recruit SMC5-SMC6 complex to PML nuclear bodies and sites of viral replication.; [Isoform 1]: Inhibits the protease activity of CAPN3.; [Isoform 5]: Inhibits the protease activity of CAPN3.
Uniprot ID
Q8NDZ2
Ensemble ID
ENST00000332772.4
HGNC ID
HGNC:24779

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HPAP
 Probe Info  		4.41  LDD0062  [1]
IA-alkyne
 Probe Info  		C216(5.05); C430(6.95)  LDD1704  [2]
IPM
 Probe Info  		C683(1.71)  LDD1701  [3]
DBIA
 Probe Info  		C665(0.88)  LDD0531  [4]
VSF
 Probe Info  		N.A.  LDD0007  [5]
Phosphinate-6
 Probe Info  		C430(0.00); C81(0.00)  LDD0018  [6]
AOyne
 Probe Info  		15.00  LDD0443  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C665(0.88)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C230(1.04); C237(1.04); C251(1.04); C665(1.22)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C230(0.86); C251(0.86)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C230(1.02); C251(1.02)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C230(0.87); C251(0.87)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C230(0.80); C251(0.80)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C230(0.93); C251(0.93)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C230(0.96); C251(0.96)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C230(0.62); C251(0.62)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C230(0.99); C251(1.02)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C230(1.27); C251(0.73)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C230(0.73); C251(0.59)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C230(1.06); C237(1.06); C251(1.06); C665(1.28)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C230(0.74); C251(1.05)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C230(1.06); C251(0.77)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C230(0.73); C251(0.89)  LDD0546  [4]
 LDCM0230  AC113 PaTu 8988t C665(0.80)  LDD1109  [4]
 LDCM0231  AC114 PaTu 8988t C665(0.85)  LDD1110  [4]
 LDCM0232  AC115 PaTu 8988t C665(0.96)  LDD1111  [4]
 LDCM0233  AC116 PaTu 8988t C665(1.44)  LDD1112  [4]
 LDCM0234  AC117 PaTu 8988t C665(1.00)  LDD1113  [4]
 LDCM0235  AC118 PaTu 8988t C665(0.84)  LDD1114  [4]
 LDCM0236  AC119 PaTu 8988t C665(1.30)  LDD1115  [4]
 LDCM0237  AC12 HCT 116 C230(0.79); C237(0.79); C251(0.79); C665(1.08)  LDD0554  [4]
 LDCM0238  AC120 PaTu 8988t C665(0.99)  LDD1117  [4]
 LDCM0239  AC121 PaTu 8988t C665(0.75)  LDD1118  [4]
 LDCM0240  AC122 PaTu 8988t C665(0.93)  LDD1119  [4]
 LDCM0241  AC123 PaTu 8988t C665(0.79)  LDD1120  [4]
 LDCM0242  AC124 PaTu 8988t C665(0.87)  LDD1121  [4]
 LDCM0243  AC125 PaTu 8988t C665(0.77)  LDD1122  [4]
 LDCM0244  AC126 PaTu 8988t C665(1.57)  LDD1123  [4]
 LDCM0245  AC127 PaTu 8988t C665(0.96)  LDD1124  [4]
 LDCM0246  AC128 HEK-293T C665(1.06); C230(0.89); C237(0.89); C251(0.89)  LDD0844  [4]
 LDCM0247  AC129 HEK-293T C665(1.04); C230(1.23); C237(1.23); C251(1.23)  LDD0845  [4]
 LDCM0249  AC130 HEK-293T C665(1.02); C230(1.33); C237(1.33); C251(1.33)  LDD0847  [4]
 LDCM0250  AC131 HEK-293T C665(0.81); C230(0.84); C237(0.84); C251(0.84)  LDD0848  [4]
 LDCM0251  AC132 HEK-293T C665(1.18); C230(1.41); C237(1.41); C251(1.41)  LDD0849  [4]
 LDCM0252  AC133 HEK-293T C665(0.67); C230(1.08); C237(1.08); C251(1.08)  LDD0850  [4]
 LDCM0253  AC134 HEK-293T C665(1.24); C230(1.13); C237(1.13); C251(1.13)  LDD0851  [4]
 LDCM0254  AC135 HEK-293T C665(0.84); C230(1.01); C237(1.01); C251(1.01)  LDD0852  [4]
 LDCM0255  AC136 HEK-293T C665(0.98); C230(0.70); C237(0.70); C251(0.70)  LDD0853  [4]
 LDCM0256  AC137 HEK-293T C665(1.19); C230(0.84); C237(0.84); C251(0.84)  LDD0854  [4]
 LDCM0257  AC138 HEK-293T C665(1.28); C230(1.00); C237(1.00); C251(1.00)  LDD0855  [4]
 LDCM0258  AC139 HEK-293T C665(1.22); C230(0.95); C237(0.95); C251(0.95)  LDD0856  [4]
 LDCM0259  AC14 HCT 116 C230(0.86); C237(0.86); C251(0.86); C665(1.32)  LDD0576  [4]
 LDCM0260  AC140 HEK-293T C665(1.09); C230(0.99); C237(0.99); C251(0.99)  LDD0858  [4]
 LDCM0261  AC141 HEK-293T C665(1.15); C230(0.88); C237(0.88); C251(0.88)  LDD0859  [4]
 LDCM0262  AC142 HEK-293T C665(1.22); C230(1.40); C237(1.40); C251(1.40)  LDD0860  [4]
 LDCM0263  AC143 HCT 116 C230(0.80); C237(0.80); C251(0.80)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C230(0.93); C237(0.93); C251(0.93)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C230(1.24); C237(1.24); C251(1.24)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C230(0.96); C237(0.96); C251(0.96)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C230(1.01); C237(1.01); C251(1.01)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C230(1.46); C237(1.46); C251(1.46)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C230(0.96); C237(0.96); C251(0.96)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C230(0.61); C237(0.61); C251(0.61); C665(1.27)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C230(0.74); C237(0.74); C251(0.74)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C230(1.14); C237(1.14); C251(1.14)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C230(1.17); C237(1.17); C251(1.17)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C230(1.49); C237(1.49); C251(1.49)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C230(1.13); C237(1.13); C251(1.13)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C230(0.98); C237(0.98); C251(0.98)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C230(0.81); C237(0.81); C251(0.81)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C230(0.93); C237(0.93); C251(0.93)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C665(1.02)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C665(1.11)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C665(1.31)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C665(0.93)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C665(1.07)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C665(0.95)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C665(1.09)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C665(1.17)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C665(1.04)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C665(1.47)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C665(1.24)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C665(1.51)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C665(1.43)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C665(1.45)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C665(0.99)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C665(1.61)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C665(1.38)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C665(1.72)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C665(1.37)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C665(1.32)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C665(0.73)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C665(0.93)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C665(1.02)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C665(0.97)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C665(1.01)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C665(1.01)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C665(1.50)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C665(0.98)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C665(1.26)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C665(1.09)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C665(1.21)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C665(1.35)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C665(1.19)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C665(1.73)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C665(1.75)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C665(1.24)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C665(1.00)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C665(1.63)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C665(1.16)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C665(1.36)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C665(1.51)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C665(1.16)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C665(1.79)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C665(1.89)  LDD0636  [4]
 LDCM0320  AC57 HEK-293T C665(0.73); C230(0.80); C237(0.91); C251(0.80)  LDD0918  [4]
 LDCM0321  AC58 HEK-293T C665(0.83); C230(1.19); C237(1.13); C251(1.19)  LDD0919  [4]
 LDCM0322  AC59 HEK-293T C665(0.95); C230(1.04); C237(1.13); C251(1.04)  LDD0920  [4]
 LDCM0323  AC6 HCT 116 C230(0.75); C237(0.75); C251(0.75); C665(1.54)  LDD0640  [4]
 LDCM0324  AC60 HEK-293T C665(0.65); C230(0.65); C237(0.73); C251(0.65)  LDD0922  [4]
 LDCM0325  AC61 HEK-293T C665(0.90); C230(0.47); C237(0.68); C251(0.47)  LDD0923  [4]
 LDCM0326  AC62 HEK-293T C665(1.07); C230(0.47); C237(0.72); C251(0.47)  LDD0924  [4]
 LDCM0327  AC63 HEK-293T C665(0.99); C230(0.55); C237(0.70); C251(0.55)  LDD0925  [4]
 LDCM0328  AC64 HEK-293T C665(1.12); C230(0.47); C237(0.72); C251(0.47)  LDD0926  [4]
 LDCM0329  AC65 HEK-293T C665(0.88); C230(0.56); C237(0.72); C251(0.56)  LDD0927  [4]
 LDCM0330  AC66 HEK-293T C665(1.00); C230(0.56); C237(0.76); C251(0.56)  LDD0928  [4]
 LDCM0331  AC67 HEK-293T C665(1.00); C230(0.68); C237(0.75); C251(0.68)  LDD0929  [4]
 LDCM0332  AC68 HCT 116 C230(0.95); C237(0.95); C251(0.95)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C230(1.07); C237(1.07); C251(1.07)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C230(0.80); C237(0.80); C251(0.80); C665(1.30)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C230(1.11); C237(1.11); C251(1.11)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C230(0.99); C237(0.99); C251(0.99)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C230(1.02); C237(1.02); C251(1.02)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C230(1.76); C237(1.76); C251(1.76)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C230(1.61); C237(1.61); C251(1.61)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C230(2.30); C237(2.30); C251(2.30)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C230(1.76); C237(1.76); C251(1.76)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C230(1.18); C237(1.18); C251(1.18)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C230(1.19); C237(1.19); C251(1.19)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C230(1.06); C237(1.06); C251(1.06)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C230(0.95); C237(0.95); C251(0.95); C665(1.10)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C230(1.35); C237(1.35); C251(1.35)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C230(0.89); C237(0.89); C251(0.89)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C230(1.48); C237(1.48); C251(1.48)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C230(1.20); C237(1.20); C251(1.20)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C230(1.01); C237(1.01); C251(1.01)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C230(1.06); C237(1.06); C251(1.06)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C230(1.23); C237(1.23); C251(1.23)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C230(1.35); C237(1.35); C251(1.35)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C230(0.97); C237(0.97); C251(0.97)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C230(1.40); C237(1.40); C251(1.40)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C230(0.65); C237(0.65); C251(0.65)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C230(1.85); C237(1.85); C251(1.85)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C230(2.04); C237(2.04); C251(2.04)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C230(2.40); C237(2.40); C251(2.40)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C230(1.73); C237(1.73); C251(1.73)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C230(1.20); C237(1.20); C251(1.20)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C230(2.85); C237(2.85); C251(2.85)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C230(1.95); C237(1.95); C251(1.95)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C230(1.05); C251(1.05)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C230(0.51); C251(0.51)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C230(0.76); C237(0.76); C251(0.76); C665(1.17)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C230(0.86); C237(0.86); C251(0.86); C665(1.35)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C230(0.71); C237(0.71); C251(0.71); C665(2.09)  LDD0592  [4]
 LDCM0367  CL1 HEK-293T C202(0.95); C230(1.66); C237(1.66); C251(1.66)  LDD0965  [4]
 LDCM0368  CL10 HEK-293T C202(0.14); C230(2.55); C237(2.55); C251(2.55)  LDD0966  [4]
 LDCM0369  CL100 HCT 116 C665(1.02)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C230(0.91); C237(0.91); C251(0.91); C665(1.37)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C230(0.97); C237(0.97); C251(0.97); C665(1.38)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C230(0.78); C237(0.78); C251(0.78); C665(1.24)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C230(1.15); C237(1.15); C251(1.15); C665(1.37)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C665(1.65)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C665(1.35)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C665(1.48)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C665(1.62)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C665(1.47)  LDD0695  [4]
 LDCM0379  CL11 HEK-293T C202(0.14); C230(1.18); C237(1.18); C251(1.18)  LDD0977  [4]
 LDCM0380  CL110 HCT 116 C665(1.51)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C665(1.03)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C665(1.24)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C665(1.45)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C665(1.35)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C665(1.48)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C665(1.50)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C665(1.57)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C665(0.99)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C665(1.09)  LDD0706  [4]
 LDCM0390  CL12 HEK-293T C202(0.14); C230(1.13); C237(1.13); C251(1.13)  LDD0988  [4]
 LDCM0391  CL120 HCT 116 C665(1.05)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C665(1.03)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C665(1.31)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C665(1.83)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C665(1.73)  LDD0712  [4]
 LDCM0396  CL125 HEK-293T C665(0.83); C230(1.34); C237(1.15); C251(1.34)  LDD0994  [4]
 LDCM0397  CL126 HEK-293T C665(0.60); C230(1.16); C237(1.08); C251(1.16)  LDD0995  [4]
 LDCM0398  CL127 HEK-293T C665(0.82); C230(1.49); C237(1.29); C251(1.49)  LDD0996  [4]
 LDCM0399  CL128 HEK-293T C665(0.85); C230(1.10); C237(1.12); C251(1.10)  LDD0997  [4]
 LDCM0400  CL13 HEK-293T C202(2.49); C230(0.96); C237(0.96); C251(0.96)  LDD0998  [4]
 LDCM0401  CL14 HEK-293T C202(1.14); C230(1.38); C237(1.38); C251(1.38)  LDD0999  [4]
 LDCM0402  CL15 HEK-293T C202(0.41); C230(3.24); C237(3.24); C251(3.24)  LDD1000  [4]
 LDCM0403  CL16 HCT 116 C230(0.95); C237(0.95); C251(0.95)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C230(1.96); C237(1.96); C251(1.96)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C230(0.80); C237(0.80); C251(0.80)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C230(1.01); C237(1.01); C251(1.01)  LDD0723  [4]
 LDCM0407  CL2 HEK-293T C202(1.37); C230(1.25); C237(1.25); C251(1.25)  LDD1005  [4]
 LDCM0408  CL20 HCT 116 C230(0.95); C237(0.95); C251(0.95)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C230(1.46); C237(1.46); C251(1.46)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C230(0.56); C237(0.56); C251(0.56)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C230(0.95); C237(0.95); C251(0.95)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C230(0.91); C237(0.91); C251(0.91)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C230(0.75); C237(0.75); C251(0.75)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C230(1.08); C237(1.08); C251(1.08)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C230(1.09); C237(1.09); C251(1.09)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C230(1.57); C237(1.57); C251(1.57)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C230(1.11); C237(1.11); C251(1.11)  LDD0734  [4]
 LDCM0418  CL3 HEK-293T C202(1.57); C230(0.96); C237(0.96); C251(0.96)  LDD1016  [4]
 LDCM0419  CL30 HCT 116 C230(1.10); C237(1.10); C251(1.10)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C665(0.96)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C230(0.74); C237(0.74); C251(0.74); C665(0.88)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C230(0.56); C237(0.56); C251(0.56); C665(1.05)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C230(1.25); C237(1.25); C251(1.25); C665(0.63)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C230(0.67); C237(0.67); C251(0.67); C665(0.90)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C230(0.63); C237(0.63); C251(0.63); C665(1.17)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C230(0.63); C237(0.63); C251(0.63); C665(0.98)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C230(0.76); C237(0.76); C251(0.76); C665(0.86)  LDD0745  [4]
 LDCM0429  CL4 HEK-293T C202(1.82); C230(1.62); C237(1.62); C251(1.62)  LDD1027  [4]
 LDCM0430  CL40 HCT 116 C230(0.96); C237(0.96); C251(0.96); C665(0.89)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C230(0.49); C237(0.49); C251(0.49); C665(0.94)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C230(0.86); C237(0.86); C251(0.86); C665(0.92)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C230(0.85); C237(0.85); C251(0.85); C665(1.04)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C230(0.67); C237(0.67); C251(0.67); C665(0.92)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C230(0.66); C237(0.66); C251(0.66); C665(1.08)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C230(0.98); C237(0.98); C251(0.98)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C230(0.91); C237(0.91); C251(0.91)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C230(0.87); C237(0.87); C251(0.87)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C230(0.75); C237(0.75); C251(0.75)  LDD0756  [4]
 LDCM0440  CL5 HEK-293T C202(1.78); C230(1.34); C237(1.34); C251(1.34)  LDD1038  [4]
 LDCM0441  CL50 HCT 116 C230(0.90); C237(0.90); C251(0.90)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C230(0.78); C237(0.78); C251(0.78)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C230(1.63); C237(1.63); C251(1.63)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C230(1.15); C237(1.15); C251(1.15)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C230(1.21); C237(1.21); C251(1.21)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C230(0.80); C237(0.80); C251(0.80)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C230(0.90); C237(0.90); C251(0.90)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C230(1.01); C237(1.01); C251(1.01)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C230(1.19); C237(1.19); C251(1.19)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C230(0.85); C237(0.85); C251(0.85)  LDD0767  [4]
 LDCM0451  CL6 HEK-293T C202(1.15); C230(1.17); C237(1.17); C251(1.17)  LDD1049  [4]
 LDCM0452  CL60 HCT 116 C230(1.00); C237(1.00); C251(1.00)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C665(1.29)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C665(1.17)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C665(1.11)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C665(1.10)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C665(1.14)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C665(1.13)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C665(0.99)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C665(0.89)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C665(1.10)  LDD0778  [4]
 LDCM0462  CL7 HEK-293T C202(1.24); C230(1.01); C237(1.01); C251(1.01)  LDD1060  [4]
 LDCM0463  CL70 HCT 116 C665(1.06)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C665(1.05)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C665(1.18)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C665(1.20)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C665(1.02)  LDD0784  [4]
 LDCM0469  CL76 HEK-293T C188(0.75); C230(0.80); C237(0.80); C251(0.80)  LDD1067  [4]
 LDCM0470  CL77 HEK-293T C188(0.62); C230(1.01); C237(1.01); C251(1.01)  LDD1068  [4]
 LDCM0471  CL78 HEK-293T C188(2.25); C230(0.93); C237(0.93); C251(0.93)  LDD1069  [4]
 LDCM0472  CL79 HEK-293T C188(0.92); C230(0.77); C237(0.77); C251(0.77)  LDD1070  [4]
 LDCM0473  CL8 HEK-293T C202(0.14); C237(0.61); C251(3.80); C683(1.14)  LDD1071  [4]
 LDCM0474  CL80 HEK-293T C188(1.69); C230(1.08); C237(1.08); C251(1.08)  LDD1072  [4]
 LDCM0475  CL81 HEK-293T C188(1.09); C230(0.85); C237(0.85); C251(0.85)  LDD1073  [4]
 LDCM0476  CL82 HEK-293T C188(0.89); C230(0.75); C237(0.75); C251(0.75)  LDD1074  [4]
 LDCM0477  CL83 HEK-293T C188(0.86); C230(0.84); C237(0.84); C251(0.84)  LDD1075  [4]
 LDCM0478  CL84 HEK-293T C188(2.54); C230(1.20); C237(1.20); C251(1.20)  LDD1076  [4]
 LDCM0479  CL85 HEK-293T C188(1.67); C230(0.83); C237(0.83); C251(0.83)  LDD1077  [4]
 LDCM0480  CL86 HEK-293T C188(1.62); C230(0.90); C237(0.90); C251(0.90)  LDD1078  [4]
 LDCM0481  CL87 HEK-293T C188(1.38); C230(1.00); C237(1.00); C251(1.00)  LDD1079  [4]
 LDCM0482  CL88 HEK-293T C188(1.43); C230(1.07); C237(1.07); C251(1.07)  LDD1080  [4]
 LDCM0483  CL89 HEK-293T C188(1.60); C230(0.97); C237(0.97); C251(0.97)  LDD1081  [4]
 LDCM0484  CL9 HEK-293T C202(1.20); C237(0.66); C251(1.23); C683(0.93)  LDD1082  [4]
 LDCM0485  CL90 HEK-293T C188(1.38); C230(2.36); C237(2.36); C251(2.36)  LDD1083  [4]
 LDCM0486  CL91 HCT 116 C665(0.82)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C665(0.75)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C665(0.86)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C665(0.94)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C665(0.75)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C665(0.90)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C665(1.00)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C665(1.01)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C665(0.99)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C216(1.05); C430(1.06); C81(0.80); C665(1.30)  LDD1698  [8]
 LDCM0468  Fragment33 HCT 116 C665(1.09)  LDD0785  [4]
 LDCM0427  Fragment51 HCT 116 C230(0.81); C237(0.81); C251(0.81); C665(0.88)  LDD0744  [4]
 LDCM0022  KB02 HEK-293T C216(0.96); C81(1.05); C730(0.77); C683(0.78)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C216(1.01); C81(1.02); C730(0.96); C683(0.89)  LDD1497  [8]
 LDCM0024  KB05 RD C81(3.09); C430(3.37)  LDD3401  [9]
 LDCM0014  Panhematin HEK-293T 4.41  LDD0062  [1]

References

1 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
2 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840