Details of the Target

General Information of Target

Target ID LDTP11915
Target Name Protein salvador homolog 1 (SAV1)
Gene Name SAV1
Gene ID 60485
Synonyms
WW45; Protein salvador homolog 1; 45 kDa WW domain protein; hWW45
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEPAAGFLSPRPFQRAAAAPAPPAGPGPPPSALRGPELEMLAGLPTSDPGRLITDPRSGR
TYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHR
HIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRG
ILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPE
ADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPR
DRPSIDQILRHDFFTKGYTPDRLPISSCVTVPDLTPPNPARSLFAKVTKSLFGRKKKSKN
HAQERDEVSGLVSGLMRTSVGHQDARPEAPAASGPAPVSLVETAPEDSSPRGTLASSGDG
FEEGLTVATVVESALCALRNCIAFMPPAEQNPAPLAQPEPLVWVSKWVDYSNKFGFGYQL
SSRRVAVLFNDGTHMALSANRKTVHYNPTSTKHFSFSVGAVPRALQPQLGILRYFASYME
QHLMKGGDLPSVEEVEVPAPPLLLQWVKTDQALLMLFSDGTVQVNFYGDHTKLILSGWEP
LLVTFVARNRSACTYLASHLRQLGCSPDLRQRLRYALRLLRDRSPA
Target Bioclass
Other
Subcellular location
Nucleus
Function
Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation.
Uniprot ID
Q9H4B6
Ensemble ID
ENST00000324679.5
HGNC ID
HGNC:17795

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C51(4.15)  LDD0171  [1]
HPAP
 Probe Info  		3.95  LDD0062  [2]
DBIA
 Probe Info  		C266(0.82)  LDD0531  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]
TFBX
 Probe Info  		N.A.  LDD0027  [5]
IPM
 Probe Info  		C266(0.00); C51(0.00)  LDD2156  [6]
AOyne
 Probe Info  		15.00  LDD0443  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C51(4.15)  LDD0171  [1]
 LDCM0214  AC1 HCT 116 C266(0.82)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C266(0.74)  LDD0532  [3]
 LDCM0216  AC100 HEK-293T C266(0.87)  LDD0814  [3]
 LDCM0217  AC101 HEK-293T C266(0.85)  LDD0815  [3]
 LDCM0218  AC102 HEK-293T C266(0.71)  LDD0816  [3]
 LDCM0219  AC103 HEK-293T C266(0.90)  LDD0817  [3]
 LDCM0220  AC104 HEK-293T C266(0.82)  LDD0818  [3]
 LDCM0221  AC105 HEK-293T C266(1.02)  LDD0819  [3]
 LDCM0222  AC106 HEK-293T C266(0.67)  LDD0820  [3]
 LDCM0223  AC107 HEK-293T C266(0.83)  LDD0821  [3]
 LDCM0224  AC108 HEK-293T C266(0.63)  LDD0822  [3]
 LDCM0225  AC109 HEK-293T C266(0.85)  LDD0823  [3]
 LDCM0226  AC11 HCT 116 C266(0.66)  LDD0543  [3]
 LDCM0227  AC110 HEK-293T C266(0.76)  LDD0825  [3]
 LDCM0228  AC111 HEK-293T C266(0.91)  LDD0826  [3]
 LDCM0229  AC112 HEK-293T C266(0.84)  LDD0827  [3]
 LDCM0230  AC113 HCT 116 C266(0.90)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C266(0.95)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C266(1.01)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C266(0.93)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C266(0.92)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C266(0.92)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C266(1.04)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C266(0.71)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C266(1.00)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C266(0.75)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C266(0.91)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C266(0.80)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C266(0.79)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C266(0.85)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C266(0.77)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C266(0.78)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C266(0.76)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C266(0.86)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C266(0.92)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C266(0.96)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C266(1.06)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C266(0.97)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C266(1.28)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C266(1.05)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C266(1.08)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C266(1.05)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C266(1.83)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C266(1.34)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C266(0.78)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C266(1.59)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C266(1.52)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C266(1.19)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C266(1.02)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C266(0.80)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C266(0.94)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C266(0.81)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C266(0.97)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C266(0.95)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C266(1.07)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C266(0.88)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C266(1.17)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C266(0.96)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C266(0.77)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C266(0.94)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C266(0.84)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C266(0.95)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C266(0.94)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C266(0.85)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C266(0.85)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C266(0.80)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C266(1.00)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C266(1.05)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C266(0.87)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C266(0.87)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C266(0.90)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C266(0.82)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C266(0.86)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C266(0.90)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C266(0.91)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C266(0.97)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C266(0.89)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C266(1.04)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C266(0.96)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C266(0.98)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C266(0.83)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C266(0.95)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C266(0.89)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C266(1.13)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C266(0.98)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C266(1.20)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C266(1.16)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C266(1.09)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C266(0.98)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C266(0.86)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C266(1.13)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C266(1.34)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C266(1.07)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C266(1.16)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C266(1.38)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C266(1.45)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C266(1.15)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C266(1.01)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C266(0.95)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C266(0.97)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C266(0.88)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C266(0.95)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C266(0.98)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C266(1.04)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C266(1.15)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C266(0.89)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C266(1.33)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C266(1.39)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C266(0.86)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C266(0.86)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C266(1.09)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C266(1.05)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C266(1.13)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C266(0.86)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C266(0.96)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C266(0.94)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C266(1.01)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C266(0.93)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C266(0.98)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C266(1.10)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C266(1.12)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C266(1.01)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C266(0.87)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C266(1.09)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C266(0.88)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C266(1.04)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C266(1.10)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C266(0.98)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C266(1.07)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C266(0.93)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C266(1.12)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C266(1.03)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C266(1.06)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C266(0.94)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C266(1.00)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C266(1.09)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C266(1.08)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C266(1.11)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C266(1.05)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C266(1.45)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C266(1.00)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C266(0.93)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C266(0.95)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C266(1.14)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C266(0.89)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C266(1.12)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C266(1.05)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C266(1.00)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C266(1.19)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C266(1.01)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C266(1.02)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C266(1.05)  LDD0681  [3]
 LDCM0365  AC98 HEK-293T C266(0.83)  LDD0963  [3]
 LDCM0366  AC99 HEK-293T C266(0.79)  LDD0964  [3]
 LDCM0248  AKOS034007472 HCT 116 C266(0.77)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C266(0.75)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C266(1.12)  LDD0592  [3]
 LDCM0367  CL1 HEK-293T C266(0.93); C51(0.95)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C266(1.02); C51(0.86)  LDD1572  [8]
 LDCM0369  CL100 HCT 116 C266(0.88)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C266(0.96)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C266(0.83)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C266(0.72)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C266(0.94)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C266(0.78)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C266(0.75)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C266(0.92)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C266(0.72)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C266(0.99)  LDD0695  [3]
 LDCM0379  CL11 HEK-293T C266(1.10); C51(0.75)  LDD1583  [8]
 LDCM0380  CL110 HCT 116 C266(0.80)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C266(0.90)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C266(0.83)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C266(0.92)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C266(0.90)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C266(1.02)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C266(1.06)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C266(1.20)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C266(1.07)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C266(0.99)  LDD0706  [3]
 LDCM0390  CL12 HEK-293T C266(0.84); C51(1.09)  LDD1594  [8]
 LDCM0391  CL120 HCT 116 C266(0.95)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C266(1.20)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C266(1.24)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C266(1.31)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C266(1.13)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C266(0.96)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C266(0.95)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C266(0.99)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C266(0.87)  LDD0716  [3]
 LDCM0400  CL13 HEK-293T C266(0.94); C51(1.00)  LDD1604  [8]
 LDCM0401  CL14 HEK-293T C266(0.89); C51(1.15)  LDD1605  [8]
 LDCM0402  CL15 HEK-293T C266(1.03); C51(1.11)  LDD1606  [8]
 LDCM0403  CL16 HEK-293T C266(0.87)  LDD1001  [3]
 LDCM0404  CL17 HEK-293T C266(0.98)  LDD1002  [3]
 LDCM0405  CL18 HEK-293T C266(1.20)  LDD1003  [3]
 LDCM0406  CL19 HEK-293T C266(0.91)  LDD1004  [3]
 LDCM0407  CL2 HEK-293T C266(0.96); C51(0.93)  LDD1611  [8]
 LDCM0408  CL20 HEK-293T C266(1.03)  LDD1006  [3]
 LDCM0409  CL21 HEK-293T C266(1.17)  LDD1007  [3]
 LDCM0410  CL22 HEK-293T C266(1.08)  LDD1008  [3]
 LDCM0411  CL23 HEK-293T C266(0.84)  LDD1009  [3]
 LDCM0412  CL24 HEK-293T C266(1.07)  LDD1010  [3]
 LDCM0413  CL25 HEK-293T C266(1.12)  LDD1011  [3]
 LDCM0414  CL26 HEK-293T C266(0.85)  LDD1012  [3]
 LDCM0415  CL27 HEK-293T C266(1.07)  LDD1013  [3]
 LDCM0416  CL28 HEK-293T C266(0.95)  LDD1014  [3]
 LDCM0417  CL29 HEK-293T C266(0.91)  LDD1015  [3]
 LDCM0418  CL3 HEK-293T C266(0.96); C51(1.27)  LDD1622  [8]
 LDCM0419  CL30 HEK-293T C266(0.90)  LDD1017  [3]
 LDCM0420  CL31 HEK-293T C266(1.04); C51(0.91)  LDD1624  [8]
 LDCM0421  CL32 HEK-293T C266(1.10)  LDD1625  [8]
 LDCM0422  CL33 HEK-293T C266(1.03); C51(0.69)  LDD1626  [8]
 LDCM0423  CL34 HEK-293T C266(1.09); C51(0.97)  LDD1627  [8]
 LDCM0424  CL35 HEK-293T C266(1.09); C51(0.86)  LDD1628  [8]
 LDCM0425  CL36 HEK-293T C266(0.93); C51(1.28)  LDD1629  [8]
 LDCM0426  CL37 HEK-293T C266(0.87); C51(1.16)  LDD1630  [8]
 LDCM0428  CL39 HEK-293T C266(0.86); C51(1.02)  LDD1632  [8]
 LDCM0429  CL4 HEK-293T C266(0.95)  LDD1633  [8]
 LDCM0430  CL40 HEK-293T C266(1.06)  LDD1634  [8]
 LDCM0431  CL41 HEK-293T C266(1.05); C51(0.77)  LDD1635  [8]
 LDCM0432  CL42 HEK-293T C266(0.96)  LDD1636  [8]
 LDCM0433  CL43 HEK-293T C266(1.11); C51(1.01)  LDD1637  [8]
 LDCM0434  CL44 HEK-293T C266(1.20)  LDD1638  [8]
 LDCM0435  CL45 HEK-293T C266(1.09); C51(0.79)  LDD1639  [8]
 LDCM0436  CL46 HCT 116 C266(0.90)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C266(1.00)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C266(0.91)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C266(0.81)  LDD0756  [3]
 LDCM0440  CL5 HEK-293T C266(1.17); C51(1.04)  LDD1644  [8]
 LDCM0441  CL50 HCT 116 C266(1.00)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C266(0.91)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C266(1.03)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C266(1.10)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C266(0.91)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C266(1.00)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C266(0.94)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C266(0.99)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C266(0.88)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C266(0.84)  LDD0767  [3]
 LDCM0451  CL6 HEK-293T C266(0.94)  LDD1654  [8]
 LDCM0452  CL60 HCT 116 C266(0.87)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C266(0.92)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C266(0.91)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C266(0.81)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C266(0.87)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C266(0.86)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C266(0.88)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C266(0.92)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C266(1.17)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C266(0.93)  LDD0778  [3]
 LDCM0462  CL7 HEK-293T C266(1.05); C51(1.11)  LDD1665  [8]
 LDCM0463  CL70 HCT 116 C266(1.07)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C266(0.96)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C266(1.03)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C266(0.93)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C266(0.94)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C266(1.08)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C266(1.27)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C266(1.04)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C266(1.04)  LDD0789  [3]
 LDCM0473  CL8 HEK-293T C266(0.85)  LDD1676  [8]
 LDCM0474  CL80 HCT 116 C266(0.98)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C266(0.98)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C266(0.97)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C266(1.10)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C266(0.98)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C266(1.13)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C266(1.14)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C266(1.13)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C266(1.12)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C266(1.03)  LDD0800  [3]
 LDCM0484  CL9 HEK-293T C266(0.99); C51(1.25)  LDD1687  [8]
 LDCM0485  CL90 HCT 116 C266(1.15)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C266(1.18)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C266(1.14)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C266(0.93)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C266(1.01)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C266(1.09)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C266(1.11)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C266(1.20)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C266(0.92)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C266(0.84)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C266(0.86); C51(1.17)  LDD1698  [8]
 LDCM0625  F8 Ramos C51(1.38)  LDD2187  [9]
 LDCM0572  Fragment10 Ramos C51(1.22)  LDD2189  [9]
 LDCM0573  Fragment11 Ramos C51(0.66)  LDD2190  [9]
 LDCM0574  Fragment12 Ramos C51(0.84)  LDD2191  [9]
 LDCM0575  Fragment13 Ramos C51(0.80)  LDD2192  [9]
 LDCM0576  Fragment14 Ramos C51(0.36)  LDD2193  [9]
 LDCM0579  Fragment20 Ramos C51(0.83)  LDD2194  [9]
 LDCM0580  Fragment21 Ramos C51(0.59)  LDD2195  [9]
 LDCM0582  Fragment23 Ramos C51(1.00)  LDD2196  [9]
 LDCM0578  Fragment27 Ramos C51(0.84)  LDD2197  [9]
 LDCM0586  Fragment28 Ramos C51(0.75)  LDD2198  [9]
 LDCM0588  Fragment30 Ramos C51(0.80)  LDD2199  [9]
 LDCM0589  Fragment31 Ramos C51(0.71)  LDD2200  [9]
 LDCM0590  Fragment32 Ramos C51(1.18)  LDD2201  [9]
 LDCM0468  Fragment33 HCT 116 C266(0.95)  LDD0785  [3]
 LDCM0596  Fragment38 Ramos C51(0.52)  LDD2203  [9]
 LDCM0566  Fragment4 Ramos C51(1.29)  LDD2184  [9]
 LDCM0427  Fragment51 HEK-293T C266(0.95); C51(1.06)  LDD1631  [8]
 LDCM0610  Fragment52 Ramos C51(0.88)  LDD2204  [9]
 LDCM0614  Fragment56 Ramos C51(1.73)  LDD2205  [9]
 LDCM0569  Fragment7 Ramos C51(0.96)  LDD2186  [9]
 LDCM0571  Fragment9 Ramos C51(1.15)  LDD2188  [9]
 LDCM0022  KB02 HEK-293T C266(0.96); C51(0.84)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C266(0.98); C51(1.00)  LDD1497  [8]
 LDCM0024  KB05 SKMEL24 C266(1.32)  LDD3323  [10]
 LDCM0014  Panhematin HEK-293T 3.95  LDD0062  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein kinase 3 (STK3) STE Ser/Thr protein kinase family Q13188
Serine/threonine-protein kinase 4 (STK4) STE Ser/Thr protein kinase family Q13043
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
HCLS1-associated protein X-1 (HAX1) HAX1 family O00165
Protein salvador homolog 1 (SAV1) . Q9H4B6

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
10 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840