Details of the Target

General Information of Target

Target ID LDTP07738
Target Name BCL-6 corepressor (BCOR)
Gene Name BCOR
Gene ID 54880
Synonyms
KIAA1575; BCL-6 corepressor; BCoR
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLSATPLYGNVHSWMNSERVRMCGASEDRKILVNDGDASKARLELREENPLNHNVVDAST
AHRIDGLAALSMDRTGLIREGLRVPGNIVYSSLCGLGSEKGREAATSTLGGLGFSSERNP
EMQFKPNTPETVEASAVSGKPPNGFSAIYKTPPGIQKSAVATAEALGLDRPASDKQSPLN
INGASYLRLPWVNPYMEGATPAIYPFLDSPNKYSLNMYKALLPQQSYSLAQPLYSPVCTN
GERFLYLPPPHYVGPHIPSSLASPMRLSTPSASPAIPPLVHCADKSLPWKMGVSPGNPVD
SHAYPHIQNSKQPRVPSAKAVTSGLPGDTALLLPPSPRPSPRVHLPTQPAADTYSEFHKH
YARISTSPSVALSKPYMTVSSEFPAARLSNGKYPKAPEGGEGAQPVPGHARKTAVQDRKD
GSSPPLLEKQTVTKDVTDKPLDLSSKVVDVDASKADHMKKMAPTVLVHSRAGSGLVLSGS
EIPKETLSPPGNGCAIYRSEIISTAPSSWVVPGPSPNEENNGKSMSLKNKALDWAIPQQR
SSSCPRMGGTDAVITNVSGSVSSAGRPASASPAPNANADGTKTSRSSVETTPSVIQHVGQ
PPATPAKHSSSTSSKGAKASNPEPSFKANENGLPPSSIFLSPNEAFRSPPIPYPRSYLPY
PAPEGIAVSPLSLHGKGPVYPHPVLLPNGSLFPGHLAPKPGLPYGLPTGRPEFVTYQDAL
GLGMVHPMLIPHTPIEITKEEKPERRSRSHERARYEDPTLRNRFSEILETSSTKLHPDVP
TDKNLKPNPNWNQGKTVVKSDKLVYVDLLREEPDAKTDTNVSKPSFAAESVGQSAEPPKP
SVEPALQQHRDFIALREELGRISDFHETYTFKQPVFTVSKDSVLAGTNKENLGLPVSTPF
LEPPLGSDGPAVTFGKTQEDPKPFCVGSAPPSVDVTPTYTKDGADEAESNDGKVLKPKPS
KLAKRIANSAGYVGDRFKCVTTELYADSSQLSREQRALQMEGLQEDSILCLPAAYCERAM
MRFSELEMKEREGGHPATKDSEMCKFSPADWERLKGNQDKKPKSVTLEEAIAEQNESERC
EYSVGNKHRDPFEAPEDKDLPVEKYFVERQPVSEPPADQVASDMPHSPTLRVDRKRKVSG
DSSHTETTAEEVPEDPLLKAKRRRVSKDDWPEREMTNSSSNHLEDPHYSELTNLKVCIEL
TGLHPKKQRHLLHLRERWEQQVSAADGKPGRQSRKEVTQATQPEAIPQGTNITEEKPGRK
RAEAKGNRSWSEESLKPSDNEQGLPVFSGSPPMKSLSSTSAGGKKQAQPSCAPASRPPAK
QQKIKENQKTDVLCADEEEDCQAASLLQKYTDNSEKPSGKRLCKTKHLIPQESRRGLPLT
GEYYVENADGKVTVRRFRKRPEPSSDYDLSPAKQEPKPFDRLQQLLPASQSTQLPCSSSP
QETTQSRPMPPEARRLIVNKNAGETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCA
LHEACARGWLNIVRHLLEYGADVNCSAQDGTRPLHDAVENDHLEIVRLLLSYGADPTLAT
YSGRTIMKMTHSELMEKFLTDYLNDLQGRNDDDASGTWDFYGSSVCEPDDESGYDVLANP
PGPEDQDDDDDAYSDVFEFEFSETPLLPCYNIQVSVAQGPRNWLLLSDVLKKLKMSSRIF
RCNFPNVEIVTIAEAEFYRQVSASLLFSCSKDLEAFNPESKELLDLVEFTNEIQTLLGSS
VEWLHPSDLASDNYW
Target Bioclass
Other
Family
BCOR family
Subcellular location
Nucleus
Function
Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).
Uniprot ID
Q6W2J9
Ensemble ID
ENST00000342274.8
HGNC ID
HGNC:20893

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL51 SNV: p.N1459S DBIA    Probe Info 
COLO320 SNV: p.Y660S DBIA    Probe Info 
COLO792 SNV: p.S1024P DBIA    Probe Info 
HCT116 Insertion: p.Q1208TfsTer8
SNV: p.C94Y		 .
HCT15 SNV: p.T759I .
HEC1 SNV: p.S1024T DBIA    Probe Info 
HEPG2 SNV: p.N1459S .
HT SNV: p.K140N DBIA    Probe Info 
IM95 SNV: p.Q1321Ter DBIA    Probe Info 
JURLMK1 SNV: p.K786Ter .
MCC13 Deletion: p.R1316GfsTer53
SNV: p.R1316M
Substitution: p.G254N		 DBIA    Probe Info 
MDAMB468 SNV: p.E1172Q .
MEWO SNV: p.S138F; p.P652L DBIA    Probe Info 
MFE319 SNV: p.R1454Q DBIA    Probe Info 
MKN45 Deletion: p.E519KfsTer28 DBIA    Probe Info 
MOLT4 SNV: p.G154E; p.P407S IA-alkyne    Probe Info 
NCIH1048 SNV: p.R850H .
NCIH1993 SNV: p.P178S .
NCIH716 SNV: p.L1510V .
OCIAML2 SNV: p.D1752Y DBIA    Probe Info 
OV90 SNV: p.P255R DBIA    Probe Info 
REH SNV: p.V1286G DBIA    Probe Info 
SF295 SNV: p.Q918L .
SISO SNV: p.N1057S DBIA    Probe Info 
SKN Deletion: p.D1541EfsTer24 DBIA    Probe Info 
SNU245 Deletion: p.D975_R976del; p.F977QfsTer40 .
SNU869 SNV: p.K1098E .
SW756 SNV: p.T868A .
TE10 SNV: p.N1057S DBIA    Probe Info 
TOV21G SNV: p.N1459S DBIA    Probe Info 
WM2664 Insertion: p.A1695GfsTer25 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y1350(17.86)  LDD0257  [1]
STPyne
 Probe Info  		K1055(0.34)  LDD0277  [2]
AHL-Pu-1
 Probe Info  		C1341(2.77)  LDD0168  [3]
HPAP
 Probe Info  		3.08  LDD0062  [4]
DBIA
 Probe Info  		C23(2.92); C1010(2.08); C1016(2.08); C94(2.50)  LDD0080  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [7]
IPM
 Probe Info  		N.A.  LDD0005  [8]
TFBX
 Probe Info  		N.A.  LDD0148  [9]
VSF
 Probe Info  		C1080(0.00); C1311(0.00)  LDD0007  [8]
YN-1
 Probe Info  		D1712(0.00); E1714(0.00)  LDD0447  [10]
Phosphinate-6
 Probe Info  		C94(0.00); C1334(0.00); C23(0.00); C979(0.00)  LDD0018  [11]
AOyne
 Probe Info  		15.00  LDD0443  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C1341(2.77)  LDD0168  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C1341(2.35); C1334(2.79); C1311(2.42)  LDD0169  [3]
 LDCM0214  AC1 HEK-293T C1488(0.98)  LDD0812  [5]
 LDCM0215  AC10 HEK-293T C1488(1.07)  LDD0813  [5]
 LDCM0216  AC100 HEK-293T C1488(1.00)  LDD0814  [5]
 LDCM0217  AC101 HEK-293T C1488(0.95)  LDD0815  [5]
 LDCM0218  AC102 HEK-293T C1488(0.97)  LDD0816  [5]
 LDCM0219  AC103 HEK-293T C1488(0.99)  LDD0817  [5]
 LDCM0220  AC104 HEK-293T C1488(0.87)  LDD0818  [5]
 LDCM0221  AC105 HEK-293T C1488(1.17)  LDD0819  [5]
 LDCM0222  AC106 HEK-293T C1488(0.93)  LDD0820  [5]
 LDCM0223  AC107 HEK-293T C1488(1.03)  LDD0821  [5]
 LDCM0224  AC108 HEK-293T C1488(1.02)  LDD0822  [5]
 LDCM0225  AC109 HEK-293T C1488(1.02)  LDD0823  [5]
 LDCM0226  AC11 HEK-293T C1488(0.95)  LDD0824  [5]
 LDCM0227  AC110 HEK-293T C1488(1.11)  LDD0825  [5]
 LDCM0228  AC111 HEK-293T C1488(1.12)  LDD0826  [5]
 LDCM0229  AC112 HEK-293T C1488(1.10)  LDD0827  [5]
 LDCM0230  AC113 PaTu 8988t C1488(0.93)  LDD1109  [5]
 LDCM0231  AC114 PaTu 8988t C1488(1.00)  LDD1110  [5]
 LDCM0232  AC115 PaTu 8988t C1488(1.08)  LDD1111  [5]
 LDCM0233  AC116 PaTu 8988t C1488(1.11)  LDD1112  [5]
 LDCM0234  AC117 PaTu 8988t C1488(0.87)  LDD1113  [5]
 LDCM0235  AC118 PaTu 8988t C1488(1.13)  LDD1114  [5]
 LDCM0236  AC119 PaTu 8988t C1488(1.24)  LDD1115  [5]
 LDCM0237  AC12 HEK-293T C1488(1.05)  LDD0835  [5]
 LDCM0238  AC120 PaTu 8988t C1488(1.16)  LDD1117  [5]
 LDCM0239  AC121 PaTu 8988t C1488(1.54)  LDD1118  [5]
 LDCM0240  AC122 PaTu 8988t C1488(1.06)  LDD1119  [5]
 LDCM0241  AC123 PaTu 8988t C1488(1.03)  LDD1120  [5]
 LDCM0242  AC124 PaTu 8988t C1488(1.30)  LDD1121  [5]
 LDCM0243  AC125 PaTu 8988t C1488(1.05)  LDD1122  [5]
 LDCM0244  AC126 PaTu 8988t C1488(1.32)  LDD1123  [5]
 LDCM0245  AC127 PaTu 8988t C1488(1.42)  LDD1124  [5]
 LDCM0246  AC128 HEK-293T C1488(1.06)  LDD0844  [5]
 LDCM0247  AC129 HEK-293T C1488(1.25)  LDD0845  [5]
 LDCM0249  AC130 HEK-293T C1488(1.22)  LDD0847  [5]
 LDCM0250  AC131 HEK-293T C1488(1.03)  LDD0848  [5]
 LDCM0251  AC132 HEK-293T C1488(1.23)  LDD0849  [5]
 LDCM0252  AC133 HEK-293T C1488(1.35)  LDD0850  [5]
 LDCM0253  AC134 HEK-293T C1488(1.25)  LDD0851  [5]
 LDCM0254  AC135 HEK-293T C1488(1.15)  LDD0852  [5]
 LDCM0255  AC136 HEK-293T C1488(1.27)  LDD0853  [5]
 LDCM0256  AC137 HEK-293T C1488(1.33)  LDD0854  [5]
 LDCM0257  AC138 HEK-293T C1488(1.33)  LDD0855  [5]
 LDCM0258  AC139 HEK-293T C1488(1.23)  LDD0856  [5]
 LDCM0259  AC14 HEK-293T C1488(1.05)  LDD0857  [5]
 LDCM0260  AC140 HEK-293T C1488(1.35)  LDD0858  [5]
 LDCM0261  AC141 HEK-293T C1488(1.29)  LDD0859  [5]
 LDCM0262  AC142 HEK-293T C1488(1.51)  LDD0860  [5]
 LDCM0263  AC143 HEK-293T C1488(1.08)  LDD0861  [5]
 LDCM0264  AC144 HEK-293T C1488(1.16)  LDD0862  [5]
 LDCM0265  AC145 HEK-293T C1488(1.33)  LDD0863  [5]
 LDCM0266  AC146 HEK-293T C1488(1.17)  LDD0864  [5]
 LDCM0267  AC147 HEK-293T C1488(1.11)  LDD0865  [5]
 LDCM0268  AC148 HEK-293T C1488(1.03)  LDD0866  [5]
 LDCM0269  AC149 HEK-293T C1488(0.99)  LDD0867  [5]
 LDCM0270  AC15 HEK-293T C1488(1.07)  LDD0868  [5]
 LDCM0271  AC150 HEK-293T C1488(0.92)  LDD0869  [5]
 LDCM0272  AC151 HEK-293T C1488(0.98)  LDD0870  [5]
 LDCM0273  AC152 HEK-293T C1488(1.05)  LDD0871  [5]
 LDCM0274  AC153 HEK-293T C1488(1.16)  LDD0872  [5]
 LDCM0621  AC154 HEK-293T C1488(1.03)  LDD2162  [5]
 LDCM0622  AC155 HEK-293T C1488(1.26)  LDD2163  [5]
 LDCM0623  AC156 HEK-293T C1488(1.18)  LDD2164  [5]
 LDCM0624  AC157 HEK-293T C1488(1.03)  LDD2165  [5]
 LDCM0276  AC17 HEK-293T C1488(1.24)  LDD0874  [5]
 LDCM0277  AC18 HEK-293T C1488(1.24)  LDD0875  [5]
 LDCM0278  AC19 HEK-293T C1488(1.18)  LDD0876  [5]
 LDCM0279  AC2 HEK-293T C1488(1.22)  LDD0877  [5]
 LDCM0280  AC20 HEK-293T C1488(1.23)  LDD0878  [5]
 LDCM0281  AC21 HEK-293T C1488(1.11)  LDD0879  [5]
 LDCM0282  AC22 HEK-293T C1488(1.23)  LDD0880  [5]
 LDCM0283  AC23 HEK-293T C1488(2.60)  LDD0881  [5]
 LDCM0284  AC24 HEK-293T C1488(1.21)  LDD0882  [5]
 LDCM0285  AC25 HEK-293T C23(1.13); C1311(1.04); C1080(1.15); C979(1.04)  LDD1524  [13]
 LDCM0286  AC26 HEK-293T C23(0.97); C1311(1.00); C1080(1.04); C979(1.06)  LDD1525  [13]
 LDCM0287  AC27 HEK-293T C1311(1.04); C1080(0.82); C979(1.17); C1197(1.06)  LDD1526  [13]
 LDCM0288  AC28 HEK-293T C23(1.01); C1311(1.01); C1080(1.11); C979(0.99)  LDD1527  [13]
 LDCM0289  AC29 HEK-293T C23(1.12); C1311(1.07); C1080(0.97); C979(1.04)  LDD1528  [13]
 LDCM0290  AC3 HEK-293T C1488(0.92)  LDD0888  [5]
 LDCM0291  AC30 HEK-293T C1311(0.96); C1080(1.05); C979(1.00); C1197(1.00)  LDD1530  [13]
 LDCM0292  AC31 HEK-293T C23(1.22); C1311(1.07); C1080(1.06); C979(0.89)  LDD1531  [13]
 LDCM0293  AC32 HEK-293T C23(1.22); C1311(0.96); C1080(0.99); C979(0.90)  LDD1532  [13]
 LDCM0294  AC33 HEK-293T C23(1.08); C1311(1.10); C1080(0.90); C979(1.14)  LDD1533  [13]
 LDCM0295  AC34 HEK-293T C23(0.98); C1311(1.09); C1080(1.05); C979(1.14)  LDD1534  [13]
 LDCM0296  AC35 HEK-293T C1488(1.07)  LDD0894  [5]
 LDCM0297  AC36 HEK-293T C1488(1.09)  LDD0895  [5]
 LDCM0298  AC37 HEK-293T C1488(1.21)  LDD0896  [5]
 LDCM0299  AC38 HEK-293T C1488(1.12)  LDD0897  [5]
 LDCM0300  AC39 HEK-293T C1488(1.18)  LDD0898  [5]
 LDCM0301  AC4 HEK-293T C1488(0.90)  LDD0899  [5]
 LDCM0302  AC40 HEK-293T C1488(1.18)  LDD0900  [5]
 LDCM0303  AC41 HEK-293T C1488(1.19)  LDD0901  [5]
 LDCM0304  AC42 HEK-293T C1488(1.12)  LDD0902  [5]
 LDCM0305  AC43 HEK-293T C1488(1.15)  LDD0903  [5]
 LDCM0306  AC44 HEK-293T C1488(1.15)  LDD0904  [5]
 LDCM0307  AC45 HEK-293T C1488(1.21)  LDD0905  [5]
 LDCM0308  AC46 HEK-293T C1488(1.01)  LDD0906  [5]
 LDCM0309  AC47 HEK-293T C1488(1.22)  LDD0907  [5]
 LDCM0310  AC48 HEK-293T C1488(1.05)  LDD0908  [5]
 LDCM0311  AC49 HEK-293T C1488(1.07)  LDD0909  [5]
 LDCM0312  AC5 HEK-293T C1488(1.01)  LDD0910  [5]
 LDCM0313  AC50 HEK-293T C1488(0.94)  LDD0911  [5]
 LDCM0314  AC51 HEK-293T C1488(1.24)  LDD0912  [5]
 LDCM0315  AC52 HEK-293T C1488(1.21)  LDD0913  [5]
 LDCM0316  AC53 HEK-293T C1488(5.14)  LDD0914  [5]
 LDCM0317  AC54 HEK-293T C1488(1.32)  LDD0915  [5]
 LDCM0318  AC55 HEK-293T C1488(1.14)  LDD0916  [5]
 LDCM0319  AC56 HEK-293T C1488(1.11)  LDD0917  [5]
 LDCM0320  AC57 HEK-293T C1488(1.33)  LDD0918  [5]
 LDCM0321  AC58 HEK-293T C1488(1.26)  LDD0919  [5]
 LDCM0322  AC59 HEK-293T C1488(1.06)  LDD0920  [5]
 LDCM0323  AC6 HEK-293T C1488(0.96)  LDD0921  [5]
 LDCM0324  AC60 HEK-293T C1488(0.94)  LDD0922  [5]
 LDCM0325  AC61 HEK-293T C1488(1.44)  LDD0923  [5]
 LDCM0326  AC62 HEK-293T C1488(1.22)  LDD0924  [5]
 LDCM0327  AC63 HEK-293T C1488(1.27)  LDD0925  [5]
 LDCM0328  AC64 HEK-293T C1488(1.08)  LDD0926  [5]
 LDCM0329  AC65 HEK-293T C1488(1.34)  LDD0927  [5]
 LDCM0330  AC66 HEK-293T C1488(1.14)  LDD0928  [5]
 LDCM0331  AC67 HEK-293T C1488(1.32)  LDD0929  [5]
 LDCM0332  AC68 HEK-293T C1488(1.09)  LDD0930  [5]
 LDCM0333  AC69 HEK-293T C1488(1.21)  LDD0931  [5]
 LDCM0334  AC7 HEK-293T C1488(0.97)  LDD0932  [5]
 LDCM0335  AC70 HEK-293T C1488(1.32)  LDD0933  [5]
 LDCM0336  AC71 HEK-293T C1488(1.06)  LDD0934  [5]
 LDCM0337  AC72 HEK-293T C1488(1.22)  LDD0935  [5]
 LDCM0338  AC73 HEK-293T C1488(1.13)  LDD0936  [5]
 LDCM0339  AC74 HEK-293T C1488(0.99)  LDD0937  [5]
 LDCM0340  AC75 HEK-293T C1488(1.10)  LDD0938  [5]
 LDCM0341  AC76 HEK-293T C1488(1.24)  LDD0939  [5]
 LDCM0342  AC77 HEK-293T C1488(1.24)  LDD0940  [5]
 LDCM0343  AC78 HEK-293T C1488(1.24)  LDD0941  [5]
 LDCM0344  AC79 HEK-293T C1488(1.00)  LDD0942  [5]
 LDCM0345  AC8 HEK-293T C1488(1.14)  LDD0943  [5]
 LDCM0346  AC80 HEK-293T C1488(1.19)  LDD0944  [5]
 LDCM0347  AC81 HEK-293T C1488(1.53)  LDD0945  [5]
 LDCM0348  AC82 HEK-293T C1488(1.33)  LDD0946  [5]
 LDCM0349  AC83 HEK-293T C1488(1.10)  LDD0947  [5]
 LDCM0350  AC84 HEK-293T C1488(1.57)  LDD0948  [5]
 LDCM0351  AC85 HEK-293T C1488(1.46)  LDD0949  [5]
 LDCM0352  AC86 HEK-293T C1488(1.32)  LDD0950  [5]
 LDCM0353  AC87 HEK-293T C1488(1.28)  LDD0951  [5]
 LDCM0354  AC88 HEK-293T C1488(1.44)  LDD0952  [5]
 LDCM0355  AC89 HEK-293T C1488(1.50)  LDD0953  [5]
 LDCM0357  AC90 HEK-293T C1488(1.26)  LDD0955  [5]
 LDCM0358  AC91 HEK-293T C1488(1.06)  LDD0956  [5]
 LDCM0359  AC92 HEK-293T C1488(1.51)  LDD0957  [5]
 LDCM0360  AC93 HEK-293T C1488(1.10)  LDD0958  [5]
 LDCM0361  AC94 HEK-293T C1488(1.14)  LDD0959  [5]
 LDCM0362  AC95 HEK-293T C1488(1.26)  LDD0960  [5]
 LDCM0363  AC96 HEK-293T C1488(0.98)  LDD0961  [5]
 LDCM0364  AC97 HEK-293T C1488(1.09)  LDD0962  [5]
 LDCM0365  AC98 HEK-293T C1488(0.87)  LDD0963  [5]
 LDCM0366  AC99 HEK-293T C1488(1.01)  LDD0964  [5]
 LDCM0248  AKOS034007472 HEK-293T C1488(1.02)  LDD0846  [5]
 LDCM0356  AKOS034007680 HEK-293T C1488(1.15)  LDD0954  [5]
 LDCM0275  AKOS034007705 HEK-293T C1488(1.14)  LDD0873  [5]
 LDCM0367  CL1 HEK-293T C1488(2.43)  LDD0965  [5]
 LDCM0368  CL10 HEK-293T C1488(1.35)  LDD0966  [5]
 LDCM0369  CL100 HEK-293T C1488(0.96)  LDD0967  [5]
 LDCM0370  CL101 HEK-293T C1488(1.07)  LDD0968  [5]
 LDCM0371  CL102 HEK-293T C1488(1.27)  LDD0969  [5]
 LDCM0372  CL103 HEK-293T C1488(1.19)  LDD0970  [5]
 LDCM0373  CL104 HEK-293T C1488(1.08)  LDD0971  [5]
 LDCM0374  CL105 HEK-293T C1488(1.27)  LDD0972  [5]
 LDCM0375  CL106 HEK-293T C1488(1.29)  LDD0973  [5]
 LDCM0376  CL107 HEK-293T C1488(1.18)  LDD0974  [5]
 LDCM0377  CL108 HEK-293T C1488(1.22)  LDD0975  [5]
 LDCM0378  CL109 HEK-293T C1488(1.18)  LDD0976  [5]
 LDCM0379  CL11 HEK-293T C1488(1.34)  LDD0977  [5]
 LDCM0380  CL110 HEK-293T C1488(1.40)  LDD0978  [5]
 LDCM0381  CL111 HEK-293T C1488(1.65)  LDD0979  [5]
 LDCM0382  CL112 HEK-293T C23(0.95); C1311(0.80); C1080(1.04); C979(1.02)  LDD1586  [13]
 LDCM0383  CL113 HEK-293T C23(1.13); C1311(1.19); C1080(0.94); C979(0.96)  LDD1587  [13]
 LDCM0384  CL114 HEK-293T C23(1.02); C1311(1.11); C1080(1.06); C979(0.77)  LDD1588  [13]
 LDCM0385  CL115 HEK-293T C23(0.96); C1311(1.07); C1080(1.03); C979(1.03)  LDD1589  [13]
 LDCM0386  CL116 HEK-293T C23(1.12); C1311(0.86); C1080(1.00); C979(1.05)  LDD1590  [13]
 LDCM0387  CL117 HEK-293T C1488(1.10)  LDD0985  [5]
 LDCM0388  CL118 HEK-293T C1488(1.07)  LDD0986  [5]
 LDCM0389  CL119 HEK-293T C1488(1.17)  LDD0987  [5]
 LDCM0390  CL12 HEK-293T C1488(1.18)  LDD0988  [5]
 LDCM0391  CL120 HEK-293T C1488(1.24)  LDD0989  [5]
 LDCM0392  CL121 HEK-293T C1488(1.11)  LDD0990  [5]
 LDCM0393  CL122 HEK-293T C1488(1.16)  LDD0991  [5]
 LDCM0394  CL123 HEK-293T C1488(1.05)  LDD0992  [5]
 LDCM0395  CL124 HEK-293T C1488(1.21)  LDD0993  [5]
 LDCM0396  CL125 HEK-293T C1488(1.14)  LDD0994  [5]
 LDCM0397  CL126 HEK-293T C1488(1.33)  LDD0995  [5]
 LDCM0398  CL127 HEK-293T C1488(1.33)  LDD0996  [5]
 LDCM0399  CL128 HEK-293T C1488(1.07)  LDD0997  [5]
 LDCM0400  CL13 HEK-293T C1488(1.23)  LDD0998  [5]
 LDCM0401  CL14 HEK-293T C1488(1.35)  LDD0999  [5]
 LDCM0402  CL15 HEK-293T C1488(2.10)  LDD1000  [5]
 LDCM0403  CL16 HEK-293T C1488(0.80)  LDD1001  [5]
 LDCM0404  CL17 HEK-293T C1488(1.71)  LDD1002  [5]
 LDCM0405  CL18 HEK-293T C1488(0.94)  LDD1003  [5]
 LDCM0406  CL19 HEK-293T C1488(1.03)  LDD1004  [5]
 LDCM0407  CL2 HEK-293T C1488(2.06)  LDD1005  [5]
 LDCM0408  CL20 HEK-293T C1488(1.05)  LDD1006  [5]
 LDCM0409  CL21 HEK-293T C1488(6.49)  LDD1007  [5]
 LDCM0410  CL22 HEK-293T C1488(1.28)  LDD1008  [5]
 LDCM0411  CL23 HEK-293T C1488(0.81)  LDD1009  [5]
 LDCM0412  CL24 HEK-293T C1488(0.90)  LDD1010  [5]
 LDCM0413  CL25 HEK-293T C1488(1.15)  LDD1011  [5]
 LDCM0414  CL26 HEK-293T C1488(0.99)  LDD1012  [5]
 LDCM0415  CL27 HEK-293T C1488(1.08)  LDD1013  [5]
 LDCM0416  CL28 HEK-293T C1488(1.20)  LDD1014  [5]
 LDCM0417  CL29 HEK-293T C1488(1.06)  LDD1015  [5]
 LDCM0418  CL3 HEK-293T C1488(1.14)  LDD1016  [5]
 LDCM0419  CL30 HEK-293T C1488(1.17)  LDD1017  [5]
 LDCM0420  CL31 HEK-293T C1488(1.33)  LDD1018  [5]
 LDCM0421  CL32 HEK-293T C1488(1.06)  LDD1019  [5]
 LDCM0422  CL33 HEK-293T C1488(2.39)  LDD1020  [5]
 LDCM0423  CL34 HEK-293T C1488(1.44)  LDD1021  [5]
 LDCM0424  CL35 HEK-293T C1488(1.09)  LDD1022  [5]
 LDCM0425  CL36 HEK-293T C1488(1.15)  LDD1023  [5]
 LDCM0426  CL37 HEK-293T C1488(1.05)  LDD1024  [5]
 LDCM0428  CL39 HEK-293T C1488(1.33)  LDD1026  [5]
 LDCM0429  CL4 HEK-293T C1488(1.35)  LDD1027  [5]
 LDCM0430  CL40 HEK-293T C1488(0.92)  LDD1028  [5]
 LDCM0431  CL41 HEK-293T C1488(0.78)  LDD1029  [5]
 LDCM0432  CL42 HEK-293T C1488(0.83)  LDD1030  [5]
 LDCM0433  CL43 HEK-293T C1488(1.12)  LDD1031  [5]
 LDCM0434  CL44 HEK-293T C1488(0.94)  LDD1032  [5]
 LDCM0435  CL45 HEK-293T C1488(1.32)  LDD1033  [5]
 LDCM0436  CL46 HEK-293T C1488(1.06)  LDD1034  [5]
 LDCM0437  CL47 HEK-293T C1488(1.19)  LDD1035  [5]
 LDCM0438  CL48 HEK-293T C1488(1.13)  LDD1036  [5]
 LDCM0439  CL49 HEK-293T C1488(1.05)  LDD1037  [5]
 LDCM0440  CL5 HEK-293T C1488(1.34)  LDD1038  [5]
 LDCM0441  CL50 HEK-293T C1488(1.05)  LDD1039  [5]
 LDCM0442  CL51 HEK-293T C1488(1.06)  LDD1040  [5]
 LDCM0443  CL52 HEK-293T C1488(0.96)  LDD1041  [5]
 LDCM0444  CL53 HEK-293T C1488(1.02)  LDD1042  [5]
 LDCM0445  CL54 HEK-293T C1488(1.28)  LDD1043  [5]
 LDCM0446  CL55 HEK-293T C1488(1.24)  LDD1044  [5]
 LDCM0447  CL56 HEK-293T C1488(1.34)  LDD1045  [5]
 LDCM0448  CL57 HEK-293T C1488(1.16)  LDD1046  [5]
 LDCM0449  CL58 HEK-293T C1488(1.10)  LDD1047  [5]
 LDCM0450  CL59 HEK-293T C1488(1.19)  LDD1048  [5]
 LDCM0451  CL6 HEK-293T C1488(1.79)  LDD1049  [5]
 LDCM0452  CL60 HEK-293T C1488(1.25)  LDD1050  [5]
 LDCM0453  CL61 HEK-293T C1488(1.03)  LDD1051  [5]
 LDCM0454  CL62 HEK-293T C1488(1.30)  LDD1052  [5]
 LDCM0455  CL63 HEK-293T C1488(1.06)  LDD1053  [5]
 LDCM0456  CL64 HEK-293T C1488(1.43)  LDD1054  [5]
 LDCM0457  CL65 HEK-293T C1488(1.27)  LDD1055  [5]
 LDCM0458  CL66 HEK-293T C1488(1.25)  LDD1056  [5]
 LDCM0459  CL67 HEK-293T C1488(1.18)  LDD1057  [5]
 LDCM0460  CL68 HEK-293T C1488(1.67)  LDD1058  [5]
 LDCM0461  CL69 HEK-293T C1488(1.37)  LDD1059  [5]
 LDCM0462  CL7 HEK-293T C1488(1.15)  LDD1060  [5]
 LDCM0463  CL70 HEK-293T C1488(1.09)  LDD1061  [5]
 LDCM0464  CL71 HEK-293T C1488(1.16)  LDD1062  [5]
 LDCM0465  CL72 HEK-293T C1488(0.99)  LDD1063  [5]
 LDCM0466  CL73 HEK-293T C1488(1.61)  LDD1064  [5]
 LDCM0467  CL74 HEK-293T C1488(1.18)  LDD1065  [5]
 LDCM0469  CL76 HEK-293T C1488(1.13)  LDD1067  [5]
 LDCM0470  CL77 HEK-293T C1488(1.80)  LDD1068  [5]
 LDCM0471  CL78 HEK-293T C1488(1.20)  LDD1069  [5]
 LDCM0472  CL79 HEK-293T C1488(1.19)  LDD1070  [5]
 LDCM0473  CL8 HEK-293T C1488(1.43)  LDD1071  [5]
 LDCM0474  CL80 HEK-293T C1488(1.16)  LDD1072  [5]
 LDCM0475  CL81 HEK-293T C1488(1.22)  LDD1073  [5]
 LDCM0476  CL82 HEK-293T C1488(1.00)  LDD1074  [5]
 LDCM0477  CL83 HEK-293T C1488(1.03)  LDD1075  [5]
 LDCM0478  CL84 HEK-293T C1488(1.18)  LDD1076  [5]
 LDCM0479  CL85 HEK-293T C1488(1.30)  LDD1077  [5]
 LDCM0480  CL86 HEK-293T C1488(1.63)  LDD1078  [5]
 LDCM0481  CL87 HEK-293T C1488(1.42)  LDD1079  [5]
 LDCM0482  CL88 HEK-293T C1488(1.23)  LDD1080  [5]
 LDCM0483  CL89 HEK-293T C1488(1.17)  LDD1081  [5]
 LDCM0484  CL9 HEK-293T C1488(1.07)  LDD1082  [5]
 LDCM0485  CL90 HEK-293T C1488(2.44)  LDD1083  [5]
 LDCM0486  CL91 HEK-293T C1488(1.13)  LDD1084  [5]
 LDCM0487  CL92 HEK-293T C1488(2.20)  LDD1085  [5]
 LDCM0488  CL93 HEK-293T C1488(1.76)  LDD1086  [5]
 LDCM0489  CL94 HEK-293T C1488(1.34)  LDD1087  [5]
 LDCM0490  CL95 HEK-293T C1488(1.29)  LDD1088  [5]
 LDCM0491  CL96 HEK-293T C1488(1.09)  LDD1089  [5]
 LDCM0492  CL97 HEK-293T C1488(1.28)  LDD1090  [5]
 LDCM0493  CL98 HEK-293T C1488(1.06)  LDD1091  [5]
 LDCM0494  CL99 HEK-293T C1488(1.05)  LDD1092  [5]
 LDCM0495  E2913 HEK-293T C23(0.93); C1311(1.08); C1080(1.16); C979(1.02)  LDD1698  [13]
 LDCM0468  Fragment33 HEK-293T C1488(1.45)  LDD1066  [5]
 LDCM0427  Fragment51 HEK-293T C1488(0.99)  LDD1025  [5]
 LDCM0022  KB02 HCT 116 C23(2.92); C1010(2.08); C1016(2.08); C94(2.50)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C23(2.04); C1010(2.42); C1016(2.42); C94(1.92)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C23(3.61); C1010(3.47); C1016(3.47); C94(3.37)  LDD0082  [5]
 LDCM0014  Panhematin HEK-293T 3.08  LDD0062  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
N-alpha-acetyltransferase 10 (NAA10) Acetyltransferase family P41227
Lysine-specific demethylase 2B (KDM2B) JHDM1 histone demethylase family Q8NHM5
Ubiquitin carboxyl-terminal hydrolase 7 (USP7) Peptidase C19 family Q93009
Polycomb group RING finger protein 1 (PCGF1) . Q9BSM1
Polycomb group RING finger protein 3 (PCGF3) . Q3KNV8
Polycomb group RING finger protein 5 (PCGF5) . Q86SE9
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Chromobox protein homolog 8 (CBX8) . Q9HC52
Protein AF-9 (MLLT3) . P42568

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402