Details of the Target

General Information of Target

Target ID LDTP06284
Target Name TNFAIP3-interacting protein 1 (TNIP1)
Gene Name TNIP1
Gene ID 10318
Synonyms
KIAA0113; NAF1; TNFAIP3-interacting protein 1; A20-binding inhibitor of NF-kappa-B activation 1; ABIN-1; HIV-1 Nef-interacting protein; Nef-associated factor 1; Naf1; Nip40-1; Virion-associated nuclear shuttling protein; VAN; hVAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEGRGPYRIYDPGGSVPSGEASAAFERLVKENSRLKEKMQGIKMLGELLEESQMEATRLR
QKAEELVKDNELLPPPSPSLGSFDPLAELTGKDSNVTASPTAPACPSDKPAPVQKPPSSG
TSSEFEVVTPEEQNSPESSSHANAMALGPLPREDGNLMLHLQRLETTLSVCAEEPDHGQL
FTHLGRMALEFNRLASKVHKNEQRTSILQTLCEQLRKENEALKAKLDKGLEQRDQAAERL
REENLELKKLLMSNGNKEGASGRPGSPKMEGTGKKAVAGQQQASVTAGKVPEVVALGAAE
KKVKMLEQQRSELLEVNKQWDQHFRSMKQQYEQKITELRQKLADLQKQVTDLEAEREQKQ
RDFDRKLLLAKSKIEMEETDKEQLTAEAKELRQKVKYLQDQLSPLTRQREYQEKEIQRLN
KALEEALSIQTPPSSPPTAFGSPEGAGALLRKQELVTQNELLKQQVKIFEEDFQRERSDR
ERMNEEKEELKKQVEKLQAQVTLSNAQLKAFKDEEKAREALRQQKRKAKASGERYHVEPH
PEHLCGAYPYAYPPMPAMVPHHGFEDWSQIRYPPPPMAMEHPPPLPNSRLFHLPEYTWRL
PCGGVRNPNQSSQVMDPPTARPTEPESPKNDREGPQ
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating TAX1BP1 and A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection.
Uniprot ID
Q15025
Ensemble ID
ENST00000315050.11
HGNC ID
HGNC:16903

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MCC13 SNV: p.N254I
Substitution: p.A295V		 .
MFE319 SNV: p.L164M .
NALM6 SNV: p.R193Ter .
RL952 SNV: p.E519K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K200(5.96); K334(1.66); K452(5.73)  LDD0277  [2]
BTD
 Probe Info  		C602(2.23)  LDD2141  [3]
NAIA_5
 Probe Info  		C212(20.00)  LDD2227  [4]
HPAP
 Probe Info  		5.28  LDD0062  [5]
DBIA
 Probe Info  		C212(0.95)  LDD0531  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [4]
IPM
 Probe Info  		N.A.  LDD0147  [8]
TFBX
 Probe Info  		N.A.  LDD0148  [8]
AOyne
 Probe Info  		15.00  LDD0443  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C212(0.95)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C212(1.07)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C212(1.05)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C212(1.02)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C212(0.89)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C212(1.00)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C212(0.80)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C212(1.05)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C212(1.05)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C212(0.99)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C212(0.98)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C212(1.02)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C212(1.13)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C212(1.28)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C212(1.05)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C212(1.10)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C212(1.08)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C212(0.98)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C212(0.88)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C212(1.04)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C212(0.91)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C212(0.95)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C212(1.14)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C212(1.03)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C212(1.03)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C212(0.92)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C212(1.24)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C212(0.79)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C212(1.00)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C212(0.96)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C212(0.98)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C212(1.20)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C212(1.02)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C212(1.19)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C212(1.07)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C212(1.22)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C212(1.25)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C212(1.34)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C212(1.09)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C212(0.93)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C212(1.51)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C212(1.15)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C212(1.01)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C212(1.28)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C212(1.00)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C212(1.22)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C212(1.24)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C212(1.19)  LDD0579  [6]
 LDCM0270  AC15 HCT 116 C212(1.04)  LDD0587  [6]
 LDCM0276  AC17 HCT 116 C212(0.97)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C212(0.90)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C212(1.00)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C212(1.00)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C212(1.03)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C212(1.05)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C212(0.98)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C212(1.01)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C212(1.04)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C212(0.98)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C212(1.17)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C212(1.04)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C212(1.12)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C212(1.03)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C212(1.02)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C212(1.19)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C212(1.07)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C212(1.19)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C212(1.05)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C212(0.96)  LDD0612  [6]
 LDCM0296  AC35 HEK-293T C212(0.82)  LDD0894  [6]
 LDCM0297  AC36 HEK-293T C212(1.46)  LDD0895  [6]
 LDCM0298  AC37 HEK-293T C212(1.85)  LDD0896  [6]
 LDCM0299  AC38 HEK-293T C212(1.70)  LDD0897  [6]
 LDCM0300  AC39 HEK-293T C212(1.12)  LDD0898  [6]
 LDCM0301  AC4 HCT 116 C212(1.01)  LDD0618  [6]
 LDCM0302  AC40 HEK-293T C212(1.07)  LDD0900  [6]
 LDCM0303  AC41 HEK-293T C212(1.05)  LDD0901  [6]
 LDCM0304  AC42 HEK-293T C212(1.17)  LDD0902  [6]
 LDCM0305  AC43 HEK-293T C212(0.96)  LDD0903  [6]
 LDCM0306  AC44 HEK-293T C212(1.33)  LDD0904  [6]
 LDCM0307  AC45 HEK-293T C212(1.73)  LDD0905  [6]
 LDCM0308  AC46 HEK-293T C212(0.83)  LDD0906  [6]
 LDCM0309  AC47 HEK-293T C212(0.98)  LDD0907  [6]
 LDCM0310  AC48 HEK-293T C212(1.30)  LDD0908  [6]
 LDCM0311  AC49 HEK-293T C212(1.30)  LDD0909  [6]
 LDCM0312  AC5 HCT 116 C212(1.06)  LDD0629  [6]
 LDCM0313  AC50 HEK-293T C212(1.11)  LDD0911  [6]
 LDCM0314  AC51 HEK-293T C212(1.73)  LDD0912  [6]
 LDCM0315  AC52 HEK-293T C212(1.55)  LDD0913  [6]
 LDCM0316  AC53 HEK-293T C212(1.39)  LDD0914  [6]
 LDCM0317  AC54 HEK-293T C212(1.38)  LDD0915  [6]
 LDCM0318  AC55 HEK-293T C212(1.43)  LDD0916  [6]
 LDCM0319  AC56 HEK-293T C212(1.25)  LDD0917  [6]
 LDCM0320  AC57 HCT 116 C212(0.92)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C212(0.99)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C212(0.91)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C212(1.35)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C212(1.07)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C212(1.02)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C212(0.86)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C212(1.04)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C212(1.34)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C212(1.01)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C212(0.92)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C212(0.95)  LDD0648  [6]
 LDCM0332  AC68 HEK-293T C212(0.98)  LDD0930  [6]
 LDCM0333  AC69 HEK-293T C212(0.88)  LDD0931  [6]
 LDCM0334  AC7 HCT 116 C212(1.06)  LDD0651  [6]
 LDCM0335  AC70 HEK-293T C212(1.07)  LDD0933  [6]
 LDCM0336  AC71 HEK-293T C212(0.88)  LDD0934  [6]
 LDCM0337  AC72 HEK-293T C212(1.03)  LDD0935  [6]
 LDCM0338  AC73 HEK-293T C212(0.92)  LDD0936  [6]
 LDCM0339  AC74 HEK-293T C212(0.88)  LDD0937  [6]
 LDCM0340  AC75 HEK-293T C212(1.18)  LDD0938  [6]
 LDCM0341  AC76 HEK-293T C212(1.15)  LDD0939  [6]
 LDCM0342  AC77 HEK-293T C212(0.94)  LDD0940  [6]
 LDCM0343  AC78 HEK-293T C212(1.07)  LDD0941  [6]
 LDCM0344  AC79 HEK-293T C212(0.87)  LDD0942  [6]
 LDCM0345  AC8 HCT 116 C212(0.91)  LDD0662  [6]
 LDCM0346  AC80 HEK-293T C212(1.00)  LDD0944  [6]
 LDCM0347  AC81 HEK-293T C212(0.92)  LDD0945  [6]
 LDCM0348  AC82 HEK-293T C212(1.30)  LDD0946  [6]
 LDCM0349  AC83 HEK-293T C212(1.15)  LDD0947  [6]
 LDCM0350  AC84 HEK-293T C212(1.69)  LDD0948  [6]
 LDCM0351  AC85 HEK-293T C212(1.16)  LDD0949  [6]
 LDCM0352  AC86 HEK-293T C212(1.35)  LDD0950  [6]
 LDCM0353  AC87 HEK-293T C212(1.33)  LDD0951  [6]
 LDCM0354  AC88 HEK-293T C212(1.55)  LDD0952  [6]
 LDCM0355  AC89 HEK-293T C212(1.45)  LDD0953  [6]
 LDCM0357  AC90 HEK-293T C212(1.46)  LDD0955  [6]
 LDCM0358  AC91 HEK-293T C212(1.32)  LDD0956  [6]
 LDCM0359  AC92 HEK-293T C212(1.55)  LDD0957  [6]
 LDCM0360  AC93 HEK-293T C212(1.57)  LDD0958  [6]
 LDCM0361  AC94 HEK-293T C212(1.61)  LDD0959  [6]
 LDCM0362  AC95 HEK-293T C212(1.44)  LDD0960  [6]
 LDCM0363  AC96 HEK-293T C212(1.54)  LDD0961  [6]
 LDCM0364  AC97 HEK-293T C212(2.59)  LDD0962  [6]
 LDCM0365  AC98 HCT 116 C212(1.22)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C212(1.16)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C212(1.13)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C212(1.08)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C212(1.45)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 12.92  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C212(20.00)  LDD2227  [4]
 LDCM0367  CL1 HEK-293T C602(1.57); C105(0.79); C171(0.98)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C602(2.52); C105(1.11); C171(1.18)  LDD1572  [10]
 LDCM0369  CL100 HCT 116 C212(0.99)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C212(1.20)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C212(1.06)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C212(0.97)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C212(1.08)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C212(1.02)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C212(1.17)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C212(1.16)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C212(1.09)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C212(1.02)  LDD0695  [6]
 LDCM0379  CL11 HEK-293T C602(1.69); C105(1.80); C171(0.94)  LDD1583  [10]
 LDCM0380  CL110 HCT 116 C212(0.99)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C212(0.94)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C212(1.11)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C212(1.00)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C212(1.10)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C212(1.12)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C212(1.02)  LDD0703  [6]
 LDCM0387  CL117 HEK-293T C212(1.29)  LDD0985  [6]
 LDCM0388  CL118 HEK-293T C212(1.27)  LDD0986  [6]
 LDCM0389  CL119 HEK-293T C212(1.09)  LDD0987  [6]
 LDCM0390  CL12 HEK-293T C171(1.45)  LDD1594  [10]
 LDCM0391  CL120 HEK-293T C212(1.34)  LDD0989  [6]
 LDCM0392  CL121 HEK-293T C212(1.64)  LDD0990  [6]
 LDCM0393  CL122 HEK-293T C212(0.89)  LDD0991  [6]
 LDCM0394  CL123 HEK-293T C212(0.95)  LDD0992  [6]
 LDCM0395  CL124 HEK-293T C212(1.25)  LDD0993  [6]
 LDCM0396  CL125 HCT 116 C212(1.02)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C212(0.88)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C212(0.90)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C212(0.99)  LDD0716  [6]
 LDCM0400  CL13 HEK-293T C602(1.29); C105(1.16); C171(1.17)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C602(1.19); C105(0.94)  LDD1605  [10]
 LDCM0402  CL15 HEK-293T C602(1.32); C105(0.86)  LDD1606  [10]
 LDCM0403  CL16 HCT 116 C212(1.24)  LDD0720  [6]
 LDCM0404  CL17 HEK-293T C171(0.97)  LDD1608  [10]
 LDCM0406  CL19 HEK-293T C171(1.03)  LDD1610  [10]
 LDCM0407  CL2 HEK-293T C602(1.13); C105(1.02)  LDD1611  [10]
 LDCM0408  CL20 HEK-293T C171(1.05)  LDD1612  [10]
 LDCM0410  CL22 HEK-293T C602(1.34); C105(1.69); C171(1.01)  LDD1614  [10]
 LDCM0411  CL23 HEK-293T C602(1.16); C105(1.92); C171(1.01)  LDD1615  [10]
 LDCM0412  CL24 HEK-293T C171(0.91)  LDD1616  [10]
 LDCM0413  CL25 HEK-293T C602(0.96); C105(1.18); C171(1.21)  LDD1617  [10]
 LDCM0414  CL26 HEK-293T C602(1.06); C105(1.03)  LDD1618  [10]
 LDCM0415  CL27 HEK-293T C602(0.86); C105(0.83)  LDD1619  [10]
 LDCM0416  CL28 HEK-293T C105(0.94)  LDD1620  [10]
 LDCM0417  CL29 HEK-293T C171(0.94)  LDD1621  [10]
 LDCM0418  CL3 HEK-293T C602(0.97); C105(1.02)  LDD1622  [10]
 LDCM0420  CL31 HCT 116 C212(0.94)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C212(1.22)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C212(1.13)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C212(1.15)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C212(1.13)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C212(0.93)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C212(1.11)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C212(1.08)  LDD0745  [6]
 LDCM0429  CL4 HEK-293T C105(0.80)  LDD1633  [10]
 LDCM0430  CL40 HCT 116 C212(1.21)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C212(0.97)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C212(1.14)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C212(1.22)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C212(1.09)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C212(1.06)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C212(1.48)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C212(1.21)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C212(1.25)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C212(1.25)  LDD0756  [6]
 LDCM0440  CL5 HEK-293T C171(1.18)  LDD1644  [10]
 LDCM0441  CL50 HCT 116 C212(1.40)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C212(1.18)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C212(1.17)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C212(1.20)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C212(1.39)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C212(1.21)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C212(1.17)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C212(1.41)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C212(1.16)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C212(1.04)  LDD0767  [6]
 LDCM0452  CL60 HCT 116 C212(1.46)  LDD0769  [6]
 LDCM0453  CL61 HEK-293T C212(0.91)  LDD1051  [6]
 LDCM0454  CL62 HEK-293T C212(1.63)  LDD1052  [6]
 LDCM0455  CL63 HEK-293T C212(1.36)  LDD1053  [6]
 LDCM0456  CL64 HEK-293T C212(1.00)  LDD1054  [6]
 LDCM0457  CL65 HEK-293T C212(0.81)  LDD1055  [6]
 LDCM0458  CL66 HEK-293T C212(1.05)  LDD1056  [6]
 LDCM0459  CL67 HEK-293T C212(0.99)  LDD1057  [6]
 LDCM0460  CL68 HEK-293T C212(1.10)  LDD1058  [6]
 LDCM0461  CL69 HEK-293T C212(1.06)  LDD1059  [6]
 LDCM0462  CL7 HEK-293T C171(0.97)  LDD1665  [10]
 LDCM0463  CL70 HEK-293T C212(0.90)  LDD1061  [6]
 LDCM0464  CL71 HEK-293T C212(1.18)  LDD1062  [6]
 LDCM0465  CL72 HEK-293T C212(1.24)  LDD1063  [6]
 LDCM0466  CL73 HEK-293T C212(1.12)  LDD1064  [6]
 LDCM0467  CL74 HEK-293T C212(1.89)  LDD1065  [6]
 LDCM0469  CL76 HEK-293T C105(0.74)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C171(0.95)  LDD1673  [10]
 LDCM0472  CL79 HEK-293T C171(1.07)  LDD1675  [10]
 LDCM0473  CL8 HEK-293T C171(1.16)  LDD1676  [10]
 LDCM0474  CL80 HEK-293T C171(0.96)  LDD1677  [10]
 LDCM0476  CL82 HEK-293T C602(1.11); C105(1.46); C171(1.01)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C602(1.47); C105(1.49); C171(0.85)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C171(1.25)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C602(0.90); C105(0.99); C171(1.01)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C602(0.90); C105(0.96)  LDD1683  [10]
 LDCM0481  CL87 HEK-293T C602(1.08); C105(1.01)  LDD1684  [10]
 LDCM0482  CL88 HEK-293T C105(0.70)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C171(1.02)  LDD1686  [10]
 LDCM0486  CL91 HCT 116 C212(1.06)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C212(1.15)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C212(1.11)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C212(1.03)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C212(1.15)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C212(1.04)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C212(1.02)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C212(1.08)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C212(1.03)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C602(1.14); C105(1.05)  LDD1698  [10]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C602(1.59)  LDD1702  [3]
 LDCM0468  Fragment33 HEK-293T C212(1.38)  LDD1066  [6]
 LDCM0427  Fragment51 HCT 116 C212(1.44)  LDD0744  [6]
 LDCM0022  KB02 HEK-293T C105(0.97)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C105(0.98)  LDD1497  [10]
 LDCM0024  KB05 MEWO C602(1.93)  LDD3319  [11]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C602(2.23)  LDD2141  [3]
 LDCM0014  Panhematin HEK-293T 5.28  LDD0062  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cell division cycle protein 23 homolog (CDC23) APC8/CDC23 family Q9UJX2
Bifunctional polynucleotide phosphatase/kinase (PNKP) DNA 3' phosphatase family Q96T60
Peroxisomal bifunctional enzyme (EHHADH) Enoyl-CoA hydratase/isomerase family; 3-hydroxyacyl-CoA dehydrogenase family Q08426
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (HDDC3) MESH1 family Q8N4P3
Nucleoside diphosphate kinase homolog 7 (NME7) NDK family Q9Y5B8
Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) Peptidase C64 family P21580
E3 ubiquitin-protein ligase RNF8 (RNF8) RNF8 family O76064
Transcription initiation factor IIB (GTF2B) TFIIB family Q00403
Kinesin-like protein KIFC3 (KIFC3) Kinesin family Q9BVG8
Tumor susceptibility gene 101 protein (TSG101) Ubiquitin-conjugating enzyme family Q99816
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) . Q13526
RalA-binding protein 1 (RALBP1) . Q15311
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-1 complex subunit mu-1 (AP1M1) Adaptor complexes medium subunit family Q9BXS5
Hsp90 co-chaperone Cdc37 (CDC37) CDC37 family Q16543
Optineurin (OPTN) . Q96CV9
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear factor NF-kappa-B p105 subunit (NFKB1) . P19838
Zinc finger and BTB domain-containing protein 25 (ZBTB25) . P24278
Other
Click To Hide/Show 48 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1) ATG8 family Q9H0R8
Gamma-aminobutyric acid receptor-associated protein-like 2 (GABARAPL2) ATG8 family P60520
Microtubule-associated proteins 1A/1B light chain 3A (MAP1LC3A) ATG8 family Q9H492
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) ATG8 family Q9GZQ8
Microtubule-associated proteins 1A/1B light chain 3C (MAP1LC3C) ATG8 family Q9BXW4
Bystin (BYSL) Bystin family Q13895
Cell death-inducing p53-target protein 1 (CDIP1) CDIP1/LITAF family Q9H305
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF) CDIP1/LITAF family Q99732
Cilia- and flagella-associated protein 53 (CFAP53) CFAP53 family Q96M91
Cyclin-G1 (CCNG1) Cyclin family P51959
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Protein FAM161A (FAM161A) FAM161 family Q3B820
Protein FAM168A (FAM168A) FAM168 family Q92567
Pre-mRNA-splicing regulator WTAP (WTAP) Fl(2)d family Q15007
Keratin-associated protein 19-3 (KRTAP19-3) KRTAP type 19 family Q7Z4W3
Keratin-associated protein 19-5 (KRTAP19-5) KRTAP type 19 family Q3LI72
Keratin-associated protein 19-7 (KRTAP19-7) KRTAP type 19 family Q3SYF9
Keratin-associated protein 6-1 (KRTAP6-1) KRTAP type 6 family Q3LI64
Keratin-associated protein 6-2 (KRTAP6-2) KRTAP type 6 family Q3LI66
Keratin-associated protein 8-1 (KRTAP8-1) KRTAP type 8 family Q8IUC2
MOB kinase activator 1B (MOB1B) MOB1/phocein family Q7L9L4
MOB kinase activator 3C (MOB3C) MOB1/phocein family Q70IA8
Kinetochore protein NDC80 homolog (NDC80) NDC80/HEC1 family O14777
Spermatogenesis-associated protein 2 (SPATA2) SPATA2 family Q9UM82
Vacuolar protein sorting-associated protein 33B (VPS33B) STXBP/unc-18/SEC1 family Q9H267
Alpha-taxilin (TXLNA) Taxilin family P40222
Transcription elongation factor A N-terminal and central domain-containing protein 2 (TCEANC2) TCEANC2 family Q96MN5
Transcription elongation factor A protein 2 (TCEA2) TFS-II family Q15560
UPF0488 protein C8orf33 (C8orf33) UPF0488 family Q9H7E9
Zinc finger HIT domain-containing protein 1 (ZNHIT1) ZNHIT1 family O43257
ARF GTPase-activating protein GIT2 (GIT2) . Q14161
Coiled-coil domain-containing protein 112 (CCDC112) . Q8NEF3
DAZ-associated protein 2 (DAZAP2) . Q15038
Developmental pluripotency-associated protein 4 (DPPA4) . Q7L190
Elongin-A (ELOA) . Q14241
Leukocyte receptor cluster member 8 (LENG8) . Q96PV6
Melanoma-associated antigen B18 (MAGEB18) . Q96M61
Melanoma-associated antigen H1 (MAGEH1) . Q9H213
Microspherule protein 1 (MCRS1) . Q96EZ8
MKI67 FHA domain-interacting nucleolar phosphoprotein (NIFK) . Q9BYG3
Mortality factor 4-like protein 1 (MORF4L1) . Q9UBU8
Mortality factor 4-like protein 2 (MORF4L2) . Q15014
NF-kappa-B essential modulator (IKBKG) . Q9Y6K9
Smad nuclear-interacting protein 1 (SNIP1) . Q8TAD8
Tax1-binding protein 1 (TAX1BP1) . Q86VP1
TNFAIP3-interacting protein 1 (TNIP1) . Q15025
TNFAIP3-interacting protein 3 (TNIP3) . Q96KP6
Zinc finger matrin-type protein 2 (ZMAT2) . Q96NC0

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840