Details of the Target

General Information of Target

Target ID LDTP05702
Target Name Forkhead box protein C1 (FOXC1)
Gene Name FOXC1
Gene ID 2296
Synonyms
FKHL7; FREAC3; Forkhead box protein C1; Forkhead-related protein FKHL7; Forkhead-related transcription factor 3; FREAC-3
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MQARYSVSSPNSLGVVPYLGGEQSYYRAAAAAAGGGYTAMPAPMSVYSHPAHAEQYPGGM
ARAYGPYTPQPQPKDMVKPPYSYIALITMAIQNAPDKKITLNGIYQFIMDRFPFYRDNKQ
GWQNSIRHNLSLNECFVKVPRDDKKPGKGSYWTLDPDSYNMFENGSFLRRRRRFKKKDAV
KDKEEKDRLHLKEPPPPGRQPPPAPPEQADGNAPGPQPPPVRIQDIKTENGTCPSPPQPL
SPAAALGSGSAAAVPKIESPDSSSSSLSSGSSPPGSLPSARPLSLDGADSAPPPPAPSAP
PPHHSQGFSVDNIMTSLRGSPQSAAAELSSGLLASAAASSRAGIAPPLALGAYSPGQSSL
YSSPCSQTSSAGSSGGGGGGAGAAGGAGGAGTYHCNLQAMSLYAAGERGGHLQGAPGGAG
GSAVDDPLPDYSLPPVTSSSSSSLSHGGGGGGGGGGQEAGHHPAAHQGRLTSWYLNQAGG
DLGHLASAAAAAAAAGYPGQQQNFHSVREMFESQRIGLNNSPVNGNSSCQMAFPSSQSLY
RTSGAFVYDCSKF
Target Type
Literature-reported
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function
DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development . Acts either as a transcriptional activator or repressor. Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes . Upon DNA-binding, promotes DNA bending. Acts as a transcriptional coactivator. Stimulates Indian hedgehog (Ihh)-induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification. Acts also as a transcriptional coregulator by increasing DNA-binding capacity of GLI2 in breast cancer cells. Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye. Cooperates with transcription factor FOXC2 in regulating expression of genes that maintain podocyte integrity. Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals. Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion. Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression. Plays a role in the gene regulatory network essential for epidermal keratinocyte terminal differentiation. Essential developmental transcriptional factor required for mesoderm-derived tissues, such as the somites, skin, bone and cartilage. Positively regulates CXCL12 and stem cell factor expression in bone marrow mesenchymal progenitor cells, and hence plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner. Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression. May function as a tumor suppressor.
TTD ID
T99829
Uniprot ID
Q12948
DrugMap ID
TTNT3YA
Ensemble ID
ENST00000645831.2
HGNC ID
HGNC:3800

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y25(9.44); Y548(8.33)  LDD0257  [1]
AHL-Pu-1
 Probe Info  		C550(4.30)  LDD0168  [2]
HPAP
 Probe Info  		3.23  LDD0062  [3]
DBIA
 Probe Info  		C529(3.48); C550(2.46); C135(1.75)  LDD0080  [4]
IA-alkyne
 Probe Info  		C550(0.00); C135(0.00)  LDD0165  [5]
TFBX
 Probe Info  		N.A.  LDD0027  [6]
IPM
 Probe Info  		N.A.  LDD0147  [6]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [7]
Acrolein
 Probe Info  		N.A.  LDD0217  [8]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [8]
Methacrolein
 Probe Info  		N.A.  LDD0218  [8]
AOyne
 Probe Info  		15.00  LDD0443  [9]
HHS-465
 Probe Info  		N.A.  LDD2240  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C550(4.30)  LDD0168  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C550(6.75)  LDD0169  [2]
 LDCM0214  AC1 HEK-293T C529(0.65)  LDD0812  [4]
 LDCM0215  AC10 HEK-293T C529(0.97)  LDD0813  [4]
 LDCM0216  AC100 HEK-293T C529(1.02)  LDD0814  [4]
 LDCM0217  AC101 HEK-293T C529(0.99)  LDD0815  [4]
 LDCM0218  AC102 HEK-293T C529(1.20)  LDD0816  [4]
 LDCM0219  AC103 HEK-293T C529(1.09)  LDD0817  [4]
 LDCM0220  AC104 HEK-293T C529(1.11)  LDD0818  [4]
 LDCM0221  AC105 HEK-293T C529(1.26)  LDD0819  [4]
 LDCM0222  AC106 HEK-293T C529(0.92)  LDD0820  [4]
 LDCM0223  AC107 HEK-293T C529(1.18)  LDD0821  [4]
 LDCM0224  AC108 HEK-293T C529(1.16)  LDD0822  [4]
 LDCM0225  AC109 HEK-293T C529(1.04)  LDD0823  [4]
 LDCM0226  AC11 HEK-293T C529(0.86)  LDD0824  [4]
 LDCM0227  AC110 HEK-293T C529(0.89)  LDD0825  [4]
 LDCM0228  AC111 HEK-293T C529(1.20)  LDD0826  [4]
 LDCM0229  AC112 HEK-293T C529(1.03)  LDD0827  [4]
 LDCM0230  AC113 HEK-293T C529(1.33)  LDD0828  [4]
 LDCM0231  AC114 HEK-293T C529(1.54)  LDD0829  [4]
 LDCM0232  AC115 HEK-293T C529(1.19)  LDD0830  [4]
 LDCM0233  AC116 HEK-293T C529(1.57)  LDD0831  [4]
 LDCM0234  AC117 HEK-293T C529(2.17)  LDD0832  [4]
 LDCM0235  AC118 HEK-293T C529(1.31)  LDD0833  [4]
 LDCM0236  AC119 HEK-293T C529(1.50)  LDD0834  [4]
 LDCM0237  AC12 HEK-293T C529(0.80)  LDD0835  [4]
 LDCM0238  AC120 HEK-293T C529(1.67)  LDD0836  [4]
 LDCM0239  AC121 HEK-293T C529(2.30)  LDD0837  [4]
 LDCM0240  AC122 HEK-293T C529(1.47)  LDD0838  [4]
 LDCM0241  AC123 HEK-293T C529(2.08)  LDD0839  [4]
 LDCM0242  AC124 HEK-293T C529(2.20)  LDD0840  [4]
 LDCM0243  AC125 HEK-293T C529(1.78)  LDD0841  [4]
 LDCM0244  AC126 HEK-293T C529(2.70)  LDD0842  [4]
 LDCM0245  AC127 HEK-293T C529(3.00)  LDD0843  [4]
 LDCM0246  AC128 HEK-293T C529(1.04)  LDD0844  [4]
 LDCM0247  AC129 HEK-293T C529(0.87)  LDD0845  [4]
 LDCM0249  AC130 HEK-293T C529(1.46)  LDD0847  [4]
 LDCM0250  AC131 HEK-293T C529(0.95)  LDD0848  [4]
 LDCM0251  AC132 HEK-293T C529(1.11)  LDD0849  [4]
 LDCM0252  AC133 HEK-293T C529(0.89)  LDD0850  [4]
 LDCM0253  AC134 HEK-293T C529(0.94)  LDD0851  [4]
 LDCM0254  AC135 HEK-293T C529(1.33)  LDD0852  [4]
 LDCM0255  AC136 HEK-293T C529(0.81)  LDD0853  [4]
 LDCM0256  AC137 HEK-293T C529(0.69)  LDD0854  [4]
 LDCM0257  AC138 HEK-293T C529(0.83)  LDD0855  [4]
 LDCM0258  AC139 HEK-293T C529(1.21)  LDD0856  [4]
 LDCM0259  AC14 HEK-293T C529(1.09)  LDD0857  [4]
 LDCM0260  AC140 HEK-293T C529(0.89)  LDD0858  [4]
 LDCM0261  AC141 HEK-293T C529(0.92)  LDD0859  [4]
 LDCM0262  AC142 HEK-293T C529(1.54)  LDD0860  [4]
 LDCM0263  AC143 HEK-293T C529(0.94)  LDD0861  [4]
 LDCM0264  AC144 HEK-293T C529(0.88)  LDD0862  [4]
 LDCM0265  AC145 HEK-293T C529(1.14)  LDD0863  [4]
 LDCM0266  AC146 HEK-293T C529(0.98)  LDD0864  [4]
 LDCM0267  AC147 HEK-293T C529(1.00)  LDD0865  [4]
 LDCM0268  AC148 HEK-293T C529(1.08)  LDD0866  [4]
 LDCM0269  AC149 HEK-293T C529(0.72)  LDD0867  [4]
 LDCM0270  AC15 HEK-293T C529(0.98)  LDD0868  [4]
 LDCM0271  AC150 HEK-293T C529(0.92)  LDD0869  [4]
 LDCM0272  AC151 HEK-293T C529(1.08)  LDD0870  [4]
 LDCM0273  AC152 HEK-293T C529(0.81)  LDD0871  [4]
 LDCM0274  AC153 HEK-293T C529(0.86)  LDD0872  [4]
 LDCM0621  AC154 HEK-293T C529(0.90)  LDD2162  [4]
 LDCM0622  AC155 HEK-293T C529(1.10)  LDD2163  [4]
 LDCM0623  AC156 HEK-293T C529(1.28)  LDD2164  [4]
 LDCM0624  AC157 HEK-293T C529(0.83)  LDD2165  [4]
 LDCM0276  AC17 HEK-293T C529(0.51)  LDD0874  [4]
 LDCM0277  AC18 HEK-293T C529(0.46)  LDD0875  [4]
 LDCM0278  AC19 HEK-293T C529(0.41)  LDD0876  [4]
 LDCM0279  AC2 HEK-293T C529(1.16)  LDD0877  [4]
 LDCM0280  AC20 HEK-293T C529(0.43)  LDD0878  [4]
 LDCM0281  AC21 HEK-293T C529(0.49)  LDD0879  [4]
 LDCM0282  AC22 HEK-293T C529(0.67)  LDD0880  [4]
 LDCM0283  AC23 HEK-293T C529(0.43)  LDD0881  [4]
 LDCM0284  AC24 HEK-293T C529(0.50)  LDD0882  [4]
 LDCM0285  AC25 HEK-293T C135(0.71); C233(1.02); C550(1.15)  LDD1524  [11]
 LDCM0286  AC26 HEK-293T C135(0.91); C233(0.97); C529(0.96); C550(0.98)  LDD1525  [11]
 LDCM0287  AC27 HEK-293T C135(0.99); C529(0.93); C550(1.06)  LDD1526  [11]
 LDCM0288  AC28 HEK-293T C135(0.99); C233(0.93); C529(1.06); C550(0.98)  LDD1527  [11]
 LDCM0289  AC29 HEK-293T C135(1.01); C233(1.09); C529(1.01); C550(0.98)  LDD1528  [11]
 LDCM0290  AC3 HEK-293T C529(0.68)  LDD0888  [4]
 LDCM0291  AC30 HEK-293T C135(0.97); C529(1.02); C550(1.13)  LDD1530  [11]
 LDCM0292  AC31 HEK-293T C135(1.03); C233(0.88); C529(0.99); C550(0.88)  LDD1531  [11]
 LDCM0293  AC32 HEK-293T C135(1.02); C233(0.93)  LDD1532  [11]
 LDCM0294  AC33 HEK-293T C135(0.60); C233(1.08); C550(1.04)  LDD1533  [11]
 LDCM0295  AC34 HEK-293T C135(1.11); C233(1.07); C529(1.01); C550(1.14)  LDD1534  [11]
 LDCM0296  AC35 HEK-293T C135(1.01); C529(0.96); C550(1.12)  LDD1535  [11]
 LDCM0297  AC36 HEK-293T C135(1.06); C233(0.97); C529(0.98); C550(1.03)  LDD1536  [11]
 LDCM0298  AC37 HEK-293T C135(1.03); C233(0.94); C529(1.09); C550(0.92)  LDD1537  [11]
 LDCM0299  AC38 HEK-293T C135(1.03); C529(0.97); C550(1.13)  LDD1538  [11]
 LDCM0300  AC39 HEK-293T C135(1.05); C233(0.91); C529(1.01); C550(1.03)  LDD1539  [11]
 LDCM0301  AC4 HEK-293T C529(0.78)  LDD0899  [4]
 LDCM0302  AC40 HEK-293T C135(1.04); C233(1.03)  LDD1541  [11]
 LDCM0303  AC41 HEK-293T C135(0.68); C233(1.16); C550(1.04)  LDD1542  [11]
 LDCM0304  AC42 HEK-293T C135(1.06); C233(1.07); C529(1.07); C550(1.15)  LDD1543  [11]
 LDCM0305  AC43 HEK-293T C135(0.97); C529(1.05); C550(1.09)  LDD1544  [11]
 LDCM0306  AC44 HEK-293T C135(1.01); C233(0.83); C529(0.98); C550(1.05)  LDD1545  [11]
 LDCM0307  AC45 HEK-293T C135(0.94); C233(0.97); C529(1.20); C550(1.02)  LDD1546  [11]
 LDCM0308  AC46 HEK-293T C135(0.95); C529(1.15); C550(1.11)  LDD1547  [11]
 LDCM0309  AC47 HEK-293T C135(0.98); C233(0.88); C529(1.07); C550(1.04)  LDD1548  [11]
 LDCM0310  AC48 HEK-293T C135(1.05); C233(0.99)  LDD1549  [11]
 LDCM0311  AC49 HEK-293T C135(0.59); C233(1.15); C550(1.03)  LDD1550  [11]
 LDCM0312  AC5 HEK-293T C529(0.72)  LDD0910  [4]
 LDCM0313  AC50 HEK-293T C135(1.09); C233(1.01); C529(0.97); C550(1.09)  LDD1552  [11]
 LDCM0314  AC51 HEK-293T C135(1.05); C529(0.99); C550(1.10)  LDD1553  [11]
 LDCM0315  AC52 HEK-293T C135(1.03); C233(1.06); C529(1.01); C550(1.06)  LDD1554  [11]
 LDCM0316  AC53 HEK-293T C135(0.93); C233(1.11); C529(0.96); C550(1.04)  LDD1555  [11]
 LDCM0317  AC54 HEK-293T C135(0.97); C529(1.25); C550(1.11)  LDD1556  [11]
 LDCM0318  AC55 HEK-293T C135(1.00); C233(0.93); C529(1.11); C550(1.10)  LDD1557  [11]
 LDCM0319  AC56 HEK-293T C135(1.05); C233(0.97)  LDD1558  [11]
 LDCM0320  AC57 HEK-293T C529(1.13)  LDD0918  [4]
 LDCM0321  AC58 HEK-293T C529(1.00)  LDD0919  [4]
 LDCM0322  AC59 HEK-293T C529(0.84)  LDD0920  [4]
 LDCM0323  AC6 HEK-293T C529(1.50)  LDD0921  [4]
 LDCM0324  AC60 HEK-293T C529(0.69)  LDD0922  [4]
 LDCM0325  AC61 HEK-293T C529(0.82)  LDD0923  [4]
 LDCM0326  AC62 HEK-293T C529(0.68)  LDD0924  [4]
 LDCM0327  AC63 HEK-293T C529(0.65)  LDD0925  [4]
 LDCM0328  AC64 HEK-293T C529(0.89)  LDD0926  [4]
 LDCM0329  AC65 HEK-293T C529(0.86)  LDD0927  [4]
 LDCM0330  AC66 HEK-293T C529(0.71)  LDD0928  [4]
 LDCM0331  AC67 HEK-293T C529(0.81)  LDD0929  [4]
 LDCM0332  AC68 HEK-293T C529(0.63)  LDD0930  [4]
 LDCM0333  AC69 HEK-293T C529(0.62)  LDD0931  [4]
 LDCM0334  AC7 HEK-293T C529(1.11)  LDD0932  [4]
 LDCM0335  AC70 HEK-293T C529(0.66)  LDD0933  [4]
 LDCM0336  AC71 HEK-293T C529(0.74)  LDD0934  [4]
 LDCM0337  AC72 HEK-293T C529(0.79)  LDD0935  [4]
 LDCM0338  AC73 HEK-293T C529(1.02)  LDD0936  [4]
 LDCM0339  AC74 HEK-293T C529(0.57)  LDD0937  [4]
 LDCM0340  AC75 HEK-293T C529(1.02)  LDD0938  [4]
 LDCM0341  AC76 HEK-293T C529(1.02)  LDD0939  [4]
 LDCM0342  AC77 HEK-293T C529(0.99)  LDD0940  [4]
 LDCM0343  AC78 HEK-293T C529(0.87)  LDD0941  [4]
 LDCM0344  AC79 HEK-293T C529(0.97)  LDD0942  [4]
 LDCM0345  AC8 HEK-293T C529(0.83)  LDD0943  [4]
 LDCM0346  AC80 HEK-293T C529(1.14)  LDD0944  [4]
 LDCM0347  AC81 HEK-293T C529(1.00)  LDD0945  [4]
 LDCM0348  AC82 HEK-293T C529(0.85)  LDD0946  [4]
 LDCM0365  AC98 HEK-293T C529(1.13)  LDD0963  [4]
 LDCM0366  AC99 HEK-293T C529(0.94)  LDD0964  [4]
 LDCM0248  AKOS034007472 HEK-293T C529(1.04)  LDD0846  [4]
 LDCM0356  AKOS034007680 HEK-293T C529(0.95)  LDD0954  [4]
 LDCM0275  AKOS034007705 HEK-293T C529(1.28)  LDD0873  [4]
 LDCM0020  ARS-1620 HCC44 C550(1.28)  LDD2171  [4]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [8]
 LDCM0367  CL1 HEK-293T C529(1.61)  LDD0965  [4]
 LDCM0368  CL10 HEK-293T C529(1.43)  LDD0966  [4]
 LDCM0369  CL100 HEK-293T C529(1.13)  LDD0967  [4]
 LDCM0370  CL101 HEK-293T C529(1.15)  LDD0968  [4]
 LDCM0371  CL102 HEK-293T C529(1.19)  LDD0969  [4]
 LDCM0372  CL103 HEK-293T C529(1.06)  LDD0970  [4]
 LDCM0373  CL104 HEK-293T C529(0.92)  LDD0971  [4]
 LDCM0374  CL105 HEK-293T C529(0.47)  LDD0972  [4]
 LDCM0375  CL106 HEK-293T C529(0.33)  LDD0973  [4]
 LDCM0376  CL107 HEK-293T C529(0.40)  LDD0974  [4]
 LDCM0377  CL108 HEK-293T C529(0.44)  LDD0975  [4]
 LDCM0378  CL109 HEK-293T C529(0.42)  LDD0976  [4]
 LDCM0379  CL11 HEK-293T C529(1.24)  LDD0977  [4]
 LDCM0380  CL110 HEK-293T C529(0.53)  LDD0978  [4]
 LDCM0381  CL111 HEK-293T C529(0.40)  LDD0979  [4]
 LDCM0382  CL112 HEK-293T C135(1.32); C233(1.03); C529(1.07); C550(0.94)  LDD1586  [11]
 LDCM0383  CL113 HEK-293T C135(1.05); C233(1.04); C529(0.91)  LDD1587  [11]
 LDCM0384  CL114 HEK-293T C135(0.93); C233(0.83); C529(1.17); C550(0.99)  LDD1588  [11]
 LDCM0385  CL115 HEK-293T C135(1.06); C233(0.92); C529(0.98); C550(1.18)  LDD1589  [11]
 LDCM0386  CL116 HEK-293T C135(0.85); C233(0.89); C529(0.95); C550(1.02)  LDD1590  [11]
 LDCM0387  CL117 HEK-293T C135(1.03); C233(1.12); C529(1.07)  LDD1591  [11]
 LDCM0388  CL118 HEK-293T C135(0.95); C233(1.05); C529(1.12); C550(1.29)  LDD1592  [11]
 LDCM0389  CL119 HEK-293T C135(1.06); C233(0.91); C529(0.98); C550(1.08)  LDD1593  [11]
 LDCM0390  CL12 HEK-293T C529(1.14)  LDD0988  [4]
 LDCM0391  CL120 HEK-293T C135(0.84); C233(1.06); C529(0.94); C550(1.12)  LDD1595  [11]
 LDCM0392  CL121 HEK-293T C135(1.04); C233(1.10); C529(1.11)  LDD1596  [11]
 LDCM0393  CL122 HEK-293T C135(0.98); C233(0.97); C529(1.09); C550(1.11)  LDD1597  [11]
 LDCM0394  CL123 HEK-293T C135(0.95); C233(0.88); C529(1.02); C550(0.96)  LDD1598  [11]
 LDCM0395  CL124 HEK-293T C135(0.83); C233(1.12); C529(0.96); C550(1.21)  LDD1599  [11]
 LDCM0396  CL125 HEK-293T C529(1.07)  LDD0994  [4]
 LDCM0397  CL126 HEK-293T C529(1.12)  LDD0995  [4]
 LDCM0398  CL127 HEK-293T C529(1.26)  LDD0996  [4]
 LDCM0399  CL128 HEK-293T C529(1.11)  LDD0997  [4]
 LDCM0400  CL13 HEK-293T C529(1.16)  LDD0998  [4]
 LDCM0401  CL14 HEK-293T C529(1.19)  LDD0999  [4]
 LDCM0402  CL15 HEK-293T C529(1.62)  LDD1000  [4]
 LDCM0403  CL16 HEK-293T C529(1.01)  LDD1001  [4]
 LDCM0404  CL17 HEK-293T C529(1.28)  LDD1002  [4]
 LDCM0405  CL18 HEK-293T C529(1.23)  LDD1003  [4]
 LDCM0406  CL19 HEK-293T C529(1.29)  LDD1004  [4]
 LDCM0407  CL2 HEK-293T C529(1.41)  LDD1005  [4]
 LDCM0408  CL20 HEK-293T C529(1.32)  LDD1006  [4]
 LDCM0409  CL21 HEK-293T C529(1.40)  LDD1007  [4]
 LDCM0410  CL22 HEK-293T C529(1.26)  LDD1008  [4]
 LDCM0411  CL23 HEK-293T C529(1.14)  LDD1009  [4]
 LDCM0412  CL24 HEK-293T C529(1.31)  LDD1010  [4]
 LDCM0413  CL25 HEK-293T C529(1.46)  LDD1011  [4]
 LDCM0414  CL26 HEK-293T C529(1.13)  LDD1012  [4]
 LDCM0415  CL27 HEK-293T C529(1.35)  LDD1013  [4]
 LDCM0416  CL28 HEK-293T C529(1.09)  LDD1014  [4]
 LDCM0417  CL29 HEK-293T C529(1.34)  LDD1015  [4]
 LDCM0418  CL3 HEK-293T C529(1.16)  LDD1016  [4]
 LDCM0419  CL30 HEK-293T C529(1.26)  LDD1017  [4]
 LDCM0420  CL31 HEK-293T C135(0.93); C529(1.10); C550(1.16)  LDD1624  [11]
 LDCM0421  CL32 HEK-293T C135(1.16); C233(0.85); C529(1.02); C550(1.16)  LDD1625  [11]
 LDCM0422  CL33 HEK-293T C135(0.83); C233(0.80); C529(1.19); C550(1.14)  LDD1626  [11]
 LDCM0423  CL34 HEK-293T C135(1.00); C529(0.80); C550(1.35)  LDD1627  [11]
 LDCM0424  CL35 HEK-293T C135(1.01); C233(0.88); C529(0.86); C550(1.23)  LDD1628  [11]
 LDCM0425  CL36 HEK-293T C135(1.09); C233(0.99)  LDD1629  [11]
 LDCM0426  CL37 HEK-293T C135(1.08); C233(0.98); C529(1.05)  LDD1630  [11]
 LDCM0428  CL39 HEK-293T C135(0.97); C233(1.04); C529(0.89); C550(1.02)  LDD1632  [11]
 LDCM0429  CL4 HEK-293T C529(1.17)  LDD1027  [4]
 LDCM0430  CL40 HEK-293T C135(1.16); C233(1.25); C529(0.99); C550(1.13)  LDD1634  [11]
 LDCM0431  CL41 HEK-293T C135(0.67); C233(0.94); C550(1.02)  LDD1635  [11]
 LDCM0432  CL42 HEK-293T C135(0.90); C233(0.86); C529(1.00); C550(1.10)  LDD1636  [11]
 LDCM0433  CL43 HEK-293T C135(1.13); C529(0.84); C550(1.03)  LDD1637  [11]
 LDCM0434  CL44 HEK-293T C135(0.88); C233(1.04); C529(1.01); C550(1.08)  LDD1638  [11]
 LDCM0435  CL45 HEK-293T C135(0.97); C233(0.94); C529(1.13); C550(1.12)  LDD1639  [11]
 LDCM0436  CL46 HEK-293T C135(0.93); C529(1.07); C550(1.48)  LDD1640  [11]
 LDCM0437  CL47 HEK-293T C135(0.97); C233(0.83); C529(0.89); C550(1.24)  LDD1641  [11]
 LDCM0438  CL48 HEK-293T C135(1.05); C233(1.03)  LDD1642  [11]
 LDCM0439  CL49 HEK-293T C135(1.22); C233(1.05); C529(1.17)  LDD1643  [11]
 LDCM0440  CL5 HEK-293T C529(1.06)  LDD1038  [4]
 LDCM0441  CL50 HEK-293T C135(1.04); C233(0.86); C529(1.20); C550(1.18)  LDD1645  [11]
 LDCM0443  CL52 HEK-293T C135(1.06); C233(1.48); C529(1.03); C550(1.18)  LDD1646  [11]
 LDCM0444  CL53 HEK-293T C135(0.68); C233(0.85); C550(1.04)  LDD1647  [11]
 LDCM0445  CL54 HEK-293T C135(1.27); C233(1.09); C529(1.03); C550(1.04)  LDD1648  [11]
 LDCM0446  CL55 HEK-293T C135(1.10); C529(0.96); C550(1.14)  LDD1649  [11]
 LDCM0447  CL56 HEK-293T C135(1.12); C233(0.86); C529(1.14); C550(1.18)  LDD1650  [11]
 LDCM0448  CL57 HEK-293T C135(1.00); C233(0.84); C529(1.01); C550(1.34)  LDD1651  [11]
 LDCM0449  CL58 HEK-293T C135(0.98); C529(0.87); C550(1.72)  LDD1652  [11]
 LDCM0450  CL59 HEK-293T C135(1.02); C233(0.97); C529(1.00); C550(1.30)  LDD1653  [11]
 LDCM0451  CL6 HEK-293T C529(1.45)  LDD1049  [4]
 LDCM0452  CL60 HEK-293T C135(1.13); C233(1.03)  LDD1655  [11]
 LDCM0453  CL61 HEK-293T C135(1.13); C233(1.04); C529(1.12)  LDD1656  [11]
 LDCM0454  CL62 HEK-293T C135(1.07); C233(0.99); C529(1.22); C550(1.02)  LDD1657  [11]
 LDCM0455  CL63 HEK-293T C135(1.10); C233(0.97); C529(0.95); C550(0.87)  LDD1658  [11]
 LDCM0456  CL64 HEK-293T C135(0.90); C233(0.80); C529(1.12); C550(1.10)  LDD1659  [11]
 LDCM0457  CL65 HEK-293T C135(0.79); C233(1.13); C550(1.13)  LDD1660  [11]
 LDCM0458  CL66 HEK-293T C135(0.82); C233(1.09); C529(0.93); C550(1.02)  LDD1661  [11]
 LDCM0459  CL67 HEK-293T C135(1.04); C529(0.98); C550(1.15)  LDD1662  [11]
 LDCM0460  CL68 HEK-293T C135(1.16); C233(0.83); C529(1.05); C550(1.18)  LDD1663  [11]
 LDCM0461  CL69 HEK-293T C135(0.99); C233(1.02); C529(1.24); C550(1.02)  LDD1664  [11]
 LDCM0462  CL7 HEK-293T C529(1.36)  LDD1060  [4]
 LDCM0463  CL70 HEK-293T C135(0.99); C529(0.81); C550(1.53)  LDD1666  [11]
 LDCM0464  CL71 HEK-293T C135(1.03); C233(1.00); C529(1.18); C550(1.67)  LDD1667  [11]
 LDCM0465  CL72 HEK-293T C135(1.11); C233(1.02)  LDD1668  [11]
 LDCM0466  CL73 HEK-293T C135(1.04); C233(1.01); C529(1.08)  LDD1669  [11]
 LDCM0467  CL74 HEK-293T C135(1.03); C233(0.84); C529(0.99); C550(1.06)  LDD1670  [11]
 LDCM0469  CL76 HEK-293T C135(1.25); C233(0.88); C529(1.16); C550(1.10)  LDD1672  [11]
 LDCM0470  CL77 HEK-293T C135(0.58); C233(1.01); C550(0.97)  LDD1673  [11]
 LDCM0471  CL78 HEK-293T C135(1.22); C233(0.98); C529(1.04); C550(1.02)  LDD1674  [11]
 LDCM0472  CL79 HEK-293T C135(1.04); C529(0.96); C550(1.16)  LDD1675  [11]
 LDCM0473  CL8 HEK-293T C529(2.08)  LDD1071  [4]
 LDCM0474  CL80 HEK-293T C135(1.00); C233(0.84); C529(0.93); C550(1.08)  LDD1677  [11]
 LDCM0475  CL81 HEK-293T C135(0.96); C233(0.98); C529(1.22); C550(1.23)  LDD1678  [11]
 LDCM0476  CL82 HEK-293T C135(0.96); C529(0.99); C550(1.15)  LDD1679  [11]
 LDCM0477  CL83 HEK-293T C135(1.01); C233(0.86); C529(0.89); C550(1.30)  LDD1680  [11]
 LDCM0478  CL84 HEK-293T C135(1.02); C233(0.93)  LDD1681  [11]
 LDCM0479  CL85 HEK-293T C135(1.03); C233(1.07); C529(1.15)  LDD1682  [11]
 LDCM0480  CL86 HEK-293T C135(1.02); C233(0.93); C529(1.20); C550(1.05)  LDD1683  [11]
 LDCM0481  CL87 HEK-293T C135(0.96); C233(0.89); C529(1.05); C550(0.99)  LDD1684  [11]
 LDCM0482  CL88 HEK-293T C135(1.43); C233(1.30); C529(1.14); C550(1.03)  LDD1685  [11]
 LDCM0483  CL89 HEK-293T C135(0.64); C233(1.05); C550(1.00)  LDD1686  [11]
 LDCM0484  CL9 HEK-293T C529(1.26)  LDD1082  [4]
 LDCM0485  CL90 HEK-293T C135(1.08); C233(0.93); C529(1.22); C550(1.27)  LDD1688  [11]
 LDCM0486  CL91 HEK-293T C529(0.88)  LDD1084  [4]
 LDCM0487  CL92 HEK-293T C529(0.87)  LDD1085  [4]
 LDCM0488  CL93 HEK-293T C529(0.65)  LDD1086  [4]
 LDCM0489  CL94 HEK-293T C529(0.81)  LDD1087  [4]
 LDCM0490  CL95 HEK-293T C529(0.78)  LDD1088  [4]
 LDCM0491  CL96 HEK-293T C529(0.78)  LDD1089  [4]
 LDCM0492  CL97 HEK-293T C529(1.07)  LDD1090  [4]
 LDCM0493  CL98 HEK-293T C529(0.61)  LDD1091  [4]
 LDCM0494  CL99 HEK-293T C529(0.67)  LDD1092  [4]
 LDCM0495  E2913 HEK-293T C135(1.17); C233(0.89); C529(1.11); C550(1.35)  LDD1698  [11]
 LDCM0468  Fragment33 HEK-293T C135(0.93); C233(0.97); C529(1.02); C550(1.08)  LDD1671  [11]
 LDCM0427  Fragment51 HEK-293T C135(1.06); C233(0.90); C529(1.13); C550(1.08)  LDD1631  [11]
 LDCM0022  KB02 HCT 116 C529(3.48); C550(2.46); C135(1.75)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C529(1.94); C550(2.00); C135(1.92)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C529(9.01); C550(3.21); C135(1.67)  LDD0082  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C550(0.67)  LDD2206  [12]
 LDCM0628  OTUB2-COV-1 HEK-293T C550(0.73)  LDD2207  [12]
 LDCM0014  Panhematin HEK-293T 3.23  LDD0062  [3]
 LDCM0021  THZ1 HCT 116 C550(1.28)  LDD2173  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Filamin-A (FLNA) Filamin family P21333
Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) MAM33 family Q07021
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pre-B-cell leukemia transcription factor 1 (PBX1) TALE/PBX homeobox family P40424

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.