Details of the Target

General Information of Target

Target ID LDTP00493
Target Name Calmegin (CLGN)
Gene Name CLGN
Gene ID 1047
Synonyms
Calmegin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MHFQAFWLCLGLLFISINAEFMDDDVETEDFEENSEEIDVNESELSSEIKYKTPQPIGEV
YFAETFDSGRLAGWVLSKAKKDDMDEEISIYDGRWEIEELKENQVPGDRGLVLKSRAKHH
AISAVLAKPFIFADKPLIVQYEVNFQDGIDCGGAYIKLLADTDDLILENFYDKTSYIIMF
GPDKCGEDYKLHFIFRHKHPKTGVFEEKHAKPPDVDLKKFFTDRKTHLYTLVMNPDDTFE
VLVDQTVVNKGSLLEDVVPPIKPPKEIEDPNDKKPEEWDERAKIPDPSAVKPEDWDESEP
AQIEDSSVVKPAGWLDDEPKFIPDPNAEKPDDWNEDTDGEWEAPQILNPACRIGCGEWKP
PMIDNPKYKGVWRPPLVDNPNYQGIWSPRKIPNPDYFEDDHPFLLTSFSALGLELWSMTS
DIYFDNFIICSEKEVADHWAADGWRWKIMIANANKPGVLKQLMAAAEGHPWLWLIYLVTA
GVPIALITSFCWPRKVKKKHKDTEYKKTDICIPQTKGVLEQEEKEEKAALEKPMDLEEEK
KQNDGEMLEKEEESEPEEKSEEEIEIIEGQEESNQSNKSGSEDEMKEADESTGSGDGPIK
SVRKRRVRKD
Target Bioclass
Other
Family
Calreticulin family
Subcellular location
Endoplasmic reticulum membrane
Function
Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions.
Uniprot ID
O14967
Ensemble ID
ENST00000325617.10
HGNC ID
HGNC:2060
ChEMBL ID
CHEMBL4295653

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 Deletion: p.K219SfsTer14 .
HCT15 SNV: p.E277G DBIA    Probe Info 
LOXIMVI SNV: p.P394L .
MCC13 SNV: p.D272N .
MEWO SNV: p.E563K .
SW756 SNV: p.E37Q DBIA    Probe Info 
TGBC52TKB SNV: p.I131V DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K501(6.67); K507(10.00)  LDD0277  [1]
BTD
 Probe Info  		C511(0.97)  LDD1700  [2]
AHL-Pu-1
 Probe Info  		C511(2.21)  LDD0169  [3]
DBIA
 Probe Info  		C151(2.11)  LDD0080  [4]
5E-2FA
 Probe Info  		N.A.  LDD2235  [5]
m-APA
 Probe Info  		N.A.  LDD2231  [5]
IA-alkyne
 Probe Info  		C185(0.00); C511(0.00)  LDD0165  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [7]
DA-P3
 Probe Info  		N.A.  LDD0178  [8]
IPM
 Probe Info  		N.A.  LDD0005  [9]
VSF
 Probe Info  		N.A.  LDD0007  [9]
Acrolein
 Probe Info  		N.A.  LDD0217  [10]
W1
 Probe Info  		N.A.  LDD0236  [11]
NAIA_5
 Probe Info  		N.A.  LDD2223  [12]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		20.00  LDD0471  [13]
FFF probe14
 Probe Info  		20.00  LDD0477  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C511(0.76)  LDD2142  [2]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C511(0.85)  LDD2112  [2]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C511(0.96)  LDD2095  [2]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C511(0.95)  LDD2130  [2]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C511(0.99)  LDD2117  [2]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C511(0.98)  LDD2152  [2]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C511(0.96)  LDD2103  [2]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C511(0.92)  LDD2131  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C511(2.21)  LDD0169  [3]
 LDCM0214  AC1 HCT 116 C151(0.92); C185(1.23)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C151(1.06)  LDD0532  [4]
 LDCM0216  AC100 PaTu 8988t C151(0.84); C511(1.09); C185(0.86)  LDD1095  [4]
 LDCM0217  AC101 PaTu 8988t C151(0.77); C511(1.23); C185(0.84)  LDD1096  [4]
 LDCM0218  AC102 PaTu 8988t C151(0.63); C511(1.39); C185(0.72)  LDD1097  [4]
 LDCM0219  AC103 PaTu 8988t C151(0.69); C511(1.20); C185(0.78)  LDD1098  [4]
 LDCM0220  AC104 PaTu 8988t C151(0.77); C511(1.10); C185(0.74)  LDD1099  [4]
 LDCM0221  AC105 PaTu 8988t C151(0.73); C511(1.18); C185(0.52)  LDD1100  [4]
 LDCM0222  AC106 PaTu 8988t C151(0.93); C511(1.75); C185(0.77)  LDD1101  [4]
 LDCM0223  AC107 PaTu 8988t C151(1.03); C511(1.03); C185(0.76)  LDD1102  [4]
 LDCM0224  AC108 PaTu 8988t C151(0.84); C511(1.10); C185(0.76)  LDD1103  [4]
 LDCM0225  AC109 PaTu 8988t C151(0.74); C511(1.53); C185(0.89)  LDD1104  [4]
 LDCM0226  AC11 HCT 116 C151(1.07)  LDD0543  [4]
 LDCM0227  AC110 PaTu 8988t C151(0.83); C511(1.36); C185(0.62)  LDD1106  [4]
 LDCM0228  AC111 PaTu 8988t C151(0.80); C511(1.74); C185(0.58)  LDD1107  [4]
 LDCM0229  AC112 PaTu 8988t C151(0.81); C511(0.91); C185(0.73)  LDD1108  [4]
 LDCM0230  AC113 HCT 116 C185(1.28)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C185(1.33)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C185(0.95)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C185(0.97)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C185(1.00)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C185(0.96)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C185(1.13)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C151(0.94)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C185(0.88)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C185(0.87)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C185(1.09)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C185(0.80)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C185(0.74)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C185(0.72)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C185(0.82)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C185(0.90)  LDD0562  [4]
 LDCM0246  AC128 HEK-293T C151(0.98)  LDD0844  [4]
 LDCM0247  AC129 HEK-293T C151(1.23)  LDD0845  [4]
 LDCM0249  AC130 HEK-293T C151(1.29)  LDD0847  [4]
 LDCM0250  AC131 HEK-293T C151(1.00)  LDD0848  [4]
 LDCM0251  AC132 HEK-293T C151(1.05)  LDD0849  [4]
 LDCM0252  AC133 HEK-293T C151(1.13)  LDD0850  [4]
 LDCM0253  AC134 HEK-293T C151(1.44)  LDD0851  [4]
 LDCM0254  AC135 HEK-293T C151(1.09)  LDD0852  [4]
 LDCM0255  AC136 HEK-293T C151(1.02)  LDD0853  [4]
 LDCM0256  AC137 HEK-293T C151(1.43)  LDD0854  [4]
 LDCM0257  AC138 HEK-293T C151(1.52)  LDD0855  [4]
 LDCM0258  AC139 HEK-293T C151(1.36)  LDD0856  [4]
 LDCM0259  AC14 HCT 116 C151(0.88)  LDD0576  [4]
 LDCM0260  AC140 HEK-293T C151(1.25)  LDD0858  [4]
 LDCM0261  AC141 HEK-293T C151(1.45)  LDD0859  [4]
 LDCM0262  AC142 HEK-293T C151(1.21)  LDD0860  [4]
 LDCM0263  AC143 HEK-293T C151(1.06)  LDD0861  [4]
 LDCM0264  AC144 HEK-293T C151(1.49)  LDD0862  [4]
 LDCM0265  AC145 HEK-293T C151(1.34)  LDD0863  [4]
 LDCM0266  AC146 HEK-293T C151(1.25)  LDD0864  [4]
 LDCM0267  AC147 HEK-293T C151(1.37)  LDD0865  [4]
 LDCM0268  AC148 HEK-293T C151(1.21)  LDD0866  [4]
 LDCM0269  AC149 HEK-293T C151(1.19)  LDD0867  [4]
 LDCM0270  AC15 HCT 116 C151(0.95)  LDD0587  [4]
 LDCM0271  AC150 HEK-293T C151(1.18)  LDD0869  [4]
 LDCM0272  AC151 HEK-293T C151(1.10)  LDD0870  [4]
 LDCM0273  AC152 HEK-293T C151(1.25)  LDD0871  [4]
 LDCM0274  AC153 HEK-293T C151(1.19)  LDD0872  [4]
 LDCM0621  AC154 HEK-293T C151(1.15)  LDD2162  [4]
 LDCM0622  AC155 HEK-293T C151(1.34)  LDD2163  [4]
 LDCM0623  AC156 HEK-293T C151(1.26)  LDD2164  [4]
 LDCM0624  AC157 HEK-293T C151(1.55)  LDD2165  [4]
 LDCM0276  AC17 HCT 116 C185(1.28)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C185(1.32)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C185(1.32)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C151(0.96); C185(1.24)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C185(1.00)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C185(0.83)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C185(1.23)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C185(1.44)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C185(1.02)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C185(0.86)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C185(0.80)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C185(0.91)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C185(0.80)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C185(0.82)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C151(0.95); C185(1.18)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C185(0.83)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C185(0.77)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C185(1.00)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C185(1.06)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C185(0.75)  LDD0612  [4]
 LDCM0296  AC35 PaTu 8988t C151(1.03); C511(1.12); C185(1.11)  LDD1175  [4]
 LDCM0297  AC36 PaTu 8988t C151(1.12); C511(1.09); C185(1.12)  LDD1176  [4]
 LDCM0298  AC37 PaTu 8988t C151(1.04); C511(1.35); C185(1.27)  LDD1177  [4]
 LDCM0299  AC38 PaTu 8988t C151(1.25); C511(1.29); C185(1.47)  LDD1178  [4]
 LDCM0300  AC39 PaTu 8988t C151(1.10); C511(1.31); C185(1.47)  LDD1179  [4]
 LDCM0301  AC4 HCT 116 C151(1.00); C185(1.23)  LDD0618  [4]
 LDCM0302  AC40 PaTu 8988t C151(1.22); C511(1.60); C185(1.46)  LDD1181  [4]
 LDCM0303  AC41 PaTu 8988t C151(1.04); C511(1.25); C185(1.07)  LDD1182  [4]
 LDCM0304  AC42 PaTu 8988t C151(1.15); C511(1.45); C185(1.33)  LDD1183  [4]
 LDCM0305  AC43 PaTu 8988t C151(0.94); C511(1.21); C185(1.21)  LDD1184  [4]
 LDCM0306  AC44 PaTu 8988t C151(1.17); C511(1.87); C185(1.64)  LDD1185  [4]
 LDCM0307  AC45 PaTu 8988t C151(1.20); C511(1.51); C185(1.49)  LDD1186  [4]
 LDCM0308  AC46 HCT 116 C185(1.15); C151(1.27)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C185(1.08); C151(1.27)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C185(0.74); C151(1.16)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C185(0.87); C151(1.24)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C151(0.90); C185(1.53)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C185(1.06); C151(1.24)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C185(1.26); C151(1.39)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C185(0.84); C151(1.09)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C185(1.19); C151(1.36)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C185(0.70); C151(1.12)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C185(1.02); C151(1.54)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C185(0.85); C151(1.14)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C185(0.86); C151(1.02)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C151(0.76); C185(0.97)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C151(0.64); C185(1.13)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C151(1.15)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C151(0.90); C185(1.55)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C185(0.70); C151(0.90)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C151(0.65); C185(1.02)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C151(0.76); C185(0.97)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C151(0.88); C185(0.89)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C151(0.92); C185(1.02)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C151(0.85); C185(0.91)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C151(0.69); C185(1.03)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C151(0.62); C185(0.76)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C151(0.77); C185(1.03)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C151(1.02)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C151(0.77); C185(0.87)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C151(0.56); C185(0.95)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C151(0.74); C185(1.00)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C151(0.91); C185(1.07)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C151(0.72); C185(1.07)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C185(0.79); C151(0.86)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C151(0.57); C185(1.04)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C151(0.72); C185(0.95)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C151(0.71); C185(0.82)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C151(0.68); C185(1.00)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C151(1.00)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C151(0.67); C185(0.89)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C151(0.53); C185(0.72)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C151(0.52); C185(0.69)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C185(1.06)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C185(0.88)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C185(1.24)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C185(1.17)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C185(1.01)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C185(1.04)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C185(1.13)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C185(1.13)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C185(0.93)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C185(1.03)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C185(1.42)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C185(0.95)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C185(0.96)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C185(0.92)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C185(0.97)  LDD0681  [4]
 LDCM0365  AC98 PaTu 8988t C151(1.60); C511(1.23); C185(0.86)  LDD1244  [4]
 LDCM0366  AC99 PaTu 8988t C151(0.85); C511(1.37); C185(0.74)  LDD1245  [4]
 LDCM0545  Acetamide MDA-MB-231 C511(0.45)  LDD2138  [2]
 LDCM0520  AKOS000195272 MDA-MB-231 C511(0.57)  LDD2113  [2]
 LDCM0248  AKOS034007472 HCT 116 C151(0.83)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C151(0.86)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C151(0.98)  LDD0592  [4]
 LDCM0498  BS-3668 MDA-MB-231 C511(0.67)  LDD2091  [2]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [10]
 LDCM0367  CL1 HCT 116 C185(0.95)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C185(1.05)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C151(1.08); C185(1.13)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C151(1.04)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C151(0.77)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C151(0.99)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C151(0.85)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C185(1.18)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C185(1.17)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C185(0.96)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C185(1.11)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C185(0.96)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C185(0.68)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C185(1.02)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C185(1.32)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C185(0.79)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C185(1.00)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C185(0.78)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C185(0.90)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C185(0.96)  LDD0703  [4]
 LDCM0387  CL117 PaTu 8988t C151(0.94); C511(1.11); C185(1.05)  LDD1266  [4]
 LDCM0388  CL118 PaTu 8988t C151(1.35); C511(1.27); C185(1.17)  LDD1267  [4]
 LDCM0389  CL119 PaTu 8988t C151(1.13); C511(1.25); C185(1.19)  LDD1268  [4]
 LDCM0390  CL12 HCT 116 C185(0.96)  LDD0707  [4]
 LDCM0391  CL120 PaTu 8988t C151(1.07); C511(1.07); C185(1.20)  LDD1270  [4]
 LDCM0392  CL121 HCT 116 C151(1.08); C185(1.20)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C185(0.97); C151(1.16)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C185(0.80); C151(1.11)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C185(0.86); C151(1.10)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C151(0.76); C185(1.00)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C151(0.75); C185(0.83)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C151(0.60); C185(0.90)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C185(0.85); C151(1.02)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C185(1.36)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C185(0.43)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C185(1.04)  LDD0719  [4]
 LDCM0403  CL16 PaTu 8988t C511(1.32); C185(0.55)  LDD1282  [4]
 LDCM0404  CL17 HCT 116 C185(0.92)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C185(1.04)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C185(1.06)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C185(0.98)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C185(1.23)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C185(1.05)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C185(1.14)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C185(0.89)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C185(1.09)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C185(0.87)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C185(1.15)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C185(1.24)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C185(1.21)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C185(0.56)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C185(1.04)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C185(0.24)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C185(0.87)  LDD0737  [4]
 LDCM0421  CL32 PaTu 8988t C151(1.05); C511(1.00)  LDD1300  [4]
 LDCM0422  CL33 PaTu 8988t C151(0.72); C511(0.99)  LDD1301  [4]
 LDCM0423  CL34 PaTu 8988t C151(1.29); C511(1.43)  LDD1302  [4]
 LDCM0424  CL35 PaTu 8988t C511(1.11); C151(1.00)  LDD1303  [4]
 LDCM0425  CL36 PaTu 8988t C151(1.35); C511(0.43)  LDD1304  [4]
 LDCM0426  CL37 PaTu 8988t C151(0.84); C511(1.28)  LDD1305  [4]
 LDCM0428  CL39 PaTu 8988t C151(1.15); C511(1.34)  LDD1307  [4]
 LDCM0429  CL4 HCT 116 C185(0.82)  LDD0746  [4]
 LDCM0430  CL40 PaTu 8988t C151(1.03); C511(1.54)  LDD1309  [4]
 LDCM0431  CL41 PaTu 8988t C151(0.81); C511(0.85)  LDD1310  [4]
 LDCM0432  CL42 PaTu 8988t C151(0.74); C511(0.91)  LDD1311  [4]
 LDCM0433  CL43 PaTu 8988t C151(0.84); C511(1.07)  LDD1312  [4]
 LDCM0434  CL44 PaTu 8988t C151(1.16); C511(1.50)  LDD1313  [4]
 LDCM0435  CL45 PaTu 8988t C151(0.92); C511(1.50)  LDD1314  [4]
 LDCM0436  CL46 HEK-293T C511(1.12)  LDD1034  [4]
 LDCM0437  CL47 HEK-293T C511(1.13)  LDD1035  [4]
 LDCM0438  CL48 HEK-293T C511(1.10)  LDD1036  [4]
 LDCM0439  CL49 HEK-293T C511(1.24)  LDD1037  [4]
 LDCM0440  CL5 HCT 116 C185(0.98)  LDD0757  [4]
 LDCM0441  CL50 HEK-293T C511(1.56)  LDD1039  [4]
 LDCM0442  CL51 HEK-293T C511(1.40)  LDD1040  [4]
 LDCM0443  CL52 HEK-293T C511(0.93)  LDD1041  [4]
 LDCM0444  CL53 HEK-293T C511(1.09)  LDD1042  [4]
 LDCM0445  CL54 HEK-293T C511(1.42)  LDD1043  [4]
 LDCM0446  CL55 HEK-293T C511(1.26)  LDD1044  [4]
 LDCM0447  CL56 HEK-293T C511(1.34)  LDD1045  [4]
 LDCM0448  CL57 HEK-293T C511(1.38)  LDD1046  [4]
 LDCM0449  CL58 HEK-293T C511(1.26)  LDD1047  [4]
 LDCM0450  CL59 HEK-293T C511(1.36)  LDD1048  [4]
 LDCM0451  CL6 HCT 116 C185(1.23)  LDD0768  [4]
 LDCM0452  CL60 HEK-293T C511(1.51)  LDD1050  [4]
 LDCM0453  CL61 HCT 116 C151(1.44)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C151(1.99)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C151(1.15)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C151(1.55)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C151(1.00)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C151(1.12)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C151(0.92)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C151(0.72)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C151(1.72)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C185(0.96)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C151(1.08)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C151(1.19)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C151(1.36)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C151(0.96)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C151(1.03)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C151(0.57)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C151(0.70)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C151(0.69)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C151(0.80)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C185(0.81)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C151(0.74)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C151(0.99)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C151(0.85)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C151(0.66)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C151(0.75)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C151(0.58)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C151(0.63)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C151(0.63)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C151(0.44)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C151(0.57)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C185(1.16)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C151(0.75)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C151(1.27); C185(1.26)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C151(1.24); C185(1.02)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C151(1.09); C185(1.05)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C151(1.10); C185(1.08)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C151(1.15); C185(1.24)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C151(1.02); C185(1.19)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C151(1.11); C185(0.94)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C151(1.10); C185(1.22)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C151(1.13); C185(1.32)  LDD0811  [4]
 LDCM0027  Dopamine HEK-293T 10.66  LDD0179  [8]
 LDCM0495  E2913 HEK-293T C511(0.97); C151(0.95)  LDD1698  [14]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C511(1.44)  LDD1702  [2]
 LDCM0468  Fragment33 HCT 116 C151(1.45)  LDD0785  [4]
 LDCM0427  Fragment51 PaTu 8988t C151(1.22); C511(1.14)  LDD1306  [4]
 LDCM0022  KB02 HCT 116 C151(2.11)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C151(1.94)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C151(1.27)  LDD0082  [4]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C511(0.77)  LDD2102  [2]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C511(0.55)  LDD2121  [2]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C511(1.29)  LDD2090  [2]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C511(0.87)  LDD2092  [2]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C511(1.06)  LDD2093  [2]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C511(1.04)  LDD2094  [2]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C511(0.56)  LDD2096  [2]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C511(0.88)  LDD2097  [2]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C511(1.00)  LDD2098  [2]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C511(0.74)  LDD2099  [2]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C511(0.68)  LDD2100  [2]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C511(0.47)  LDD2101  [2]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C511(0.94)  LDD2104  [2]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C511(1.72)  LDD2105  [2]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C511(0.72)  LDD2106  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C511(0.80)  LDD2107  [2]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C511(0.77)  LDD2108  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C511(0.67)  LDD2109  [2]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C511(1.83)  LDD2110  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C511(0.93)  LDD2111  [2]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C511(0.66)  LDD2114  [2]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C511(0.44)  LDD2115  [2]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C511(0.85)  LDD2116  [2]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C511(0.81)  LDD2118  [2]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C511(2.16)  LDD2119  [2]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C511(0.84)  LDD2120  [2]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C511(0.87)  LDD2122  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C511(0.69)  LDD2123  [2]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C511(0.72)  LDD2124  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C511(0.76)  LDD2125  [2]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C511(0.80)  LDD2126  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C511(0.93)  LDD2127  [2]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C511(0.88)  LDD2128  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C511(0.88)  LDD2129  [2]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C511(0.60)  LDD2133  [2]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C511(0.54)  LDD2134  [2]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C511(0.79)  LDD2135  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C511(1.12)  LDD2136  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C511(0.87)  LDD2137  [2]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C511(0.97)  LDD1700  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C511(0.75)  LDD2140  [2]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C511(0.66)  LDD2141  [2]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C511(0.99)  LDD2143  [2]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C511(2.13)  LDD2144  [2]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C511(4.37)  LDD2145  [2]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C511(0.75)  LDD2146  [2]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C511(3.29)  LDD2147  [2]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C511(0.59)  LDD2148  [2]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C511(0.82)  LDD2149  [2]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C511(1.19)  LDD2151  [2]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C511(1.48)  LDD2153  [2]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402