Details of the Target

General Information of Target

Target ID LDTP00398
Target Name Insulin receptor substrate 4 (IRS4)
Gene Name IRS4
Gene ID 8471
Synonyms
Insulin receptor substrate 4; IRS-4; 160 kDa phosphotyrosine protein; py160; Phosphoprotein of 160 kDa; pp160
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASCSFTRDQATRRLRGAAAAAAAALAAVVTTPLLSSGTPTALIGTGSSCPGAMWLSTAT
GSRSDSESEEEDLPVGEEVCKRGYLRKQKHGHRRYFVLKLETADAPARLEYYENARKFRH
SVRAAAAAAAAAASGAAIPPLIPPRRVITLYQCFSVSQRADARYRHLIALFTQDEYFAMV
AENESEQESWYLLLSRLILESKRRRCGTLGAQPDGEPAALAAAAAAEPPFYKDVWQVIVK
PRGLGHRKELSGVFRLCLTDEEVVFVRLNTEVASVVVQLLSIRRCGHSEQYFFLEVGRST
VIGPGELWMQVDDCVVAQNMHELFLEKMRALCADEYRARCRSYSISIGAHLLTLLSARRH
LGLVPLEPGGWLRRSRFEQFCHLRAIGDGEDEMLFTRRFVTPSEPVAHSRRGRLHLPRGR
RSRRAVSVPASFFRRLAPSPARPRHPAEAPNNGARLSSEVSGSGSGNFGEEGNPQGKEDQ
EGSGGDYMPMNNWGSGNGRGSGGGQGSNGQGSSSHSSGGNQCSGEGQGSRGGQGSNGQGS
GGNQCSRDGQGTAGGHGSGGGQRPGGGHGSGGGQGPGDGHGSGGGKNSGGGKGSGSGKGS
DGDGERGKSLKKRSYFGKLTQSKQQQMPPPPPPPPPPPPAGGTGGKGKSGGRFRLYFCVD
RGATKECKEAKEVKDAEIPEGAARGPHRARAFDEDEDDPYVPMRPGVATPLVSSSDYMPM
APQNVSASKKRHSRSPFEDSRGYMMMFPRVSPPPAPSPPKAPDTNKEDDSKDNDSESDYM
FMAPGAGAIPKNPRNPQGGSSSKSWSSYFSLPNPFRSSPLGQNDNSEYVPMLPGKFLGRG
LDKEVSYNWDPKDAASKPSGEGSFSKPGDGGSPSKPSDHEPPKNKAKRPNRLSFITKGYK
IKPKPQKPTHEQREADSSSDYVNMDFTKRESNTPAPSTQGLPDSWGIIAEPRQSAFSNYV
NVEFGVPFPNPANDLSDLLRAIPRANPLSLDSARWPLPPLPLSATGSNAIEEEGDYIEVI
FNSAMTPAMALADSAIRYDAETGRIYVVDPFSECCMDISLSPSRCSEPPPVARLLQEEEQ
ERRRPQSRSQSFFAAARAAVSAFPTDSLERDLSPSSAPAVASAAEPTLALSQVVAAASAL
AAAPGIGAAAAAAGFDSASARWFQPVANAADAEAVRGAQDVAGGSNPGAHNPSANLARGD
NQAGGAAAAAAAPEPPPRSRRVPRPPEREDSDNDDDTHVRMDFARRDNQFDSPKRGR
Target Bioclass
Other
Subcellular location
Cell membrane
Function
Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2.
Uniprot ID
O14654
Ensemble ID
ENST00000564206.2
HGNC ID
HGNC:6128

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 23 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alkylaryl probe 1
 Probe Info  		20.00  LDD0385  [1]
CHEMBL5175495
 Probe Info  		7.46  LDD0196  [2]
TH211
 Probe Info  		Y1038(20.00); Y743(20.00); Y899(20.00); Y1046(19.61)  LDD0257  [3]
TH214
 Probe Info  		Y743(20.00); Y808(20.00)  LDD0258  [3]
TH216
 Probe Info  		Y656(20.00); Y1038(19.59); Y828(18.66); Y112(10.94)  LDD0259  [3]
ONAyne
 Probe Info  		N.A.  LDD0273  [4]
AHL-Pu-1
 Probe Info  		C285(3.06)  LDD0168  [5]
HHS-465
 Probe Info  		Y808(9.91); Y828(9.90)  LDD2237  [6]
DBIA
 Probe Info  		C1054(6.91); C332(2.58); C1065(3.47); C1055(3.60)  LDD0080  [7]
ATP probe
 Probe Info  		K618(0.00); K240(0.00); K99(0.00)  LDD0199  [8]
IA-alkyne
 Probe Info  		C332(0.00); C1054(0.00); C545(0.00)  LDD0032  [9]
DA-P3
 Probe Info  		C522(0.00); C545(0.00)  LDD0178  [10]
ENE
 Probe Info  		C545(0.00); C1065(0.00); C522(0.00)  LDD0006  [11]
IPM
 Probe Info  		C332(0.00); C1054(0.00); C1065(0.00); C285(0.00)  LDD0005  [11]
NHS
 Probe Info  		N.A.  LDD0010  [11]
NPM
 Probe Info  		N.A.  LDD0016  [11]
PPMS
 Probe Info  		C545(0.00); C522(0.00)  LDD0008  [11]
SF
 Probe Info  		Y1038(0.00); Y111(0.00)  LDD0028  [12]
VSF
 Probe Info  		C206(0.00); C1054(0.00); C522(0.00); C1055(0.00)  LDD0007  [11]
Phosphinate-6
 Probe Info  		C667(0.00); C522(0.00); C1065(0.00); C658(0.00)  LDD0018  [13]
1c-yne
 Probe Info  		K843(0.00); K803(0.00)  LDD0228  [14]
W1
 Probe Info  		E113(0.00); Y112(0.00); N114(0.00)  LDD0236  [15]
AOyne
 Probe Info  		9.90  LDD0443  [16]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		14.66  LDD0471  [17]
FFF probe13
 Probe Info  		17.36  LDD0475  [17]
FFF probe14
 Probe Info  		12.50  LDD0477  [17]
FFF probe2
 Probe Info  		9.46  LDD0463  [17]
FFF probe3
 Probe Info  		17.65  LDD0464  [17]
OEA-DA
 Probe Info  		3.33  LDD0046  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C285(3.06)  LDD0168  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C153(2.76); C1055(2.10); C658(2.13); C545(2.03)  LDD0169  [5]
 LDCM0214  AC1 HEK-293T C545(1.12); C1065(0.95); C332(1.09); C381(1.02)  LDD1507  [19]
 LDCM0215  AC10 HEK-293T C545(1.01); C332(0.97); C381(0.97); C285(0.94)  LDD1508  [19]
 LDCM0226  AC11 HEK-293T C545(1.08); C1065(1.03); C332(0.94); C381(1.08)  LDD1509  [19]
 LDCM0237  AC12 HEK-293T C545(0.95); C1065(1.01); C332(0.91); C381(1.06)  LDD1510  [19]
 LDCM0259  AC14 HEK-293T C545(1.00); C1065(1.09); C332(0.94); C381(1.05)  LDD1512  [19]
 LDCM0270  AC15 HEK-293T C545(0.95); C1065(0.98); C332(0.92); C381(1.10)  LDD1513  [19]
 LDCM0276  AC17 HEK-293T C545(1.03); C1065(1.05); C332(0.92); C381(1.01)  LDD1515  [19]
 LDCM0277  AC18 HEK-293T C545(1.05); C332(1.01); C381(0.96); C285(0.97)  LDD1516  [19]
 LDCM0278  AC19 HEK-293T C545(2.25); C1065(1.35); C332(1.07); C381(1.10)  LDD1517  [19]
 LDCM0279  AC2 HEK-293T C545(1.06); C332(1.05); C381(0.98); C285(0.94)  LDD1518  [19]
 LDCM0280  AC20 HEK-293T C545(1.02); C1065(0.97); C332(0.94); C381(1.02)  LDD1519  [19]
 LDCM0281  AC21 HEK-293T C545(0.99); C1065(1.02); C332(0.93); C381(0.96)  LDD1520  [19]
 LDCM0282  AC22 HEK-293T C545(0.95); C1065(1.02); C332(1.02); C381(0.98)  LDD1521  [19]
 LDCM0283  AC23 HEK-293T C545(0.97); C1065(0.91); C332(0.96); C381(1.02)  LDD1522  [19]
 LDCM0284  AC24 HEK-293T C545(0.98); C1065(0.98); C332(1.03); C381(0.97)  LDD1523  [19]
 LDCM0285  AC25 HEK-293T C545(1.04); C1065(0.83); C332(0.93); C381(1.10)  LDD1524  [19]
 LDCM0286  AC26 HEK-293T C545(1.02); C332(1.00); C381(1.05); C285(0.95)  LDD1525  [19]
 LDCM0287  AC27 HEK-293T C545(1.14); C1065(0.99); C332(0.94); C381(1.13)  LDD1526  [19]
 LDCM0288  AC28 HEK-293T C545(0.99); C1065(0.99); C332(0.94); C381(0.98)  LDD1527  [19]
 LDCM0289  AC29 HEK-293T C545(0.98); C1065(1.12); C332(0.93); C381(0.97)  LDD1528  [19]
 LDCM0290  AC3 HEK-293T C545(1.08); C1065(1.07); C332(0.96); C381(1.02)  LDD1529  [19]
 LDCM0291  AC30 HEK-293T C545(0.98); C1065(1.02); C332(0.98); C381(1.03)  LDD1530  [19]
 LDCM0292  AC31 HEK-293T C545(0.89); C1065(0.87); C332(0.94); C381(1.01)  LDD1531  [19]
 LDCM0293  AC32 HEK-293T C545(0.85); C1065(0.95); C332(0.93); C381(1.02)  LDD1532  [19]
 LDCM0294  AC33 HEK-293T C545(1.08); C1065(0.92); C332(0.97); C381(1.09)  LDD1533  [19]
 LDCM0295  AC34 HEK-293T C545(1.06); C332(0.97); C381(0.99); C285(0.96)  LDD1534  [19]
 LDCM0296  AC35 HEK-293T C545(1.09); C1065(0.96); C332(0.92); C381(1.00)  LDD1535  [19]
 LDCM0297  AC36 HEK-293T C545(0.97); C1065(1.01); C332(0.82); C381(0.97)  LDD1536  [19]
 LDCM0298  AC37 HEK-293T C545(0.97); C1065(1.05); C332(0.88); C381(0.89)  LDD1537  [19]
 LDCM0299  AC38 HEK-293T C545(0.99); C1065(0.96); C332(0.93); C381(1.06)  LDD1538  [19]
 LDCM0300  AC39 HEK-293T C545(1.03); C1065(1.54); C332(0.91); C381(1.04)  LDD1539  [19]
 LDCM0301  AC4 HEK-293T C545(1.04); C1065(1.00); C332(0.85); C381(0.97)  LDD1540  [19]
 LDCM0302  AC40 HEK-293T C545(0.84); C1065(0.98); C332(0.89); C381(1.06)  LDD1541  [19]
 LDCM0303  AC41 HEK-293T C545(1.14); C1065(0.93); C332(0.96); C381(1.14)  LDD1542  [19]
 LDCM0304  AC42 HEK-293T C545(1.14); C332(0.97); C381(1.02); C285(0.85)  LDD1543  [19]
 LDCM0305  AC43 HEK-293T C545(0.98); C1065(0.93); C332(0.93); C381(1.04)  LDD1544  [19]
 LDCM0306  AC44 HEK-293T C545(1.02); C1065(1.06); C332(0.91); C381(1.13)  LDD1545  [19]
 LDCM0307  AC45 HEK-293T C545(1.03); C1065(1.05); C332(0.88); C381(0.90)  LDD1546  [19]
 LDCM0308  AC46 HEK-293T C545(1.05); C1065(1.05); C332(0.92); C381(1.00)  LDD1547  [19]
 LDCM0309  AC47 HEK-293T C545(0.97); C1065(0.91); C332(0.86); C381(1.03)  LDD1548  [19]
 LDCM0310  AC48 HEK-293T C545(0.97); C1065(0.97); C332(0.84); C381(0.98)  LDD1549  [19]
 LDCM0311  AC49 HEK-293T C545(1.06); C1065(1.02); C332(1.00); C381(1.08)  LDD1550  [19]
 LDCM0312  AC5 HEK-293T C545(0.98); C1065(1.05); C332(0.93); C381(0.90)  LDD1551  [19]
 LDCM0313  AC50 HEK-293T C545(1.02); C332(1.01); C381(0.98); C285(0.88)  LDD1552  [19]
 LDCM0314  AC51 HEK-293T C545(1.04); C1065(1.11); C332(0.91); C381(1.06)  LDD1553  [19]
 LDCM0315  AC52 HEK-293T C545(1.00); C1065(1.04); C332(0.92); C381(1.04)  LDD1554  [19]
 LDCM0316  AC53 HEK-293T C545(1.00); C1065(1.04); C332(1.01); C381(0.92)  LDD1555  [19]
 LDCM0317  AC54 HEK-293T C545(0.94); C1065(1.03); C332(0.98); C381(1.02)  LDD1556  [19]
 LDCM0318  AC55 HEK-293T C545(0.94); C1065(0.93); C332(0.93); C381(1.04)  LDD1557  [19]
 LDCM0319  AC56 HEK-293T C545(0.95); C1065(0.96); C332(0.94); C381(0.98)  LDD1558  [19]
 LDCM0320  AC57 HEK-293T C545(1.13); C1065(1.09); C332(0.90); C381(1.04)  LDD1559  [19]
 LDCM0321  AC58 HEK-293T C545(1.07); C332(0.97); C381(0.99); C285(0.86)  LDD1560  [19]
 LDCM0322  AC59 HEK-293T C545(1.06); C1065(0.98); C332(0.92); C381(1.03)  LDD1561  [19]
 LDCM0323  AC6 HEK-293T C545(1.07); C1065(0.95); C332(0.90); C381(1.02)  LDD1562  [19]
 LDCM0324  AC60 HEK-293T C545(1.07); C1065(0.99); C332(0.87); C381(1.05)  LDD1563  [19]
 LDCM0325  AC61 HEK-293T C545(1.02); C1065(1.04); C332(0.98); C381(0.96)  LDD1564  [19]
 LDCM0326  AC62 HEK-293T C545(1.10); C1065(1.02); C332(0.97); C381(0.98)  LDD1565  [19]
 LDCM0327  AC63 HEK-293T C545(1.04); C1065(1.17); C332(0.98); C381(1.00)  LDD1566  [19]
 LDCM0328  AC64 HEK-293T C545(0.96); C1065(0.95); C332(0.90); C381(0.98)  LDD1567  [19]
 LDCM0334  AC7 HEK-293T C545(1.03); C1065(0.86); C332(0.94); C381(1.04)  LDD1568  [19]
 LDCM0345  AC8 HEK-293T C545(1.05); C1065(0.93); C332(0.97); C381(1.02)  LDD1569  [19]
 LDCM0248  AKOS034007472 HEK-293T C545(0.96); C1065(1.03); C332(0.88); C381(0.95)  LDD1511  [19]
 LDCM0356  AKOS034007680 HEK-293T C545(1.10); C1065(1.20); C332(0.93); C381(1.06)  LDD1570  [19]
 LDCM0275  AKOS034007705 HEK-293T C545(0.97); C1065(0.91); C332(0.97); C381(0.98)  LDD1514  [19]
 LDCM0367  CL1 HEK-293T C545(1.03); C1065(0.83); C332(1.00); C381(1.02)  LDD1571  [19]
 LDCM0368  CL10 HEK-293T C545(0.86); C1065(1.15); C332(1.15); C381(1.84)  LDD1572  [19]
 LDCM0369  CL100 HEK-293T C545(1.05); C1065(1.04); C332(0.89); C381(0.98)  LDD1573  [19]
 LDCM0370  CL101 HEK-293T C545(1.04); C1065(1.06); C332(0.95); C381(0.94)  LDD1574  [19]
 LDCM0371  CL102 HEK-293T C545(1.12); C1065(1.04); C332(0.95); C381(1.07)  LDD1575  [19]
 LDCM0372  CL103 HEK-293T C545(1.03); C1065(0.95); C381(1.05); C285(1.04)  LDD1576  [19]
 LDCM0373  CL104 HEK-293T C545(1.00); C1065(1.05); C332(0.93); C381(0.95)  LDD1577  [19]
 LDCM0374  CL105 HEK-293T C545(1.03); C1065(1.01); C332(0.97); C381(1.02)  LDD1578  [19]
 LDCM0375  CL106 HEK-293T C545(1.09); C1065(0.93); C332(1.00); C381(1.09)  LDD1579  [19]
 LDCM0376  CL107 HEK-293T C545(1.00); C1065(1.14); C381(1.01); C285(1.05)  LDD1580  [19]
 LDCM0377  CL108 HEK-293T C545(1.03); C1065(1.06); C332(0.93); C381(1.01)  LDD1581  [19]
 LDCM0378  CL109 HEK-293T C545(0.95); C1065(1.06); C332(0.93); C381(1.09)  LDD1582  [19]
 LDCM0379  CL11 HEK-293T C545(0.79); C1065(0.89); C332(0.97); C381(1.39)  LDD1583  [19]
 LDCM0380  CL110 HEK-293T C545(1.00); C1065(1.07); C332(0.98); C381(1.12)  LDD1584  [19]
 LDCM0381  CL111 HEK-293T C545(1.00); C1065(0.98); C381(1.15); C285(1.07)  LDD1585  [19]
 LDCM0382  CL112 HEK-293T C545(0.98); C1065(1.18); C332(0.96); C381(1.02)  LDD1586  [19]
 LDCM0383  CL113 HEK-293T C545(1.15); C1065(0.99); C332(0.98); C381(1.04)  LDD1587  [19]
 LDCM0384  CL114 HEK-293T C545(1.09); C1065(1.14); C332(0.99); C381(1.17)  LDD1588  [19]
 LDCM0385  CL115 HEK-293T C545(1.02); C1065(1.00); C381(1.07); C285(1.04)  LDD1589  [19]
 LDCM0386  CL116 HEK-293T C545(1.04); C1065(1.16); C332(0.92); C381(0.93)  LDD1590  [19]
 LDCM0387  CL117 HEK-293T C545(1.08); C1065(1.04); C332(0.89); C381(0.96)  LDD1591  [19]
 LDCM0388  CL118 HEK-293T C545(1.19); C1065(1.06); C332(0.96); C381(1.00)  LDD1592  [19]
 LDCM0389  CL119 HEK-293T C545(0.99); C1065(1.14); C381(0.97); C285(1.00)  LDD1593  [19]
 LDCM0390  CL12 HEK-293T C545(0.83); C1065(0.97); C332(0.88); C381(1.00)  LDD1594  [19]
 LDCM0391  CL120 HEK-293T C545(1.07); C1065(1.07); C332(0.93); C381(1.01)  LDD1595  [19]
 LDCM0392  CL121 HEK-293T C545(1.09); C1065(1.06); C332(0.91); C381(1.08)  LDD1596  [19]
 LDCM0393  CL122 HEK-293T C545(1.11); C1065(1.02); C332(0.98); C381(0.97)  LDD1597  [19]
 LDCM0394  CL123 HEK-293T C545(0.94); C1065(1.21); C381(1.17); C285(1.03)  LDD1598  [19]
 LDCM0395  CL124 HEK-293T C545(1.01); C1065(1.20); C332(0.97); C381(1.12)  LDD1599  [19]
 LDCM0396  CL125 HEK-293T C545(1.09); C1065(1.05); C332(0.97); C381(0.93)  LDD1600  [19]
 LDCM0397  CL126 HEK-293T C545(1.05); C1065(0.96); C332(0.93); C381(0.97)  LDD1601  [19]
 LDCM0398  CL127 HEK-293T C545(1.07); C1065(0.99); C381(1.01); C285(0.97)  LDD1602  [19]
 LDCM0399  CL128 HEK-293T C545(1.08); C1065(1.09); C332(0.97); C381(0.98)  LDD1603  [19]
 LDCM0400  CL13 HEK-293T C545(1.28); C1065(1.03); C332(1.00); C381(1.16)  LDD1604  [19]
 LDCM0401  CL14 HEK-293T C545(1.09); C1065(0.90); C332(0.92); C381(0.93)  LDD1605  [19]
 LDCM0402  CL15 HEK-293T C545(1.10); C1065(1.05); C381(1.23); C285(1.12)  LDD1606  [19]
 LDCM0403  CL16 HEK-293T C545(0.99); C1065(1.11); C332(0.89); C381(1.04)  LDD1607  [19]
 LDCM0404  CL17 HEK-293T C545(1.18); C1065(1.08); C332(1.37); C381(1.38)  LDD1608  [19]
 LDCM0405  CL18 HEK-293T C545(0.88); C332(0.99); C381(1.02); C285(0.96)  LDD1609  [19]
 LDCM0406  CL19 HEK-293T C545(0.86); C1065(1.06); C332(0.92); C381(1.11)  LDD1610  [19]
 LDCM0407  CL2 HEK-293T C545(1.13); C1065(0.84); C332(1.01); C381(0.95)  LDD1611  [19]
 LDCM0408  CL20 HEK-293T C545(0.85); C1065(0.95); C332(0.89); C381(1.22)  LDD1612  [19]
 LDCM0409  CL21 HEK-293T C545(0.91); C1065(0.96); C332(1.00); C381(1.38)  LDD1613  [19]
 LDCM0410  CL22 HEK-293T C545(0.88); C1065(1.08); C332(1.06); C381(1.26)  LDD1614  [19]
 LDCM0411  CL23 HEK-293T C545(0.69); C1065(0.98); C332(1.01); C381(1.19)  LDD1615  [19]
 LDCM0412  CL24 HEK-293T C545(0.84); C1065(1.13); C332(0.97); C381(0.97)  LDD1616  [19]
 LDCM0413  CL25 HEK-293T C545(1.04); C1065(0.99); C332(0.99); C381(1.06)  LDD1617  [19]
 LDCM0414  CL26 HEK-293T C545(0.97); C1065(0.94); C332(1.01); C381(0.95)  LDD1618  [19]
 LDCM0415  CL27 HEK-293T C545(0.93); C1065(1.00); C381(1.03); C285(1.11)  LDD1619  [19]
 LDCM0416  CL28 HEK-293T C545(0.94); C1065(1.06); C332(0.97); C381(1.06)  LDD1620  [19]
 LDCM0417  CL29 HEK-293T C545(1.00); C1065(0.78); C332(1.04); C381(1.09)  LDD1621  [19]
 LDCM0418  CL3 HEK-293T C545(0.98); C1065(0.98); C381(1.05); C285(1.21)  LDD1622  [19]
 LDCM0419  CL30 HEK-293T C545(0.91); C332(1.01); C381(0.98); C285(0.95)  LDD1623  [19]
 LDCM0420  CL31 HEK-293T C545(0.94); C1065(1.36); C332(0.98); C381(1.14)  LDD1624  [19]
 LDCM0421  CL32 HEK-293T C545(0.85); C1065(0.93); C332(0.95); C381(1.13)  LDD1625  [19]
 LDCM0422  CL33 HEK-293T C545(0.80); C1065(1.32); C332(1.05); C381(1.61)  LDD1626  [19]
 LDCM0423  CL34 HEK-293T C545(0.83); C1065(1.07); C332(1.02); C381(1.30)  LDD1627  [19]
 LDCM0424  CL35 HEK-293T C545(0.72); C1065(0.90); C332(0.96); C381(1.33)  LDD1628  [19]
 LDCM0425  CL36 HEK-293T C545(0.81); C1065(0.99); C332(0.99); C381(1.16)  LDD1629  [19]
 LDCM0426  CL37 HEK-293T C545(1.02); C1065(0.94); C332(0.87); C381(0.92)  LDD1630  [19]
 LDCM0428  CL39 HEK-293T C545(0.89); C1065(1.02); C381(1.15); C285(1.21)  LDD1632  [19]
 LDCM0429  CL4 HEK-293T C545(1.03); C1065(1.00); C332(0.98); C381(0.97)  LDD1633  [19]
 LDCM0430  CL40 HEK-293T C545(0.91); C1065(1.01); C332(0.86); C381(0.97)  LDD1634  [19]
 LDCM0431  CL41 HEK-293T C545(0.97); C1065(1.13); C332(1.02); C381(1.22)  LDD1635  [19]
 LDCM0432  CL42 HEK-293T C545(0.94); C332(0.96); C381(1.01); C285(1.01)  LDD1636  [19]
 LDCM0433  CL43 HEK-293T C545(0.84); C1065(0.85); C332(0.99); C381(1.00)  LDD1637  [19]
 LDCM0434  CL44 HEK-293T C545(0.95); C1065(1.04); C332(0.97); C381(1.12)  LDD1638  [19]
 LDCM0435  CL45 HEK-293T C545(0.83); C1065(1.16); C332(0.96); C381(1.19)  LDD1639  [19]
 LDCM0436  CL46 HEK-293T C545(0.85); C1065(0.99); C332(1.12); C381(1.34)  LDD1640  [19]
 LDCM0437  CL47 HEK-293T C545(0.86); C1065(0.82); C332(0.97); C381(1.40)  LDD1641  [19]
 LDCM0438  CL48 HEK-293T C545(0.84); C1065(1.08); C332(1.01); C381(1.09)  LDD1642  [19]
 LDCM0439  CL49 HEK-293T C545(1.01); C1065(0.90); C332(0.84); C381(0.98)  LDD1643  [19]
 LDCM0440  CL5 HEK-293T C545(1.16); C1065(1.01); C332(0.86); C381(1.05)  LDD1644  [19]
 LDCM0441  CL50 HEK-293T C545(0.92); C1065(0.89); C332(0.94); C381(1.00)  LDD1645  [19]
 LDCM0443  CL52 HEK-293T C545(0.97); C1065(1.11); C332(0.86); C381(0.99)  LDD1646  [19]
 LDCM0444  CL53 HEK-293T C545(0.99); C1065(1.07); C332(0.81); C381(1.23)  LDD1647  [19]
 LDCM0445  CL54 HEK-293T C545(0.95); C332(0.98); C381(1.19); C285(1.05)  LDD1648  [19]
 LDCM0446  CL55 HEK-293T C545(0.99); C1065(0.94); C332(0.97); C381(1.04)  LDD1649  [19]
 LDCM0447  CL56 HEK-293T C545(0.88); C1065(1.02); C332(0.92); C381(1.15)  LDD1650  [19]
 LDCM0448  CL57 HEK-293T C545(1.01); C1065(1.16); C332(1.00); C381(1.27)  LDD1651  [19]
 LDCM0449  CL58 HEK-293T C545(0.80); C1065(1.01); C332(0.96); C381(1.41)  LDD1652  [19]
 LDCM0450  CL59 HEK-293T C545(0.82); C1065(1.11); C332(0.96); C381(1.39)  LDD1653  [19]
 LDCM0451  CL6 HEK-293T C545(0.99); C332(0.94); C381(1.19); C285(1.07)  LDD1654  [19]
 LDCM0452  CL60 HEK-293T C545(0.80); C1065(0.99); C332(0.98); C381(1.06)  LDD1655  [19]
 LDCM0453  CL61 HEK-293T C545(0.97); C1065(0.88); C332(0.92); C381(0.93)  LDD1656  [19]
 LDCM0454  CL62 HEK-293T C545(1.01); C1065(0.93); C332(0.94); C381(0.96)  LDD1657  [19]
 LDCM0455  CL63 HEK-293T C545(0.99); C1065(1.05); C381(1.04); C285(0.92)  LDD1658  [19]
 LDCM0456  CL64 HEK-293T C545(0.99); C1065(1.08); C332(0.98); C381(1.07)  LDD1659  [19]
 LDCM0457  CL65 HEK-293T C545(0.95); C1065(1.24); C332(0.89); C381(1.09)  LDD1660  [19]
 LDCM0458  CL66 HEK-293T C545(0.96); C332(1.00); C381(1.02); C285(1.02)  LDD1661  [19]
 LDCM0459  CL67 HEK-293T C545(1.01); C1065(0.98); C332(0.92); C381(1.03)  LDD1662  [19]
 LDCM0460  CL68 HEK-293T C545(0.86); C1065(0.99); C332(0.98); C381(1.12)  LDD1663  [19]
 LDCM0461  CL69 HEK-293T C545(0.84); C1065(1.08); C332(0.96); C381(1.05)  LDD1664  [19]
 LDCM0462  CL7 HEK-293T C545(0.97); C1065(0.91); C332(0.96); C381(1.11)  LDD1665  [19]
 LDCM0463  CL70 HEK-293T C545(0.84); C1065(1.02); C332(0.97); C381(1.22)  LDD1666  [19]
 LDCM0464  CL71 HEK-293T C545(0.86); C1065(1.11); C332(0.99); C381(1.33)  LDD1667  [19]
 LDCM0465  CL72 HEK-293T C545(0.77); C1065(1.02); C332(1.00); C381(1.14)  LDD1668  [19]
 LDCM0466  CL73 HEK-293T C545(0.99); C1065(1.01); C332(0.94); C381(1.05)  LDD1669  [19]
 LDCM0467  CL74 HEK-293T C545(1.02); C1065(0.93); C332(0.91); C381(0.92)  LDD1670  [19]
 LDCM0469  CL76 HEK-293T C545(1.03); C1065(1.00); C332(0.93); C381(1.00)  LDD1672  [19]
 LDCM0470  CL77 HEK-293T C545(0.94); C1065(1.16); C332(1.00); C381(1.34)  LDD1673  [19]
 LDCM0471  CL78 HEK-293T C545(0.95); C332(0.94); C381(1.02); C285(0.92)  LDD1674  [19]
 LDCM0472  CL79 HEK-293T C545(0.96); C1065(1.04); C332(0.90); C381(1.01)  LDD1675  [19]
 LDCM0473  CL8 HEK-293T C545(0.85); C1065(1.12); C332(0.93); C381(1.95)  LDD1676  [19]
 LDCM0474  CL80 HEK-293T C545(0.85); C1065(1.02); C332(0.92); C381(1.02)  LDD1677  [19]
 LDCM0475  CL81 HEK-293T C545(0.89); C1065(1.07); C332(0.94); C381(1.10)  LDD1678  [19]
 LDCM0476  CL82 HEK-293T C545(0.90); C1065(1.09); C332(0.97); C381(1.18)  LDD1679  [19]
 LDCM0477  CL83 HEK-293T C545(0.83); C1065(1.05); C332(1.01); C381(1.27)  LDD1680  [19]
 LDCM0478  CL84 HEK-293T C545(0.83); C1065(1.05); C332(1.01); C381(1.09)  LDD1681  [19]
 LDCM0479  CL85 HEK-293T C545(1.05); C1065(0.91); C332(0.87); C381(0.89)  LDD1682  [19]
 LDCM0480  CL86 HEK-293T C545(1.02); C1065(0.84); C332(0.88); C381(0.87)  LDD1683  [19]
 LDCM0481  CL87 HEK-293T C545(1.04); C1065(1.13); C381(1.06); C285(1.05)  LDD1684  [19]
 LDCM0482  CL88 HEK-293T C545(1.01); C1065(1.05); C332(0.88); C381(0.89)  LDD1685  [19]
 LDCM0483  CL89 HEK-293T C545(0.95); C1065(0.98); C332(1.04); C381(1.02)  LDD1686  [19]
 LDCM0484  CL9 HEK-293T C545(0.95); C1065(1.03); C332(0.95); C381(1.07)  LDD1687  [19]
 LDCM0485  CL90 HEK-293T C545(1.07); C332(1.18); C381(1.74); C285(1.17)  LDD1688  [19]
 LDCM0486  CL91 HEK-293T C545(1.01); C1065(1.06); C332(0.96); C381(1.05)  LDD1689  [19]
 LDCM0487  CL92 HEK-293T C545(0.95); C1065(1.08); C332(0.85); C381(1.08)  LDD1690  [19]
 LDCM0488  CL93 HEK-293T C545(0.89); C1065(0.99); C332(0.89); C381(1.09)  LDD1691  [19]
 LDCM0489  CL94 HEK-293T C545(0.87); C1065(1.05); C332(0.97); C381(1.04)  LDD1692  [19]
 LDCM0490  CL95 HEK-293T C545(0.86); C1065(1.39); C332(1.01); C381(1.50)  LDD1693  [19]
 LDCM0491  CL96 HEK-293T C545(1.01); C1065(0.98); C332(0.96); C381(1.05)  LDD1694  [19]
 LDCM0492  CL97 HEK-293T C545(1.08); C1065(0.94); C332(0.86); C381(0.99)  LDD1695  [19]
 LDCM0493  CL98 HEK-293T C545(1.04); C1065(0.90); C332(0.97); C381(1.03)  LDD1696  [19]
 LDCM0494  CL99 HEK-293T C545(1.03); C1065(1.04); C381(1.03); C285(1.01)  LDD1697  [19]
 LDCM0495  E2913 HEK-293T C545(0.92); C1065(0.98); C381(1.11); C285(0.97)  LDD1698  [19]
 LDCM0468  Fragment33 HEK-293T C545(0.94); C1065(0.97); C381(1.05); C285(1.02)  LDD1671  [19]
 LDCM0427  Fragment51 HEK-293T C545(1.09); C1065(0.90); C332(0.98); C381(0.94)  LDD1631  [19]
 LDCM0022  KB02 HCT 116 C1054(6.91); C332(2.58); C1065(3.47); C1055(3.60)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C1054(6.83); C332(2.29); C1065(4.07); C1055(4.11)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C1054(9.52); C332(4.53); C1065(4.47); C1055(4.01)  LDD0082  [7]
 LDCM0627  NUDT7-COV-1 HEK-293T C257(1.06); C1065(0.61); C332(0.49); C206(0.48)  LDD2206  [20]
 LDCM0628  OTUB2-COV-1 HEK-293T C381(1.57); C206(0.83); C332(0.78); C1065(0.72)  LDD2207  [20]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Prostaglandin E synthase 3 (PTGES3) P23/wos2 family Q15185
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Microtubule-associated proteins 1A/1B light chain 3A (MAP1LC3A) ATG8 family Q9H492
Adapter molecule crk (CRK) CRK family P46108

References

1 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
2 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
10 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
15 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
18 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
20 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.