Details of the Target

General Information of Target

Target ID LDTP01392
Target Name Probable cytosolic iron-sulfur protein assembly protein CIAO1 (CIAO1)
Gene Name CIAO1
Gene ID 9391
Synonyms
CIA1; WDR39; Probable cytosolic iron-sulfur protein assembly protein CIAO1; WD repeat-containing protein 39
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKDSLVLLGRVPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGH
QRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLL
ATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREE
EDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPS
WKCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQ
AHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQRPEGL
Target Bioclass
Other
Family
WD repeat CIA1 family
Subcellular location
Cytoplasm
Function
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures ACO1 and stabilizes IREB2. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation. {|HAMAP-Rule:MF_03037}.
Uniprot ID
O76071
Ensemble ID
ENST00000488633.2
HGNC ID
HGNC:14280

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.36  LDD0402  [1]
STPyne
 Probe Info  		K2(3.56)  LDD0277  [2]
IPM
 Probe Info  		C52(0.00); C234(0.00); C123(0.00)  LDD0241  [3]
BTD
 Probe Info  		C212(0.96)  LDD2107  [4]
AHL-Pu-1
 Probe Info  		C234(2.85)  LDD0168  [5]
DBIA
 Probe Info  		C243(1.16); C245(1.16); C123(1.16); C234(0.94)  LDD0078  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C322(0.00); C212(0.00); C97(0.00); C234(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C123(0.00); C212(0.00)  LDD0032  [8]
Lodoacetamide azide
 Probe Info  		C322(0.00); C52(0.00); C97(0.00); C123(0.00)  LDD0037  [7]
NAIA_4
 Probe Info  		C52(0.00); C97(0.00); C123(0.00); C234(0.00)  LDD2226  [9]
TFBX
 Probe Info  		N.A.  LDD0027  [10]
DA-P3
 Probe Info  		N.A.  LDD0178  [11]
Phosphinate-6
 Probe Info  		C234(0.00); C212(0.00)  LDD0018  [12]
Acrolein
 Probe Info  		C97(0.00); C234(0.00); C212(0.00); C123(0.00)  LDD0217  [13]
Methacrolein
 Probe Info  		C97(0.00); C123(0.00); C212(0.00)  LDD0218  [13]
NAIA_5
 Probe Info  		C322(0.00); C52(0.00); C97(0.00); C212(0.00)  LDD2223  [9]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C234(2.85)  LDD0168  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C212(2.02); C234(4.47)  LDD0169  [5]
 LDCM0214  AC1 HCT 116 C123(0.94); C19(0.62); C212(1.90); C234(1.21)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C123(0.91); C19(0.55); C234(1.22); C34(0.55)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C123(0.70); C19(0.91); C212(0.93); C234(0.99)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C123(0.63); C19(0.56); C212(0.49); C234(0.95)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C123(0.75); C19(0.66); C212(0.46); C234(0.98)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C123(0.58); C19(0.93); C212(0.50); C234(1.11)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C123(0.60); C19(0.50); C212(0.69); C234(1.07)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C123(0.66); C19(0.63); C212(0.51); C234(1.08)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C123(0.65); C19(0.77); C212(0.56); C234(1.09)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C123(0.62); C19(0.51); C212(0.45); C234(1.03)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C123(0.75); C19(0.44); C212(0.82); C234(1.01)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C123(0.67); C19(0.94); C212(0.57); C234(0.86)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C123(0.92); C19(0.59); C234(1.31); C34(0.59)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C123(0.69); C19(0.64); C212(0.72); C234(0.88)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C123(0.67); C19(0.47); C212(0.66); C234(0.92)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C123(0.62); C19(0.49); C212(0.54); C234(0.96)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C123(1.03); C234(0.99); C52(1.12); C72(1.01)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C123(0.91); C234(1.16); C52(1.25); C72(1.05)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C123(0.85); C234(1.25); C52(1.24); C72(0.92)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C123(0.98); C234(1.27); C52(1.20); C72(0.76)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C123(0.93); C234(1.15); C52(1.14); C72(0.94)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C123(1.00); C234(1.13); C52(1.34); C72(0.85)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C123(0.90); C234(1.22); C52(1.13); C72(0.68)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C123(1.02); C19(0.83); C234(1.29); C34(0.83)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C123(0.96); C234(1.30); C52(1.28); C72(1.00)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C123(0.92); C234(1.19); C52(1.18); C72(0.76)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C123(0.88); C234(1.26); C52(1.30); C72(0.76)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C123(0.85); C234(0.98); C52(1.03); C72(0.77)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C123(1.06); C234(1.15); C52(1.06); C72(0.97)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C123(1.22); C234(1.15); C52(1.13); C72(0.83)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C123(0.87); C234(1.19); C52(1.33); C72(0.80)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C123(0.97); C234(1.18); C52(1.19); C72(0.73)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C123(0.94); C234(1.06); C261(0.81); C271(0.81)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C123(0.93); C234(0.85); C261(0.81); C271(0.81)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C123(0.95); C234(0.99); C261(0.86); C271(0.86)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C123(0.94); C234(0.82); C261(1.05); C271(1.05)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C123(0.96); C234(0.93); C261(0.93); C271(0.93)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C123(0.92); C234(1.01); C261(0.79); C271(0.79)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C123(0.88); C234(1.08); C261(0.75); C271(0.75)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C123(0.93); C234(1.00); C261(0.90); C271(0.90)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C123(0.95); C234(1.17); C261(0.83); C271(0.83)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C123(0.89); C234(1.02); C261(1.02); C271(1.02)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C123(0.90); C234(1.14); C261(0.82); C271(0.82)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C123(0.88); C234(1.08); C261(1.03); C271(1.03)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C123(1.00); C19(0.62); C234(1.31); C34(0.62)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C123(0.80); C234(1.12); C261(0.86); C271(0.86)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C123(0.87); C234(1.24); C261(0.89); C271(0.89)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C123(0.90); C234(1.08); C261(1.03); C271(1.03)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C123(0.86); C19(1.09); C212(1.17); C234(1.06)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C212(0.63); C123(0.93); C52(1.02); C72(1.04)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C212(0.73); C123(0.82); C52(0.98); C72(0.98)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C212(0.63); C72(0.77); C86(0.77); C123(0.93)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C212(0.73); C72(0.75); C86(0.75); C123(0.85)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C19(0.66); C34(0.66); C72(0.68); C86(0.68)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C72(0.77); C86(0.77); C212(0.82); C123(0.87)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C19(0.69); C34(0.69); C72(0.92); C123(1.01)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C212(0.50); C123(0.95); C72(0.99); C86(0.99)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C123(0.91); C52(1.06); C72(1.15); C86(1.15)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C212(0.87); C123(0.90); C52(1.03); C72(1.05)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C19(0.59); C34(0.59); C72(0.65); C86(0.65)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C123(0.85); C19(1.32); C212(0.69); C234(1.18)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C123(0.93); C19(1.32); C212(0.83); C234(1.28)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C123(0.93); C19(0.99); C212(0.93); C234(1.00)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C123(1.02); C19(1.52); C212(1.01); C234(0.98)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C72(0.68); C86(0.68); C52(0.99); C123(1.04)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C72(0.55); C86(0.55); C123(0.94); C52(1.16)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C72(0.63); C86(0.63); C212(0.98); C123(1.08)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C19(0.84); C34(0.84); C123(0.87); C261(0.88)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C72(0.58); C86(0.58); C52(0.96); C123(0.98)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C72(0.59); C86(0.59); C52(0.96); C234(1.02)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C72(0.54); C86(0.54); C52(0.95); C123(0.97)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C72(0.75); C86(0.75); C234(0.93); C52(0.95)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C72(0.79); C86(0.79); C52(0.94); C123(1.03)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C72(0.92); C86(0.92); C123(1.03); C234(1.07)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C72(0.87); C86(0.87); C123(0.99); C234(1.15)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C123(1.14); C52(1.14); C234(1.20); C72(1.29)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C72(0.92); C86(0.92); C123(0.98); C52(1.14)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C123(1.04); C234(1.16); C52(1.18); C72(1.18)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C19(0.66); C34(0.66); C52(0.90); C123(1.01)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C72(0.72); C86(0.72); C123(1.01); C212(1.23)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C72(1.00); C86(1.00); C123(1.07); C234(1.18)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C72(0.85); C86(0.85); C123(1.01); C212(1.27)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C72(0.87); C86(0.87); C123(1.05); C212(1.21)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C72(0.89); C86(0.89); C123(0.99); C212(1.17)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C52(0.89); C212(0.93); C234(0.94); C123(1.10)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C52(0.96); C234(1.00); C72(1.07); C86(1.07)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C52(0.98); C234(1.04); C72(1.10); C86(1.10)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C52(0.86); C72(0.94); C86(0.94); C212(0.97)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C72(0.83); C86(0.83); C52(0.96); C123(1.01)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C19(0.61); C34(0.61); C261(0.75); C271(0.75)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C72(0.81); C86(0.81); C52(0.91); C123(0.98)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C72(0.85); C86(0.85); C123(1.07); C234(1.14)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C72(0.83); C86(0.83); C52(0.93); C123(1.07)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C72(0.90); C86(0.90); C52(1.04); C123(1.12)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C72(0.80); C86(0.80); C123(1.02); C212(1.07)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C72(0.95); C86(0.95); C123(1.04); C212(1.07)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C212(0.90); C52(1.01); C123(1.04); C234(1.06)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C123(0.99); C52(1.02); C212(1.03); C234(1.04)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C123(0.95); C52(1.08); C212(1.15); C234(1.16)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C52(0.98); C123(1.07); C212(1.13); C234(1.30)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C19(0.49); C34(0.49); C261(0.57); C271(0.57)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C52(0.99); C212(1.05); C123(1.09); C234(1.23)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C52(0.84); C234(0.99); C123(1.02); C212(1.30)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C52(0.97); C212(0.98); C123(1.04); C234(1.22)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C123(0.86); C212(0.97); C52(0.99); C234(1.04)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C212(1.05); C52(1.10); C123(1.13); C234(1.20)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C123(0.90); C52(1.07); C212(1.11); C234(1.26)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C212(0.82); C52(0.88); C123(0.90); C234(1.36)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C86(0.71); C72(0.76); C52(0.98); C123(1.05)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C52(0.82); C86(0.88); C72(0.93); C123(1.06)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C123(0.99); C52(1.02); C86(1.12); C72(1.13)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C19(0.70); C34(0.70); C72(0.80); C123(0.93)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C86(0.77); C72(0.78); C52(1.00); C123(1.07)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C86(0.76); C72(0.80); C52(0.96); C123(1.10)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C86(0.69); C72(0.81); C123(1.00); C52(1.01)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C86(0.66); C72(0.67); C52(0.98); C123(1.00)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C86(0.62); C72(0.69); C52(0.97); C123(0.98)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C86(0.64); C72(0.69); C52(1.04); C123(1.19)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C86(0.79); C72(0.85); C52(0.92); C123(1.15)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C86(0.40); C72(0.49); C123(0.76); C52(0.98)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C72(0.67); C86(0.67); C212(0.93); C52(1.04)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C212(0.78); C72(0.90); C86(0.90); C234(0.96)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C19(0.63); C34(0.63); C72(0.84); C123(0.90)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C72(0.49); C86(0.49); C52(0.70); C212(0.76)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C72(0.55); C86(0.55); C212(0.72); C52(0.84)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C72(0.83); C86(0.83); C123(0.91); C52(0.95)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C72(0.71); C86(0.71); C52(0.75); C212(0.81)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C72(0.55); C86(0.55); C212(0.80); C52(0.84)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C72(0.44); C86(0.44); C52(0.60); C212(0.75)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C52(0.91); C212(0.93); C123(0.95); C234(1.06)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C72(0.43); C86(0.43); C123(0.84); C52(0.85)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C72(0.72); C86(0.72); C212(0.84); C52(0.95)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C72(0.67); C86(0.67); C123(0.85); C212(0.87)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C19(0.46); C34(0.46); C123(0.96); C72(0.98)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C72(0.79); C86(0.79); C123(0.88); C212(0.93)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C19(0.09); C34(0.09); C72(0.71); C86(0.71)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C72(0.22); C86(0.22); C52(0.46); C212(0.78)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C19(0.59); C34(0.59); C86(0.79); C123(0.88)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C19(0.61); C34(0.61); C86(0.75); C123(0.83)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C19(0.63); C34(0.63); C86(0.81); C123(0.86)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C86(0.81); C72(0.89); C19(0.93); C34(0.93)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C123(0.82); C86(0.94); C72(0.95); C52(0.96)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C123(0.88); C52(1.04); C234(1.11); C19(1.15)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C123(0.84); C19(0.86); C34(0.86); C52(0.95)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C72(0.77); C234(1.03); C123(1.03); C52(1.04)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C19(0.64); C34(0.64); C86(0.86); C123(0.96)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C19(0.55); C34(0.55); C123(0.82); C72(0.89)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C123(0.88); C72(0.96); C86(1.06); C19(1.13)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C19(0.57); C34(0.57); C123(1.04); C52(1.04)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C19(0.81); C34(0.81); C52(0.89); C234(1.12)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C19(0.80); C34(0.80); C123(0.83); C86(0.86)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C19(0.67); C34(0.67); C123(0.86); C86(0.97)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C19(0.19); C34(0.19); C212(0.28); C123(0.44)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C19(0.52); C34(0.52); C212(0.58); C123(0.62)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C123(1.00); C19(0.90); C234(1.12); C34(0.90)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C19(0.64); C34(0.64); C72(0.94); C123(0.95)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C19(0.63); C34(0.63); C123(1.02); C72(1.08)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 11.42  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C243(1.16); C245(1.16); C123(1.16); C234(0.94)  LDD0078  [6]
 LDCM0108  Chloroacetamide HeLa C97(0.00); C123(0.00); C322(0.00); C234(0.00)  LDD0222  [13]
 LDCM0367  CL1 HCT 116 C261(0.74); C271(0.74); C52(0.80); C212(0.87)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C261(0.89); C271(0.89); C123(1.12); C72(1.14)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C19(0.69); C34(0.69); C261(0.75); C271(0.75)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C19(0.76); C34(0.76); C72(0.79); C123(0.90)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C123(0.90); C72(0.96); C52(1.08); C19(1.15)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C19(0.50); C34(0.50); C123(0.90); C72(0.93)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C19(0.75); C34(0.75); C123(0.95); C52(1.06)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C72(0.49); C86(0.49); C123(0.92); C52(1.09)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C72(0.47); C86(0.47); C212(0.90); C123(0.96)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C72(0.37); C86(0.37); C123(0.91); C52(1.09)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C72(0.53); C86(0.53); C123(0.94); C212(1.06)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C72(0.71); C86(0.71); C212(0.86); C52(1.02)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C72(0.83); C86(0.83); C19(0.93); C34(0.93)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C72(0.40); C86(0.40); C123(0.74); C212(0.93)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C72(0.66); C86(0.66); C123(0.77); C212(0.77)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C72(0.69); C86(0.69); C123(0.94); C52(1.01)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C72(0.93); C86(0.93); C123(0.99); C52(1.25)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C72(0.69); C86(0.69); C123(0.85); C52(1.06)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C72(0.79); C86(0.79); C123(0.89); C212(1.01)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C72(0.90); C86(0.90); C123(0.96); C52(1.14)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C72(0.85); C86(0.85); C52(0.97); C123(0.98)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C72(0.91); C86(0.91); C52(1.09); C234(1.09)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C72(1.06); C86(1.06); C123(1.07); C52(1.09)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C261(0.91); C271(0.91); C72(0.94); C86(0.94)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C72(0.80); C86(0.80); C123(1.02); C234(1.10)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C123(0.84); C212(1.27); C234(1.36); C52(1.61)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C123(0.77); C212(0.87); C52(0.96); C234(1.15)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C123(0.50); C212(0.66); C52(0.87); C234(1.10)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C212(0.93); C123(0.94); C52(1.02); C234(1.20)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C72(0.87); C86(0.88); C52(0.89); C123(1.05)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C72(0.95); C52(0.96); C123(0.97); C86(0.98)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C86(0.63); C72(0.68); C52(0.90); C123(0.96)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C86(0.77); C72(0.80); C123(1.01); C52(1.06)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C212(0.90); C72(0.96); C86(0.96); C261(1.04)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C72(0.85); C86(0.85); C52(0.90); C234(0.93)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C212(0.80); C52(1.10); C234(1.18); C123(1.20)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C123(0.94); C19(1.00); C34(1.00); C52(1.19)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C19(0.70); C34(0.70); C123(0.76); C261(1.00)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C19(0.78); C34(0.78); C123(0.85); C234(1.28)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C123(0.88); C19(1.05); C34(1.05); C52(1.20)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C261(0.84); C271(0.84); C72(0.93); C86(0.93)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C123(0.89); C52(1.31); C234(1.37); C72(1.56)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C123(0.76); C19(0.87); C34(0.87); C261(1.01)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C19(0.84); C34(0.84); C123(0.87); C72(1.00)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C19(0.68); C34(0.68); C123(0.87); C52(1.34)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C19(0.89); C34(0.89); C123(1.12); C52(1.23)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C123(0.98); C19(1.54); C234(1.45); C261(1.40)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C123(0.80); C19(1.51); C234(1.33); C261(1.73)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C123(1.06); C19(0.96); C234(1.30); C261(1.68)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C123(0.98); C19(1.09); C234(1.48); C261(1.35)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C123(1.02); C19(0.91); C234(1.41); C261(1.48)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C123(1.10); C19(1.49); C212(0.97); C234(0.99)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C123(0.91); C19(1.09); C234(1.34); C261(1.52)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C123(0.84); C19(1.03); C234(1.10); C261(0.69)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C123(1.02); C19(0.64); C234(1.23); C261(1.84)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C123(0.70); C19(0.65); C234(1.02); C261(0.62)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C123(0.92); C19(1.24); C234(1.31); C261(0.72)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C123(0.85); C19(1.40); C234(1.32); C261(1.30)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C123(1.03); C19(1.41); C234(1.18); C261(1.09)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C123(0.95); C19(0.90); C234(1.29); C261(0.82)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C123(0.82); C19(1.35); C234(1.34); C261(0.56)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C123(1.16); C19(1.45); C212(0.95); C234(0.91)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C123(0.85); C19(1.07); C234(1.21); C261(0.78)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C123(1.01); C19(0.88); C234(1.16); C261(0.81)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C123(0.78); C19(0.58); C234(1.50); C261(0.51)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C123(1.00); C19(0.98); C234(1.29); C261(0.88)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C123(0.89); C19(0.93); C234(1.20); C261(0.79)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C123(0.98); C19(0.86); C234(1.39); C261(0.73)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C123(1.00); C212(1.04); C234(0.92); C52(1.12)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C123(1.31); C212(0.75); C234(0.92); C52(1.01)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C123(1.17); C212(0.86); C234(0.88); C52(0.94)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C123(1.02); C212(0.87); C234(0.95); C52(0.99)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C123(1.21); C19(1.17); C212(1.29); C234(1.01)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C123(1.33); C212(0.78); C234(0.85); C52(0.89)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C123(1.07); C212(0.70); C234(0.93); C52(1.00)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C123(1.14); C212(0.72); C234(0.96); C52(1.04)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C123(0.97); C212(0.64); C234(0.71); C52(0.87)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C123(0.95); C212(0.62); C234(0.80); C52(0.98)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C123(1.42); C212(0.82); C234(0.80); C52(1.05)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C123(1.46); C212(0.74); C234(1.04); C52(1.14)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C123(1.56); C212(0.79); C234(0.92); C52(0.96)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C123(1.16); C212(1.13); C234(0.87); C52(1.04)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C123(1.19); C212(0.88); C234(0.91); C52(1.05)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C123(1.14); C19(1.17); C212(1.05); C234(1.04)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C123(1.32); C212(0.89); C234(0.95); C52(0.96)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C123(1.04); C212(1.12); C234(1.14); C52(1.16)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C123(1.12); C212(1.30); C234(1.15); C52(1.13)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C123(1.11); C212(1.25); C234(1.16); C52(1.07)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C123(1.13); C212(1.57); C234(1.35); C52(1.12)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C123(1.17); C212(1.00); C234(1.12); C52(1.12)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C123(0.96); C212(1.19); C234(1.50); C52(1.22)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C123(1.24); C212(0.99); C234(1.35); C52(1.14)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C123(1.09); C212(0.70); C234(1.37); C52(1.10)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C123(1.05); C212(0.90); C234(1.19); C52(1.03)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C123(1.30); C19(1.01); C212(1.34); C234(1.26)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C123(1.16); C212(0.90); C234(1.18); C52(1.14)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C123(1.10); C212(0.97); C234(1.20); C52(1.18)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C123(1.30); C212(1.12); C234(1.10); C52(1.14)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C123(1.02); C212(0.62); C234(1.24); C52(1.03)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C123(1.09); C212(0.82); C234(1.18); C52(1.12)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C123(0.83); C19(0.79); C212(0.81); C234(1.11)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C123(0.72); C19(0.83); C212(0.44); C234(0.98)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C123(0.79); C19(0.94); C212(0.74); C234(1.18)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C123(0.93); C19(1.12); C212(0.69); C234(1.20)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C123(0.98); C19(1.09); C212(0.45); C234(1.19)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C123(0.80); C19(0.83); C212(1.08); C234(1.18)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C123(0.84); C19(0.88); C212(1.03); C234(1.22)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C123(0.94); C19(0.78); C212(0.75); C234(1.41)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C123(0.81); C19(0.75); C212(0.70); C234(1.31)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C123(0.76); C19(0.52); C212(0.84); C234(1.59)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C123(0.82); C19(1.02); C212(0.68); C234(1.20)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C123(0.90); C19(0.73); C212(0.71); C234(1.16)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C123(0.87); C19(0.89); C212(0.68); C234(1.21)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C123(0.91); C19(0.73); C212(0.67); C234(1.34)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C123(0.87); C19(0.41); C212(0.63); C234(1.61)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C123(1.06); C19(1.15); C212(0.95); C234(1.11)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C123(0.60); C19(0.65); C212(0.37); C234(0.95)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C123(0.78); C19(0.75); C212(1.55); C234(1.07)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C123(0.70); C19(0.53); C212(1.08); C234(0.99)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C123(0.90); C19(0.86); C212(1.14); C234(1.03)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C123(0.89); C19(0.64); C212(0.98); C234(1.00)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C123(0.71); C19(0.66); C212(1.10); C234(1.12)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C123(0.91); C19(0.77); C212(1.40); C234(1.08)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C123(0.87); C19(0.80); C212(1.20); C234(1.08)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C123(0.79); C19(0.71); C212(2.07); C234(1.15)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C123(0.95); C19(0.66); C212(2.09); C234(1.18)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C212(0.82); C97(0.95); C234(0.92); C123(1.05)  LDD1698  [15]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C243(2.22); C123(1.07)  LDD1702  [4]
 LDCM0625  F8 Ramos C212(1.20); C52(0.88); C123(1.08); C97(1.31)  LDD2187  [16]
 LDCM0572  Fragment10 Ramos C212(0.68); C52(0.59); C123(0.69); C97(0.70)  LDD2189  [16]
 LDCM0573  Fragment11 Ramos C212(0.72); C52(0.26); C123(5.98); C97(0.15)  LDD2190  [16]
 LDCM0574  Fragment12 Ramos C212(1.10); C52(0.66); C123(0.65); C97(0.66)  LDD2191  [16]
 LDCM0575  Fragment13 Ramos C212(0.90); C52(0.93); C123(1.13); C97(0.83)  LDD2192  [16]
 LDCM0576  Fragment14 Ramos C212(0.47); C52(0.70); C123(1.05); C97(0.96)  LDD2193  [16]
 LDCM0579  Fragment20 Ramos C212(0.79); C52(0.70); C123(0.71); C97(0.68)  LDD2194  [16]
 LDCM0580  Fragment21 Ramos C212(0.86); C52(0.95); C123(0.83); C97(0.96)  LDD2195  [16]
 LDCM0582  Fragment23 Ramos C212(0.95); C52(0.79); C123(0.67); C97(0.72)  LDD2196  [16]
 LDCM0578  Fragment27 Ramos C212(0.95); C52(1.16); C123(0.89); C97(1.08)  LDD2197  [16]
 LDCM0586  Fragment28 Ramos C212(0.48); C52(1.10); C123(0.74); C97(1.02)  LDD2198  [16]
 LDCM0588  Fragment30 Ramos C212(1.52); C52(0.98); C123(0.99); C97(0.91)  LDD2199  [16]
 LDCM0589  Fragment31 Ramos C212(1.52); C52(1.19); C123(1.01); C97(0.86)  LDD2200  [16]
 LDCM0590  Fragment32 Ramos C212(1.12); C52(0.55); C123(0.48); C97(0.49)  LDD2201  [16]
 LDCM0468  Fragment33 HCT 116 C123(1.03); C212(1.20); C234(1.21); C52(1.22)  LDD0785  [6]
 LDCM0596  Fragment38 Ramos C212(1.23); C52(0.98); C123(0.83); C97(0.86)  LDD2203  [16]
 LDCM0566  Fragment4 Ramos C212(0.85); C52(0.82); C123(1.05); C97(0.72)  LDD2184  [16]
 LDCM0427  Fragment51 HCT 116 C123(0.79); C19(0.79); C234(1.35); C261(0.70)  LDD0744  [6]
 LDCM0610  Fragment52 Ramos C212(1.54); C52(1.26); C123(1.27); C97(0.85)  LDD2204  [16]
 LDCM0614  Fragment56 Ramos C212(3.01); C52(1.04); C123(1.14); C97(0.97)  LDD2205  [16]
 LDCM0569  Fragment7 Ramos C212(0.70); C52(0.73); C123(0.94); C97(1.05)  LDD2186  [16]
 LDCM0571  Fragment9 Ramos C212(0.57); C52(0.67); C123(0.75); C97(0.66)  LDD2188  [16]
 LDCM0107  IAA HeLa C123(0.00); H60(0.00); C52(0.00); C97(0.00)  LDD0221  [13]
 LDCM0022  KB02 HCT 116 C123(1.34); C261(1.62); C271(1.62); C72(1.69)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C123(1.32); C261(1.30); C271(1.30); C72(1.24)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C123(1.90); C261(1.26); C271(1.26); C72(1.25)  LDD0082  [6]
 LDCM0109  NEM HeLa N.A.  LDD0223  [13]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C212(0.96)  LDD2107  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C212(1.31)  LDD2136  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C243(0.57)  LDD2206  [17]
 LDCM0628  OTUB2-COV-1 HEK-293T C243(1.42); C97(1.41); C123(0.97)  LDD2207  [17]
 LDCM0131  RA190 MM1.R C72(1.43); C52(1.11)  LDD0304  [18]
 LDCM0021  THZ1 HCT 116 C234(0.94); C52(0.94); C19(1.04); C34(1.04)  LDD2173  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
General transcription and DNA repair factor IIH helicase subunit XPD (ERCC2) Helicase family P18074
S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 (RSAD2) RSAD2 family Q8WXG1
DNA topoisomerase 3-beta-1 (TOP3B) Type IA topoisomerase family O95985
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sodium bicarbonate cotransporter 3 (SLC4A7) Anion exchanger (TC 2.A.31) family Q9Y6M7
Membrane-associated progesterone receptor component 1 (PGRMC1) Cytochrome b5 family O00264
Protein shisa-6 (SHISA6) Shisa family Q6ZSJ9
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein MOX-1 (MEOX1) . P50221
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Splicing factor 1 (SF1) BBP/SF1 family Q15637
HAUS augmin-like complex subunit 3 (HAUS3) HAUS3 family Q68CZ6
MMS19 nucleotide excision repair protein homolog (MMS19) MET18/MMS19 family Q96T76
Cytosolic iron-sulfur assembly component 2A (CIAO2A) MIP18 family Q9H5X1
Cytosolic iron-sulfur assembly component 2B (CIAO2B) MIP18 family Q9Y3D0
T-complex protein 10A homolog 1 (TCP10L) TCP10 family Q8TDR4
Ankyrin repeat domain-containing protein 55 (ANKRD55) . Q3KP44
Regulator of G-protein signaling 2 (RGS2) . P41220

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
12 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
17 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
18 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.