Details of the Target

General Information of Target

Target ID LDTP08621
Target Name Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6 (PLPP6)
Gene Name PLPP6
Gene ID 403313
Synonyms
PDP1; PPAPDC2; Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6; EC 3.1.3.-; EC 3.6.1.-; EC 3.6.1.68; Lipid phosphatase-related protein-B; LPRP-B; PA-PSP; Phosphatidic acid phosphatase type 2 domain-containing protein 2; PPAP2 domain-containing protein 2; Phospholipid phosphatase 6; Presqualene diphosphate phosphatase; Type 1 polyisoprenoid diphosphate phosphatase
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MPSPRRSMEGRPLGVSASSSSSSPGSPAHGGGGGGSRFEFQSLLSSRATAVDPTCARLRA
SESPVHRRGSFPLAAAGPSQSPAPPLPEEDRMDLNPSFLGIALRSLLAIDLWLSKKLGVC
AGESSSWGSVRPLMKLLEISGHGIPWLLGTLYCLCRSDSWAGREVLMNLLFALLLDLLLV
ALIKGLVRRRRPAHNQMDMFVTLSVDKYSFPSGHATRAALMSRFILNHLVLAIPLRVLVV
LWAFVLGLSRVMLGRHNVTDVAFGFFLGYMQYSIVDYCWLSPHNAPVLFLLWSQR
Target Bioclass
Enzyme
Family
PA-phosphatase related phosphoesterase family
Subcellular location
Endoplasmic reticulum membrane
Function
Magnesium-independent polyisoprenoid diphosphatase that catalyzes the sequential dephosphorylation of presqualene, farnesyl, geranyl and geranylgeranyl diphosphates. Functions in the innate immune response through the dephosphorylation of presqualene diphosphate which acts as a potent inhibitor of the signaling pathways contributing to polymorphonuclear neutrophils activation. May regulate the biosynthesis of cholesterol and related sterols by dephosphorylating presqualene and farnesyl diphosphate, two key intermediates in this biosynthetic pathway. May also play a role in protein prenylation by acting on farnesyl diphosphate and its derivative geranylgeranyl diphosphate, two precursors for the addition of isoprenoid anchors to membrane proteins. Has a lower activity towards phosphatidic acid (PA), but through phosphatidic acid dephosphorylation may participate in the biosynthesis of phospholipids and triacylglycerols. May also act on ceramide-1-P, lysophosphatidic acid (LPA) and sphing-4-enine 1-phosphate/sphingosine-1-phosphate.
Uniprot ID
Q8IY26
Ensemble ID
ENST00000381883.5
HGNC ID
HGNC:23682

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C55(2.51)  LDD0170  [1]
DBIA
 Probe Info  		C55(0.91)  LDD0078  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
NAIA_5
 Probe Info  		N.A.  LDD2224  [4]
TFBX
 Probe Info  		N.A.  LDD0027  [5]
WYneN
 Probe Info  		N.A.  LDD0021  [6]
DA-P3
 Probe Info  		N.A.  LDD0178  [7]
IPM
 Probe Info  		C55(0.00); C120(0.00)  LDD0005  [6]
W1
 Probe Info  		N.A.  LDD0236  [8]
AOyne
 Probe Info  		15.00  LDD0443  [9]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OEA-DA
 Probe Info  		13.82  LDD0046  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C55(2.51)  LDD0170  [1]
 LDCM0026  4SU-RNA+native RNA DM93 C55(2.45)  LDD0171  [1]
 LDCM0214  AC1 HEK-293T C55(1.15); C153(1.02)  LDD1507  [11]
 LDCM0215  AC10 HEK-293T C55(0.97); C120(0.98)  LDD1508  [11]
 LDCM0226  AC11 HEK-293T C55(0.99); C120(1.00)  LDD1509  [11]
 LDCM0237  AC12 HEK-293T C55(0.99); C120(0.94)  LDD1510  [11]
 LDCM0259  AC14 HEK-293T C55(1.13); C120(0.92)  LDD1512  [11]
 LDCM0270  AC15 HEK-293T C55(1.01); C120(0.95)  LDD1513  [11]
 LDCM0276  AC17 HEK-293T C55(1.06); C153(1.09)  LDD1515  [11]
 LDCM0277  AC18 HEK-293T C55(1.03); C120(0.99)  LDD1516  [11]
 LDCM0278  AC19 HEK-293T C55(1.06); C120(1.25)  LDD1517  [11]
 LDCM0279  AC2 HEK-293T C55(1.03); C120(1.06)  LDD1518  [11]
 LDCM0280  AC20 HEK-293T C55(1.02); C120(1.02)  LDD1519  [11]
 LDCM0281  AC21 HEK-293T C55(1.08); C120(0.80)  LDD1520  [11]
 LDCM0282  AC22 HEK-293T C55(1.11); C120(1.10)  LDD1521  [11]
 LDCM0283  AC23 HEK-293T C55(1.06); C120(0.93)  LDD1522  [11]
 LDCM0284  AC24 HEK-293T C55(1.02); C120(0.89)  LDD1523  [11]
 LDCM0285  AC25 HEK-293T C55(1.12); C153(1.27)  LDD1524  [11]
 LDCM0286  AC26 HEK-293T C55(0.95); C120(0.93)  LDD1525  [11]
 LDCM0287  AC27 HEK-293T C55(1.01); C120(0.94)  LDD1526  [11]
 LDCM0288  AC28 HEK-293T C55(1.05); C120(0.85)  LDD1527  [11]
 LDCM0289  AC29 HEK-293T C55(1.04); C120(0.87)  LDD1528  [11]
 LDCM0290  AC3 HEK-293T C55(0.99); C120(1.08)  LDD1529  [11]
 LDCM0291  AC30 HEK-293T C55(1.07); C120(0.95)  LDD1530  [11]
 LDCM0292  AC31 HEK-293T C55(1.01); C120(1.07)  LDD1531  [11]
 LDCM0293  AC32 HEK-293T C55(0.97); C120(0.95)  LDD1532  [11]
 LDCM0294  AC33 HEK-293T C55(1.10); C153(1.03)  LDD1533  [11]
 LDCM0295  AC34 HEK-293T C55(1.01); C120(1.09)  LDD1534  [11]
 LDCM0296  AC35 HEK-293T C55(1.01); C120(0.96)  LDD1535  [11]
 LDCM0297  AC36 HEK-293T C55(1.04); C120(0.95)  LDD1536  [11]
 LDCM0298  AC37 HEK-293T C55(1.02); C120(0.76)  LDD1537  [11]
 LDCM0299  AC38 HEK-293T C55(1.13); C120(0.90)  LDD1538  [11]
 LDCM0300  AC39 HEK-293T C55(1.08); C120(1.01)  LDD1539  [11]
 LDCM0301  AC4 HEK-293T C55(1.04); C120(1.06)  LDD1540  [11]
 LDCM0302  AC40 HEK-293T C55(1.04); C120(1.00)  LDD1541  [11]
 LDCM0303  AC41 HEK-293T C55(1.11); C153(1.15)  LDD1542  [11]
 LDCM0304  AC42 HEK-293T C55(1.05); C120(1.00)  LDD1543  [11]
 LDCM0305  AC43 HEK-293T C55(0.97); C120(0.97)  LDD1544  [11]
 LDCM0306  AC44 HEK-293T C55(1.01); C120(1.00)  LDD1545  [11]
 LDCM0307  AC45 HEK-293T C55(1.13); C120(0.76)  LDD1546  [11]
 LDCM0308  AC46 HEK-293T C55(1.14); C120(0.87)  LDD1547  [11]
 LDCM0309  AC47 HEK-293T C55(1.08); C120(1.07)  LDD1548  [11]
 LDCM0310  AC48 HEK-293T C55(1.18); C120(0.99)  LDD1549  [11]
 LDCM0311  AC49 HEK-293T C55(1.02); C153(1.06)  LDD1550  [11]
 LDCM0312  AC5 HEK-293T C55(1.07); C120(0.95)  LDD1551  [11]
 LDCM0313  AC50 HEK-293T C55(1.07); C120(1.00)  LDD1552  [11]
 LDCM0314  AC51 HEK-293T C55(1.01); C120(0.99)  LDD1553  [11]
 LDCM0315  AC52 HEK-293T C55(1.04); C120(0.98)  LDD1554  [11]
 LDCM0316  AC53 HEK-293T C55(1.00); C120(0.84)  LDD1555  [11]
 LDCM0317  AC54 HEK-293T C55(1.17); C120(1.04)  LDD1556  [11]
 LDCM0318  AC55 HEK-293T C55(1.10); C120(1.08)  LDD1557  [11]
 LDCM0319  AC56 HEK-293T C55(1.11); C120(1.01)  LDD1558  [11]
 LDCM0320  AC57 HEK-293T C55(1.07); C153(1.08)  LDD1559  [11]
 LDCM0321  AC58 HEK-293T C55(1.01); C120(0.99)  LDD1560  [11]
 LDCM0322  AC59 HEK-293T C55(0.96); C120(0.92)  LDD1561  [11]
 LDCM0323  AC6 HEK-293T C55(1.03); C120(1.07)  LDD1562  [11]
 LDCM0324  AC60 HEK-293T C55(1.05); C120(0.98)  LDD1563  [11]
 LDCM0325  AC61 HEK-293T C55(1.05); C120(0.82)  LDD1564  [11]
 LDCM0326  AC62 HEK-293T C55(1.11); C120(1.05)  LDD1565  [11]
 LDCM0327  AC63 HEK-293T C55(1.03); C120(1.13)  LDD1566  [11]
 LDCM0328  AC64 HEK-293T C55(1.15); C120(1.06)  LDD1567  [11]
 LDCM0334  AC7 HEK-293T C55(1.00); C120(0.98)  LDD1568  [11]
 LDCM0345  AC8 HEK-293T C55(1.04); C120(1.02)  LDD1569  [11]
 LDCM0248  AKOS034007472 HEK-293T C55(1.11); C120(0.75)  LDD1511  [11]
 LDCM0356  AKOS034007680 HEK-293T C55(1.10); C153(1.16)  LDD1570  [11]
 LDCM0275  AKOS034007705 HEK-293T C55(1.05); C120(0.98)  LDD1514  [11]
 LDCM0020  ARS-1620 HCC44 C55(0.91)  LDD0078  [2]
 LDCM0632  CL-Sc Hep-G2 C55(0.83)  LDD2227  [4]
 LDCM0367  CL1 HEK-293T C55(0.97)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C55(1.08); C120(1.21)  LDD1572  [11]
 LDCM0369  CL100 HEK-293T C55(0.89); C120(1.08); C153(1.02)  LDD1573  [11]
 LDCM0370  CL101 HEK-293T C55(1.03)  LDD1574  [11]
 LDCM0371  CL102 HEK-293T C55(0.95); C120(1.25)  LDD1575  [11]
 LDCM0372  CL103 HEK-293T C120(0.98)  LDD1576  [11]
 LDCM0373  CL104 HEK-293T C55(0.96); C120(1.06); C153(1.11)  LDD1577  [11]
 LDCM0374  CL105 HEK-293T C55(1.05)  LDD1578  [11]
 LDCM0375  CL106 HEK-293T C55(1.05); C120(1.00)  LDD1579  [11]
 LDCM0376  CL107 HEK-293T C120(0.98)  LDD1580  [11]
 LDCM0377  CL108 HEK-293T C55(0.91); C120(0.96); C153(1.18)  LDD1581  [11]
 LDCM0378  CL109 HEK-293T C55(0.99)  LDD1582  [11]
 LDCM0379  CL11 HEK-293T C55(1.06); C120(0.96)  LDD1583  [11]
 LDCM0380  CL110 HEK-293T C55(0.90); C120(1.19)  LDD1584  [11]
 LDCM0381  CL111 HEK-293T C120(1.11)  LDD1585  [11]
 LDCM0382  CL112 HEK-293T C55(1.19); C120(1.08); C153(0.93)  LDD1586  [11]
 LDCM0383  CL113 HEK-293T C55(1.04)  LDD1587  [11]
 LDCM0384  CL114 HEK-293T C55(1.00); C120(1.56)  LDD1588  [11]
 LDCM0385  CL115 HEK-293T C120(0.87)  LDD1589  [11]
 LDCM0386  CL116 HEK-293T C55(0.99); C120(0.98); C153(0.97)  LDD1590  [11]
 LDCM0387  CL117 HEK-293T C55(1.04)  LDD1591  [11]
 LDCM0388  CL118 HEK-293T C55(0.89); C120(1.09)  LDD1592  [11]
 LDCM0389  CL119 HEK-293T C120(0.92)  LDD1593  [11]
 LDCM0390  CL12 HEK-293T C55(1.03); C120(0.88)  LDD1594  [11]
 LDCM0391  CL120 HEK-293T C55(1.01); C120(1.00); C153(1.14)  LDD1595  [11]
 LDCM0392  CL121 HEK-293T C55(1.10)  LDD1596  [11]
 LDCM0393  CL122 HEK-293T C55(0.95); C120(1.21)  LDD1597  [11]
 LDCM0394  CL123 HEK-293T C120(1.12)  LDD1598  [11]
 LDCM0395  CL124 HEK-293T C55(1.04); C120(1.06); C153(1.20)  LDD1599  [11]
 LDCM0396  CL125 HEK-293T C55(1.02)  LDD1600  [11]
 LDCM0397  CL126 HEK-293T C55(0.92); C120(1.24)  LDD1601  [11]
 LDCM0398  CL127 HEK-293T C120(1.12)  LDD1602  [11]
 LDCM0399  CL128 HEK-293T C55(0.96); C120(1.15); C153(1.01)  LDD1603  [11]
 LDCM0400  CL13 HEK-293T C55(1.14)  LDD1604  [11]
 LDCM0401  CL14 HEK-293T C55(1.00); C120(1.20)  LDD1605  [11]
 LDCM0402  CL15 HEK-293T C120(1.06)  LDD1606  [11]
 LDCM0403  CL16 HEK-293T C55(0.91); C120(0.97); C153(1.08)  LDD1607  [11]
 LDCM0404  CL17 HEK-293T C55(1.13); C153(1.08)  LDD1608  [11]
 LDCM0405  CL18 HEK-293T C55(1.05); C120(0.92)  LDD1609  [11]
 LDCM0406  CL19 HEK-293T C55(1.14); C120(0.77)  LDD1610  [11]
 LDCM0407  CL2 HEK-293T C55(0.91); C120(1.10)  LDD1611  [11]
 LDCM0408  CL20 HEK-293T C55(1.07); C120(0.68)  LDD1612  [11]
 LDCM0409  CL21 HEK-293T C55(1.04); C120(0.73)  LDD1613  [11]
 LDCM0410  CL22 HEK-293T C55(1.19); C120(0.77)  LDD1614  [11]
 LDCM0411  CL23 HEK-293T C55(1.06); C120(0.80)  LDD1615  [11]
 LDCM0412  CL24 HEK-293T C55(1.18); C120(0.77)  LDD1616  [11]
 LDCM0413  CL25 HEK-293T C55(1.03)  LDD1617  [11]
 LDCM0414  CL26 HEK-293T C55(0.90); C120(1.03)  LDD1618  [11]
 LDCM0415  CL27 HEK-293T C120(0.93)  LDD1619  [11]
 LDCM0416  CL28 HEK-293T C55(1.14); C120(0.87); C153(1.18)  LDD1620  [11]
 LDCM0417  CL29 HEK-293T C55(1.01); C153(1.22)  LDD1621  [11]
 LDCM0418  CL3 HEK-293T C120(1.07)  LDD1622  [11]
 LDCM0419  CL30 HEK-293T C55(0.96); C120(0.90)  LDD1623  [11]
 LDCM0420  CL31 HEK-293T C55(1.03); C120(0.85)  LDD1624  [11]
 LDCM0421  CL32 HEK-293T C55(1.00); C120(0.79)  LDD1625  [11]
 LDCM0422  CL33 HEK-293T C55(1.07); C120(1.06)  LDD1626  [11]
 LDCM0423  CL34 HEK-293T C55(1.18); C120(0.78)  LDD1627  [11]
 LDCM0424  CL35 HEK-293T C55(1.18); C120(0.78)  LDD1628  [11]
 LDCM0425  CL36 HEK-293T C55(1.09); C120(0.77)  LDD1629  [11]
 LDCM0426  CL37 HEK-293T C55(0.98)  LDD1630  [11]
 LDCM0428  CL39 HEK-293T C120(0.88)  LDD1632  [11]
 LDCM0429  CL4 HEK-293T C55(0.85); C120(0.98); C153(1.07)  LDD1633  [11]
 LDCM0430  CL40 HEK-293T C55(0.92); C120(0.92); C153(1.09)  LDD1634  [11]
 LDCM0431  CL41 HEK-293T C55(1.10); C153(1.11)  LDD1635  [11]
 LDCM0432  CL42 HEK-293T C55(0.97); C120(0.82)  LDD1636  [11]
 LDCM0433  CL43 HEK-293T C55(1.01); C120(0.84)  LDD1637  [11]
 LDCM0434  CL44 HEK-293T C55(1.12); C120(0.77)  LDD1638  [11]
 LDCM0435  CL45 HEK-293T C55(1.09); C120(0.68)  LDD1639  [11]
 LDCM0436  CL46 HEK-293T C55(1.11); C120(0.77)  LDD1640  [11]
 LDCM0437  CL47 HEK-293T C55(1.08); C120(0.86)  LDD1641  [11]
 LDCM0438  CL48 HEK-293T C55(1.19); C120(0.90)  LDD1642  [11]
 LDCM0439  CL49 HEK-293T C55(1.08)  LDD1643  [11]
 LDCM0440  CL5 HEK-293T C55(1.10); C153(1.03)  LDD1644  [11]
 LDCM0441  CL50 HEK-293T C55(0.89); C120(1.15)  LDD1645  [11]
 LDCM0443  CL52 HEK-293T C55(0.87); C120(0.89); C153(1.11)  LDD1646  [11]
 LDCM0444  CL53 HEK-293T C55(1.16); C153(1.19)  LDD1647  [11]
 LDCM0445  CL54 HEK-293T C55(1.11); C120(1.12)  LDD1648  [11]
 LDCM0446  CL55 HEK-293T C55(1.05); C120(0.87)  LDD1649  [11]
 LDCM0447  CL56 HEK-293T C55(1.06); C120(0.78)  LDD1650  [11]
 LDCM0448  CL57 HEK-293T C55(1.07); C120(0.79)  LDD1651  [11]
 LDCM0449  CL58 HEK-293T C55(1.26); C120(0.79)  LDD1652  [11]
 LDCM0450  CL59 HEK-293T C55(1.16); C120(0.91)  LDD1653  [11]
 LDCM0451  CL6 HEK-293T C55(1.02); C120(1.20)  LDD1654  [11]
 LDCM0452  CL60 HEK-293T C55(1.20); C120(0.69)  LDD1655  [11]
 LDCM0453  CL61 HEK-293T C55(1.04)  LDD1656  [11]
 LDCM0454  CL62 HEK-293T C55(0.98); C120(0.97)  LDD1657  [11]
 LDCM0455  CL63 HEK-293T C120(1.02)  LDD1658  [11]
 LDCM0456  CL64 HEK-293T C55(0.96); C120(1.15); C153(1.32)  LDD1659  [11]
 LDCM0457  CL65 HEK-293T C55(1.18); C153(1.19)  LDD1660  [11]
 LDCM0458  CL66 HEK-293T C55(1.03); C120(0.90)  LDD1661  [11]
 LDCM0459  CL67 HEK-293T C55(0.98); C120(0.85)  LDD1662  [11]
 LDCM0460  CL68 HEK-293T C55(1.02); C120(0.79)  LDD1663  [11]
 LDCM0461  CL69 HEK-293T C55(1.03); C120(0.78)  LDD1664  [11]
 LDCM0462  CL7 HEK-293T C55(1.13); C120(0.87)  LDD1665  [11]
 LDCM0463  CL70 HEK-293T C55(1.16); C120(0.74)  LDD1666  [11]
 LDCM0464  CL71 HEK-293T C55(1.02); C120(0.84)  LDD1667  [11]
 LDCM0465  CL72 HEK-293T C55(1.10); C120(0.89)  LDD1668  [11]
 LDCM0466  CL73 HEK-293T C55(1.00)  LDD1669  [11]
 LDCM0467  CL74 HEK-293T C55(1.01); C120(1.05)  LDD1670  [11]
 LDCM0469  CL76 HEK-293T C55(1.06); C120(1.00); C153(1.09)  LDD1672  [11]
 LDCM0470  CL77 HEK-293T C55(1.12); C153(1.04)  LDD1673  [11]
 LDCM0471  CL78 HEK-293T C55(1.03); C120(0.96)  LDD1674  [11]
 LDCM0472  CL79 HEK-293T C55(0.97); C120(0.81)  LDD1675  [11]
 LDCM0473  CL8 HEK-293T C55(1.14); C120(2.57)  LDD1676  [11]
 LDCM0474  CL80 HEK-293T C55(0.95); C120(0.75)  LDD1677  [11]
 LDCM0475  CL81 HEK-293T C55(1.14); C120(0.71)  LDD1678  [11]
 LDCM0476  CL82 HEK-293T C55(1.12); C120(0.83)  LDD1679  [11]
 LDCM0477  CL83 HEK-293T C55(1.05); C120(0.93)  LDD1680  [11]
 LDCM0478  CL84 HEK-293T C55(1.27); C120(0.95)  LDD1681  [11]
 LDCM0479  CL85 HEK-293T C55(1.01)  LDD1682  [11]
 LDCM0480  CL86 HEK-293T C55(0.99); C120(1.36)  LDD1683  [11]
 LDCM0481  CL87 HEK-293T C120(1.09)  LDD1684  [11]
 LDCM0482  CL88 HEK-293T C55(0.92); C120(1.08); C153(0.91)  LDD1685  [11]
 LDCM0483  CL89 HEK-293T C55(1.11); C153(0.92)  LDD1686  [11]
 LDCM0484  CL9 HEK-293T C55(1.04); C120(0.68)  LDD1687  [11]
 LDCM0485  CL90 HEK-293T C55(1.25); C120(1.67)  LDD1688  [11]
 LDCM0486  CL91 HEK-293T C55(0.74); C120(0.94)  LDD1689  [11]
 LDCM0487  CL92 HEK-293T C55(1.10); C120(0.92)  LDD1690  [11]
 LDCM0488  CL93 HEK-293T C55(1.04); C120(0.90)  LDD1691  [11]
 LDCM0489  CL94 HEK-293T C55(1.14); C120(0.93)  LDD1692  [11]
 LDCM0490  CL95 HEK-293T C55(1.01); C120(1.65)  LDD1693  [11]
 LDCM0491  CL96 HEK-293T C55(1.60); C120(1.09)  LDD1694  [11]
 LDCM0492  CL97 HEK-293T C55(0.94)  LDD1695  [11]
 LDCM0493  CL98 HEK-293T C55(1.01); C120(1.10)  LDD1696  [11]
 LDCM0494  CL99 HEK-293T C120(0.99)  LDD1697  [11]
 LDCM0634  CY-0357 Hep-G2 C55(2.37)  LDD2228  [4]
 LDCM0495  E2913 HEK-293T C120(0.91)  LDD1698  [11]
 LDCM0625  F8 Ramos C55(1.68)  LDD2187  [12]
 LDCM0572  Fragment10 Ramos C55(2.26)  LDD2189  [12]
 LDCM0573  Fragment11 Ramos C55(0.27)  LDD2190  [12]
 LDCM0574  Fragment12 Ramos C55(1.62)  LDD2191  [12]
 LDCM0575  Fragment13 Ramos C55(0.79)  LDD2192  [12]
 LDCM0576  Fragment14 Ramos C55(2.30)  LDD2193  [12]
 LDCM0580  Fragment21 Ramos C55(0.82)  LDD2195  [12]
 LDCM0582  Fragment23 Ramos C55(0.54)  LDD2196  [12]
 LDCM0578  Fragment27 Ramos C55(0.69)  LDD2197  [12]
 LDCM0586  Fragment28 Ramos C55(0.55)  LDD2198  [12]
 LDCM0588  Fragment30 Ramos C55(1.14)  LDD2199  [12]
 LDCM0589  Fragment31 Ramos C55(0.87)  LDD2200  [12]
 LDCM0590  Fragment32 Ramos C55(2.99)  LDD2201  [12]
 LDCM0468  Fragment33 HEK-293T C120(1.12)  LDD1671  [11]
 LDCM0596  Fragment38 Ramos C55(0.83)  LDD2203  [12]
 LDCM0566  Fragment4 Ramos C55(2.03)  LDD2184  [12]
 LDCM0427  Fragment51 HEK-293T C55(1.06); C120(1.12)  LDD1631  [11]
 LDCM0610  Fragment52 Ramos C55(0.97)  LDD2204  [12]
 LDCM0614  Fragment56 Ramos C55(1.32)  LDD2205  [12]
 LDCM0569  Fragment7 Ramos C55(2.73)  LDD2186  [12]
 LDCM0571  Fragment9 Ramos C55(2.87)  LDD2188  [12]
 LDCM0022  KB02 HEK-293T C55(0.97)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C55(1.03)  LDD1497  [11]
 LDCM0024  KB05 COLO792 C157(1.45)  LDD3310  [13]
 LDCM0627  NUDT7-COV-1 HEK-293T C55(1.01)  LDD2206  [14]
 LDCM0628  OTUB2-COV-1 HEK-293T C55(0.94)  LDD2207  [14]
 LDCM0112  W16 Hep-G2 C55(0.55)  LDD0239  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Catechol O-methyltransferase (COMT) Cation-dependent O-methyltransferase family P21964
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
Probable glutathione peroxidase 8 (GPX8) Glutathione peroxidase family Q8TED1
Signal peptidase complex catalytic subunit SEC11C (SEC11C) Peptidase S26B family Q9BY50
Phosphatase and actin regulator 3 (PHACTR3) Phosphatase and actin regulator family Q96KR7
E3 ubiquitin-protein ligase RNF5 (RNF5) RNF5 family Q99942
Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) . Q9Y680
Transporter and channel
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Solute carrier family 7 member 14 (SLC7A14) Cationic amino acid transporter (CAT) (TC 2.A.3.3) family Q8TBB6
Gastrokine-1 (GKN1) Gastrokine family Q9NS71
ER membrane protein complex subunit 5 (MMGT1) Membrane magnesium transporter (TC 1.A.67) family Q8N4V1
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Aquaporin-8 (AQP8) MIP/aquaporin (TC 1.A.8) family O94778
Membrane-spanning 4-domains subfamily A member 3 (MS4A3) MS4A family Q96HJ5
Syntaxin-1A (STX1A) Syntaxin family Q16623
Transmembrane protein 106C (TMEM106C) TMEM106 family Q9BVX2
C-type lectin domain family 4 member M (CLEC4M) . Q9H2X3
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) BZIP family Q96BA8
Immunoglobulin
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amphoterin-induced protein 1 (AMIGO1) AMIGO family Q86WK6
Sialic acid-binding Ig-like lectin 12 (SIGLEC12) SIGLEC (sialic acid binding Ig-like lectin) family Q96PQ1
Poliovirus receptor (PVR) Nectin family P15151
B-cell antigen receptor complex-associated protein alpha chain (CD79A) . P11912
Natural cytotoxicity triggering receptor 3 ligand 1 (NCR3LG1) . Q68D85
V-type immunoglobulin domain-containing suppressor of T-cell activation (VSIR) . Q9H7M9
Cytokine and receptor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Prolactin receptor (PRLR) Type I cytokine receptor family P16471
Interleukin-13 receptor subunit alpha-2 (IL13RA2) Type I cytokine receptor family Q14627
Interleukin-10 receptor subunit alpha (IL10RA) Type II cytokine receptor family Q13651
Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D) . Q9UBN6
Other
Click To Hide/Show 17 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Claudin-9 (CLDN9) Claudin family O95484
Gap junction beta-5 protein (GJB5) Connexin family O95377
Membrane protein FAM174A (FAM174A) FAM174 family Q8TBP5
Protein FAM209A (FAM209A) FAM209 family Q5JX71
Protein FAM210B, mitochondrial (FAM210B) FAM210 family Q96KR6
RAB6-interacting golgin (GORAB) GORAB family Q5T7V8
Low-density lipoprotein receptor class A domain-containing protein 1 (LDLRAD1) LDLR family Q5T700
Cytosolic iron-sulfur assembly component 2A (CIAO2A) MIP18 family Q9H5X1
Reticulophagy regulator 3 (RETREG3) RETREG family Q86VR2
Protein shisa-like-1 (SHISAL1) Shisa family Q3SXP7
Small cell adhesion glycoprotein (SMAGP) SMAGP family Q0VAQ4
Synaptoporin (SYNPR) Synaptophysin/synaptobrevin family Q8TBG9
Fertilization-influencing membrane protein (FIMP) . Q96LL3
Fibronectin type III domain-containing protein 9 (FNDC9) . Q8TBE3
PDZK1-interacting protein 1 (PDZK1IP1) . Q13113
Protein KASH5 (KASH5) . Q8N6L0
Serine-rich single-pass membrane protein 1 (SSMEM1) . Q8WWF3

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
8 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
14 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.