Details of the Target

General Information of Target

Target ID LDTP15388
Target Name Centromere protein L (CENPL)
Gene Name CENPL
Gene ID 91687
Synonyms
C1orf155; ICEN33; Centromere protein L; CENP-L; Interphase centromere complex protein 33
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEEPQRARSHTVTTTASSFAENFSTSSSSFAYDREFLRTLPGFLIVAEIVLGLLVWTLIA
GTEYFRVPAFGWVMFVAVFYWVLTVFFLIIYITMTYTRIPQVPWTTVGLCFNGSAFVLYL
SAAVVDASSVSPERDSHNFNSWAASSFFAFLVTICYAGNTYFSFIAWRSRTIQ
Target Bioclass
Other
Family
CENP-L/IML3 family
Subcellular location
Nucleus
Function
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.
Uniprot ID
Q8N0S6
Ensemble ID
ENST00000345664.10
HGNC ID
HGNC:17879

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.L287F .
HUCCT1 SNV: p.W199G .
LNCaP clone FGC SNV: p.A339T .
OVK18 SNV: p.P210H .
PF382 SNV: p.R30Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C52(5.02)  LDD0526  [1]
DBIA
 Probe Info  		C52(0.96)  LDD1492  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C52(1.30)  LDD1507  [2]
 LDCM0237  AC12 HEK-293T C52(1.05)  LDD1510  [2]
 LDCM0259  AC14 HEK-293T C52(1.01)  LDD1512  [2]
 LDCM0276  AC17 HEK-293T C52(1.10)  LDD1515  [2]
 LDCM0280  AC20 HEK-293T C52(1.06)  LDD1519  [2]
 LDCM0282  AC22 HEK-293T C52(1.00)  LDD1521  [2]
 LDCM0285  AC25 HEK-293T C52(1.11)  LDD1524  [2]
 LDCM0288  AC28 HEK-293T C52(0.97)  LDD1527  [2]
 LDCM0291  AC30 HEK-293T C52(0.96)  LDD1530  [2]
 LDCM0294  AC33 HEK-293T C52(1.28)  LDD1533  [2]
 LDCM0297  AC36 HEK-293T C52(1.02)  LDD1536  [2]
 LDCM0299  AC38 HEK-293T C52(0.93)  LDD1538  [2]
 LDCM0301  AC4 HEK-293T C52(0.93)  LDD1540  [2]
 LDCM0303  AC41 HEK-293T C52(1.31)  LDD1542  [2]
 LDCM0306  AC44 HEK-293T C52(1.05)  LDD1545  [2]
 LDCM0308  AC46 HEK-293T C52(0.98)  LDD1547  [2]
 LDCM0311  AC49 HEK-293T C52(1.28)  LDD1550  [2]
 LDCM0315  AC52 HEK-293T C52(0.99)  LDD1554  [2]
 LDCM0317  AC54 HEK-293T C52(1.00)  LDD1556  [2]
 LDCM0320  AC57 HEK-293T C52(1.12)  LDD1559  [2]
 LDCM0323  AC6 HEK-293T C52(1.06)  LDD1562  [2]
 LDCM0324  AC60 HEK-293T C52(0.89)  LDD1563  [2]
 LDCM0326  AC62 HEK-293T C52(1.00)  LDD1565  [2]
 LDCM0356  AKOS034007680 HEK-293T C52(1.20)  LDD1570  [2]
 LDCM0367  CL1 HEK-293T C52(0.99)  LDD1571  [2]
 LDCM0368  CL10 HEK-293T C52(1.07)  LDD1572  [2]
 LDCM0370  CL101 HEK-293T C52(1.05)  LDD1574  [2]
 LDCM0374  CL105 HEK-293T C52(0.99)  LDD1578  [2]
 LDCM0378  CL109 HEK-293T C52(1.07)  LDD1582  [2]
 LDCM0383  CL113 HEK-293T C52(0.98)  LDD1587  [2]
 LDCM0387  CL117 HEK-293T C52(0.94)  LDD1591  [2]
 LDCM0392  CL121 HEK-293T C52(1.00)  LDD1596  [2]
 LDCM0396  CL125 HEK-293T C52(1.00)  LDD1600  [2]
 LDCM0400  CL13 HEK-293T C52(1.03)  LDD1604  [2]
 LDCM0404  CL17 HEK-293T C52(1.15)  LDD1608  [2]
 LDCM0408  CL20 HEK-293T C52(0.84)  LDD1612  [2]
 LDCM0410  CL22 HEK-293T C52(1.17)  LDD1614  [2]
 LDCM0413  CL25 HEK-293T C52(0.90)  LDD1617  [2]
 LDCM0417  CL29 HEK-293T C52(1.02)  LDD1621  [2]
 LDCM0421  CL32 HEK-293T C52(0.97)  LDD1625  [2]
 LDCM0423  CL34 HEK-293T C52(1.01)  LDD1627  [2]
 LDCM0426  CL37 HEK-293T C52(0.91)  LDD1630  [2]
 LDCM0431  CL41 HEK-293T C52(1.08)  LDD1635  [2]
 LDCM0434  CL44 HEK-293T C52(0.88)  LDD1638  [2]
 LDCM0436  CL46 HEK-293T C52(1.14)  LDD1640  [2]
 LDCM0439  CL49 HEK-293T C52(0.89)  LDD1643  [2]
 LDCM0440  CL5 HEK-293T C52(1.17)  LDD1644  [2]
 LDCM0444  CL53 HEK-293T C52(1.27)  LDD1647  [2]
 LDCM0447  CL56 HEK-293T C52(0.97)  LDD1650  [2]
 LDCM0449  CL58 HEK-293T C52(1.06)  LDD1652  [2]
 LDCM0453  CL61 HEK-293T C52(1.02)  LDD1656  [2]
 LDCM0457  CL65 HEK-293T C52(1.36)  LDD1660  [2]
 LDCM0460  CL68 HEK-293T C52(0.84)  LDD1663  [2]
 LDCM0463  CL70 HEK-293T C52(0.99)  LDD1666  [2]
 LDCM0466  CL73 HEK-293T C52(1.01)  LDD1669  [2]
 LDCM0470  CL77 HEK-293T C52(1.15)  LDD1673  [2]
 LDCM0473  CL8 HEK-293T C52(0.82)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C52(1.04)  LDD1677  [2]
 LDCM0476  CL82 HEK-293T C52(1.02)  LDD1679  [2]
 LDCM0479  CL85 HEK-293T C52(1.05)  LDD1682  [2]
 LDCM0483  CL89 HEK-293T C52(1.06)  LDD1686  [2]
 LDCM0487  CL92 HEK-293T C52(1.00)  LDD1690  [2]
 LDCM0489  CL94 HEK-293T C52(1.17)  LDD1692  [2]
 LDCM0492  CL97 HEK-293T C52(1.04)  LDD1695  [2]
 LDCM0198  Dimethyl Fumarate(DMF) T cell C52(5.02)  LDD0526  [1]
 LDCM0022  KB02 HEK-293T C52(0.96)  LDD1492  [2]
 LDCM0023  KB03 HEK-293T C52(1.18)  LDD1497  [2]
 LDCM0024  KB05 HEK-293T C52(0.89)  LDD1502  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM9B (FAM9B) FAM9 family Q8IZU0

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019