Details of the Target

General Information of Target

Target ID LDTP02959
Target Name Protein SON (SON)
Gene Name SON
Gene ID 6651
Synonyms
C21orf50; DBP5; KIAA1019; NREBP; Protein SON; Bax antagonist selected in saccharomyces 1; BASS1; Negative regulatory element-binding protein; NRE-binding protein; Protein DBP-5; SON3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATNIEQIFRSFVVSKFREIQQELSSGRNEGQLNGETNTPIEGNQAGDAAASARSLPNEE
IVQKIEEVLSGVLDTELRYKPDLKEGSRKSRCVSVQTDPTDEIPTKKSKKHKKHKNKKKK
KKKEKEKKYKRQPEESESKTKSHDDGNIDLESDSFLKFDSEPSAVALELPTRAFGPSETN
ESPAVVLEPPVVSMEVSEPHILETLKPATKTAELSVVSTSVISEQSEQSVAVMPEPSMTK
ILDSFAAAPVPTTTLVLKSSEPVVTMSVEYQMKSVLKSVESTSPEPSKIMLVEPPVAKVL
EPSETLVVSSETPTEVYPEPSTSTTMDFPESSAIEALRLPEQPVDVPSEIADSSMTRPQE
LPELPKTTALELQESSVASAMELPGPPATSMPELQGPPVTPVLELPGPSATPVPELPGPL
STPVPELPGPPATAVPELPGPSVTPVPQLSQELPGLPAPSMGLEPPQEVPEPPVMAQELP
GLPLVTAAVELPEQPAVTVAMELTEQPVTTTELEQPVGMTTVEHPGHPEVTTATGLLGQP
EATMVLELPGQPVATTALELPGQPSVTGVPELPGLPSATRALELSGQPVATGALELPGPL
MAAGALEFSGQSGAAGALELLGQPLATGVLELPGQPGAPELPGQPVATVALEISVQSVVT
TSELSTMTVSQSLEVPSTTALESYNTVAQELPTTLVGETSVTVGVDPLMAPESHILASNT
METHILASNTMDSQMLASNTMDSQMLASNTMDSQMLASSTMDSQMLATSSMDSQMLATSS
MDSQMLATSTMDSQMLATSSMDSQMLATSSMDSQMLATSSMDSQMLATSSMDSQMLATST
MDSQMLATSTMDSQMLATSSMDSQMLASGTMDSQMLASGTMDAQMLASGTMDAQMLASST
QDSAMLGSKSPDPYRLAQDPYRLAQDPYRLGHDPYRLGHDAYRLGQDPYRLGHDPYRLTP
DPYRMSPRPYRIAPRSYRIAPRPYRLAPRPLMLASRRSMMMSYAAERSMMSSYERSMMSY
ERSMMSPMAERSMMSAYERSMMSAYERSMMSPMAERSMMSAYERSMMSAYERSMMSPMAD
RSMMSMGADRSMMSSYSAADRSMMSSYSAADRSMMSSYTADRSMMSMAADSYTDSYTDTY
TEAYMVPPLPPEEPPTMPPLPPEEPPMTPPLPPEEPPEGPALPTEQSALTAENTWPTEVP
SSPSEESVSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVSEAAVTVPEPPPEPESSIT
LTPVESAVVAEEHEVVPERPVTCMVSETPAMSAEPTVLASEPPVMSETAETFDSMRASGH
VASEVSTSLLVPAVTTPVLAESILEPPAMAAPESSAMAVLESSAVTVLESSTVTVLESST
VTVLEPSVVTVPEPPVVAEPDYVTIPVPVVSALEPSVPVLEPAVSVLQPSMIVSEPSVSV
QESTVTVSEPAVTVSEQTQVIPTEVAIESTPMILESSIMSSHVMKGINLSSGDQNLAPEI
GMQEIALHSGEEPHAEEHLKGDFYESEHGINIDLNINNHLIAKEMEHNTVCAAGTSPVGE
IGEEKILPTSETKQRTVLDTYPGVSEADAGETLSSTGPFALEPDATGTSKGIEFTTASTL
SLVNKYDVDLSLTTQDTEHDMVISTSPSGGSEADIEGPLPAKDIHLDLPSNNNLVSKDTE
EPLPVKESDQTLAALLSPKESSGGEKEVPPPPKETLPDSGFSANIEDINEADLVRPLLPK
DMERLTSLRAGIEGPLLASDVGRDRSAASPVVSSMPERASESSSEEKDDYEIFVKVKDTH
EKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQ
TRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRA
RSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSRRSRTPSRRSRT
PSRRSRTPSRRSRTPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRS
SERGRSPKRLTDLDKAQLLEIAKANAAAMCAKAGVPLPPNLKPAPPPTIEEKVAKKSGGA
TIEELTEKCKQIAQSKEDDDVIVNKPHVSDEEEEEPPFYHHPFKLSEPKPIFFNLNIAAA
KPTPPKSQVTLTKEFPVSSGSQHRKKEADSVYGEWVPVEKNGEENKDDDNVFSSNLPSEP
VDISTAMSERALAQKRLSENAFDLEAMSMLNRAQERIDAWAQLNSIPGQFTGSTGVQVLT
QEQLANTGAQAWIKKDQFLRAAPVTGGMGAVLMRKMGWREGEGLGKNKEGNKEPILVDFK
TDRKGLVAVGERAQKRSGNFSAAMKDLSGKHPVSALMEICNKRRWQPPEFLLVHDSGPDH
RKHFLFRVLRNGALTRPNCMFFLNRY
Target Bioclass
Transporter and channel
Subcellular location
Nucleus speckle
Function
RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1.
Uniprot ID
P18583
Ensemble ID
ENST00000300278.8
HGNC ID
HGNC:11183

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DEL SNV: p.P1698R DBIA    Probe Info 
HCT15 SNV: p.G2288D DBIA    Probe Info 
HEC1B SNV: p.T1374I .
Ishikawa (Heraklio) 02 ER SNV: p.Q477H DBIA    Probe Info 
JURKAT SNV: p.L1745I Compound 10    Probe Info 
KMRC1 SNV: p.T678M DBIA    Probe Info 
KYSE30 Deletion: p.S770_S789del DBIA    Probe Info 
L428 SNV: p.K1787N .
LN229 SNV: p.P1711R DBIA    Probe Info 
LNCaP clone FGC SNV: p.G2268S DBIA    Probe Info 
MDST8 SNV: p.V185L DBIA    Probe Info 
MFE319 SNV: p.A1542V DBIA    Probe Info 
REH SNV: p.A458P; p.S1102F DBIA    Probe Info 
RL952 SNV: p.P1169Q; p.R1963H DBIA    Probe Info 
SKMEL24 SNV: p.T798I DBIA    Probe Info 
SW480 SNV: p.M1053I .
TCCSUP SNV: p.G1650A DBIA    Probe Info 
TE11 SNV: p.D352V DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 33 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
P3
 Probe Info  		1.71  LDD0450  [2]
P8
 Probe Info  		2.37  LDD0451  [2]
TH211
 Probe Info  		Y942(15.28); Y935(5.68)  LDD0260  [3]
TH216
 Probe Info  		Y942(20.00); Y935(19.46)  LDD0259  [3]
STPyne
 Probe Info  		K16(6.42); K1802(10.00); K2055(4.94); K2108(1.64)  LDD0277  [4]
BTD
 Probe Info  		C2070(1.05)  LDD1700  [5]
AHL-Pu-1
 Probe Info  		C2380(2.66); C1551(4.62)  LDD0169  [6]
DBIA
 Probe Info  		C2380(44.16)  LDD0209  [7]
ATP probe
 Probe Info  		N.A.  LDD0199  [8]
1d-yne
 Probe Info  		N.A.  LDD0358  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C2070(0.00); C1551(0.00); C2380(0.00); C92(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		C92(0.00); C2070(0.00)  LDD0036  [10]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [11]
Lodoacetamide azide
 Probe Info  		C2070(0.00); C92(0.00); C1551(0.00); C2380(0.00)  LDD0037  [10]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [12]
TFBX
 Probe Info  		C92(0.00); C2070(0.00)  LDD0027  [12]
WYneN
 Probe Info  		C92(0.00); C2070(0.00)  LDD0021  [13]
WYneO
 Probe Info  		N.A.  LDD0022  [13]
Compound 10
 Probe Info  		C2070(0.00); C92(0.00)  LDD2216  [14]
Compound 11
 Probe Info  		C2070(0.00); C92(0.00)  LDD2213  [14]
ENE
 Probe Info  		N.A.  LDD0006  [13]
IPM
 Probe Info  		C2070(0.00); C2380(0.00); C1551(0.00); C92(0.00)  LDD0005  [13]
NPM
 Probe Info  		N.A.  LDD0016  [13]
SF
 Probe Info  		Y949(0.00); Y928, Y921(0.00)  LDD0028  [15]
VSF
 Probe Info  		C1551(0.00); C92(0.00)  LDD0007  [13]
Phosphinate-6
 Probe Info  		C92(0.00); C2070(0.00); C1551(0.00)  LDD0018  [16]
1c-yne
 Probe Info  		N.A.  LDD0228  [9]
Acrolein
 Probe Info  		C1551(0.00); C2070(0.00)  LDD0217  [17]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [17]
Methacrolein
 Probe Info  		C1551(0.00); C2070(0.00)  LDD0218  [17]
W1
 Probe Info  		C2070(0.00); C2380(0.00)  LDD0236  [18]
NAIA_5
 Probe Info  		N.A.  LDD2223  [19]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		5.78  LDD0472  [20]
FFF probe13
 Probe Info  		20.00  LDD0475  [20]
FFF probe3
 Probe Info  		6.11  LDD0465  [20]
STS-1
 Probe Info  		N.A.  LDD0137  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C2109(1.07)  LDD2112  [5]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C92(0.71)  LDD2095  [5]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C2070(0.95)  LDD2130  [5]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C2070(0.86); C2380(0.98)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C2070(1.13)  LDD2152  [5]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C2109(1.09)  LDD2103  [5]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C2070(0.73)  LDD2132  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C2380(2.66); C1551(4.62)  LDD0169  [6]
 LDCM0520  AKOS000195272 MDA-MB-231 C2070(1.16)  LDD2113  [5]
 LDCM0156  Aniline NCI-H1299 12.96  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C2070(0.42)  LDD2091  [5]
 LDCM0108  Chloroacetamide HeLa C1551(0.00); C2070(0.00); H953(0.00)  LDD0222  [17]
 LDCM0632  CL-Sc Hep-G2 C2070(1.53); C92(0.74); C92(0.69); C2109(0.69)  LDD2227  [19]
 LDCM0634  CY-0357 Hep-G2 C92(3.34)  LDD2228  [19]
 LDCM0198  Dimethyl Fumarate(DMF) T cell C92(11.68)  LDD0526  [22]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C92(1.87); C1551(1.15); C2070(1.15)  LDD1702  [5]
 LDCM0625  F8 Ramos C92(0.94); C2070(1.03)  LDD2187  [23]
 LDCM0572  Fragment10 Ramos C92(2.96); C2070(1.19)  LDD2189  [23]
 LDCM0573  Fragment11 Ramos C92(3.55)  LDD2190  [23]
 LDCM0574  Fragment12 Ramos C92(1.27); C2070(1.65)  LDD2191  [23]
 LDCM0575  Fragment13 Ramos C92(1.02); C2070(0.77)  LDD2192  [23]
 LDCM0576  Fragment14 Ramos C92(1.31); C2070(0.77)  LDD2193  [23]
 LDCM0579  Fragment20 Ramos C92(1.13); C2070(0.78)  LDD2194  [23]
 LDCM0580  Fragment21 Ramos C92(0.79); C2070(0.81)  LDD2195  [23]
 LDCM0582  Fragment23 Ramos C92(0.95); C2070(1.55)  LDD2196  [23]
 LDCM0578  Fragment27 Ramos C92(0.87); C2070(0.83)  LDD2197  [23]
 LDCM0586  Fragment28 Ramos C92(0.73); C2070(1.39)  LDD2198  [23]
 LDCM0588  Fragment30 Ramos C92(1.36); C2070(1.06)  LDD2199  [23]
 LDCM0589  Fragment31 Ramos C92(0.85); C2070(1.26)  LDD2200  [23]
 LDCM0590  Fragment32 Ramos C92(1.85); C2070(2.98)  LDD2201  [23]
 LDCM0468  Fragment33 Ramos C92(1.21); C2070(1.09)  LDD2202  [23]
 LDCM0596  Fragment38 Ramos C92(0.85); C2070(1.00)  LDD2203  [23]
 LDCM0566  Fragment4 Ramos C92(0.58); C2070(0.73)  LDD2184  [23]
 LDCM0610  Fragment52 Ramos C92(1.46); C2070(1.01)  LDD2204  [23]
 LDCM0614  Fragment56 Ramos C92(1.25); C2070(3.05)  LDD2205  [23]
 LDCM0569  Fragment7 Ramos C92(1.31); C2070(1.17)  LDD2186  [23]
 LDCM0571  Fragment9 Ramos C92(2.42); C2070(0.88)  LDD2188  [23]
 LDCM0107  IAA HeLa N.A.  LDD0221  [17]
 LDCM0022  KB02 Ramos C92(1.44); C2070(1.14)  LDD2182  [23]
 LDCM0023  KB03 Jurkat C2380(44.16)  LDD0209  [7]
 LDCM0024  KB05 COLO792 C2420(2.79)  LDD3310  [24]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C2109(1.01)  LDD2102  [5]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C2070(0.59)  LDD2121  [5]
 LDCM0109  NEM HeLa N.A.  LDD0223  [17]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C2070(0.55)  LDD2089  [5]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C2070(0.98)  LDD2093  [5]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C2070(0.81); C2109(0.98)  LDD2096  [5]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C2109(1.20)  LDD2098  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C2070(0.79)  LDD2099  [5]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C2109(1.18)  LDD2105  [5]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C2109(0.91)  LDD2106  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C2070(0.99)  LDD2107  [5]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C2109(0.83)  LDD2108  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C2070(0.82)  LDD2109  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C2070(0.74); C2109(0.93)  LDD2111  [5]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C2070(0.93)  LDD2116  [5]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C2070(0.70)  LDD2118  [5]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C2070(2.11); C2109(2.10)  LDD2119  [5]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C92(0.73); C2070(0.62)  LDD2122  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C2070(0.79)  LDD2123  [5]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C2070(0.92)  LDD2124  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C2070(0.87); C2109(0.75)  LDD2125  [5]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C2070(0.70)  LDD2126  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C2070(0.70)  LDD2127  [5]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C2070(1.24)  LDD2128  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C2070(0.95)  LDD2129  [5]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C2070(0.86)  LDD2133  [5]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C2070(1.19)  LDD2134  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C2070(0.93); C2109(1.00)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C92(0.85); C2070(0.98)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C2070(0.88)  LDD2137  [5]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C2070(1.05)  LDD1700  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C2070(0.67); C2109(0.62)  LDD2140  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C92(0.74); C2109(1.04)  LDD2141  [5]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C2070(1.14)  LDD2143  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C2070(1.73)  LDD2144  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C2070(0.86); C2109(1.13)  LDD2146  [5]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C2070(0.75)  LDD2148  [5]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C92(0.57); C2070(0.64)  LDD2149  [5]
 LDCM0627  NUDT7-COV-1 HEK-293T C2070(0.88)  LDD2206  [25]
 LDCM0628  OTUB2-COV-1 HEK-293T C92(1.32); C2070(0.71)  LDD2207  [25]
 LDCM0131  RA190 MM1.R C92(1.20)  LDD0304  [26]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin carboxyl-terminal hydrolase 7 (USP7) Peptidase C19 family Q93009

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
15 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
16 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
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19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
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Mass spectrometry data entry: PXD027578
24 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
25 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
26 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.