Details of the Target

General Information of Target

Target ID LDTP06020
Target Name Pro-interleukin-16 (IL16)
Gene Name IL16
Gene ID 3603
Synonyms
Pro-interleukin-16 [Cleaved into: Interleukin-16; IL-16; Lymphocyte chemoattractant factor; LCF)]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MESHSRAGKSRKSAKFRSISRSLMLCNAKTSDDGSSPDEKYPDPFEISLAQGKEGIFHSS
VQLADTSEAGPSSVPDLALASEAAQLQAAGNDRGKTCRRIFFMKESSTASSREKPGKLEA
QSSNFLFPKACHQRARSNSTSVNPYCTREIDFPMTKKSAAPTDRQPYSLCSNRKSLSQQL
DCPAGKAAGTSRPTRSLSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYG
PIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVR
TRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYRIMVEVSLQK
EAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNE
VYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQAVENTKFGKERHQWSLEGVKRLES
SWHGRPTLEKEREKNSAPPHRRAQKVMIRSSSDSSYMSGSPGGSPGSGSAEKPSSDVDIS
THSPSLPLAREPVVLSIASSRLPQESPPLPESRDSHPPLRLKKSFEILVRKPMSSKPKPP
PRKYFKSDSDPQKSLEERENSSCSSGHTPPTCGQEARELLPLLLPQEDTAGRSPSASAGC
PGPGIGPQTKSSTEGEPGWRRASPVTQTSPIKHPLLKRQARMDYSFDTTAEDPWVRISDC
IKNLFSPIMSENHGHMPLQPNASLNEEEGTQGHPDGTPPKLDTANGTPKVYKSADSSTVK
KGPPVAPKPAWFRQSLKGLRNRASDPRGLPDPALSTQPAPASREHLGSHIRASSSSSSIR
QRISSFETFGSSQLPDKGAQRLSLQPSSGEAAKPLGKHEEGRFSGLLGRGAAPTLVPQQP
EQVLSSGSPAASEARDPGVSESPPPGRQPNQKTLPPGPDPLLRLLSTQAEESQGPVLKMP
SQRARSFPLTRSQSCETKLLDEKTSKLYSISSQVSSAVMKSLLCLPSSISCAQTPCIPKE
GASPTSSSNEDSAANGSAETSALDTGFSLNLSELREYTEGLTEAKEDDDGDHSSLQSGQS
VISLLSSEELKKLIEEVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVIT
VHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTP
EAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKP
LTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKS
LQSKETTAAGDS
Target Type
Literature-reported
Target Bioclass
Other
Subcellular location
Secreted; Cytoplasm
Function
Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.; [Isoform 1]: May act as a scaffolding protein that anchors ion channels in the membrane.; Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
TTD ID
T51698
Uniprot ID
Q14005
DrugMap ID
TTW4R0B
Ensemble ID
ENST00000394652.6
HGNC ID
HGNC:5980

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
786O SNV: p.T933I .
A431 SNV: p.E748K .
CCK81 SNV: p.E676K .
HT115 SNV: p.N801D .
Ishikawa (Heraklio) 02 ER Insertion: p.S566RfsTer15 .
KMCH1 SNV: p.S804Ter .
KYSE180 SNV: p.C131W .
LN18 SNV: p.K583E .
MCC26 Substitution: p.V506I .
NCIH1155 SNV: p.E1059K .
NCIH2286 SNV: p.P727T .
NUGC3 SNV: p.K235R .
SUDHL6 SNV: p.P667S DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K1305(4.13)  LDD2218  [1]
IA-alkyne
 Probe Info  		C975(2.30); C1004(1.42); C1016(1.42)  LDD0304  [2]
DBIA
 Probe Info  		C975(1.72)  LDD3370  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0198  Dimethyl Fumarate(DMF) T cell C1004, C1011, C1016, C1017(4.07)  LDD0526  [4]
 LDCM0625  F8 Ramos C975(1.08)  LDD2187  [5]
 LDCM0572  Fragment10 Ramos C975(0.71)  LDD2189  [5]
 LDCM0573  Fragment11 Ramos C975(0.52)  LDD2190  [5]
 LDCM0574  Fragment12 Ramos C975(0.37)  LDD2191  [5]
 LDCM0575  Fragment13 Ramos C975(0.53)  LDD2192  [5]
 LDCM0576  Fragment14 Ramos C975(0.77)  LDD2193  [5]
 LDCM0579  Fragment20 Ramos C975(0.34)  LDD2194  [5]
 LDCM0580  Fragment21 Ramos C975(0.53)  LDD2195  [5]
 LDCM0582  Fragment23 Ramos C975(1.42)  LDD2196  [5]
 LDCM0578  Fragment27 Ramos C975(0.38)  LDD2197  [5]
 LDCM0586  Fragment28 Ramos C975(0.74)  LDD2198  [5]
 LDCM0588  Fragment30 Ramos C975(0.59)  LDD2199  [5]
 LDCM0589  Fragment31 Ramos C975(0.33)  LDD2200  [5]
 LDCM0590  Fragment32 Ramos C975(0.90)  LDD2201  [5]
 LDCM0468  Fragment33 Ramos C975(0.50)  LDD2202  [5]
 LDCM0596  Fragment38 Ramos C975(0.32)  LDD2203  [5]
 LDCM0566  Fragment4 Ramos C975(0.52)  LDD2184  [5]
 LDCM0610  Fragment52 Ramos C975(0.80)  LDD2204  [5]
 LDCM0614  Fragment56 Ramos C975(0.63)  LDD2205  [5]
 LDCM0569  Fragment7 Ramos C975(1.10)  LDD2186  [5]
 LDCM0571  Fragment9 Ramos C975(0.87)  LDD2188  [5]
 LDCM0022  KB02 T cell-activated C1004, C1011, C1016, C1017(6.07)  LDD1704  [4]
 LDCM0023  KB03 Jurkat C975(16.74)  LDD0315  [6]
 LDCM0024  KB05 OCI-AML-2 C975(1.72)  LDD3370  [3]
 LDCM0131  RA190 MM1.R C975(2.30); C1004(1.42); C1016(1.42)  LDD0304  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Putative histone-lysine N-methyltransferase PRDM6 (PRDM6) Class V-like SAM-binding methyltransferase superfamily Q9NQX0
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Ubiquitin thioesterase ZRANB1 (ZRANB1) Peptidase C64 family Q9UGI0
Kallikrein-6 (KLK6) Peptidase S1 family Q92876
Calcium/calmodulin-dependent protein kinase type 1 (CAMK1) CAMK Ser/Thr protein kinase family Q14012
Tribbles homolog 3 (TRIB3) CAMK Ser/Thr protein kinase family Q96RU7
Dual specificity protein phosphatase 7 (DUSP7) Protein-tyrosine phosphatase family Q16829
RanBP-type and C3HC4-type zinc finger-containing protein 1 (RBCK1) RBR family Q9BYM8
Ribose-phosphate pyrophosphokinase 1 (PRPS1) Ribose-phosphate pyrophosphokinase family P60891
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
Coagulation factor XIII A chain (F13A1) Transglutaminase family P00488
Tripartite motif-containing protein 42 (TRIM42) TRIM/RBCC family Q8IWZ5
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Annexin A6 (ANXA6) Annexin family P08133
Huntingtin (HTT) Huntingtin family P42858
Alpha-crystallin A chain (CRYAA) Small heat shock protein (HSP20) family P02489
AP-4 complex accessory subunit Tepsin (TEPSIN) . Q96N21
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 17 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 143 (ZNF143) GLI C2H2-type zinc-finger protein family P52747
Zinc finger and BTB domain-containing protein 39 (ZBTB39) Krueppel C2H2-type zinc-finger protein family O15060
Zinc finger imprinted 2 (ZIM2) Krueppel C2H2-type zinc-finger protein family Q9NZV7
Zinc finger protein 165 (ZNF165) Krueppel C2H2-type zinc-finger protein family P49910
Zinc finger protein 526 (ZNF526) Krueppel C2H2-type zinc-finger protein family Q8TF50
Zinc finger protein 572 (ZNF572) Krueppel C2H2-type zinc-finger protein family Q7Z3I7
Zinc finger protein 620 (ZNF620) Krueppel C2H2-type zinc-finger protein family Q6ZNG0
Zinc finger protein 774 (ZNF774) Krueppel C2H2-type zinc-finger protein family Q6NX45
Zinc finger protein 777 (ZNF777) Krueppel C2H2-type zinc-finger protein family Q9ULD5
Zinc finger protein 835 (ZNF835) Krueppel C2H2-type zinc-finger protein family Q9Y2P0
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901
Golgin-45 (BLZF1) . Q9H2G9
Mesoderm induction early response protein 2 (MIER2) . Q8N344
Myogenin (MYOG) . P15173
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1 (SOHLH1) . Q5JUK2
Zinc finger protein 474 (ZNF474) . Q6S9Z5
Zinc finger protein 581 (ZNF581) . Q9P0T4
Other
Click To Hide/Show 43 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
Centrosomal protein of 72 kDa (CEP72) CEP72 family Q9P209
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) Dynein heavy chain family Q14204
Protein FAM124A (FAM124A) FAM124 family Q86V42
EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2) Fibulin family O95967
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Progranulin (GRN) Granulin family P28799
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type II cuticular Hb6 (KRT86) Intermediate filament family O43790
Neurofilament light polypeptide (NEFL) Intermediate filament family P07196
Prelamin-A/C (LMNA) Intermediate filament family P02545
Janus kinase and microtubule-interacting protein 1 (JAKMIP1) JAKMIP family Q96N16
Keratin-associated protein 1-1 (KRTAP1-1) KRTAP type 1 family Q07627
Keratin-associated protein 1-3 (KRTAP1-3) KRTAP type 1 family Q8IUG1
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 3-1 (KRTAP3-1) KRTAP type 3 family Q9BYR8
Methyl-CpG-binding domain protein 3-like 1 (MBD3L1) MBD3L family Q8WWY6
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Protein Mis18-beta (OIP5) Mis18 family O43482
Prefoldin subunit 5 (PFDN5) Prefoldin subunit alpha family Q99471
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
BTB/POZ domain-containing protein KCTD9 (KCTD9) . Q7L273
Caspase recruitment domain-containing protein 10 (CARD10) . Q9BWT7
Coiled-coil domain-containing protein 184 (CCDC184) . Q52MB2
Four and a half LIM domains protein 2 (FHL2) . Q14192
Four and a half LIM domains protein 5 (FHL5) . Q5TD97
GA-binding protein subunit beta-1 (GABPB1) . Q06547
Heat shock factor 2-binding protein (HSF2BP) . O75031
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
PDZ and LIM domain protein 7 (PDLIM7) . Q9NR12
Placental protein 13-like (LGALS14) . Q8TCE9
PRKCA-binding protein (PICK1) . Q9NRD5
Proline-rich protein 13 (PRR13) . Q9NZ81
Proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1) . O43586
Protein phosphatase 1 regulatory subunit 16A (PPP1R16A) . Q96I34
RING finger protein 11 (RNF11) . Q9Y3C5
SERTA domain-containing protein 3 (SERTAD3) . Q9UJW9
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
WW domain-containing transcription regulator protein 1 (WWTR1) . Q9GZV5

References

1 Global profiling of lysine reactivity and ligandability in the human proteome. Nat Chem. 2017 Dec;9(12):1181-1190. doi: 10.1038/nchem.2826. Epub 2017 Jul 31.
2 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
5 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060