Details of the Target

General Information of Target

Target ID LDTP10362
Target Name Alpha/beta hydrolase domain-containing protein 17A (ABHD17A)
Gene Name ABHD17A
Gene ID 81926
Synonyms
C19orf27; FAM108A1; Alpha/beta hydrolase domain-containing protein 17A; Abhydrolase domain-containing protein 17A; EC 3.1.2.22
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MESSRGRPGPETDLLAVAEHQALVFGGGPGRTSSEPPAGLRVSGEEETENVGGANRHPRT
SPKTSSCGVVHRPEREALENEPGPQGTLSGAGSRRGAPGAEHEPSLSSRHKNPAPPEGKP
SSGRDCRRGGPGGGMDVEQQEEEDNDEEAAAGSRAGRSFSSRLQDSRSLDGLSEACGGAG
SSGSAESGAGGGRRATISSPLELEGTVSRHGDLTHFVANNLQLKIRLSGAPPPPPSAPAR
PCPAPAPTPTPAIPPIDPEVLRDLERLSRELGGRVDRLLRGLGGAVQELTALSVGCIQTY
RDAVDSLGEAVDMSIKGMYTLLARCEELERALQPVQGLARQVRDIRRTLEVLEALCK
Target Bioclass
Enzyme
Family
AB hydrolase superfamily, ABHD17 family
Subcellular location
Cell membrane
Function
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS. Has depalmitoylating activity towards DLG4/PSD95. May have depalmitoylating activity towards MAP6.
Uniprot ID
Q96GS6
Ensemble ID
ENST00000250974.9
HGNC ID
HGNC:28756

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C230(20.00)  LDD1709  [1]
DBIA
 Probe Info  		C101(0.95)  LDD1492  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C235
 Probe Info  		20.53  LDD1908  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C230(1.12)  LDD1507  [2]
 LDCM0215  AC10 HEK-293T C230(1.02); C101(1.03)  LDD1508  [2]
 LDCM0226  AC11 HEK-293T C230(0.94)  LDD1509  [2]
 LDCM0237  AC12 HEK-293T C205(0.88); C230(1.02); C101(0.78)  LDD1510  [2]
 LDCM0259  AC14 HEK-293T C230(1.03)  LDD1512  [2]
 LDCM0276  AC17 HEK-293T C230(0.99)  LDD1515  [2]
 LDCM0277  AC18 HEK-293T C230(1.05); C101(0.88)  LDD1516  [2]
 LDCM0278  AC19 HEK-293T C230(0.96)  LDD1517  [2]
 LDCM0279  AC2 HEK-293T C230(1.14); C101(0.89)  LDD1518  [2]
 LDCM0280  AC20 HEK-293T C205(0.89); C230(1.04); C101(1.03)  LDD1519  [2]
 LDCM0282  AC22 HEK-293T C230(0.94)  LDD1521  [2]
 LDCM0285  AC25 HEK-293T C230(1.14)  LDD1524  [2]
 LDCM0286  AC26 HEK-293T C230(1.06); C101(0.93)  LDD1525  [2]
 LDCM0287  AC27 HEK-293T C230(0.99)  LDD1526  [2]
 LDCM0288  AC28 HEK-293T C205(1.06); C230(1.02); C101(0.87)  LDD1527  [2]
 LDCM0290  AC3 HEK-293T C230(0.94)  LDD1529  [2]
 LDCM0291  AC30 HEK-293T C230(0.97)  LDD1530  [2]
 LDCM0294  AC33 HEK-293T C230(0.95)  LDD1533  [2]
 LDCM0295  AC34 HEK-293T C230(1.05); C101(1.12)  LDD1534  [2]
 LDCM0296  AC35 HEK-293T C230(0.95)  LDD1535  [2]
 LDCM0297  AC36 HEK-293T C205(0.97); C230(1.00); C101(0.85)  LDD1536  [2]
 LDCM0299  AC38 HEK-293T C230(0.86)  LDD1538  [2]
 LDCM0301  AC4 HEK-293T C205(0.97); C230(1.07); C101(1.01)  LDD1540  [2]
 LDCM0303  AC41 HEK-293T C230(0.98)  LDD1542  [2]
 LDCM0304  AC42 HEK-293T C230(1.11); C101(1.23)  LDD1543  [2]
 LDCM0305  AC43 HEK-293T C230(0.93)  LDD1544  [2]
 LDCM0306  AC44 HEK-293T C205(0.87); C230(1.03); C101(1.08)  LDD1545  [2]
 LDCM0308  AC46 HEK-293T C230(0.86)  LDD1547  [2]
 LDCM0311  AC49 HEK-293T C230(0.92)  LDD1550  [2]
 LDCM0313  AC50 HEK-293T C230(1.07); C101(1.01)  LDD1552  [2]
 LDCM0314  AC51 HEK-293T C230(0.94)  LDD1553  [2]
 LDCM0315  AC52 HEK-293T C205(0.89); C230(1.07); C101(0.91)  LDD1554  [2]
 LDCM0317  AC54 HEK-293T C230(0.91)  LDD1556  [2]
 LDCM0320  AC57 HEK-293T C230(1.07)  LDD1559  [2]
 LDCM0321  AC58 HEK-293T C230(1.10); C101(1.02)  LDD1560  [2]
 LDCM0322  AC59 HEK-293T C230(0.95)  LDD1561  [2]
 LDCM0323  AC6 HEK-293T C230(1.04)  LDD1562  [2]
 LDCM0324  AC60 HEK-293T C205(0.96); C230(1.17); C101(0.98)  LDD1563  [2]
 LDCM0326  AC62 HEK-293T C230(0.91)  LDD1565  [2]
 LDCM0356  AKOS034007680 HEK-293T C230(1.04)  LDD1570  [2]
 LDCM0367  CL1 HEK-293T C205(1.11); C230(1.04)  LDD1571  [2]
 LDCM0368  CL10 HEK-293T C230(1.40)  LDD1572  [2]
 LDCM0370  CL101 HEK-293T C205(1.29); C230(1.01)  LDD1574  [2]
 LDCM0371  CL102 HEK-293T C101(1.44)  LDD1575  [2]
 LDCM0372  CL103 HEK-293T C230(1.02)  LDD1576  [2]
 LDCM0374  CL105 HEK-293T C205(0.85); C230(1.08)  LDD1578  [2]
 LDCM0375  CL106 HEK-293T C101(1.28)  LDD1579  [2]
 LDCM0376  CL107 HEK-293T C230(0.92)  LDD1580  [2]
 LDCM0378  CL109 HEK-293T C205(0.94); C230(0.98)  LDD1582  [2]
 LDCM0380  CL110 HEK-293T C101(0.97)  LDD1584  [2]
 LDCM0381  CL111 HEK-293T C230(1.11)  LDD1585  [2]
 LDCM0383  CL113 HEK-293T C205(0.96); C230(1.03)  LDD1587  [2]
 LDCM0384  CL114 HEK-293T C101(1.01)  LDD1588  [2]
 LDCM0385  CL115 HEK-293T C230(1.02)  LDD1589  [2]
 LDCM0387  CL117 HEK-293T C205(0.95); C230(0.97)  LDD1591  [2]
 LDCM0388  CL118 HEK-293T C101(1.10)  LDD1592  [2]
 LDCM0389  CL119 HEK-293T C230(0.97)  LDD1593  [2]
 LDCM0392  CL121 HEK-293T C205(0.93); C230(1.04)  LDD1596  [2]
 LDCM0393  CL122 HEK-293T C101(1.19)  LDD1597  [2]
 LDCM0394  CL123 HEK-293T C230(1.07)  LDD1598  [2]
 LDCM0396  CL125 HEK-293T C205(0.90); C230(1.09)  LDD1600  [2]
 LDCM0397  CL126 HEK-293T C101(0.90)  LDD1601  [2]
 LDCM0398  CL127 HEK-293T C230(1.02)  LDD1602  [2]
 LDCM0400  CL13 HEK-293T C205(1.01); C230(1.17)  LDD1604  [2]
 LDCM0401  CL14 HEK-293T C101(1.05)  LDD1605  [2]
 LDCM0402  CL15 HEK-293T C230(1.31)  LDD1606  [2]
 LDCM0404  CL17 HEK-293T C230(1.34)  LDD1608  [2]
 LDCM0405  CL18 HEK-293T C230(1.05); C101(0.92)  LDD1609  [2]
 LDCM0406  CL19 HEK-293T C230(0.93)  LDD1610  [2]
 LDCM0407  CL2 HEK-293T C101(1.31)  LDD1611  [2]
 LDCM0408  CL20 HEK-293T C205(1.10); C230(1.05); C101(1.02)  LDD1612  [2]
 LDCM0410  CL22 HEK-293T C230(1.09)  LDD1614  [2]
 LDCM0413  CL25 HEK-293T C205(0.91); C230(1.21)  LDD1617  [2]
 LDCM0414  CL26 HEK-293T C101(1.06)  LDD1618  [2]
 LDCM0415  CL27 HEK-293T C230(1.04)  LDD1619  [2]
 LDCM0417  CL29 HEK-293T C230(0.92)  LDD1621  [2]
 LDCM0418  CL3 HEK-293T C230(1.18)  LDD1622  [2]
 LDCM0419  CL30 HEK-293T C230(1.02); C101(1.54)  LDD1623  [2]
 LDCM0420  CL31 HEK-293T C230(0.99)  LDD1624  [2]
 LDCM0421  CL32 HEK-293T C205(1.26); C230(1.12); C101(0.95)  LDD1625  [2]
 LDCM0423  CL34 HEK-293T C230(1.29)  LDD1627  [2]
 LDCM0426  CL37 HEK-293T C205(0.98); C230(1.15)  LDD1630  [2]
 LDCM0428  CL39 HEK-293T C230(1.01)  LDD1632  [2]
 LDCM0431  CL41 HEK-293T C230(1.52)  LDD1635  [2]
 LDCM0432  CL42 HEK-293T C230(1.12); C101(1.13)  LDD1636  [2]
 LDCM0433  CL43 HEK-293T C230(0.98)  LDD1637  [2]
 LDCM0434  CL44 HEK-293T C205(1.09); C230(1.17); C101(0.81)  LDD1638  [2]
 LDCM0436  CL46 HEK-293T C230(1.18)  LDD1640  [2]
 LDCM0439  CL49 HEK-293T C205(1.08); C230(1.16)  LDD1643  [2]
 LDCM0440  CL5 HEK-293T C230(1.15)  LDD1644  [2]
 LDCM0441  CL50 HEK-293T C101(1.11)  LDD1645  [2]
 LDCM0444  CL53 HEK-293T C230(1.02)  LDD1647  [2]
 LDCM0445  CL54 HEK-293T C230(1.25); C101(1.17)  LDD1648  [2]
 LDCM0446  CL55 HEK-293T C230(1.00)  LDD1649  [2]
 LDCM0447  CL56 HEK-293T C205(1.14); C230(1.09); C101(0.90)  LDD1650  [2]
 LDCM0449  CL58 HEK-293T C230(1.09)  LDD1652  [2]
 LDCM0451  CL6 HEK-293T C230(1.56); C101(1.35)  LDD1654  [2]
 LDCM0453  CL61 HEK-293T C205(0.88); C230(1.06)  LDD1656  [2]
 LDCM0454  CL62 HEK-293T C101(1.15)  LDD1657  [2]
 LDCM0455  CL63 HEK-293T C230(1.08)  LDD1658  [2]
 LDCM0457  CL65 HEK-293T C230(1.03)  LDD1660  [2]
 LDCM0458  CL66 HEK-293T C230(1.16); C101(1.12)  LDD1661  [2]
 LDCM0459  CL67 HEK-293T C230(1.00)  LDD1662  [2]
 LDCM0460  CL68 HEK-293T C205(1.32); C230(1.13); C101(1.31)  LDD1663  [2]
 LDCM0462  CL7 HEK-293T C230(1.04)  LDD1665  [2]
 LDCM0463  CL70 HEK-293T C230(1.01)  LDD1666  [2]
 LDCM0466  CL73 HEK-293T C205(0.84); C230(1.16)  LDD1669  [2]
 LDCM0467  CL74 HEK-293T C101(1.25)  LDD1670  [2]
 LDCM0470  CL77 HEK-293T C230(0.89)  LDD1673  [2]
 LDCM0471  CL78 HEK-293T C230(1.03); C101(0.90)  LDD1674  [2]
 LDCM0472  CL79 HEK-293T C230(0.91)  LDD1675  [2]
 LDCM0473  CL8 HEK-293T C205(1.22); C230(1.61); C101(1.00)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C205(1.09); C230(1.00); C101(1.13)  LDD1677  [2]
 LDCM0476  CL82 HEK-293T C230(0.98)  LDD1679  [2]
 LDCM0479  CL85 HEK-293T C205(0.79); C230(1.19)  LDD1682  [2]
 LDCM0480  CL86 HEK-293T C101(0.97)  LDD1683  [2]
 LDCM0481  CL87 HEK-293T C230(1.00)  LDD1684  [2]
 LDCM0483  CL89 HEK-293T C230(1.06)  LDD1686  [2]
 LDCM0485  CL90 HEK-293T C230(1.62); C101(1.29)  LDD1688  [2]
 LDCM0486  CL91 HEK-293T C230(0.94)  LDD1689  [2]
 LDCM0487  CL92 HEK-293T C205(1.12); C230(1.24); C101(1.50)  LDD1690  [2]
 LDCM0489  CL94 HEK-293T C230(1.15)  LDD1692  [2]
 LDCM0492  CL97 HEK-293T C205(1.07); C230(1.29)  LDD1695  [2]
 LDCM0493  CL98 HEK-293T C101(1.23)  LDD1696  [2]
 LDCM0494  CL99 HEK-293T C230(1.06)  LDD1697  [2]
 LDCM0495  E2913 HEK-293T C230(1.06)  LDD1698  [2]
 LDCM0468  Fragment33 HEK-293T C230(1.05)  LDD1671  [2]
 LDCM0427  Fragment51 HEK-293T C101(1.32)  LDD1631  [2]
 LDCM0022  KB02 HEK-293T C101(0.95)  LDD1492  [2]
 LDCM0023  KB03 HEK-293T C101(1.10)  LDD1497  [2]
 LDCM0024  KB05 HEK-293T C101(0.85)  LDD1502  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hematopoietic prostaglandin D synthase (HPGDS) Sigma family O60760

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587