Details of the Target

General Information of Target

Target ID LDTP10370
Target Name Solute carrier family 41 member 3 (SLC41A3)
Gene Name SLC41A3
Gene ID 54946
Synonyms
Solute carrier family 41 member 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFPVKVKVEKSELEMAKARNQLDAVLQCLLEKSHMDRERLDEEAGKTPSDTHNKDCSIAA
TGKRPSARFPHQRRKKRREMDDGLAEGGPQRSNTYVIKLFDRSVDLAQFSENTPLYPICR
AWMRNSPSVRERECSPSSPLPPLPEDEEGSEVTNSKSRDVYKLPPPTPPGPPGDACRSRI
PSPLQPEMQGTPDDEPSEPEPSPSTLIYRNMQRWKRIRQRWKEASHRNQLRYSESMKILR
EMYERQ
Target Bioclass
Transporter and channel
Family
SLC41A transporter family
Subcellular location
Mitochondrion inner membrane
Function Na(+)/Mg(2+) ion exchanger that acts as a predominant Mg(2+) efflux system at the mitochondrial inner membrane.
Uniprot ID
Q96GZ6
Ensemble ID
ENST00000315891.10
HGNC ID
HGNC:31046

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C14(1.75)  LDD3427  [1]
AHL-Pu-1
 Probe Info  		C14(2.82)  LDD0171  [2]
VSF
 Probe Info  		N.A.  LDD0007  [3]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C229
 Probe Info  		7.31  LDD1902  [4]
C231
 Probe Info  		16.22  LDD1904  [4]
C233
 Probe Info  		10.78  LDD1906  [4]
C235
 Probe Info  		17.39  LDD1908  [4]
OEA-DA
 Probe Info  		20.00  LDD0046  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C14(2.82)  LDD0171  [2]
 LDCM0214  AC1 HEK-293T C14(1.03); C323(0.97)  LDD1507  [6]
 LDCM0215  AC10 PaTu 8988t C323(1.14)  LDD1094  [7]
 LDCM0216  AC100 PaTu 8988t C323(0.87)  LDD1095  [7]
 LDCM0217  AC101 PaTu 8988t C323(1.43)  LDD1096  [7]
 LDCM0218  AC102 PaTu 8988t C323(0.88)  LDD1097  [7]
 LDCM0219  AC103 PaTu 8988t C323(0.85)  LDD1098  [7]
 LDCM0220  AC104 PaTu 8988t C323(0.81)  LDD1099  [7]
 LDCM0221  AC105 PaTu 8988t C323(1.27)  LDD1100  [7]
 LDCM0222  AC106 PaTu 8988t C323(1.16)  LDD1101  [7]
 LDCM0223  AC107 PaTu 8988t C323(1.46)  LDD1102  [7]
 LDCM0224  AC108 PaTu 8988t C323(1.10)  LDD1103  [7]
 LDCM0225  AC109 PaTu 8988t C323(1.06)  LDD1104  [7]
 LDCM0226  AC11 PaTu 8988t C323(1.35)  LDD1105  [7]
 LDCM0227  AC110 PaTu 8988t C323(0.98)  LDD1106  [7]
 LDCM0228  AC111 PaTu 8988t C323(1.08)  LDD1107  [7]
 LDCM0229  AC112 PaTu 8988t C323(0.80)  LDD1108  [7]
 LDCM0230  AC113 PaTu 8988t C323(1.30)  LDD1109  [7]
 LDCM0231  AC114 PaTu 8988t C323(1.06)  LDD1110  [7]
 LDCM0232  AC115 PaTu 8988t C323(0.86)  LDD1111  [7]
 LDCM0233  AC116 PaTu 8988t C323(0.91)  LDD1112  [7]
 LDCM0234  AC117 PaTu 8988t C323(1.24)  LDD1113  [7]
 LDCM0235  AC118 PaTu 8988t C323(0.95)  LDD1114  [7]
 LDCM0236  AC119 PaTu 8988t C323(0.73)  LDD1115  [7]
 LDCM0237  AC12 PaTu 8988t C323(1.41)  LDD1116  [7]
 LDCM0238  AC120 PaTu 8988t C323(0.97)  LDD1117  [7]
 LDCM0239  AC121 PaTu 8988t C323(0.97)  LDD1118  [7]
 LDCM0240  AC122 PaTu 8988t C323(0.88)  LDD1119  [7]
 LDCM0241  AC123 PaTu 8988t C323(1.33)  LDD1120  [7]
 LDCM0242  AC124 PaTu 8988t C323(0.92)  LDD1121  [7]
 LDCM0243  AC125 PaTu 8988t C323(0.76)  LDD1122  [7]
 LDCM0244  AC126 PaTu 8988t C323(0.95)  LDD1123  [7]
 LDCM0245  AC127 PaTu 8988t C323(0.98)  LDD1124  [7]
 LDCM0246  AC128 PaTu 8988t C323(1.24)  LDD1125  [7]
 LDCM0247  AC129 PaTu 8988t C323(1.13)  LDD1126  [7]
 LDCM0249  AC130 PaTu 8988t C323(0.89)  LDD1128  [7]
 LDCM0250  AC131 PaTu 8988t C323(1.43)  LDD1129  [7]
 LDCM0251  AC132 PaTu 8988t C323(1.47)  LDD1130  [7]
 LDCM0252  AC133 PaTu 8988t C323(1.19)  LDD1131  [7]
 LDCM0253  AC134 PaTu 8988t C323(1.28)  LDD1132  [7]
 LDCM0254  AC135 PaTu 8988t C323(1.30)  LDD1133  [7]
 LDCM0255  AC136 PaTu 8988t C323(1.32)  LDD1134  [7]
 LDCM0256  AC137 PaTu 8988t C323(1.08)  LDD1135  [7]
 LDCM0257  AC138 PaTu 8988t C323(1.59)  LDD1136  [7]
 LDCM0258  AC139 PaTu 8988t C323(1.45)  LDD1137  [7]
 LDCM0259  AC14 PaTu 8988t C323(1.00)  LDD1138  [7]
 LDCM0260  AC140 PaTu 8988t C323(0.94)  LDD1139  [7]
 LDCM0261  AC141 PaTu 8988t C323(1.19)  LDD1140  [7]
 LDCM0262  AC142 PaTu 8988t C323(1.39)  LDD1141  [7]
 LDCM0263  AC143 PaTu 8988t C323(0.64)  LDD1142  [7]
 LDCM0264  AC144 PaTu 8988t C323(0.54)  LDD1143  [7]
 LDCM0265  AC145 PaTu 8988t C323(0.71)  LDD1144  [7]
 LDCM0266  AC146 PaTu 8988t C323(0.96)  LDD1145  [7]
 LDCM0267  AC147 PaTu 8988t C323(0.55)  LDD1146  [7]
 LDCM0268  AC148 PaTu 8988t C323(0.71)  LDD1147  [7]
 LDCM0269  AC149 PaTu 8988t C323(1.22)  LDD1148  [7]
 LDCM0270  AC15 PaTu 8988t C323(1.17)  LDD1149  [7]
 LDCM0271  AC150 PaTu 8988t C323(0.66)  LDD1150  [7]
 LDCM0272  AC151 PaTu 8988t C323(0.83)  LDD1151  [7]
 LDCM0273  AC152 PaTu 8988t C323(0.56)  LDD1152  [7]
 LDCM0274  AC153 PaTu 8988t C323(0.56)  LDD1153  [7]
 LDCM0621  AC154 PaTu 8988t C323(0.86)  LDD2166  [7]
 LDCM0622  AC155 PaTu 8988t C323(0.57)  LDD2167  [7]
 LDCM0623  AC156 PaTu 8988t C323(0.59)  LDD2168  [7]
 LDCM0624  AC157 PaTu 8988t C323(1.01)  LDD2169  [7]
 LDCM0276  AC17 HEK-293T C14(1.00); C323(0.93)  LDD1515  [6]
 LDCM0277  AC18 HEK-293T C14(1.00); C323(0.73)  LDD1516  [6]
 LDCM0278  AC19 HEK-293T C14(0.93)  LDD1517  [6]
 LDCM0279  AC2 HEK-293T C14(0.97); C323(0.85)  LDD1518  [6]
 LDCM0280  AC20 HEK-293T C14(0.96); C323(0.98); C258(1.19)  LDD1519  [6]
 LDCM0281  AC21 HEK-293T C14(1.05)  LDD1520  [6]
 LDCM0282  AC22 HEK-293T C14(0.97); C323(1.09)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C14(1.04); C323(0.97)  LDD1522  [6]
 LDCM0284  AC24 HEK-293T C14(0.83); C323(1.05)  LDD1523  [6]
 LDCM0285  AC25 HEK-293T C14(1.00); C323(0.87)  LDD1524  [6]
 LDCM0286  AC26 HEK-293T C14(0.98); C323(0.85)  LDD1525  [6]
 LDCM0287  AC27 HEK-293T C14(0.99)  LDD1526  [6]
 LDCM0288  AC28 HEK-293T C14(0.99); C323(0.94); C258(1.37)  LDD1527  [6]
 LDCM0289  AC29 HEK-293T C14(0.96)  LDD1528  [6]
 LDCM0290  AC3 HEK-293T C14(0.97)  LDD1529  [6]
 LDCM0291  AC30 HEK-293T C14(0.99); C323(1.05)  LDD1530  [6]
 LDCM0292  AC31 HEK-293T C14(1.11); C323(1.15)  LDD1531  [6]
 LDCM0293  AC32 HEK-293T C14(0.91); C323(1.00)  LDD1532  [6]
 LDCM0294  AC33 HEK-293T C14(1.06); C323(1.00)  LDD1533  [6]
 LDCM0295  AC34 HEK-293T C14(1.00); C323(0.93)  LDD1534  [6]
 LDCM0296  AC35 PaTu 8988t C323(1.02)  LDD1175  [7]
 LDCM0297  AC36 PaTu 8988t C323(0.97)  LDD1176  [7]
 LDCM0298  AC37 PaTu 8988t C323(0.83)  LDD1177  [7]
 LDCM0299  AC38 PaTu 8988t C323(0.86)  LDD1178  [7]
 LDCM0300  AC39 PaTu 8988t C323(1.02)  LDD1179  [7]
 LDCM0301  AC4 HEK-293T C14(1.12); C323(1.07); C258(1.13)  LDD1540  [6]
 LDCM0302  AC40 PaTu 8988t C323(0.84)  LDD1181  [7]
 LDCM0303  AC41 PaTu 8988t C323(0.93)  LDD1182  [7]
 LDCM0304  AC42 PaTu 8988t C323(0.99)  LDD1183  [7]
 LDCM0305  AC43 PaTu 8988t C323(0.93)  LDD1184  [7]
 LDCM0306  AC44 PaTu 8988t C323(1.04)  LDD1185  [7]
 LDCM0307  AC45 PaTu 8988t C323(0.89)  LDD1186  [7]
 LDCM0308  AC46 HEK-293T C14(0.94); C323(1.15)  LDD1547  [6]
 LDCM0309  AC47 HEK-293T C14(0.98); C323(0.95)  LDD1548  [6]
 LDCM0310  AC48 HEK-293T C14(1.05); C323(1.01)  LDD1549  [6]
 LDCM0311  AC49 HEK-293T C14(0.98); C323(1.12)  LDD1550  [6]
 LDCM0312  AC5 HEK-293T C14(1.02)  LDD1551  [6]
 LDCM0313  AC50 HEK-293T C14(0.98); C323(0.99)  LDD1552  [6]
 LDCM0314  AC51 HEK-293T C14(0.95)  LDD1553  [6]
 LDCM0315  AC52 HEK-293T C14(1.03); C323(0.97); C258(1.12)  LDD1554  [6]
 LDCM0316  AC53 HEK-293T C14(1.03)  LDD1555  [6]
 LDCM0317  AC54 HEK-293T C14(1.00); C323(1.16)  LDD1556  [6]
 LDCM0318  AC55 HEK-293T C14(1.04); C323(1.01)  LDD1557  [6]
 LDCM0319  AC56 HEK-293T C14(1.07); C323(1.02)  LDD1558  [6]
 LDCM0320  AC57 HEK-293T C14(1.04); C323(0.81)  LDD1559  [6]
 LDCM0321  AC58 HEK-293T C14(1.00); C323(0.87)  LDD1560  [6]
 LDCM0322  AC59 HEK-293T C14(0.93)  LDD1561  [6]
 LDCM0323  AC6 PaTu 8988t C323(1.07)  LDD1202  [7]
 LDCM0324  AC60 HEK-293T C14(1.10); C323(0.96); C258(1.23)  LDD1563  [6]
 LDCM0325  AC61 HEK-293T C14(1.07)  LDD1564  [6]
 LDCM0326  AC62 HEK-293T C14(0.96); C323(1.30)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C14(0.95); C323(1.14)  LDD1566  [6]
 LDCM0328  AC64 HEK-293T C14(0.92); C323(1.08)  LDD1567  [6]
 LDCM0332  AC68 PaTu 8988t C323(1.06)  LDD1211  [7]
 LDCM0333  AC69 PaTu 8988t C323(1.20)  LDD1212  [7]
 LDCM0334  AC7 PaTu 8988t C323(2.37)  LDD1213  [7]
 LDCM0335  AC70 PaTu 8988t C323(0.86)  LDD1214  [7]
 LDCM0336  AC71 PaTu 8988t C323(0.74)  LDD1215  [7]
 LDCM0337  AC72 PaTu 8988t C323(1.37)  LDD1216  [7]
 LDCM0338  AC73 PaTu 8988t C323(0.82)  LDD1217  [7]
 LDCM0339  AC74 PaTu 8988t C323(0.73)  LDD1218  [7]
 LDCM0340  AC75 PaTu 8988t C323(1.06)  LDD1219  [7]
 LDCM0341  AC76 PaTu 8988t C323(0.88)  LDD1220  [7]
 LDCM0342  AC77 PaTu 8988t C323(0.84)  LDD1221  [7]
 LDCM0343  AC78 PaTu 8988t C323(1.02)  LDD1222  [7]
 LDCM0344  AC79 PaTu 8988t C323(0.96)  LDD1223  [7]
 LDCM0345  AC8 PaTu 8988t C323(0.97)  LDD1224  [7]
 LDCM0346  AC80 PaTu 8988t C323(0.70)  LDD1225  [7]
 LDCM0347  AC81 PaTu 8988t C323(2.15)  LDD1226  [7]
 LDCM0348  AC82 PaTu 8988t C323(0.95)  LDD1227  [7]
 LDCM0365  AC98 PaTu 8988t C323(1.10)  LDD1244  [7]
 LDCM0366  AC99 PaTu 8988t C323(0.99)  LDD1245  [7]
 LDCM0248  AKOS034007472 PaTu 8988t C323(0.90)  LDD1127  [7]
 LDCM0356  AKOS034007680 PaTu 8988t C323(1.43)  LDD1235  [7]
 LDCM0275  AKOS034007705 PaTu 8988t C323(1.22)  LDD1154  [7]
 LDCM0367  CL1 HEK-293T C14(1.04); C323(1.01)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C14(0.99); C323(0.87)  LDD1572  [6]
 LDCM0369  CL100 HEK-293T C14(1.15); C323(1.11)  LDD1573  [6]
 LDCM0370  CL101 PaTu 8988t C323(1.08)  LDD1249  [7]
 LDCM0371  CL102 PaTu 8988t C323(0.98)  LDD1250  [7]
 LDCM0372  CL103 PaTu 8988t C323(1.33)  LDD1251  [7]
 LDCM0373  CL104 PaTu 8988t C323(0.68)  LDD1252  [7]
 LDCM0374  CL105 HEK-293T C14(1.04); C323(0.84)  LDD1578  [6]
 LDCM0375  CL106 HEK-293T C14(0.91); C258(0.87)  LDD1579  [6]
 LDCM0376  CL107 HEK-293T C14(0.94); C323(1.00)  LDD1580  [6]
 LDCM0377  CL108 HEK-293T C14(0.90); C323(0.88)  LDD1581  [6]
 LDCM0378  CL109 HEK-293T C14(1.15); C323(0.98)  LDD1582  [6]
 LDCM0379  CL11 HEK-293T C14(1.12); C323(1.11)  LDD1583  [6]
 LDCM0380  CL110 HEK-293T C14(0.88); C258(1.07)  LDD1584  [6]
 LDCM0381  CL111 HEK-293T C14(0.97); C323(1.03)  LDD1585  [6]
 LDCM0382  CL112 HEK-293T C14(1.04); C323(0.97)  LDD1586  [6]
 LDCM0383  CL113 HEK-293T C14(1.19); C323(1.05)  LDD1587  [6]
 LDCM0384  CL114 HEK-293T C14(0.99); C258(0.84)  LDD1588  [6]
 LDCM0385  CL115 HEK-293T C14(1.07); C323(1.55)  LDD1589  [6]
 LDCM0386  CL116 HEK-293T C14(1.27); C323(0.96)  LDD1590  [6]
 LDCM0387  CL117 PaTu 8988t C323(1.06)  LDD1266  [7]
 LDCM0388  CL118 PaTu 8988t C323(1.03)  LDD1267  [7]
 LDCM0389  CL119 PaTu 8988t C323(0.84)  LDD1268  [7]
 LDCM0390  CL12 HEK-293T C14(1.28); C323(1.15)  LDD1594  [6]
 LDCM0391  CL120 PaTu 8988t C323(0.90)  LDD1270  [7]
 LDCM0392  CL121 HEK-293T C14(1.11); C323(0.86)  LDD1596  [6]
 LDCM0393  CL122 HEK-293T C14(0.97); C258(1.03)  LDD1597  [6]
 LDCM0394  CL123 HEK-293T C14(0.91); C323(1.05)  LDD1598  [6]
 LDCM0395  CL124 HEK-293T C14(1.02); C323(1.00)  LDD1599  [6]
 LDCM0396  CL125 HEK-293T C14(1.20); C323(1.09)  LDD1600  [6]
 LDCM0397  CL126 HEK-293T C14(0.86); C258(1.07)  LDD1601  [6]
 LDCM0398  CL127 HEK-293T C14(0.98); C323(0.91)  LDD1602  [6]
 LDCM0399  CL128 HEK-293T C14(1.24); C323(1.07)  LDD1603  [6]
 LDCM0400  CL13 HEK-293T C14(1.13); C323(1.08)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C14(1.06); C258(1.50)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C14(0.98); C323(1.97)  LDD1606  [6]
 LDCM0403  CL16 HEK-293T C14(0.94); C323(0.80)  LDD1607  [6]
 LDCM0404  CL17 HEK-293T C14(0.97); C323(1.05)  LDD1608  [6]
 LDCM0405  CL18 HEK-293T C14(1.06); C323(0.72)  LDD1609  [6]
 LDCM0406  CL19 HEK-293T C14(1.13)  LDD1610  [6]
 LDCM0407  CL2 HEK-293T C14(1.00); C258(0.79)  LDD1611  [6]
 LDCM0408  CL20 HEK-293T C14(1.11); C323(0.99); C258(1.16)  LDD1612  [6]
 LDCM0409  CL21 HEK-293T C14(1.01)  LDD1613  [6]
 LDCM0410  CL22 HEK-293T C14(0.96); C323(0.91)  LDD1614  [6]
 LDCM0411  CL23 HEK-293T C14(1.09); C323(1.10)  LDD1615  [6]
 LDCM0412  CL24 HEK-293T C14(1.32); C323(0.97)  LDD1616  [6]
 LDCM0413  CL25 HEK-293T C14(1.01); C323(1.07)  LDD1617  [6]
 LDCM0414  CL26 HEK-293T C14(0.91); C258(0.96)  LDD1618  [6]
 LDCM0415  CL27 HEK-293T C14(0.98); C323(1.17)  LDD1619  [6]
 LDCM0416  CL28 HEK-293T C14(0.89); C323(0.87)  LDD1620  [6]
 LDCM0417  CL29 HEK-293T C14(1.04); C323(0.87)  LDD1621  [6]
 LDCM0418  CL3 HEK-293T C14(1.04); C323(1.11)  LDD1622  [6]
 LDCM0419  CL30 HEK-293T C14(0.97); C323(0.89)  LDD1623  [6]
 LDCM0420  CL31 HEK-293T C14(1.12)  LDD1624  [6]
 LDCM0421  CL32 HEK-293T C14(0.95); C323(1.00); C258(1.25)  LDD1625  [6]
 LDCM0422  CL33 HEK-293T C14(0.83)  LDD1626  [6]
 LDCM0423  CL34 HEK-293T C14(0.93); C323(0.95)  LDD1627  [6]
 LDCM0424  CL35 HEK-293T C14(1.17); C323(0.95)  LDD1628  [6]
 LDCM0425  CL36 HEK-293T C14(1.09); C323(1.14)  LDD1629  [6]
 LDCM0426  CL37 HEK-293T C14(1.12); C323(0.93)  LDD1630  [6]
 LDCM0428  CL39 HEK-293T C14(0.99); C323(1.09)  LDD1632  [6]
 LDCM0429  CL4 HEK-293T C14(1.04); C323(1.19)  LDD1633  [6]
 LDCM0430  CL40 HEK-293T C14(1.01); C323(1.17)  LDD1634  [6]
 LDCM0431  CL41 HEK-293T C14(1.01); C323(0.98)  LDD1635  [6]
 LDCM0432  CL42 HEK-293T C14(1.00); C323(0.97)  LDD1636  [6]
 LDCM0433  CL43 HEK-293T C14(1.10)  LDD1637  [6]
 LDCM0434  CL44 HEK-293T C14(1.14); C323(0.97); C258(1.11)  LDD1638  [6]
 LDCM0435  CL45 HEK-293T C14(0.90)  LDD1639  [6]
 LDCM0436  CL46 PaTu 8988t C323(0.88)  LDD1315  [7]
 LDCM0437  CL47 PaTu 8988t C323(0.70)  LDD1316  [7]
 LDCM0438  CL48 PaTu 8988t C323(0.94)  LDD1317  [7]
 LDCM0439  CL49 PaTu 8988t C323(0.75)  LDD1318  [7]
 LDCM0440  CL5 HEK-293T C14(1.07); C323(0.96)  LDD1644  [6]
 LDCM0441  CL50 PaTu 8988t C323(0.65)  LDD1320  [7]
 LDCM0442  CL51 PaTu 8988t C323(0.70)  LDD1321  [7]
 LDCM0443  CL52 PaTu 8988t C323(0.92)  LDD1322  [7]
 LDCM0444  CL53 PaTu 8988t C323(0.58)  LDD1323  [7]
 LDCM0445  CL54 PaTu 8988t C323(0.75)  LDD1324  [7]
 LDCM0446  CL55 PaTu 8988t C323(0.74)  LDD1325  [7]
 LDCM0447  CL56 PaTu 8988t C323(0.87)  LDD1326  [7]
 LDCM0448  CL57 PaTu 8988t C323(0.83)  LDD1327  [7]
 LDCM0449  CL58 PaTu 8988t C323(0.84)  LDD1328  [7]
 LDCM0450  CL59 PaTu 8988t C323(0.77)  LDD1329  [7]
 LDCM0451  CL6 HEK-293T C14(0.98); C323(0.80)  LDD1654  [6]
 LDCM0452  CL60 PaTu 8988t C323(0.78)  LDD1331  [7]
 LDCM0453  CL61 PaTu 8988t C323(1.19)  LDD1332  [7]
 LDCM0454  CL62 PaTu 8988t C323(1.04)  LDD1333  [7]
 LDCM0455  CL63 PaTu 8988t C323(0.96)  LDD1334  [7]
 LDCM0456  CL64 PaTu 8988t C323(1.04)  LDD1335  [7]
 LDCM0457  CL65 PaTu 8988t C323(0.93)  LDD1336  [7]
 LDCM0458  CL66 PaTu 8988t C323(0.93)  LDD1337  [7]
 LDCM0459  CL67 PaTu 8988t C323(1.98)  LDD1338  [7]
 LDCM0460  CL68 PaTu 8988t C323(1.23)  LDD1339  [7]
 LDCM0461  CL69 PaTu 8988t C323(0.88)  LDD1340  [7]
 LDCM0462  CL7 HEK-293T C14(1.11)  LDD1665  [6]
 LDCM0463  CL70 PaTu 8988t C323(0.79)  LDD1342  [7]
 LDCM0464  CL71 PaTu 8988t C323(1.08)  LDD1343  [7]
 LDCM0465  CL72 PaTu 8988t C323(1.25)  LDD1344  [7]
 LDCM0466  CL73 PaTu 8988t C323(1.02)  LDD1345  [7]
 LDCM0467  CL74 PaTu 8988t C323(1.30)  LDD1346  [7]
 LDCM0469  CL76 PaTu 8988t C323(1.03)  LDD1348  [7]
 LDCM0470  CL77 PaTu 8988t C323(1.10)  LDD1349  [7]
 LDCM0471  CL78 PaTu 8988t C323(1.52)  LDD1350  [7]
 LDCM0472  CL79 PaTu 8988t C323(0.96)  LDD1351  [7]
 LDCM0473  CL8 HEK-293T C14(0.91); C323(0.85); C258(0.95)  LDD1676  [6]
 LDCM0474  CL80 PaTu 8988t C323(1.10)  LDD1353  [7]
 LDCM0475  CL81 PaTu 8988t C323(1.08)  LDD1354  [7]
 LDCM0476  CL82 PaTu 8988t C323(0.96)  LDD1355  [7]
 LDCM0477  CL83 PaTu 8988t C323(0.91)  LDD1356  [7]
 LDCM0478  CL84 PaTu 8988t C323(1.08)  LDD1357  [7]
 LDCM0479  CL85 PaTu 8988t C323(1.27)  LDD1358  [7]
 LDCM0480  CL86 PaTu 8988t C323(0.88)  LDD1359  [7]
 LDCM0481  CL87 PaTu 8988t C323(1.40)  LDD1360  [7]
 LDCM0482  CL88 PaTu 8988t C323(1.27)  LDD1361  [7]
 LDCM0483  CL89 PaTu 8988t C323(1.19)  LDD1362  [7]
 LDCM0484  CL9 HEK-293T C14(0.97)  LDD1687  [6]
 LDCM0485  CL90 PaTu 8988t C323(0.87)  LDD1364  [7]
 LDCM0486  CL91 HEK-293T C14(0.98)  LDD1689  [6]
 LDCM0487  CL92 HEK-293T C14(0.98); C323(0.93); C258(1.11)  LDD1690  [6]
 LDCM0488  CL93 HEK-293T C14(0.90)  LDD1691  [6]
 LDCM0489  CL94 HEK-293T C14(0.96); C323(0.98)  LDD1692  [6]
 LDCM0490  CL95 HEK-293T C14(0.99); C323(0.99)  LDD1693  [6]
 LDCM0491  CL96 HEK-293T C14(0.69); C323(1.22)  LDD1694  [6]
 LDCM0492  CL97 HEK-293T C14(1.18); C323(0.81)  LDD1695  [6]
 LDCM0493  CL98 HEK-293T C14(0.96); C258(0.93)  LDD1696  [6]
 LDCM0494  CL99 HEK-293T C14(1.03); C323(1.04)  LDD1697  [6]
 LDCM0495  E2913 HEK-293T C14(1.05); C323(1.12)  LDD1698  [6]
 LDCM0468  Fragment33 PaTu 8988t C323(0.80)  LDD1347  [7]
 LDCM0427  Fragment51 HEK-293T C14(0.91); C258(0.90)  LDD1631  [6]
 LDCM0022  KB02 HEK-293T C14(1.00); C323(1.05)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C14(0.98); C323(0.91)  LDD1497  [6]
 LDCM0024  KB05 SK-MEL-28 C14(1.75)  LDD3427  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) Glyceraldehyde-3-phosphate dehydrogenase family P04406
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bax inhibitor 1 (TMBIM6) BI1 family P55061
Translocator protein 2 (TSPO2) TspO/BZRP family Q5TGU0
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proto-oncogene c-Rel (REL) . Q04864
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
C-C motif chemokine 3-like 1 (CCL3L1; CCL3L3) Intercrine beta (chemokine CC) family P16619
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Single-pass membrane and coiled-coil domain-containing protein 4 (SMCO4) SMCO4 family Q9NRQ5
Suppressor of fused homolog (SUFU) SUFU family Q9UMX1
Insulin-like growth factor-binding protein 5 (IGFBP5) . P24593
Na(+)/H(+) exchange regulatory cofactor NHE-RF4 (NHERF4) . Q86UT5

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
4 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
5 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.