Details of the Target

General Information of Target

Target ID LDTP03050
Target Name Ras-related protein Rab-5A (RAB5A)
Gene Name RAB5A
Gene ID 5868
Synonyms
RAB5; Ras-related protein Rab-5A; EC 3.6.5.2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASRGATRPNGPNTGNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQ
TVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNEESFARAKNWVKELQR
QASPNIVIALSGNKADLANKRAVDFQEAQSYADDNSLLFMETSAKTSMNVNEIFMAIAKK
LPKNEPQNPGANSARGRGVDLTEPTQPTRNQCCSN
Target Bioclass
Enzyme
Family
Small GTPase superfamily, Rab family
Subcellular location
Cell membrane
Function
Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension. Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan. Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3.
Uniprot ID
P20339
Ensemble ID
ENST00000273047.9
HGNC ID
HGNC:9783

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AU565 SNV: p.R197T .
HT115 SNV: p.A164T .
MFE319 Insertion: p.N113KfsTer4
SNV: p.F21I		 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y82(18.34)  LDD0257  [2]
STPyne
 Probe Info  		K140(6.17); K179(3.59)  LDD0277  [3]
OPA-S-S-alkyne
 Probe Info  		K116(1.13)  LDD3494  [4]
DBIA
 Probe Info  		C63(3.10)  LDD3319  [5]
AHL-Pu-1
 Probe Info  		C63(2.19)  LDD0169  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [7]
IPM
 Probe Info  		N.A.  LDD0025  [8]
TFBX
 Probe Info  		N.A.  LDD0027  [8]
Acrolein
 Probe Info  		N.A.  LDD0217  [9]
Methacrolein
 Probe Info  		N.A.  LDD0218  [9]
AOyne
 Probe Info  		9.70  LDD0443  [10]
MPP-AC
 Probe Info  		N.A.  LDD0428  [11]
NAIA_5
 Probe Info  		N.A.  LDD2223  [12]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C235
 Probe Info  		17.27  LDD1908  [13]
C289
 Probe Info  		26.54  LDD1959  [13]
C314
 Probe Info  		11.47  LDD1981  [13]
FFF probe13
 Probe Info  		8.74  LDD0475  [14]
FFF probe2
 Probe Info  		18.62  LDD0463  [14]
FFF probe3
 Probe Info  		19.14  LDD0464  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C63(2.19)  LDD0169  [6]
 LDCM0214  AC1 HEK-293T C63(1.08)  LDD1507  [15]
 LDCM0215  AC10 HEK-293T C63(0.96)  LDD1508  [15]
 LDCM0226  AC11 HEK-293T C63(0.98)  LDD1509  [15]
 LDCM0237  AC12 HEK-293T C63(0.96)  LDD1510  [15]
 LDCM0259  AC14 HEK-293T C63(1.04)  LDD1512  [15]
 LDCM0263  AC143 PaTu 8988t C63(1.23)  LDD1142  [16]
 LDCM0264  AC144 PaTu 8988t C63(0.97)  LDD1143  [16]
 LDCM0265  AC145 PaTu 8988t C63(1.15)  LDD1144  [16]
 LDCM0266  AC146 PaTu 8988t C63(1.21)  LDD1145  [16]
 LDCM0267  AC147 PaTu 8988t C63(1.19)  LDD1146  [16]
 LDCM0268  AC148 PaTu 8988t C63(1.32)  LDD1147  [16]
 LDCM0269  AC149 PaTu 8988t C63(1.24)  LDD1148  [16]
 LDCM0270  AC15 HEK-293T C63(1.04)  LDD1513  [15]
 LDCM0271  AC150 PaTu 8988t C63(1.23)  LDD1150  [16]
 LDCM0272  AC151 PaTu 8988t C63(1.52)  LDD1151  [16]
 LDCM0273  AC152 PaTu 8988t C63(1.31)  LDD1152  [16]
 LDCM0274  AC153 PaTu 8988t C63(1.31)  LDD1153  [16]
 LDCM0621  AC154 PaTu 8988t C63(1.76)  LDD2166  [16]
 LDCM0622  AC155 PaTu 8988t C63(1.26)  LDD2167  [16]
 LDCM0623  AC156 PaTu 8988t C63(1.56)  LDD2168  [16]
 LDCM0624  AC157 PaTu 8988t C63(1.50)  LDD2169  [16]
 LDCM0276  AC17 HEK-293T C63(1.07)  LDD1515  [15]
 LDCM0277  AC18 HEK-293T C63(0.92)  LDD1516  [15]
 LDCM0278  AC19 HEK-293T C63(0.85)  LDD1517  [15]
 LDCM0279  AC2 HEK-293T C63(0.99)  LDD1518  [15]
 LDCM0280  AC20 HEK-293T C63(0.99)  LDD1519  [15]
 LDCM0281  AC21 HEK-293T C63(0.97)  LDD1520  [15]
 LDCM0282  AC22 HEK-293T C63(0.96)  LDD1521  [15]
 LDCM0283  AC23 HEK-293T C63(1.00)  LDD1522  [15]
 LDCM0284  AC24 HEK-293T C63(0.89)  LDD1523  [15]
 LDCM0285  AC25 PaTu 8988t C63(0.65)  LDD1164  [16]
 LDCM0286  AC26 PaTu 8988t C63(0.62)  LDD1165  [16]
 LDCM0287  AC27 PaTu 8988t C63(0.72)  LDD1166  [16]
 LDCM0288  AC28 PaTu 8988t C63(0.81)  LDD1167  [16]
 LDCM0289  AC29 PaTu 8988t C63(0.77)  LDD1168  [16]
 LDCM0290  AC3 HEK-293T C63(1.01)  LDD1529  [15]
 LDCM0291  AC30 PaTu 8988t C63(1.07)  LDD1170  [16]
 LDCM0292  AC31 PaTu 8988t C63(0.57)  LDD1171  [16]
 LDCM0293  AC32 PaTu 8988t C63(0.69)  LDD1172  [16]
 LDCM0294  AC33 PaTu 8988t C63(0.83)  LDD1173  [16]
 LDCM0295  AC34 PaTu 8988t C63(1.13)  LDD1174  [16]
 LDCM0296  AC35 HEK-293T C63(0.92)  LDD1535  [15]
 LDCM0297  AC36 HEK-293T C63(0.90)  LDD1536  [15]
 LDCM0298  AC37 HEK-293T C63(0.93)  LDD1537  [15]
 LDCM0299  AC38 HEK-293T C63(1.02)  LDD1538  [15]
 LDCM0300  AC39 HEK-293T C63(0.99)  LDD1539  [15]
 LDCM0301  AC4 HEK-293T C63(0.98)  LDD1540  [15]
 LDCM0302  AC40 HEK-293T C63(1.00)  LDD1541  [15]
 LDCM0303  AC41 HEK-293T C63(1.16)  LDD1542  [15]
 LDCM0304  AC42 HEK-293T C63(0.95)  LDD1543  [15]
 LDCM0305  AC43 HEK-293T C63(0.91)  LDD1544  [15]
 LDCM0306  AC44 HEK-293T C63(0.91)  LDD1545  [15]
 LDCM0307  AC45 HEK-293T C63(0.99)  LDD1546  [15]
 LDCM0308  AC46 PaTu 8988t C63(1.04)  LDD1187  [16]
 LDCM0309  AC47 PaTu 8988t C63(1.10)  LDD1188  [16]
 LDCM0310  AC48 PaTu 8988t C63(1.36)  LDD1189  [16]
 LDCM0311  AC49 PaTu 8988t C63(1.31)  LDD1190  [16]
 LDCM0312  AC5 HEK-293T C63(1.02)  LDD1551  [15]
 LDCM0313  AC50 PaTu 8988t C63(1.21)  LDD1192  [16]
 LDCM0314  AC51 PaTu 8988t C63(1.02)  LDD1193  [16]
 LDCM0315  AC52 PaTu 8988t C63(1.21)  LDD1194  [16]
 LDCM0316  AC53 PaTu 8988t C63(1.46)  LDD1195  [16]
 LDCM0317  AC54 PaTu 8988t C63(1.67)  LDD1196  [16]
 LDCM0318  AC55 PaTu 8988t C63(1.21)  LDD1197  [16]
 LDCM0319  AC56 PaTu 8988t C63(1.12)  LDD1198  [16]
 LDCM0320  AC57 HEK-293T C63(1.10)  LDD1559  [15]
 LDCM0321  AC58 HEK-293T C63(1.00)  LDD1560  [15]
 LDCM0322  AC59 HEK-293T C63(0.96)  LDD1561  [15]
 LDCM0323  AC6 HEK-293T C63(1.10)  LDD1562  [15]
 LDCM0324  AC60 HEK-293T C63(1.01)  LDD1563  [15]
 LDCM0325  AC61 HEK-293T C63(0.93)  LDD1564  [15]
 LDCM0326  AC62 HEK-293T C63(1.09)  LDD1565  [15]
 LDCM0327  AC63 HEK-293T C63(0.95)  LDD1566  [15]
 LDCM0328  AC64 HEK-293T C63(1.03)  LDD1567  [15]
 LDCM0334  AC7 HEK-293T C63(1.02)  LDD1568  [15]
 LDCM0345  AC8 HEK-293T C63(1.03)  LDD1569  [15]
 LDCM0248  AKOS034007472 HEK-293T C63(0.96)  LDD1511  [15]
 LDCM0356  AKOS034007680 HEK-293T C63(1.09)  LDD1570  [15]
 LDCM0275  AKOS034007705 HEK-293T C63(1.02)  LDD1514  [15]
 LDCM0156  Aniline NCI-H1299 12.98  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [9]
 LDCM0367  CL1 HEK-293T C63(0.99)  LDD1571  [15]
 LDCM0368  CL10 HEK-293T C63(1.38)  LDD1572  [15]
 LDCM0369  CL100 HEK-293T C63(1.01)  LDD1573  [15]
 LDCM0370  CL101 HEK-293T C63(1.02)  LDD1574  [15]
 LDCM0371  CL102 HEK-293T C63(1.00)  LDD1575  [15]
 LDCM0372  CL103 HEK-293T C63(1.00)  LDD1576  [15]
 LDCM0373  CL104 HEK-293T C63(1.02)  LDD1577  [15]
 LDCM0374  CL105 HEK-293T C63(0.97)  LDD1578  [15]
 LDCM0375  CL106 HEK-293T C63(1.00)  LDD1579  [15]
 LDCM0376  CL107 HEK-293T C63(1.10)  LDD1580  [15]
 LDCM0377  CL108 HEK-293T C63(0.98)  LDD1581  [15]
 LDCM0378  CL109 HEK-293T C63(0.94)  LDD1582  [15]
 LDCM0379  CL11 HEK-293T C63(1.42)  LDD1583  [15]
 LDCM0380  CL110 HEK-293T C63(1.00)  LDD1584  [15]
 LDCM0381  CL111 HEK-293T C63(0.90)  LDD1585  [15]
 LDCM0382  CL112 PaTu 8988t C63(0.63)  LDD1261  [16]
 LDCM0383  CL113 PaTu 8988t C63(0.73)  LDD1262  [16]
 LDCM0384  CL114 PaTu 8988t C63(0.60)  LDD1263  [16]
 LDCM0385  CL115 PaTu 8988t C63(0.68)  LDD1264  [16]
 LDCM0386  CL116 PaTu 8988t C63(0.51)  LDD1265  [16]
 LDCM0387  CL117 HEK-293T C63(0.92)  LDD1591  [15]
 LDCM0388  CL118 HEK-293T C63(0.94)  LDD1592  [15]
 LDCM0389  CL119 HEK-293T C63(1.02)  LDD1593  [15]
 LDCM0390  CL12 HEK-293T C63(1.56)  LDD1594  [15]
 LDCM0391  CL120 HEK-293T C63(1.08)  LDD1595  [15]
 LDCM0392  CL121 PaTu 8988t C63(1.15)  LDD1271  [16]
 LDCM0393  CL122 PaTu 8988t C63(1.30)  LDD1272  [16]
 LDCM0394  CL123 PaTu 8988t C63(1.33)  LDD1273  [16]
 LDCM0395  CL124 PaTu 8988t C63(1.19)  LDD1274  [16]
 LDCM0396  CL125 HEK-293T C63(1.01)  LDD1600  [15]
 LDCM0397  CL126 HEK-293T C63(0.96)  LDD1601  [15]
 LDCM0398  CL127 HEK-293T C63(1.06)  LDD1602  [15]
 LDCM0399  CL128 HEK-293T C63(1.04)  LDD1603  [15]
 LDCM0400  CL13 HEK-293T C63(0.93)  LDD1604  [15]
 LDCM0401  CL14 HEK-293T C63(0.97)  LDD1605  [15]
 LDCM0402  CL15 HEK-293T C63(0.95)  LDD1606  [15]
 LDCM0403  CL16 HEK-293T C63(1.11)  LDD1607  [15]
 LDCM0404  CL17 HEK-293T C63(1.03)  LDD1608  [15]
 LDCM0405  CL18 HEK-293T C63(1.11)  LDD1609  [15]
 LDCM0406  CL19 HEK-293T C63(1.16)  LDD1610  [15]
 LDCM0407  CL2 HEK-293T C63(1.15)  LDD1611  [15]
 LDCM0408  CL20 HEK-293T C63(1.08)  LDD1612  [15]
 LDCM0409  CL21 HEK-293T C63(1.30)  LDD1613  [15]
 LDCM0410  CL22 HEK-293T C63(1.40)  LDD1614  [15]
 LDCM0411  CL23 HEK-293T C63(1.40)  LDD1615  [15]
 LDCM0412  CL24 HEK-293T C63(1.50)  LDD1616  [15]
 LDCM0413  CL25 HEK-293T C63(0.96)  LDD1617  [15]
 LDCM0414  CL26 HEK-293T C63(1.03)  LDD1618  [15]
 LDCM0415  CL27 HEK-293T C63(0.96)  LDD1619  [15]
 LDCM0416  CL28 HEK-293T C63(1.07)  LDD1620  [15]
 LDCM0417  CL29 HEK-293T C63(1.10)  LDD1621  [15]
 LDCM0418  CL3 HEK-293T C63(1.17)  LDD1622  [15]
 LDCM0419  CL30 HEK-293T C63(1.06)  LDD1623  [15]
 LDCM0420  CL31 HEK-293T C63(1.08)  LDD1624  [15]
 LDCM0421  CL32 HEK-293T C63(1.04)  LDD1625  [15]
 LDCM0422  CL33 HEK-293T C63(1.01)  LDD1626  [15]
 LDCM0423  CL34 HEK-293T C63(1.31)  LDD1627  [15]
 LDCM0424  CL35 HEK-293T C63(1.29)  LDD1628  [15]
 LDCM0425  CL36 HEK-293T C63(1.44)  LDD1629  [15]
 LDCM0426  CL37 HEK-293T C63(0.99)  LDD1630  [15]
 LDCM0428  CL39 HEK-293T C63(0.87)  LDD1632  [15]
 LDCM0429  CL4 HEK-293T C63(1.17)  LDD1633  [15]
 LDCM0430  CL40 HEK-293T C63(1.03)  LDD1634  [15]
 LDCM0431  CL41 HEK-293T C63(1.01)  LDD1635  [15]
 LDCM0432  CL42 HEK-293T C63(1.04)  LDD1636  [15]
 LDCM0433  CL43 HEK-293T C63(1.07)  LDD1637  [15]
 LDCM0434  CL44 HEK-293T C63(1.00)  LDD1638  [15]
 LDCM0435  CL45 HEK-293T C63(1.12)  LDD1639  [15]
 LDCM0436  CL46 HEK-293T C63(1.19)  LDD1640  [15]
 LDCM0437  CL47 HEK-293T C63(1.36)  LDD1641  [15]
 LDCM0438  CL48 HEK-293T C63(1.26)  LDD1642  [15]
 LDCM0439  CL49 HEK-293T C63(0.95)  LDD1643  [15]
 LDCM0440  CL5 HEK-293T C63(1.10)  LDD1644  [15]
 LDCM0441  CL50 HEK-293T C63(1.03)  LDD1645  [15]
 LDCM0443  CL52 HEK-293T C63(1.08)  LDD1646  [15]
 LDCM0444  CL53 HEK-293T C63(1.00)  LDD1647  [15]
 LDCM0445  CL54 HEK-293T C63(0.95)  LDD1648  [15]
 LDCM0446  CL55 HEK-293T C63(1.07)  LDD1649  [15]
 LDCM0447  CL56 HEK-293T C63(1.13)  LDD1650  [15]
 LDCM0448  CL57 HEK-293T C63(1.17)  LDD1651  [15]
 LDCM0449  CL58 HEK-293T C63(1.27)  LDD1652  [15]
 LDCM0450  CL59 HEK-293T C63(1.33)  LDD1653  [15]
 LDCM0451  CL6 HEK-293T C63(1.07)  LDD1654  [15]
 LDCM0452  CL60 HEK-293T C63(1.28)  LDD1655  [15]
 LDCM0453  CL61 PaTu 8988t C63(0.90)  LDD1332  [16]
 LDCM0454  CL62 PaTu 8988t C63(1.12)  LDD1333  [16]
 LDCM0455  CL63 PaTu 8988t C63(0.80)  LDD1334  [16]
 LDCM0456  CL64 PaTu 8988t C63(1.02)  LDD1335  [16]
 LDCM0457  CL65 PaTu 8988t C63(1.43)  LDD1336  [16]
 LDCM0458  CL66 PaTu 8988t C63(1.29)  LDD1337  [16]
 LDCM0459  CL67 PaTu 8988t C63(1.14)  LDD1338  [16]
 LDCM0460  CL68 PaTu 8988t C63(1.15)  LDD1339  [16]
 LDCM0461  CL69 PaTu 8988t C63(1.20)  LDD1340  [16]
 LDCM0462  CL7 HEK-293T C63(1.10)  LDD1665  [15]
 LDCM0463  CL70 PaTu 8988t C63(1.14)  LDD1342  [16]
 LDCM0464  CL71 PaTu 8988t C63(0.98)  LDD1343  [16]
 LDCM0465  CL72 PaTu 8988t C63(1.18)  LDD1344  [16]
 LDCM0466  CL73 PaTu 8988t C63(1.59)  LDD1345  [16]
 LDCM0467  CL74 PaTu 8988t C63(1.09)  LDD1346  [16]
 LDCM0469  CL76 HEK-293T C63(1.07)  LDD1672  [15]
 LDCM0470  CL77 HEK-293T C63(0.97)  LDD1673  [15]
 LDCM0471  CL78 HEK-293T C63(1.01)  LDD1674  [15]
 LDCM0472  CL79 HEK-293T C63(0.98)  LDD1675  [15]
 LDCM0473  CL8 HEK-293T C63(0.90)  LDD1676  [15]
 LDCM0474  CL80 HEK-293T C63(1.08)  LDD1677  [15]
 LDCM0475  CL81 HEK-293T C63(1.18)  LDD1678  [15]
 LDCM0476  CL82 HEK-293T C63(1.18)  LDD1679  [15]
 LDCM0477  CL83 HEK-293T C63(1.20)  LDD1680  [15]
 LDCM0478  CL84 HEK-293T C63(1.22)  LDD1681  [15]
 LDCM0479  CL85 HEK-293T C63(1.00)  LDD1682  [15]
 LDCM0480  CL86 HEK-293T C63(0.98)  LDD1683  [15]
 LDCM0481  CL87 HEK-293T C63(1.05)  LDD1684  [15]
 LDCM0482  CL88 HEK-293T C63(1.14)  LDD1685  [15]
 LDCM0483  CL89 HEK-293T C63(1.17)  LDD1686  [15]
 LDCM0484  CL9 HEK-293T C63(1.18)  LDD1687  [15]
 LDCM0485  CL90 HEK-293T C63(0.82)  LDD1688  [15]
 LDCM0486  CL91 HEK-293T C63(0.99)  LDD1689  [15]
 LDCM0487  CL92 HEK-293T C63(0.97)  LDD1690  [15]
 LDCM0488  CL93 HEK-293T C63(0.97)  LDD1691  [15]
 LDCM0489  CL94 HEK-293T C63(1.17)  LDD1692  [15]
 LDCM0490  CL95 HEK-293T C63(0.98)  LDD1693  [15]
 LDCM0491  CL96 HEK-293T C63(1.11)  LDD1694  [15]
 LDCM0492  CL97 HEK-293T C63(1.00)  LDD1695  [15]
 LDCM0493  CL98 HEK-293T C63(1.05)  LDD1696  [15]
 LDCM0494  CL99 HEK-293T C63(1.04)  LDD1697  [15]
 LDCM0495  E2913 HEK-293T C63(0.97)  LDD1698  [15]
 LDCM0625  F8 Ramos C19(1.04)  LDD2187  [17]
 LDCM0572  Fragment10 Ramos C19(0.94)  LDD2189  [17]
 LDCM0574  Fragment12 Ramos C19(0.56)  LDD2191  [17]
 LDCM0575  Fragment13 Ramos C19(0.65)  LDD2192  [17]
 LDCM0576  Fragment14 Ramos C19(0.40)  LDD2193  [17]
 LDCM0579  Fragment20 Ramos C19(0.49)  LDD2194  [17]
 LDCM0580  Fragment21 Ramos C19(0.64)  LDD2195  [17]
 LDCM0582  Fragment23 Ramos C19(0.70)  LDD2196  [17]
 LDCM0578  Fragment27 Ramos C19(1.06)  LDD2197  [17]
 LDCM0586  Fragment28 Ramos C19(0.95)  LDD2198  [17]
 LDCM0588  Fragment30 Ramos C19(1.49)  LDD2199  [17]
 LDCM0589  Fragment31 Ramos C19(1.09)  LDD2200  [17]
 LDCM0590  Fragment32 Ramos C19(0.92)  LDD2201  [17]
 LDCM0468  Fragment33 PaTu 8988t C63(1.09)  LDD1347  [16]
 LDCM0596  Fragment38 Ramos C19(1.64)  LDD2203  [17]
 LDCM0566  Fragment4 Ramos C19(0.73)  LDD2184  [17]
 LDCM0427  Fragment51 HEK-293T C63(1.00)  LDD1631  [15]
 LDCM0610  Fragment52 Ramos C19(0.77)  LDD2204  [17]
 LDCM0614  Fragment56 Ramos C19(0.99)  LDD2205  [17]
 LDCM0569  Fragment7 Ramos C19(0.40)  LDD2186  [17]
 LDCM0571  Fragment9 Ramos C19(0.60)  LDD2188  [17]
 LDCM0022  KB02 HEK-293T C63(0.93)  LDD1492  [15]
 LDCM0023  KB03 HEK-293T C63(0.99)  LDD1497  [15]
 LDCM0024  KB05 MEWO C63(3.10)  LDD3319  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Inositol polyphosphate 5-phosphatase OCRL (OCRL) Inositol 1,4,5-trisphosphate 5-phosphatase type II family Q01968
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A) CAMK Ser/Thr protein kinase family Q9UQM7
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
SUN domain-containing protein 2 (SUN2) . Q9UH99
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 20 (ZNF20) Krueppel C2H2-type zinc-finger protein family P17024
Other
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein INCA1 (INCA1) INCA family Q0VD86
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Syncoilin (SYNC) Intermediate filament family Q9H7C4
Ragulator complex protein LAMTOR1 (LAMTOR1) LAMTOR1 family Q6IAA8
Cytosolic iron-sulfur assembly component 2B (CIAO2B) MIP18 family Q9Y3D0
Paraneoplastic antigen-like protein 5 (PNMA5) PNMA family Q96PV4
UPF0500 protein C1orf216 (C1orf216) UPF0500 family Q8TAB5
Alsin (ALS2) . Q96Q42
Coiled-coil domain-containing protein 120 (CCDC120) . Q96HB5
DCC-interacting protein 13-alpha (APPL1) . Q9UKG1
Early endosome antigen 1 (EEA1) . Q15075
Fanconi anemia group G protein (FANCG) . O15287
Rabankyrin-5 (ANKFY1) . Q9P2R3
Telethonin (TCAP) . O15273

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Guanosine-5'-diphosphate Small molecular drug DB04315
Guanosine-5'-triphosphate Small molecular drug DB04137
L-methionine (S)-s-oxide . DB02467

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
14 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
17 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578