Details of the Target

General Information of Target

Target ID LDTP07763
Target Name Kynurenine--oxoglutarate transaminase 3 (KYAT3)
Gene Name KYAT3
Gene ID 56267
Synonyms
CCBL2; KAT3; Kynurenine--oxoglutarate transaminase 3; EC 2.6.1.7; Cysteine-S-conjugate beta-lyase 2; EC 4.4.1.13; Kynurenine aminotransferase 3; Kynurenine aminotransferase III; KATIII; Kynurenine--glyoxylate transaminase; EC 2.6.1.63; Kynurenine--oxoglutarate transaminase III
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFLAQRSLCSLSGRAKFLKTISSSKILGFSTSAKMSLKFTNAKRIEGLDSNVWIEFTKLA
ADPSVVNLGQGFPDISPPTYVKEELSKIAAIDSLNQYTRGFGHPSLVKALSYLYEKLYQK
QIDSNKEILVTVGAYGSLFNTIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLRS
KPVYGKRWSSSDWTLDPQELESKFNSKTKAIILNTPHNPLGKVYNREELQVIADLCIKYD
TLCISDEVYEWLVYSGNKHLKIATFPGMWERTITIGSAGKTFSVTGWKLGWSIGPNHLIK
HLQTVQQNTIYTCATPLQEALAQAFWIDIKRMDDPECYFNSLPKELEVKRDRMVRLLESV
GLKPIVPDGGYFIIADVSLLDPDLSDMKNNEPYDYKFVKWMTKHKKLSAIPVSAFCNSET
KSQFEKFVRFCFIKKDSTLDAAEEIIKAWSVQKS
Target Bioclass
Enzyme
Family
Class-I pyridoxal-phosphate-dependent aminotransferase family
Function
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others. May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro).
Uniprot ID
Q6YP21
Ensemble ID
ENST00000260508.9
HGNC ID
HGNC:33238
ChEMBL ID
CHEMBL2046260

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CHL1 SNV: p.E319K DBIA    Probe Info 
DOTC24510 SNV: p.D49H DBIA    Probe Info 
HCC44 SNV: p.D376A .
HCT15 SNV: p.L129I .
SUIT2 SNV: p.P219L .
WM2664 Insertion: p.T40HfsTer7 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alkylaryl probe 1
 Probe Info  		10.00  LDD0385  [1]
TH211
 Probe Info  		Y97(14.20)  LDD0257  [2]
Probe 1
 Probe Info  		Y97(8.69); Y184(33.46)  LDD3495  [3]
BTD
 Probe Info  		C416(1.10)  LDD2089  [4]
NAIA_5
 Probe Info  		C337(20.00); C337(3.52)  LDD2227  [5]
DBIA
 Probe Info  		C236(10.08)  LDD0204  [6]
HHS-482
 Probe Info  		Y311(0.27)  LDD0285  [7]
HHS-475
 Probe Info  		Y311(0.95); Y112(1.02)  LDD0264  [8]
HHS-465
 Probe Info  		Y112(1.42)  LDD2237  [9]
Acrolein
 Probe Info  		N.A.  LDD0222  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		C313(0.00); C416(0.00); C337(0.00); C243(0.00)  LDD0038  [11]
IA-alkyne
 Probe Info  		C313(0.00); C416(0.00); C337(0.00)  LDD0036  [11]
Lodoacetamide azide
 Probe Info  		C313(0.00); C416(0.00); C337(0.00); C243(0.00)  LDD0037  [11]
NAIA_4
 Probe Info  		C313(0.00); C416(0.00)  LDD2226  [5]
IPM
 Probe Info  		C416(0.00); C337(0.00)  LDD2156  [12]
PF-06672131
 Probe Info  		N.A.  LDD0152  [13]
SF
 Probe Info  		Y184(0.00); Y112(0.00)  LDD0028  [14]
Ox-W18
 Probe Info  		N.A.  LDD2175  [15]
1c-yne
 Probe Info  		N.A.  LDD0228  [16]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C275
 Probe Info  		14.03  LDD1945  [17]
C280
 Probe Info  		8.94  LDD1950  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C416(0.66)  LDD2117  [4]
 LDCM0214  AC1 HEK-293T C337(0.96); C416(0.94); C236(1.16); C313(1.03)  LDD1507  [18]
 LDCM0215  AC10 HEK-293T C337(0.94); C416(0.84); C313(1.09); C243(0.96)  LDD1508  [18]
 LDCM0226  AC11 HEK-293T C337(1.03); C416(0.96); C236(1.14); C313(0.93)  LDD1509  [18]
 LDCM0237  AC12 HEK-293T C337(1.02); C416(1.05); C236(0.96); C313(1.09)  LDD1510  [18]
 LDCM0259  AC14 HEK-293T C337(1.01); C416(0.97); C236(1.05); C313(1.04)  LDD1512  [18]
 LDCM0270  AC15 HEK-293T C337(0.97); C416(1.03); C236(0.94); C313(0.96)  LDD1513  [18]
 LDCM0276  AC17 HEK-293T C337(0.98); C416(0.95); C236(0.96); C313(0.93)  LDD1515  [18]
 LDCM0277  AC18 HEK-293T C337(0.97); C416(0.93); C313(0.99); C243(0.86)  LDD1516  [18]
 LDCM0278  AC19 HEK-293T C337(0.94); C416(0.94); C236(0.92); C313(0.83)  LDD1517  [18]
 LDCM0279  AC2 HEK-293T C337(1.00); C416(0.88); C313(1.02); C243(1.02)  LDD1518  [18]
 LDCM0280  AC20 HEK-293T C337(1.10); C416(1.15); C236(0.99); C313(1.15)  LDD1519  [18]
 LDCM0281  AC21 HEK-293T C337(0.89); C416(0.97); C236(0.90); C313(0.86)  LDD1520  [18]
 LDCM0282  AC22 HEK-293T C337(1.02); C416(1.02); C236(1.01); C313(1.06)  LDD1521  [18]
 LDCM0283  AC23 HEK-293T C337(0.94); C416(1.03); C236(0.87); C313(0.96)  LDD1522  [18]
 LDCM0284  AC24 HEK-293T C337(1.06); C416(1.06); C236(0.93); C313(1.21)  LDD1523  [18]
 LDCM0285  AC25 HEK-293T C337(1.05); C416(0.93); C236(0.97); C313(1.13)  LDD1524  [18]
 LDCM0286  AC26 HEK-293T C337(1.08); C416(0.94); C313(0.94); C243(0.83)  LDD1525  [18]
 LDCM0287  AC27 HEK-293T C337(1.03); C416(0.96); C236(0.95); C313(0.92)  LDD1526  [18]
 LDCM0288  AC28 HEK-293T C337(0.98); C416(1.03); C236(1.05); C313(1.13)  LDD1527  [18]
 LDCM0289  AC29 HEK-293T C337(1.04); C416(1.00); C236(0.98); C313(0.96)  LDD1528  [18]
 LDCM0290  AC3 HEK-293T C337(0.98); C416(0.91); C236(1.04); C313(1.03)  LDD1529  [18]
 LDCM0291  AC30 HEK-293T C337(0.96); C416(0.97); C236(1.06); C313(1.05)  LDD1530  [18]
 LDCM0292  AC31 HEK-293T C337(0.97); C416(0.95); C236(0.90); C313(0.93)  LDD1531  [18]
 LDCM0293  AC32 HEK-293T C337(0.97); C416(1.01); C236(0.95); C313(0.94)  LDD1532  [18]
 LDCM0294  AC33 HEK-293T C337(0.99); C416(0.96); C236(0.83); C313(0.91)  LDD1533  [18]
 LDCM0295  AC34 HEK-293T C337(1.02); C416(0.93); C313(1.05); C243(0.89)  LDD1534  [18]
 LDCM0296  AC35 HEK-293T C337(1.06); C416(0.93); C236(0.99); C313(1.01)  LDD1535  [18]
 LDCM0297  AC36 HEK-293T C337(0.96); C416(1.07); C236(0.96); C313(1.05)  LDD1536  [18]
 LDCM0298  AC37 HEK-293T C337(0.93); C416(1.02); C236(1.17); C313(0.92)  LDD1537  [18]
 LDCM0299  AC38 HEK-293T C337(1.05); C416(1.04); C236(1.11); C313(0.99)  LDD1538  [18]
 LDCM0300  AC39 HEK-293T C337(0.95); C416(1.06); C236(0.90); C313(0.95)  LDD1539  [18]
 LDCM0301  AC4 HEK-293T C337(0.98); C416(1.02); C236(1.01); C313(1.04)  LDD1540  [18]
 LDCM0302  AC40 HEK-293T C337(0.92); C416(0.93); C236(1.12); C313(0.89)  LDD1541  [18]
 LDCM0303  AC41 HEK-293T C337(0.97); C416(1.04); C236(0.97); C313(1.14)  LDD1542  [18]
 LDCM0304  AC42 HEK-293T C337(0.94); C416(0.96); C313(1.05); C243(0.90)  LDD1543  [18]
 LDCM0305  AC43 HEK-293T C337(1.07); C416(0.93); C236(1.00); C313(1.08)  LDD1544  [18]
 LDCM0306  AC44 HEK-293T C337(0.97); C416(1.06); C236(1.01); C313(1.10)  LDD1545  [18]
 LDCM0307  AC45 HEK-293T C337(0.95); C416(0.89); C236(1.05); C313(0.92)  LDD1546  [18]
 LDCM0308  AC46 HEK-293T C337(1.01); C416(0.98); C236(1.02); C313(1.07)  LDD1547  [18]
 LDCM0309  AC47 HEK-293T C337(0.99); C416(1.04); C236(0.95); C313(1.05)  LDD1548  [18]
 LDCM0310  AC48 HEK-293T C337(1.00); C416(1.00); C236(0.96); C313(1.08)  LDD1549  [18]
 LDCM0311  AC49 HEK-293T C337(1.02); C416(1.01); C236(0.99); C313(1.19)  LDD1550  [18]
 LDCM0312  AC5 HEK-293T C337(0.97); C416(0.93); C236(1.14); C313(0.95)  LDD1551  [18]
 LDCM0313  AC50 HEK-293T C337(0.94); C416(1.00); C313(0.91); C243(1.14)  LDD1552  [18]
 LDCM0314  AC51 HEK-293T C337(1.02); C416(0.97); C236(0.98); C313(0.96)  LDD1553  [18]
 LDCM0315  AC52 HEK-293T C337(1.04); C416(1.07); C236(1.08); C313(1.02)  LDD1554  [18]
 LDCM0316  AC53 HEK-293T C337(0.97); C416(0.97); C236(1.11); C313(0.96)  LDD1555  [18]
 LDCM0317  AC54 HEK-293T C337(1.05); C416(0.99); C236(0.98); C313(1.02)  LDD1556  [18]
 LDCM0318  AC55 HEK-293T C337(0.96); C416(1.07); C236(0.95); C313(1.01)  LDD1557  [18]
 LDCM0319  AC56 HEK-293T C337(1.03); C416(0.96); C236(0.97); C313(1.02)  LDD1558  [18]
 LDCM0320  AC57 HEK-293T C337(1.05); C416(0.97); C236(1.11); C313(1.03)  LDD1559  [18]
 LDCM0321  AC58 HEK-293T C337(0.90); C416(0.92); C313(0.99); C243(0.87)  LDD1560  [18]
 LDCM0322  AC59 HEK-293T C337(1.00); C416(0.94); C236(1.10); C313(0.93)  LDD1561  [18]
 LDCM0323  AC6 HEK-293T C337(0.98); C416(1.00); C236(0.97); C313(1.12)  LDD1562  [18]
 LDCM0324  AC60 HEK-293T C337(1.04); C416(1.03); C236(1.05); C313(1.12)  LDD1563  [18]
 LDCM0325  AC61 HEK-293T C337(1.00); C416(1.02); C236(1.09); C313(0.94)  LDD1564  [18]
 LDCM0326  AC62 HEK-293T C337(0.94); C416(0.96); C236(1.02); C313(1.02)  LDD1565  [18]
 LDCM0327  AC63 HEK-293T C337(1.01); C416(0.95); C236(0.96); C313(0.97)  LDD1566  [18]
 LDCM0328  AC64 HEK-293T C337(1.04); C416(0.92); C236(0.95); C313(1.06)  LDD1567  [18]
 LDCM0334  AC7 HEK-293T C337(0.94); C416(1.09); C236(1.07); C313(0.99)  LDD1568  [18]
 LDCM0345  AC8 HEK-293T C337(0.94); C416(1.07); C236(0.96); C313(1.19)  LDD1569  [18]
 LDCM0248  AKOS034007472 HEK-293T C337(1.00); C416(0.91); C236(0.95); C313(0.88)  LDD1511  [18]
 LDCM0356  AKOS034007680 HEK-293T C337(0.97); C416(0.97); C236(0.88); C313(1.01)  LDD1570  [18]
 LDCM0275  AKOS034007705 HEK-293T C337(1.02); C416(0.98); C236(1.08); C313(1.11)  LDD1514  [18]
 LDCM0102  BDHI 8 Jurkat C236(10.08)  LDD0204  [6]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [10]
 LDCM0632  CL-Sc Hep-G2 C337(20.00); C337(3.52)  LDD2227  [5]
 LDCM0367  CL1 HEK-293T C337(0.98); C416(0.85); C236(0.89); C313(0.92)  LDD1571  [18]
 LDCM0368  CL10 HEK-293T C337(1.06); C416(0.76); C236(0.95); C313(1.01)  LDD1572  [18]
 LDCM0369  CL100 HEK-293T C337(0.97); C416(0.97); C236(1.28); C313(0.95)  LDD1573  [18]
 LDCM0370  CL101 HEK-293T C337(0.92); C416(1.00); C236(0.95); C313(0.87)  LDD1574  [18]
 LDCM0371  CL102 HEK-293T C337(0.95); C416(0.79); C313(1.11); C243(0.83)  LDD1575  [18]
 LDCM0372  CL103 HEK-293T C337(0.98); C416(1.07); C236(1.00); C313(0.96)  LDD1576  [18]
 LDCM0373  CL104 HEK-293T C337(0.93); C416(1.01); C236(0.92); C313(1.00)  LDD1577  [18]
 LDCM0374  CL105 HEK-293T C337(0.96); C416(0.83); C236(0.97); C313(0.87)  LDD1578  [18]
 LDCM0375  CL106 HEK-293T C337(0.95); C416(0.87); C313(0.82); C243(0.94)  LDD1579  [18]
 LDCM0376  CL107 HEK-293T C337(0.95); C416(1.03); C236(0.98); C313(1.19)  LDD1580  [18]
 LDCM0377  CL108 HEK-293T C337(0.94); C416(1.08); C236(0.95); C313(0.97)  LDD1581  [18]
 LDCM0378  CL109 HEK-293T C337(1.02); C416(0.88); C236(0.90); C313(0.89)  LDD1582  [18]
 LDCM0379  CL11 HEK-293T C337(0.92); C416(1.08); C236(0.78); C313(0.92)  LDD1583  [18]
 LDCM0380  CL110 HEK-293T C337(0.93); C416(0.80); C313(0.88); C243(0.79)  LDD1584  [18]
 LDCM0381  CL111 HEK-293T C337(0.91); C416(0.94); C236(1.10); C313(1.03)  LDD1585  [18]
 LDCM0382  CL112 HEK-293T C337(0.92); C416(0.93); C236(0.83); C313(0.97)  LDD1586  [18]
 LDCM0383  CL113 HEK-293T C337(0.91); C416(0.97); C236(1.01); C313(0.98)  LDD1587  [18]
 LDCM0384  CL114 HEK-293T C337(0.89); C416(0.85); C313(0.96); C243(1.07)  LDD1588  [18]
 LDCM0385  CL115 HEK-293T C337(0.94); C416(1.04); C236(1.03); C313(1.10)  LDD1589  [18]
 LDCM0386  CL116 HEK-293T C337(1.04); C416(1.11); C236(0.99); C313(0.93)  LDD1590  [18]
 LDCM0387  CL117 HEK-293T C337(0.93); C416(0.94); C236(0.98); C313(0.89)  LDD1591  [18]
 LDCM0388  CL118 HEK-293T C337(0.93); C416(0.96); C313(0.99); C243(1.18)  LDD1592  [18]
 LDCM0389  CL119 HEK-293T C337(1.02); C416(1.17); C236(1.07); C313(0.95)  LDD1593  [18]
 LDCM0390  CL12 HEK-293T C337(1.13); C416(1.06); C236(1.23); C313(0.93)  LDD1594  [18]
 LDCM0391  CL120 HEK-293T C337(0.93); C416(1.02); C236(0.95); C313(0.95)  LDD1595  [18]
 LDCM0392  CL121 HEK-293T C337(0.90); C416(0.92); C236(0.99); C313(0.97)  LDD1596  [18]
 LDCM0393  CL122 HEK-293T C337(0.92); C416(0.95); C313(0.89); C243(1.03)  LDD1597  [18]
 LDCM0394  CL123 HEK-293T C337(1.11); C416(0.90); C236(1.09); C313(0.83)  LDD1598  [18]
 LDCM0395  CL124 HEK-293T C337(1.00); C416(1.01); C236(0.89); C313(0.98)  LDD1599  [18]
 LDCM0396  CL125 HEK-293T C337(0.87); C416(0.92); C236(0.92); C313(0.94)  LDD1600  [18]
 LDCM0397  CL126 HEK-293T C337(0.92); C416(0.89); C313(0.94); C243(1.14)  LDD1601  [18]
 LDCM0398  CL127 HEK-293T C337(1.06); C416(1.08); C236(0.96); C313(0.97)  LDD1602  [18]
 LDCM0399  CL128 HEK-293T C337(1.03); C416(1.04); C236(1.48); C313(0.92)  LDD1603  [18]
 LDCM0400  CL13 HEK-293T C337(0.78); C416(0.83); C236(1.02); C313(0.85)  LDD1604  [18]
 LDCM0401  CL14 HEK-293T C337(0.93); C416(1.01); C313(0.96); C243(1.05)  LDD1605  [18]
 LDCM0402  CL15 HEK-293T C337(0.90); C416(0.84); C236(1.04); C313(0.93)  LDD1606  [18]
 LDCM0403  CL16 HEK-293T C337(1.04); C416(1.17); C236(0.99); C313(0.92)  LDD1607  [18]
 LDCM0404  CL17 HEK-293T C337(0.98); C416(0.80); C236(0.61); C313(0.84)  LDD1608  [18]
 LDCM0405  CL18 HEK-293T C337(1.05); C416(1.10); C313(0.92); C243(1.11)  LDD1609  [18]
 LDCM0406  CL19 HEK-293T C337(1.11); C416(0.96); C236(1.12); C313(0.84)  LDD1610  [18]
 LDCM0407  CL2 HEK-293T C337(0.93); C416(0.98); C313(0.82); C243(1.00)  LDD1611  [18]
 LDCM0408  CL20 HEK-293T C337(1.09); C416(1.23); C236(1.06); C313(0.95)  LDD1612  [18]
 LDCM0409  CL21 HEK-293T C337(1.24); C416(0.84); C236(0.58); C313(0.96)  LDD1613  [18]
 LDCM0410  CL22 HEK-293T C337(1.08); C416(1.19); C236(1.36); C313(0.97)  LDD1614  [18]
 LDCM0411  CL23 HEK-293T C337(0.90); C416(1.16); C236(0.82); C313(0.93)  LDD1615  [18]
 LDCM0412  CL24 HEK-293T C337(1.17); C416(1.18); C236(1.15); C313(0.99)  LDD1616  [18]
 LDCM0413  CL25 HEK-293T C337(0.97); C416(0.83); C236(0.96); C313(0.80)  LDD1617  [18]
 LDCM0414  CL26 HEK-293T C337(0.89); C416(0.92); C313(0.89); C243(1.03)  LDD1618  [18]
 LDCM0415  CL27 HEK-293T C337(0.95); C416(1.08); C236(0.99); C313(1.14)  LDD1619  [18]
 LDCM0416  CL28 HEK-293T C337(1.06); C416(1.00); C236(0.85); C313(0.94)  LDD1620  [18]
 LDCM0417  CL29 HEK-293T C337(0.99); C416(1.00); C236(0.94); C313(0.97)  LDD1621  [18]
 LDCM0418  CL3 HEK-293T C337(0.99); C416(1.15); C236(1.05); C313(1.01)  LDD1622  [18]
 LDCM0419  CL30 HEK-293T C337(0.97); C416(1.05); C313(0.86); C243(0.88)  LDD1623  [18]
 LDCM0420  CL31 HEK-293T C337(1.10); C416(0.92); C236(1.04); C313(0.89)  LDD1624  [18]
 LDCM0421  CL32 HEK-293T C337(1.11); C416(1.21); C236(1.07); C313(0.96)  LDD1625  [18]
 LDCM0422  CL33 HEK-293T C337(1.24); C416(0.75); C236(0.50); C313(0.81)  LDD1626  [18]
 LDCM0423  CL34 HEK-293T C337(1.23); C416(1.12); C236(1.27); C313(1.03)  LDD1627  [18]
 LDCM0424  CL35 HEK-293T C337(0.89); C416(1.18); C236(0.82); C313(0.95)  LDD1628  [18]
 LDCM0425  CL36 HEK-293T C337(1.16); C416(1.11); C236(1.11); C313(1.00)  LDD1629  [18]
 LDCM0426  CL37 HEK-293T C337(0.87); C416(0.86); C236(0.97); C313(0.83)  LDD1630  [18]
 LDCM0428  CL39 HEK-293T C337(1.15); C416(0.90); C236(0.98); C313(1.31)  LDD1632  [18]
 LDCM0429  CL4 HEK-293T C337(1.02); C416(1.09); C236(0.98); C313(0.91)  LDD1633  [18]
 LDCM0430  CL40 HEK-293T C337(0.98); C416(1.09); C236(1.06); C313(0.92)  LDD1634  [18]
 LDCM0431  CL41 HEK-293T C337(0.96); C416(0.84); C236(0.95); C313(1.04)  LDD1635  [18]
 LDCM0432  CL42 HEK-293T C337(0.93); C416(0.99); C313(0.97); C243(1.11)  LDD1636  [18]
 LDCM0433  CL43 HEK-293T C337(1.04); C416(1.01); C236(1.08); C313(0.84)  LDD1637  [18]
 LDCM0434  CL44 HEK-293T C337(1.09); C416(1.22); C236(1.14); C313(1.20)  LDD1638  [18]
 LDCM0435  CL45 HEK-293T C337(1.18); C416(0.85); C236(0.67); C313(0.84)  LDD1639  [18]
 LDCM0436  CL46 HEK-293T C337(1.10); C416(1.10); C236(1.17); C313(0.98)  LDD1640  [18]
 LDCM0437  CL47 HEK-293T C337(0.91); C416(1.12); C236(0.80); C313(1.01)  LDD1641  [18]
 LDCM0438  CL48 HEK-293T C337(1.07); C416(1.24); C236(1.02); C313(1.01)  LDD1642  [18]
 LDCM0439  CL49 HEK-293T C337(0.92); C416(0.92); C236(0.98); C313(1.06)  LDD1643  [18]
 LDCM0440  CL5 HEK-293T C337(1.07); C416(1.06); C236(0.94); C313(0.93)  LDD1644  [18]
 LDCM0441  CL50 HEK-293T C337(0.95); C416(0.85); C313(0.88); C243(0.96)  LDD1645  [18]
 LDCM0443  CL52 HEK-293T C337(0.99); C416(1.05); C236(0.95); C313(0.88)  LDD1646  [18]
 LDCM0444  CL53 HEK-293T C337(1.04); C416(0.80); C236(0.72); C313(0.90)  LDD1647  [18]
 LDCM0445  CL54 HEK-293T C337(1.15); C416(0.74); C313(0.77); C243(0.86)  LDD1648  [18]
 LDCM0446  CL55 HEK-293T C337(1.10); C416(1.02); C236(1.16); C313(0.89)  LDD1649  [18]
 LDCM0447  CL56 HEK-293T C337(1.00); C416(1.07); C236(1.02); C313(1.02)  LDD1650  [18]
 LDCM0448  CL57 HEK-293T C337(1.14); C416(0.78); C236(0.68); C313(0.80)  LDD1651  [18]
 LDCM0449  CL58 HEK-293T C337(0.95); C416(1.09); C236(1.33); C313(0.96)  LDD1652  [18]
 LDCM0450  CL59 HEK-293T C337(0.93); C416(1.24); C236(0.93); C313(0.90)  LDD1653  [18]
 LDCM0451  CL6 HEK-293T C337(1.17); C416(0.79); C313(0.95); C243(0.84)  LDD1654  [18]
 LDCM0452  CL60 HEK-293T C337(1.02); C416(1.09); C236(1.07); C313(1.04)  LDD1655  [18]
 LDCM0453  CL61 HEK-293T C337(0.80); C416(0.99); C236(1.08); C313(0.94)  LDD1656  [18]
 LDCM0454  CL62 HEK-293T C337(0.89); C416(1.01); C313(1.01); C243(1.06)  LDD1657  [18]
 LDCM0455  CL63 HEK-293T C337(0.96); C416(1.10); C236(0.99); C313(1.02)  LDD1658  [18]
 LDCM0456  CL64 HEK-293T C337(1.01); C416(0.84); C236(0.80); C313(0.78)  LDD1659  [18]
 LDCM0457  CL65 HEK-293T C337(0.97); C416(1.06); C236(0.89); C313(0.94)  LDD1660  [18]
 LDCM0458  CL66 HEK-293T C337(0.93); C416(0.95); C313(0.91); C243(0.87)  LDD1661  [18]
 LDCM0459  CL67 HEK-293T C337(1.04); C416(1.09); C236(1.11); C313(0.96)  LDD1662  [18]
 LDCM0460  CL68 HEK-293T C337(1.05); C416(1.05); C236(1.02); C313(0.92)  LDD1663  [18]
 LDCM0461  CL69 HEK-293T C337(1.07); C416(0.99); C236(0.75); C313(0.92)  LDD1664  [18]
 LDCM0462  CL7 HEK-293T C337(1.05); C416(1.04); C236(1.13); C313(0.91)  LDD1665  [18]
 LDCM0463  CL70 HEK-293T C337(1.16); C416(1.16); C236(1.25); C313(0.96)  LDD1666  [18]
 LDCM0464  CL71 HEK-293T C337(0.91); C416(1.05); C236(0.83); C313(0.84)  LDD1667  [18]
 LDCM0465  CL72 HEK-293T C337(0.97); C416(1.11); C236(1.08); C313(0.92)  LDD1668  [18]
 LDCM0466  CL73 HEK-293T C337(0.82); C416(0.82); C236(1.01); C313(0.97)  LDD1669  [18]
 LDCM0467  CL74 HEK-293T C337(0.86); C416(0.96); C313(0.95); C243(1.05)  LDD1670  [18]
 LDCM0469  CL76 HEK-293T C337(0.98); C416(1.08); C236(1.05); C313(0.90)  LDD1672  [18]
 LDCM0470  CL77 HEK-293T C337(1.08); C416(0.77); C236(0.74); C313(1.07)  LDD1673  [18]
 LDCM0471  CL78 HEK-293T C337(1.00); C416(1.01); C313(0.94); C243(0.89)  LDD1674  [18]
 LDCM0472  CL79 HEK-293T C337(1.04); C416(1.04); C236(1.18); C313(0.93)  LDD1675  [18]
 LDCM0473  CL8 HEK-293T C337(1.43); C416(0.66); C236(0.78); C313(1.08)  LDD1676  [18]
 LDCM0474  CL80 HEK-293T C337(1.09); C416(1.23); C236(1.12); C313(0.98)  LDD1677  [18]
 LDCM0475  CL81 HEK-293T C337(1.03); C416(1.06); C236(0.78); C313(0.96)  LDD1678  [18]
 LDCM0476  CL82 HEK-293T C337(1.03); C416(1.13); C236(1.11); C313(1.01)  LDD1679  [18]
 LDCM0477  CL83 HEK-293T C337(0.97); C416(1.10); C236(0.89); C313(0.87)  LDD1680  [18]
 LDCM0478  CL84 HEK-293T C337(1.12); C416(1.07); C236(1.10); C313(0.86)  LDD1681  [18]
 LDCM0479  CL85 HEK-293T C337(0.83); C416(0.88); C236(1.05); C313(1.02)  LDD1682  [18]
 LDCM0480  CL86 HEK-293T C337(0.87); C416(0.95); C313(1.17); C243(1.24)  LDD1683  [18]
 LDCM0481  CL87 HEK-293T C337(0.90); C416(1.13); C236(1.07); C313(1.14)  LDD1684  [18]
 LDCM0482  CL88 HEK-293T C337(0.95); C416(1.05); C236(1.28); C313(1.02)  LDD1685  [18]
 LDCM0483  CL89 HEK-293T C337(0.98); C416(1.03); C236(1.13); C313(0.98)  LDD1686  [18]
 LDCM0484  CL9 HEK-293T C337(1.11); C416(0.97); C236(0.70); C313(0.86)  LDD1687  [18]
 LDCM0485  CL90 HEK-293T C337(1.16); C416(0.54); C313(0.95); C243(0.65)  LDD1688  [18]
 LDCM0486  CL91 HEK-293T C337(1.00); C416(1.02); C236(1.17); C313(0.95)  LDD1689  [18]
 LDCM0487  CL92 HEK-293T C337(1.04); C416(1.02); C236(1.01); C313(1.12)  LDD1690  [18]
 LDCM0488  CL93 HEK-293T C337(1.07); C416(0.85); C236(0.79); C313(0.75)  LDD1691  [18]
 LDCM0489  CL94 HEK-293T C337(1.11); C416(1.09); C236(1.20); C313(0.92)  LDD1692  [18]
 LDCM0490  CL95 HEK-293T C337(0.73); C416(0.76); C236(0.74); C313(0.92)  LDD1693  [18]
 LDCM0491  CL96 HEK-293T C337(0.94); C416(0.90); C236(1.01); C313(0.64)  LDD1694  [18]
 LDCM0492  CL97 HEK-293T C337(0.93); C416(0.87); C236(0.91); C313(0.86)  LDD1695  [18]
 LDCM0493  CL98 HEK-293T C337(0.92); C416(0.93); C313(0.99); C243(0.99)  LDD1696  [18]
 LDCM0494  CL99 HEK-293T C337(0.93); C416(0.96); C236(1.06); C313(1.02)  LDD1697  [18]
 LDCM0495  E2913 HEK-293T C337(0.77); C416(0.92); C236(1.09); C313(0.96)  LDD1698  [18]
 LDCM0625  F8 Ramos C416(0.87)  LDD2187  [19]
 LDCM0572  Fragment10 Ramos C416(0.67)  LDD2189  [19]
 LDCM0573  Fragment11 Ramos C416(2.24)  LDD2190  [19]
 LDCM0574  Fragment12 Ramos C416(0.77)  LDD2191  [19]
 LDCM0575  Fragment13 Ramos C416(0.83)  LDD2192  [19]
 LDCM0576  Fragment14 Ramos C416(0.64)  LDD2193  [19]
 LDCM0579  Fragment20 Ramos C416(0.65)  LDD2194  [19]
 LDCM0580  Fragment21 Ramos C416(0.92)  LDD2195  [19]
 LDCM0582  Fragment23 Ramos C416(0.95)  LDD2196  [19]
 LDCM0578  Fragment27 Ramos C416(0.83)  LDD2197  [19]
 LDCM0588  Fragment30 Ramos C416(0.85)  LDD2199  [19]
 LDCM0589  Fragment31 Ramos C416(0.63)  LDD2200  [19]
 LDCM0590  Fragment32 Ramos C416(0.60)  LDD2201  [19]
 LDCM0468  Fragment33 HEK-293T C337(1.01); C416(1.12); C236(1.06); C313(0.98)  LDD1671  [18]
 LDCM0596  Fragment38 Ramos C416(0.86)  LDD2203  [19]
 LDCM0566  Fragment4 Ramos C416(0.53)  LDD2184  [19]
 LDCM0427  Fragment51 HEK-293T C337(0.90); C416(0.96); C313(0.91); C243(1.02)  LDD1631  [18]
 LDCM0610  Fragment52 Ramos C416(1.16)  LDD2204  [19]
 LDCM0614  Fragment56 Ramos C416(1.08)  LDD2205  [19]
 LDCM0569  Fragment7 Ramos C416(0.80)  LDD2186  [19]
 LDCM0571  Fragment9 Ramos C416(0.59)  LDD2188  [19]
 LDCM0116  HHS-0101 DM93 Y311(0.95); Y112(1.02)  LDD0264  [8]
 LDCM0117  HHS-0201 DM93 Y311(0.99); Y112(1.26)  LDD0265  [8]
 LDCM0118  HHS-0301 DM93 Y112(0.96); Y311(1.27)  LDD0266  [8]
 LDCM0119  HHS-0401 DM93 Y112(1.10); Y311(2.53)  LDD0267  [8]
 LDCM0120  HHS-0701 DM93 Y311(1.28); Y112(1.29)  LDD0268  [8]
 LDCM0123  JWB131 DM93 Y311(0.27)  LDD0285  [7]
 LDCM0124  JWB142 DM93 Y311(0.26); Y97(1.80)  LDD0286  [7]
 LDCM0125  JWB146 DM93 Y311(0.34); Y97(0.62)  LDD0287  [7]
 LDCM0126  JWB150 DM93 Y311(0.74); Y97(2.12)  LDD0288  [7]
 LDCM0127  JWB152 DM93 Y311(0.36); Y97(0.87)  LDD0289  [7]
 LDCM0128  JWB198 DM93 Y311(0.18); Y97(0.11)  LDD0290  [7]
 LDCM0129  JWB202 DM93 Y97(0.27)  LDD0291  [7]
 LDCM0130  JWB211 DM93 Y311(0.39)  LDD0292  [7]
 LDCM0022  KB02 HEK-293T C337(0.89); C416(1.11); C313(1.03)  LDD1492  [18]
 LDCM0023  KB03 HEK-293T C337(1.03); C416(0.98); C313(1.24)  LDD1497  [18]
 LDCM0024  KB05 HMCB C416(2.03)  LDD3312  [20]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C416(1.10)  LDD2089  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C416(0.43)  LDD2125  [4]
 LDCM0099  Phenelzine HEK-293T 4.00  LDD0386  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pyridoxal Phosphate Small molecular drug DB00114

References

1 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
7 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
8 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
9 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
13 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
14 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
15 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
16 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
17 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
20 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840