Details of the Target

General Information of Target

Target ID LDTP14819
Target Name Heat shock 70 kDa protein 14 (HSPA14)
Gene Name HSPA14
Gene ID 51182
Synonyms
HSP60; HSP70L1; Heat shock 70 kDa protein 14; HSP70-like protein 1; Heat shock protein HSP60
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MDPVACEDVAVNFTQEEWALLDISQRKLYREVMLETFRNLTSIGKKWKDQNIEYEYQNPR
RNFRSLIEGNVNEIKEDSHCGETFTQVPDDRLNFQEKKASPEAKSCDNFVCGEVGIGNSS
FNMNIRGDIGHKAYEYQDYAPKPYKCQQPKKAFRYHPSFRTQERNHTGEKPYACKECGKT
FISHSGIRRRMVMHSGDGPYKCKFCGKAVHCLRLYLIHERTHTGEKPYECKQCVKSFSYS
ATHRIHERTHTGEKPYECQQCGKAFHSSSSFQAHKRTHTGGKPYECKQCGKSFSWCHSFQ
IHERTHTGEKPCECSKCNKAFRSYRSYLRHKRSHTGEKPYQCKECRKAFTYPSSLRRHER
THSAKKPYECKQCGKALSYKFSNTPKNALWRKTL
Target Bioclass
Other
Family
Heat shock protein 70 family
Subcellular location
Cytoplasm, cytosol
Function
Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity.
Uniprot ID
Q0VDF9
Ensemble ID
ENST00000378372.8
HGNC ID
HGNC:29526
ChEMBL ID
CHEMBL5169146

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K260(6.27); K483(5.83)  LDD0277  [2]
IPM
 Probe Info  		N.A.  LDD0241  [3]
Probe 1
 Probe Info  		Y100(41.43)  LDD3495  [4]
BTD
 Probe Info  		C335(1.21)  LDD2097  [5]
DBIA
 Probe Info  		C335(32.33)  LDD0209  [6]
5E-2FA
 Probe Info  		N.A.  LDD2235  [7]
ATP probe
 Probe Info  		K94(0.00); K97(0.00); K66(0.00); K68(0.00)  LDD0199  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C304(0.00); C335(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [10]
Lodoacetamide azide
 Probe Info  		C304(0.00); C440(0.00); C335(0.00)  LDD0037  [9]
NAIA_4
 Probe Info  		N.A.  LDD2226  [11]
TFBX
 Probe Info  		N.A.  LDD0027  [12]
Acrolein
 Probe Info  		N.A.  LDD0217  [13]
W1
 Probe Info  		N.A.  LDD0236  [3]
AOyne
 Probe Info  		12.40  LDD0443  [14]
NAIA_5
 Probe Info  		C304(0.00); C335(0.00)  LDD2223  [11]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C280
 Probe Info  		22.94  LDD1950  [15]
FFF probe13
 Probe Info  		12.14  LDD0475  [16]
FFF probe3
 Probe Info  		5.19  LDD0465  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C335(0.93)  LDD2152  [5]
 LDCM0214  AC1 HCT 116 C335(1.09); C304(1.05)  LDD0531  [17]
 LDCM0215  AC10 HCT 116 C335(0.93); C304(0.88)  LDD0532  [17]
 LDCM0216  AC100 HCT 116 C335(1.17)  LDD0533  [17]
 LDCM0217  AC101 HCT 116 C335(0.70)  LDD0534  [17]
 LDCM0218  AC102 HCT 116 C335(1.02)  LDD0535  [17]
 LDCM0219  AC103 HCT 116 C335(0.41)  LDD0536  [17]
 LDCM0220  AC104 HCT 116 C335(0.43)  LDD0537  [17]
 LDCM0221  AC105 HCT 116 C335(0.45)  LDD0538  [17]
 LDCM0222  AC106 HCT 116 C335(0.41)  LDD0539  [17]
 LDCM0223  AC107 HCT 116 C335(0.36)  LDD0540  [17]
 LDCM0224  AC108 HCT 116 C335(0.73)  LDD0541  [17]
 LDCM0225  AC109 HCT 116 C335(1.91)  LDD0542  [17]
 LDCM0226  AC11 HCT 116 C335(0.88); C304(0.78)  LDD0543  [17]
 LDCM0227  AC110 HCT 116 C335(0.99)  LDD0544  [17]
 LDCM0228  AC111 HCT 116 C335(1.00)  LDD0545  [17]
 LDCM0229  AC112 HCT 116 C335(0.71)  LDD0546  [17]
 LDCM0230  AC113 HCT 116 C335(1.15); C280(0.53); C293(0.53)  LDD0547  [17]
 LDCM0231  AC114 HCT 116 C335(0.86); C280(0.45); C293(0.45)  LDD0548  [17]
 LDCM0232  AC115 HCT 116 C335(0.66); C280(0.20); C293(0.20)  LDD0549  [17]
 LDCM0233  AC116 HCT 116 C335(0.76); C280(0.19); C293(0.19)  LDD0550  [17]
 LDCM0234  AC117 HCT 116 C335(0.94); C280(0.55); C293(0.55)  LDD0551  [17]
 LDCM0235  AC118 HCT 116 C335(1.08); C280(0.59); C293(0.59)  LDD0552  [17]
 LDCM0236  AC119 HCT 116 C335(1.23); C280(0.57); C293(0.57)  LDD0553  [17]
 LDCM0237  AC12 HCT 116 C335(0.90); C304(1.00)  LDD0554  [17]
 LDCM0238  AC120 HCT 116 C335(0.86); C280(0.43); C293(0.43)  LDD0555  [17]
 LDCM0239  AC121 HCT 116 C335(1.26); C280(0.47); C293(0.47)  LDD0556  [17]
 LDCM0240  AC122 HCT 116 C335(1.19); C280(0.88); C293(0.88)  LDD0557  [17]
 LDCM0241  AC123 HCT 116 C335(1.15); C280(0.43); C293(0.43)  LDD0558  [17]
 LDCM0242  AC124 HCT 116 C335(1.10); C280(0.45); C293(0.45)  LDD0559  [17]
 LDCM0243  AC125 HCT 116 C335(1.09); C280(0.50); C293(0.50)  LDD0560  [17]
 LDCM0244  AC126 HCT 116 C335(0.69); C280(0.23); C293(0.23)  LDD0561  [17]
 LDCM0245  AC127 HCT 116 C335(0.77); C280(0.28); C293(0.28)  LDD0562  [17]
 LDCM0246  AC128 HCT 116 C335(0.73); C280(0.69); C293(0.69)  LDD0563  [17]
 LDCM0247  AC129 HCT 116 C335(1.15); C280(2.51); C293(2.51)  LDD0564  [17]
 LDCM0249  AC130 HCT 116 C335(0.84); C280(0.83); C293(0.83)  LDD0566  [17]
 LDCM0250  AC131 HCT 116 C335(1.21); C280(1.28); C293(1.28)  LDD0567  [17]
 LDCM0251  AC132 HCT 116 C335(1.57); C280(1.65); C293(1.65)  LDD0568  [17]
 LDCM0252  AC133 HCT 116 C335(0.90); C280(1.87); C293(1.87)  LDD0569  [17]
 LDCM0253  AC134 HCT 116 C335(0.72); C280(1.43); C293(1.43)  LDD0570  [17]
 LDCM0254  AC135 HCT 116 C335(0.91); C280(1.04); C293(1.04)  LDD0571  [17]
 LDCM0255  AC136 HCT 116 C335(0.88); C280(1.12); C293(1.12)  LDD0572  [17]
 LDCM0256  AC137 HCT 116 C335(1.27); C280(1.06); C293(1.06)  LDD0573  [17]
 LDCM0257  AC138 HCT 116 C335(0.98); C280(1.54); C293(1.54)  LDD0574  [17]
 LDCM0258  AC139 HCT 116 C335(1.27); C280(1.12); C293(1.12)  LDD0575  [17]
 LDCM0259  AC14 HCT 116 C335(0.79); C304(0.89)  LDD0576  [17]
 LDCM0260  AC140 HCT 116 C335(0.98); C280(0.85); C293(0.85)  LDD0577  [17]
 LDCM0261  AC141 HCT 116 C335(1.01); C280(0.93); C293(0.93)  LDD0578  [17]
 LDCM0262  AC142 HCT 116 C335(1.83); C280(2.39); C293(2.39)  LDD0579  [17]
 LDCM0263  AC143 HCT 116 C335(0.97); C280(1.02); C293(1.02)  LDD0580  [17]
 LDCM0264  AC144 HCT 116 C335(0.38); C280(0.86); C293(0.86)  LDD0581  [17]
 LDCM0265  AC145 HCT 116 C280(0.70); C293(0.70); C335(0.79)  LDD0582  [17]
 LDCM0266  AC146 HCT 116 C280(0.69); C293(0.69); C335(0.72)  LDD0583  [17]
 LDCM0267  AC147 HCT 116 C335(0.34); C280(0.56); C293(0.56)  LDD0584  [17]
 LDCM0268  AC148 HCT 116 C335(0.22); C280(0.40); C293(0.40)  LDD0585  [17]
 LDCM0269  AC149 HCT 116 C335(0.32); C280(0.55); C293(0.55)  LDD0586  [17]
 LDCM0270  AC15 HCT 116 C304(0.78); C335(1.04)  LDD0587  [17]
 LDCM0271  AC150 HCT 116 C280(0.68); C293(0.68); C335(1.38)  LDD0588  [17]
 LDCM0272  AC151 HCT 116 C280(0.69); C293(0.69); C335(0.97)  LDD0589  [17]
 LDCM0273  AC152 HCT 116 C335(0.29); C280(0.63); C293(0.63)  LDD0590  [17]
 LDCM0274  AC153 HCT 116 C335(0.20); C280(0.44); C293(0.44)  LDD0591  [17]
 LDCM0621  AC154 HCT 116 C335(0.46); C280(0.88); C293(0.88)  LDD2158  [17]
 LDCM0622  AC155 HCT 116 C335(0.46); C280(0.75); C293(0.75)  LDD2159  [17]
 LDCM0623  AC156 HCT 116 C335(1.22); C280(0.74); C293(0.74)  LDD2160  [17]
 LDCM0624  AC157 HCT 116 C335(1.31); C280(0.75); C293(0.75)  LDD2161  [17]
 LDCM0276  AC17 HCT 116 C335(1.02); C304(1.06)  LDD0593  [17]
 LDCM0277  AC18 HCT 116 C304(0.63); C335(1.32)  LDD0594  [17]
 LDCM0278  AC19 HCT 116 C304(1.01); C335(1.02)  LDD0595  [17]
 LDCM0279  AC2 HCT 116 C304(0.88); C335(1.08)  LDD0596  [17]
 LDCM0280  AC20 HCT 116 C304(0.99); C335(1.11)  LDD0597  [17]
 LDCM0281  AC21 HCT 116 C304(0.90); C335(1.05)  LDD0598  [17]
 LDCM0282  AC22 HCT 116 C335(1.08); C304(1.09)  LDD0599  [17]
 LDCM0283  AC23 HCT 116 C335(0.94); C304(1.01)  LDD0600  [17]
 LDCM0284  AC24 HCT 116 C335(0.95); C304(1.33)  LDD0601  [17]
 LDCM0285  AC25 HCT 116 C280(0.84); C293(0.84); C304(0.92); C335(1.23)  LDD0602  [17]
 LDCM0286  AC26 HCT 116 C280(0.70); C293(0.70); C335(0.76); C304(0.80)  LDD0603  [17]
 LDCM0287  AC27 HCT 116 C335(0.66); C304(0.78); C280(0.94); C293(0.94)  LDD0604  [17]
 LDCM0288  AC28 HCT 116 C280(0.76); C293(0.76); C304(0.81); C335(1.03)  LDD0605  [17]
 LDCM0289  AC29 HCT 116 C280(0.79); C293(0.79); C335(0.81); C304(0.87)  LDD0606  [17]
 LDCM0290  AC3 HCT 116 C335(0.81); C304(0.89)  LDD0607  [17]
 LDCM0291  AC30 HCT 116 C335(0.72); C280(0.81); C293(0.81); C304(0.85)  LDD0608  [17]
 LDCM0292  AC31 HCT 116 C280(0.81); C293(0.81); C304(0.90); C335(0.93)  LDD0609  [17]
 LDCM0293  AC32 HCT 116 C304(0.49); C335(0.65); C280(0.69); C293(0.69)  LDD0610  [17]
 LDCM0294  AC33 HCT 116 C304(0.62); C280(1.12); C293(1.12); C335(1.13)  LDD0611  [17]
 LDCM0295  AC34 HCT 116 C304(0.45); C280(1.03); C293(1.03); C335(1.06)  LDD0612  [17]
 LDCM0296  AC35 HEK-293T C280(1.09); C293(1.09); C304(1.34); C335(0.68)  LDD0894  [17]
 LDCM0297  AC36 HEK-293T C280(0.83); C293(0.83); C304(1.47); C335(0.95)  LDD0895  [17]
 LDCM0298  AC37 HEK-293T C280(0.83); C293(0.83); C304(1.65); C335(0.86)  LDD0896  [17]
 LDCM0299  AC38 HEK-293T C280(0.93); C293(0.93); C304(1.27); C335(0.94)  LDD0897  [17]
 LDCM0300  AC39 HEK-293T C280(0.84); C293(0.84); C304(1.44); C335(0.95)  LDD0898  [17]
 LDCM0301  AC4 HCT 116 C304(0.71); C335(0.90)  LDD0618  [17]
 LDCM0302  AC40 HEK-293T C280(1.38); C293(1.38); C304(1.10); C335(1.05)  LDD0900  [17]
 LDCM0303  AC41 HEK-293T C280(0.94); C293(0.94); C304(1.23); C335(0.83)  LDD0901  [17]
 LDCM0304  AC42 HEK-293T C280(1.02); C293(1.02); C304(1.45); C335(0.95)  LDD0902  [17]
 LDCM0305  AC43 HEK-293T C280(0.67); C293(0.67); C304(1.08); C335(0.72)  LDD0903  [17]
 LDCM0306  AC44 HEK-293T C280(0.80); C293(0.80); C304(1.28); C335(0.95)  LDD0904  [17]
 LDCM0307  AC45 HEK-293T C280(1.04); C293(1.04); C304(1.36); C335(1.01)  LDD0905  [17]
 LDCM0308  AC46 HCT 116 C280(0.99); C293(0.99); C304(1.22); C335(1.52)  LDD0625  [17]
 LDCM0309  AC47 HCT 116 C280(0.92); C293(0.92); C304(0.95); C335(1.22)  LDD0626  [17]
 LDCM0310  AC48 HCT 116 C280(1.12); C293(1.12); C304(2.02); C335(2.07)  LDD0627  [17]
 LDCM0311  AC49 HCT 116 C304(0.39); C280(0.44); C293(0.44); C335(0.86)  LDD0628  [17]
 LDCM0312  AC5 HCT 116 C304(0.73); C335(0.96)  LDD0629  [17]
 LDCM0313  AC50 HCT 116 C304(0.37); C280(0.42); C293(0.42); C335(0.88)  LDD0630  [17]
 LDCM0314  AC51 HCT 116 C280(1.40); C293(1.40); C335(1.54); C304(1.66)  LDD0631  [17]
 LDCM0315  AC52 HCT 116 C280(0.73); C293(0.73); C304(0.74); C335(1.14)  LDD0632  [17]
 LDCM0316  AC53 HCT 116 C304(0.52); C280(0.62); C293(0.62); C335(1.01)  LDD0633  [17]
 LDCM0317  AC54 HCT 116 C304(0.50); C280(0.71); C293(0.71); C335(0.90)  LDD0634  [17]
 LDCM0318  AC55 HCT 116 C280(0.40); C293(0.40); C304(0.41); C335(0.99)  LDD0635  [17]
 LDCM0319  AC56 HCT 116 C304(0.38); C280(0.41); C293(0.41); C335(0.93)  LDD0636  [17]
 LDCM0320  AC57 HCT 116 C335(0.41); C304(0.53); C280(1.46); C293(1.46)  LDD0637  [17]
 LDCM0321  AC58 HCT 116 C335(0.40); C304(0.58); C280(1.02); C293(1.02)  LDD0638  [17]
 LDCM0322  AC59 HCT 116 C335(0.22); C304(0.42); C280(0.96); C293(0.96)  LDD0639  [17]
 LDCM0323  AC6 HCT 116 C304(0.86); C335(0.97)  LDD0640  [17]
 LDCM0324  AC60 HCT 116 C335(0.61); C304(0.68); C280(1.71); C293(1.71)  LDD0641  [17]
 LDCM0325  AC61 HCT 116 C304(0.89); C280(1.45); C293(1.45); C335(1.72)  LDD0642  [17]
 LDCM0326  AC62 HCT 116 C335(0.22); C304(0.41); C280(0.79); C293(0.79)  LDD0643  [17]
 LDCM0327  AC63 HCT 116 C335(0.54); C304(0.62); C280(1.29); C293(1.29)  LDD0644  [17]
 LDCM0328  AC64 HCT 116 C335(0.26); C304(0.44); C280(0.91); C293(0.91)  LDD0645  [17]
 LDCM0329  AC65 HCT 116 C335(0.39); C304(0.62); C280(1.08); C293(1.08)  LDD0646  [17]
 LDCM0330  AC66 HCT 116 C335(0.58); C304(0.77); C280(1.39); C293(1.39)  LDD0647  [17]
 LDCM0331  AC67 HCT 116 C335(0.20); C304(0.35); C280(0.75); C293(0.75)  LDD0648  [17]
 LDCM0332  AC68 HCT 116 C280(0.80); C293(0.80); C335(0.82)  LDD0649  [17]
 LDCM0333  AC69 HCT 116 C335(0.69); C280(0.82); C293(0.82)  LDD0650  [17]
 LDCM0334  AC7 HCT 116 C335(0.93); C304(1.06)  LDD0651  [17]
 LDCM0335  AC70 HCT 116 C335(0.66); C280(0.74); C293(0.74)  LDD0652  [17]
 LDCM0336  AC71 HCT 116 C280(0.76); C293(0.76); C335(1.41)  LDD0653  [17]
 LDCM0337  AC72 HCT 116 C335(0.76); C280(0.88); C293(0.88)  LDD0654  [17]
 LDCM0338  AC73 HCT 116 C335(0.65); C280(0.68); C293(0.68)  LDD0655  [17]
 LDCM0339  AC74 HCT 116 C335(0.55); C280(0.93); C293(0.93)  LDD0656  [17]
 LDCM0340  AC75 HCT 116 C335(0.64); C280(1.07); C293(1.07)  LDD0657  [17]
 LDCM0341  AC76 HCT 116 C335(0.61); C280(0.89); C293(0.89)  LDD0658  [17]
 LDCM0342  AC77 HCT 116 C335(0.69); C280(0.77); C293(0.77)  LDD0659  [17]
 LDCM0343  AC78 HCT 116 C280(0.76); C293(0.76); C335(1.27)  LDD0660  [17]
 LDCM0344  AC79 HCT 116 C280(0.83); C293(0.83); C335(0.86)  LDD0661  [17]
 LDCM0345  AC8 HCT 116 C304(0.90); C335(0.93)  LDD0662  [17]
 LDCM0346  AC80 HCT 116 C335(0.63); C280(1.00); C293(1.00)  LDD0663  [17]
 LDCM0347  AC81 HCT 116 C280(0.89); C293(0.89); C335(1.51)  LDD0664  [17]
 LDCM0348  AC82 HCT 116 C335(0.59); C280(0.89); C293(0.89)  LDD0665  [17]
 LDCM0349  AC83 HCT 116 C335(0.44)  LDD0666  [17]
 LDCM0350  AC84 HCT 116 C335(0.51)  LDD0667  [17]
 LDCM0351  AC85 HCT 116 C335(0.84)  LDD0668  [17]
 LDCM0352  AC86 HCT 116 C335(0.69)  LDD0669  [17]
 LDCM0353  AC87 HCT 116 C335(0.99)  LDD0670  [17]
 LDCM0354  AC88 HCT 116 C335(0.74)  LDD0671  [17]
 LDCM0355  AC89 HCT 116 C335(0.51)  LDD0672  [17]
 LDCM0357  AC90 HCT 116 C335(1.33)  LDD0674  [17]
 LDCM0358  AC91 HCT 116 C335(0.47)  LDD0675  [17]
 LDCM0359  AC92 HCT 116 C335(0.38)  LDD0676  [17]
 LDCM0360  AC93 HCT 116 C335(0.62)  LDD0677  [17]
 LDCM0361  AC94 HCT 116 C335(1.11)  LDD0678  [17]
 LDCM0362  AC95 HCT 116 C335(1.37)  LDD0679  [17]
 LDCM0363  AC96 HCT 116 C335(0.69)  LDD0680  [17]
 LDCM0364  AC97 HCT 116 C335(0.53)  LDD0681  [17]
 LDCM0365  AC98 HCT 116 C335(0.19)  LDD0682  [17]
 LDCM0366  AC99 HCT 116 C335(1.18)  LDD0683  [17]
 LDCM0248  AKOS034007472 HCT 116 C335(0.96); C304(0.98)  LDD0565  [17]
 LDCM0356  AKOS034007680 HCT 116 C335(0.89); C304(0.94)  LDD0673  [17]
 LDCM0275  AKOS034007705 HCT 116 C304(0.39); C335(1.07)  LDD0592  [17]
 LDCM0156  Aniline NCI-H1299 11.63  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [13]
 LDCM0367  CL1 HCT 116 C280(1.08); C293(1.08); C304(1.20); C335(1.43)  LDD0684  [17]
 LDCM0368  CL10 HCT 116 C304(0.53); C280(0.55); C293(0.55); C335(0.58)  LDD0685  [17]
 LDCM0369  CL100 HCT 116 C304(0.74); C335(1.06)  LDD0686  [17]
 LDCM0370  CL101 HCT 116 C304(0.77); C335(1.03)  LDD0687  [17]
 LDCM0371  CL102 HCT 116 C335(0.96); C304(1.12)  LDD0688  [17]
 LDCM0372  CL103 HCT 116 C335(0.88); C304(1.11)  LDD0689  [17]
 LDCM0373  CL104 HCT 116 C304(0.96); C335(1.06)  LDD0690  [17]
 LDCM0374  CL105 HCT 116 C304(0.80); C335(1.25)  LDD0691  [17]
 LDCM0375  CL106 HCT 116 C304(0.65); C335(1.19)  LDD0692  [17]
 LDCM0376  CL107 HCT 116 C304(0.50); C335(1.07)  LDD0693  [17]
 LDCM0377  CL108 HCT 116 C304(0.47); C335(1.07)  LDD0694  [17]
 LDCM0378  CL109 HCT 116 C304(0.82); C335(1.17)  LDD0695  [17]
 LDCM0379  CL11 HCT 116 C280(0.38); C293(0.38); C304(0.39); C335(0.45)  LDD0696  [17]
 LDCM0380  CL110 HCT 116 C304(0.68); C335(1.06)  LDD0697  [17]
 LDCM0381  CL111 HCT 116 C304(0.95); C335(1.08)  LDD0698  [17]
 LDCM0382  CL112 HCT 116 C280(0.73); C293(0.73); C335(0.82); C304(0.89)  LDD0699  [17]
 LDCM0383  CL113 HCT 116 C304(0.59); C335(0.68); C280(0.82); C293(0.82)  LDD0700  [17]
 LDCM0384  CL114 HCT 116 C335(0.67); C304(0.88); C280(0.93); C293(0.93)  LDD0701  [17]
 LDCM0385  CL115 HCT 116 C304(0.76); C335(0.83); C280(1.11); C293(1.11)  LDD0702  [17]
 LDCM0386  CL116 HCT 116 C304(0.84); C335(1.04); C280(1.14); C293(1.14)  LDD0703  [17]
 LDCM0387  CL117 HEK-293T C280(1.03); C293(1.03); C304(1.30); C335(0.66)  LDD0985  [17]
 LDCM0388  CL118 HEK-293T C280(1.14); C293(1.14); C304(1.73); C335(0.74)  LDD0986  [17]
 LDCM0389  CL119 HEK-293T C280(0.88); C293(0.88); C304(1.21); C335(0.88)  LDD0987  [17]
 LDCM0390  CL12 HCT 116 C304(0.34); C335(0.36); C280(0.40); C293(0.40)  LDD0707  [17]
 LDCM0391  CL120 HEK-293T C280(0.70); C293(0.70); C304(1.09); C335(0.84)  LDD0989  [17]
 LDCM0392  CL121 HCT 116 C304(1.03); C335(1.06); C280(2.06); C293(2.06)  LDD0709  [17]
 LDCM0393  CL122 HCT 116 C304(0.96); C335(1.37); C280(1.50); C293(1.50)  LDD0710  [17]
 LDCM0394  CL123 HCT 116 C304(0.45); C280(0.47); C293(0.47); C335(0.87)  LDD0711  [17]
 LDCM0395  CL124 HCT 116 C304(0.42); C280(0.49); C293(0.49); C335(0.83)  LDD0712  [17]
 LDCM0396  CL125 HCT 116 C304(0.80); C335(1.07); C280(1.46); C293(1.46)  LDD0713  [17]
 LDCM0397  CL126 HCT 116 C304(0.71); C335(0.90); C280(1.70); C293(1.70)  LDD0714  [17]
 LDCM0398  CL127 HCT 116 C304(0.79); C335(0.84); C280(1.23); C293(1.23)  LDD0715  [17]
 LDCM0399  CL128 HCT 116 C335(0.27); C304(0.52); C280(0.87); C293(0.87)  LDD0716  [17]
 LDCM0400  CL13 HCT 116 C304(0.73); C335(0.75); C280(0.78); C293(0.78)  LDD0717  [17]
 LDCM0401  CL14 HCT 116 C304(0.79); C335(0.90); C280(1.02); C293(1.02)  LDD0718  [17]
 LDCM0402  CL15 HCT 116 C304(0.79); C280(0.95); C293(0.95); C335(1.07)  LDD0719  [17]
 LDCM0403  CL16 HCT 116 C304(0.87); C280(1.26); C293(1.26); C335(1.54)  LDD0720  [17]
 LDCM0404  CL17 HCT 116 C304(0.96); C280(0.98); C293(0.98); C335(1.28)  LDD0721  [17]
 LDCM0405  CL18 HCT 116 C280(1.19); C293(1.19); C304(1.41); C335(2.10)  LDD0722  [17]
 LDCM0406  CL19 HCT 116 C304(0.92); C335(1.42); C280(2.09); C293(2.09)  LDD0723  [17]
 LDCM0407  CL2 HCT 116 C304(1.09); C280(1.42); C293(1.42); C335(1.55)  LDD0724  [17]
 LDCM0408  CL20 HCT 116 C335(0.33); C304(0.36); C280(0.65); C293(0.65)  LDD0725  [17]
 LDCM0409  CL21 HCT 116 C335(0.32); C304(0.34); C280(0.69); C293(0.69)  LDD0726  [17]
 LDCM0410  CL22 HCT 116 C335(0.26); C304(0.28); C280(0.49); C293(0.49)  LDD0727  [17]
 LDCM0411  CL23 HCT 116 C304(0.45); C335(0.48); C280(0.73); C293(0.73)  LDD0728  [17]
 LDCM0412  CL24 HCT 116 C335(0.26); C304(0.31); C280(0.59); C293(0.59)  LDD0729  [17]
 LDCM0413  CL25 HCT 116 C335(0.34); C280(0.57); C293(0.57); C304(0.34)  LDD0730  [17]
 LDCM0414  CL26 HCT 116 C335(0.57); C280(0.86); C293(0.86); C304(0.64)  LDD0731  [17]
 LDCM0415  CL27 HCT 116 C335(0.69); C280(0.88); C293(0.88); C304(0.66)  LDD0732  [17]
 LDCM0416  CL28 HCT 116 C335(0.53); C280(0.78); C293(0.78); C304(0.44)  LDD0733  [17]
 LDCM0417  CL29 HCT 116 C335(0.44); C280(0.77); C293(0.77); C304(0.43)  LDD0734  [17]
 LDCM0418  CL3 HCT 116 C335(1.17); C280(0.83); C293(0.83); C304(0.99)  LDD0735  [17]
 LDCM0419  CL30 HCT 116 C335(0.85); C280(0.98); C293(0.98); C304(0.86)  LDD0736  [17]
 LDCM0420  CL31 HCT 116 C335(0.70); C280(0.45); C293(0.45)  LDD0737  [17]
 LDCM0421  CL32 HCT 116 C335(5.60); C280(1.04); C293(1.04)  LDD0738  [17]
 LDCM0422  CL33 HCT 116 C335(1.18); C280(1.73); C293(1.73)  LDD0739  [17]
 LDCM0423  CL34 HCT 116 C335(0.29); C280(0.25); C293(0.25)  LDD0740  [17]
 LDCM0424  CL35 HCT 116 C335(0.24); C280(0.16); C293(0.16)  LDD0741  [17]
 LDCM0425  CL36 HCT 116 C335(0.35); C280(0.28); C293(0.28)  LDD0742  [17]
 LDCM0426  CL37 HCT 116 C335(0.24); C280(0.15); C293(0.15)  LDD0743  [17]
 LDCM0428  CL39 HCT 116 C335(0.28); C280(0.18); C293(0.18)  LDD0745  [17]
 LDCM0429  CL4 HCT 116 C335(1.14); C280(0.64); C293(0.64); C304(0.90)  LDD0746  [17]
 LDCM0430  CL40 HCT 116 C335(0.37); C280(0.27); C293(0.27)  LDD0747  [17]
 LDCM0431  CL41 HCT 116 C335(0.38); C280(0.37); C293(0.37)  LDD0748  [17]
 LDCM0432  CL42 HCT 116 C335(0.24); C280(0.18); C293(0.18)  LDD0749  [17]
 LDCM0433  CL43 HCT 116 C335(0.28); C280(0.21); C293(0.21)  LDD0750  [17]
 LDCM0434  CL44 HCT 116 C335(0.50); C280(0.40); C293(0.40)  LDD0751  [17]
 LDCM0435  CL45 HCT 116 C335(0.33); C280(0.19); C293(0.19)  LDD0752  [17]
 LDCM0436  CL46 HCT 116 C335(1.02); C280(1.78); C293(1.78)  LDD0753  [17]
 LDCM0437  CL47 HCT 116 C335(1.12); C280(1.28); C293(1.28)  LDD0754  [17]
 LDCM0438  CL48 HCT 116 C335(1.27); C280(1.70); C293(1.70)  LDD0755  [17]
 LDCM0439  CL49 HCT 116 C335(1.10); C280(1.52); C293(1.52)  LDD0756  [17]
 LDCM0440  CL5 HCT 116 C335(0.86); C280(0.76); C293(0.76); C304(0.88)  LDD0757  [17]
 LDCM0441  CL50 HCT 116 C335(0.92); C280(1.11); C293(1.11)  LDD0758  [17]
 LDCM0442  CL51 HCT 116 C335(1.11); C280(1.31); C293(1.31)  LDD0759  [17]
 LDCM0443  CL52 HCT 116 C335(1.11); C280(1.21); C293(1.21)  LDD0760  [17]
 LDCM0444  CL53 HCT 116 C335(0.77); C280(1.08); C293(1.08)  LDD0761  [17]
 LDCM0445  CL54 HCT 116 C335(0.83); C280(1.07); C293(1.07)  LDD0762  [17]
 LDCM0446  CL55 HCT 116 C335(0.81); C280(1.45); C293(1.45)  LDD0763  [17]
 LDCM0447  CL56 HCT 116 C335(0.94); C280(0.91); C293(0.91)  LDD0764  [17]
 LDCM0448  CL57 HCT 116 C335(0.90); C280(1.01); C293(1.01)  LDD0765  [17]
 LDCM0449  CL58 HCT 116 C335(1.07); C280(1.39); C293(1.39)  LDD0766  [17]
 LDCM0450  CL59 HCT 116 C335(0.93); C280(0.94); C293(0.94)  LDD0767  [17]
 LDCM0451  CL6 HCT 116 C335(1.66); C280(1.29); C293(1.29); C304(1.24)  LDD0768  [17]
 LDCM0452  CL60 HCT 116 C335(1.05); C280(1.22); C293(1.22)  LDD0769  [17]
 LDCM0453  CL61 HCT 116 C335(0.89); C280(0.92); C293(0.92)  LDD0770  [17]
 LDCM0454  CL62 HCT 116 C335(0.95); C280(0.99); C293(0.99)  LDD0771  [17]
 LDCM0455  CL63 HCT 116 C335(0.66); C280(1.06); C293(1.06)  LDD0772  [17]
 LDCM0456  CL64 HCT 116 C335(0.33); C280(0.75); C293(0.75)  LDD0773  [17]
 LDCM0457  CL65 HCT 116 C335(0.78); C280(0.79); C293(0.79)  LDD0774  [17]
 LDCM0458  CL66 HCT 116 C335(0.22); C280(0.53); C293(0.53)  LDD0775  [17]
 LDCM0459  CL67 HCT 116 C335(0.36); C280(0.71); C293(0.71)  LDD0776  [17]
 LDCM0460  CL68 HCT 116 C335(0.85); C280(1.44); C293(1.44)  LDD0777  [17]
 LDCM0461  CL69 HCT 116 C335(1.68); C280(1.83); C293(1.83)  LDD0778  [17]
 LDCM0462  CL7 HCT 116 C335(0.45); C280(0.47); C293(0.47); C304(0.48)  LDD0779  [17]
 LDCM0463  CL70 HCT 116 C335(0.90); C280(0.82); C293(0.82)  LDD0780  [17]
 LDCM0464  CL71 HCT 116 C335(0.54); C280(0.65); C293(0.65)  LDD0781  [17]
 LDCM0465  CL72 HCT 116 C335(0.86); C280(0.96); C293(0.96)  LDD0782  [17]
 LDCM0466  CL73 HCT 116 C335(0.56); C280(0.82); C293(0.82)  LDD0783  [17]
 LDCM0467  CL74 HCT 116 C335(0.50); C280(0.95); C293(0.95)  LDD0784  [17]
 LDCM0469  CL76 HCT 116 C280(1.12); C293(1.12); C304(1.17)  LDD0786  [17]
 LDCM0470  CL77 HCT 116 C280(0.81); C293(0.81); C304(0.85)  LDD0787  [17]
 LDCM0471  CL78 HCT 116 C280(0.61); C293(0.61); C304(0.75)  LDD0788  [17]
 LDCM0472  CL79 HCT 116 C280(0.52); C293(0.52); C304(0.38)  LDD0789  [17]
 LDCM0473  CL8 HCT 116 C335(0.40); C280(0.34); C293(0.34); C304(0.30)  LDD0790  [17]
 LDCM0474  CL80 HCT 116 C280(1.04); C293(1.04); C304(1.22)  LDD0791  [17]
 LDCM0475  CL81 HCT 116 C280(1.11); C293(1.11); C304(0.66)  LDD0792  [17]
 LDCM0476  CL82 HCT 116 C280(0.46); C293(0.46); C304(0.31)  LDD0793  [17]
 LDCM0477  CL83 HCT 116 C280(0.49); C293(0.49); C304(0.33)  LDD0794  [17]
 LDCM0478  CL84 HCT 116 C280(0.53); C293(0.53); C304(0.29)  LDD0795  [17]
 LDCM0479  CL85 HCT 116 C280(0.90); C293(0.90); C304(0.67)  LDD0796  [17]
 LDCM0480  CL86 HCT 116 C280(0.83); C293(0.83); C304(0.98)  LDD0797  [17]
 LDCM0481  CL87 HCT 116 C280(0.79); C293(0.79); C304(0.64)  LDD0798  [17]
 LDCM0482  CL88 HCT 116 C280(0.58); C293(0.58); C304(0.36)  LDD0799  [17]
 LDCM0483  CL89 HCT 116 C280(0.50); C293(0.50); C304(0.34)  LDD0800  [17]
 LDCM0484  CL9 HCT 116 C335(0.67); C280(0.54); C293(0.54); C304(0.56)  LDD0801  [17]
 LDCM0485  CL90 HCT 116 C280(0.84); C293(0.84); C304(1.12)  LDD0802  [17]
 LDCM0486  CL91 HCT 116 C335(1.12); C304(0.80)  LDD0803  [17]
 LDCM0487  CL92 HCT 116 C335(0.87); C304(0.86)  LDD0804  [17]
 LDCM0488  CL93 HCT 116 C335(1.12); C304(0.97)  LDD0805  [17]
 LDCM0489  CL94 HCT 116 C335(1.12); C304(0.71)  LDD0806  [17]
 LDCM0490  CL95 HCT 116 C335(1.31); C304(0.71)  LDD0807  [17]
 LDCM0491  CL96 HCT 116 C335(0.92); C304(0.80)  LDD0808  [17]
 LDCM0492  CL97 HCT 116 C335(0.99); C304(0.74)  LDD0809  [17]
 LDCM0493  CL98 HCT 116 C335(1.04); C304(0.73)  LDD0810  [17]
 LDCM0494  CL99 HCT 116 C335(0.86); C304(0.82)  LDD0811  [17]
 LDCM0495  E2913 HEK-293T C335(0.85); C500(0.93); C394(0.98); C304(0.94)  LDD1698  [18]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C335(10.92); C304(2.60)  LDD1702  [5]
 LDCM0468  Fragment33 HCT 116 C335(0.55); C280(0.86); C293(0.86)  LDD0785  [17]
 LDCM0427  Fragment51 HCT 116 C335(0.23); C280(0.18); C293(0.18)  LDD0744  [17]
 LDCM0022  KB02 HEK-293T C335(0.89); C500(0.97)  LDD1492  [18]
 LDCM0023  KB03 Jurkat C335(32.33)  LDD0209  [6]
 LDCM0024  KB05 COLO792 C335(8.90)  LDD3310  [19]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C335(0.54)  LDD2121  [5]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C335(1.21)  LDD2097  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C335(0.74)  LDD2111  [5]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
16 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
17 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840