Details of the Target

General Information of Target

Target ID LDTP03108
Target Name Neurofibromin (NF1)
Gene Name NF1
Gene ID 4763
Synonyms
Neurofibromin; Neurofibromatosis-related protein NF-1) [Cleaved into: Neurofibromin truncated]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTT
ILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHF
LHTCREGNQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELL
QYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENYPDEFTKLYQIPQT
DMAECAEKLFDLVDGFAESTKRKAAVWPLQIILLILCPEIIQDISKDVVDENNMNKKLFL
DSLRKALAGHGGSRQLTESAAIACVKLCKASTYINWEDNSVIFLLVQSMVVDLKNLLFNP
SKPFSRGSQPADVDLMIDCLVSCFRISPHNNQHFKICLAQNSPSTFHYVLVNSLHRIITN
SALDWWPKIDAVYCHSVELRNMFGETLHKAVQGCGAHPAIRMAPSLTFKEKVTSLKFKEK
PTDLETRSYKYLLLSMVKLIHADPKLLLCNPRKQGPETQGSTAELITGLVQLVPQSHMPE
IAQEAMEALLVLHQLDSIDLWNPDAPVETFWEISSQMLFYICKKLTSHQMLSSTEILKWL
REILICRNKFLLKNKQADRSSCHFLLFYGVGCDIPSSGNTSQMSMDHEELLRTPGASLRK
GKGNSSMDSAAGCSGTPPICRQAQTKLEVALYMFLWNPDTEAVLVAMSCFRHLCEEADIR
CGVDEVSVHNLLPNYNTFMEFASVSNMMSTGRAALQKRVMALLRRIEHPTAGNTEAWEDT
HAKWEQATKLILNYPKAKMEDGQAAESLHKTIVKRRMSHVSGGGSIDLSDTDSLQEWINM
TGFLCALGGVCLQQRSNSGLATYSPPMGPVSERKGSMISVMSSEGNADTPVSKFMDRLLS
LMVCNHEKVGLQIRTNVKDLVGLELSPALYPMLFNKLKNTISKFFDSQGQVLLTDTNTQF
VEQTIAIMKNLLDNHTEGSSEHLGQASIETMMLNLVRYVRVLGNMVHAIQIKTKLCQLVE
VMMARRDDLSFCQEMKFRNKMVEYLTDWVMGTSNQAADDDVKCLTRDLDQASMEAVVSLL
AGLPLQPEEGDGVELMEAKSQLFLKYFTLFMNLLNDCSEVEDESAQTGGRKRGMSRRLAS
LRHCTVLAMSNLLNANVDSGLMHSIGLGYHKDLQTRATFMEVLTKILQQGTEFDTLAETV
LADRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLWNM
FSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIVITSSDWQHVSFE
VDPTRLEPSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQATCHSLLNKA
TVKEKKENKKSVVSQRFPQNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGLK
LMSKILQSIANHVLFTKEEHMRPFNDFVKSNFDAARRFFLDIASDCPTSDAVNHSLSFIS
DGNVLALHRLLWNNQEKIGQYLSSNRDHKAVGRRPFDKMATLLAYLGPPEHKPVADTHWS
SLNLTSSKFEEFMTRHQVHEKEEFKALKTLSIFYQAGTSKAGNPIFYYVARRFKTGQING
DLLIYHVLLTLKPYYAKPYEIVVDLTHTGPSNRFKTDFLSKWFVVFPGFAYDNVSAVYIY
NCNSWVREYTKYHERLLTGLKGSKRLVFIDCPGKLAEHIEHEQQKLPAATLALEEDLKVF
HNALKLAHKDTKVSIKVGSTAVQVTSAERTKVLGQSVFLNDIYYASEIEEICLVDENQFT
LTIANQGTPLTFMHQECEAIVQSIIHIRTRWELSQPDSIPQHTKIRPKDVPGTLLNIALL
NLGSSDPSLRSAAYNLLCALTCTFNLKIEGQLLETSGLCIPANNTLFIVSISKTLAANEP
HLTLEFLEECISGFSKSSIELKHLCLEYMTPWLSNLVRFCKHNDDAKRQRVTAILDKLIT
MTINEKQMYPSIQAKIWGSLGQITDLLDVVLDSFIKTSATGGLGSIKAEVMADTAVALAS
GNVKLVSSKVIGRMCKIIDKTCLSPTPTLEQHLMWDDIAILARYMLMLSFNNSLDVAAHL
PYLFHVVTFLVATGPLSLRASTHGLVINIIHSLCTCSQLHFSEETKQVLRLSLTEFSLPK
FYLLFGISKVKSAAVIAFRSSYRDRSFSPGSYERETFALTSLETVTEALLEIMEACMRDI
PTCKWLDQWTELAQRFAFQYNPSLQPRALVVFGCISKRVSHGQIKQIIRILSKALESCLK
GPDTYNSQVLIEATVIALTKLQPLLNKDSPLHKALFWVAVAVLQLDEVNLYSAGTALLEQ
NLHTLDSLRIFNDKSPEEVFMAIRNPLEWHCKQMDHFVGLNFNSNFNFALVGHLLKGYRH
PSPAIVARTVRILHTLLTLVNKHRNCDKFEVNTQSVAYLAALLTVSEEVRSRCSLKHRKS
LLLTDISMENVPMDTYPIHHGDPSYRTLKETQPWSSPKGSEGYLAATYPTVGQTSPRARK
SMSLDMGQPSQANTKKLLGTRKSFDHLISDTKAPKRQEMESGITTPPKMRRVAETDYEME
TQRISSSQQHPHLRKVSVSESNVLLDEEVLTDPKIQALLLTVLATLVKYTTDEFDQRILY
EYLAEASVVFPKVFPVVHNLLDSKINTLLSLCQDPNLLNPIHGIVQSVVYHEESPPQYQT
SYLQSFGFNGLWRFAGPFSKQTQIPDYAELIVKFLDALIDTYLPGIDEETSEESLLTPTS
PYPPALQSQLSITANLNLSNSMTSLATSQHSPGIDKENVELSPTTGHCNSGRTRHGSASQ
VQKQRSAGSFKRNSIKKIV
Target Bioclass
Other
Subcellular location
Nucleus
Function Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity.
Uniprot ID
P21359
Ensemble ID
ENST00000356175.7
HGNC ID
HGNC:7765

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A204 SNV: p.L1274F DBIA    Probe Info 
ABC1 SNV: p.E1043Ter DBIA    Probe Info 
AGS SNV: p.E1459G DBIA    Probe Info 
AU565 SNV: p.A502V DBIA    Probe Info 
COLO792 SNV: p.W1236R DBIA    Probe Info 
DU145 SNV: p.P2472H DBIA    Probe Info 
FTC133 SNV: p.C167Ter .
G402 SNV: p.P1358S DBIA    Probe Info 
GB1 SNV: p.R304Ter DBIA    Probe Info 
HCT116 SNV: p.P388T .
HCT15 SNV: p.A74D; p.P2477S; p.A2617V DBIA    Probe Info 
HEC1 SNV: p.A887T DBIA    Probe Info 
HGC27 Deletion: p.L1715del; p.A1716FfsTer24 DBIA    Probe Info 
HS578T SNV: p.G2745R DBIA    Probe Info 
HT115 SNV: p.E595Ter; p.R1241Ter; p.D2545G DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.E2231D DBIA    Probe Info 
JHH6 SNV: p.R1412T DBIA    Probe Info 
KPNYN SNV: p.R461Ter DBIA    Probe Info 
LNCaP clone FGC SNV: p.A431V; p.A690V DBIA    Probe Info 
LOXIMVI SNV: p.Q1174Ter DBIA    Probe Info 
MCC13 SNV: p.Q236Ter DBIA    Probe Info 
MDAMB157 Deletion: p.S2751RfsTer27 .
MDAMB231 Insertion: p.T467HfsTer3 .
MELJUSO SNV: p.L1779P DBIA    Probe Info 
MEWO SNV: p.Q1336Ter DBIA    Probe Info 
NCIH446 SNV: p.D2346H DBIA    Probe Info 
NCIH716 SNV: p.V2111L .
NCIH82 SNV: p.S331R DBIA    Probe Info 
RD SNV: p.E977Ter DBIA    Probe Info 
RKO Deletion: p.Y628TfsTer3;p.N2341TfsTer5
SNV: p.V2205A		 DBIA    Probe Info 
RT112 SNV: p.L790P; p.K1844N DBIA    Probe Info 
SKOV3 SNV: p.G1702C DBIA    Probe Info 
SW756 SNV: p.F2708I DBIA    Probe Info 
TE11 SNV: p.D2283N DBIA    Probe Info 
TFK1 SNV: p.Q1255R DBIA    Probe Info 
TOV21G Deletion: p.P678RfsTer10 DBIA    Probe Info 
U87MG Deletion: p.F1247IfsTer18
SNV: p.K1444M		 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
BTD
 Probe Info  		C509(1.07)  LDD2127  [2]
AHL-Pu-1
 Probe Info  		C714(5.07); C680(2.53); C673(3.79); C454(2.60)  LDD0168  [3]
DBIA
 Probe Info  		C124(1.10); C673(1.09); C680(1.09); C118(0.92)  LDD0078  [4]
ATP probe
 Probe Info  		K206(0.00); K261(0.00)  LDD0199  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C93(0.00); C1016(0.00); C454(0.00); C434(0.00)  LDD0037  [6]
WYneN
 Probe Info  		N.A.  LDD0021  [7]
WYneO
 Probe Info  		N.A.  LDD0022  [7]
Compound 10
 Probe Info  		N.A.  LDD2216  [8]
Compound 11
 Probe Info  		N.A.  LDD2213  [8]
ENE
 Probe Info  		N.A.  LDD0006  [7]
IPM
 Probe Info  		C454(0.00); C904(0.00); C1711(0.00); C2808(0.00)  LDD0005  [7]
TFBX
 Probe Info  		C454(0.00); C509(0.00); C93(0.00); C1960(0.00)  LDD0148  [9]
VSF
 Probe Info  		N.A.  LDD0007  [7]
Acrolein
 Probe Info  		N.A.  LDD0217  [10]
Methacrolein
 Probe Info  		N.A.  LDD0218  [10]
AOyne
 Probe Info  		12.20  LDD0443  [11]
NAIA_5
 Probe Info  		C454(0.00); C1960(0.00)  LDD2223  [12]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C280
 Probe Info  		10.13  LDD1950  [13]
C284
 Probe Info  		23.26  LDD1954  [13]
STS-1
 Probe Info  		N.A.  LDD0137  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C714(5.07); C680(2.53); C673(3.79); C454(2.60)  LDD0168  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C714(12.53); C622(6.93); C1486(2.05); C680(2.28)  LDD0169  [3]
 LDCM0214  AC1 HEK-293T C680(1.06); C673(1.06); C1032(1.59); C124(0.97)  LDD0812  [4]
 LDCM0215  AC10 HEK-293T C680(1.05); C673(0.87); C1032(1.11); C118(0.91)  LDD0813  [4]
 LDCM0216  AC100 HEK-293T C680(1.01); C673(1.38); C1032(1.34); C118(0.80)  LDD0814  [4]
 LDCM0217  AC101 HEK-293T C680(0.94); C673(1.05); C1032(1.02); C118(0.83)  LDD0815  [4]
 LDCM0218  AC102 HEK-293T C680(1.04); C673(1.57); C1032(1.15); C118(0.76)  LDD0816  [4]
 LDCM0219  AC103 HEK-293T C680(0.90); C673(2.60); C1032(1.20); C118(1.05)  LDD0817  [4]
 LDCM0220  AC104 HEK-293T C680(1.03); C673(1.73); C1032(1.13); C118(0.93)  LDD0818  [4]
 LDCM0221  AC105 HEK-293T C680(0.98); C673(0.99); C1032(1.03); C118(0.76)  LDD0819  [4]
 LDCM0222  AC106 HEK-293T C680(1.04); C673(0.87); C1032(1.03); C118(0.67)  LDD0820  [4]
 LDCM0223  AC107 HEK-293T C680(1.06); C673(1.80); C1032(1.13); C118(0.74)  LDD0821  [4]
 LDCM0224  AC108 HEK-293T C680(0.95); C673(0.94); C1032(1.13); C118(0.73)  LDD0822  [4]
 LDCM0225  AC109 HEK-293T C680(1.11); C673(0.96); C1032(1.29); C118(0.91)  LDD0823  [4]
 LDCM0226  AC11 HEK-293T C680(1.01); C673(1.01); C1032(0.87); C118(0.88)  LDD0824  [4]
 LDCM0227  AC110 HEK-293T C680(1.02); C673(5.05); C1032(2.12); C118(0.72)  LDD0825  [4]
 LDCM0228  AC111 HEK-293T C680(1.07); C673(0.90); C1032(1.05); C118(0.80)  LDD0826  [4]
 LDCM0229  AC112 HEK-293T C680(0.94); C673(3.99); C1032(1.97); C118(0.78)  LDD0827  [4]
 LDCM0230  AC113 HEK-293T C680(0.91); C673(1.00); C1032(1.29); C118(1.02)  LDD0828  [4]
 LDCM0231  AC114 HEK-293T C680(0.85); C673(1.06); C1032(1.38); C118(1.15)  LDD0829  [4]
 LDCM0232  AC115 HEK-293T C680(0.96); C673(1.08); C1032(1.36); C118(1.14)  LDD0830  [4]
 LDCM0233  AC116 HEK-293T C680(0.89); C673(1.10); C1032(1.75); C118(1.31)  LDD0831  [4]
 LDCM0234  AC117 HEK-293T C680(0.96); C673(1.30); C1032(2.01); C118(1.01)  LDD0832  [4]
 LDCM0235  AC118 HEK-293T C680(1.08); C673(1.59); C1032(1.78); C118(1.48)  LDD0833  [4]
 LDCM0236  AC119 HEK-293T C680(1.02); C673(2.00); C1032(1.86); C118(1.10)  LDD0834  [4]
 LDCM0237  AC12 HEK-293T C680(1.05); C673(1.12); C1032(0.97); C118(0.91)  LDD0835  [4]
 LDCM0238  AC120 HEK-293T C680(0.97); C673(1.47); C1032(2.30); C118(1.00)  LDD0836  [4]
 LDCM0239  AC121 HEK-293T C680(0.92); C673(1.72); C1032(2.64); C118(1.06)  LDD0837  [4]
 LDCM0240  AC122 HEK-293T C680(0.98); C673(2.77); C1032(3.12); C118(0.96)  LDD0838  [4]
 LDCM0241  AC123 HEK-293T C680(0.81); C673(3.02); C1032(3.20); C118(1.13)  LDD0839  [4]
 LDCM0242  AC124 HEK-293T C680(0.96); C673(1.84); C1032(1.83); C118(0.92)  LDD0840  [4]
 LDCM0243  AC125 HEK-293T C680(1.02); C673(3.63); C1032(2.49); C118(0.95)  LDD0841  [4]
 LDCM0244  AC126 HEK-293T C680(1.18); C673(1.23); C1032(1.75); C118(1.05)  LDD0842  [4]
 LDCM0245  AC127 HEK-293T C680(0.89); C673(3.57); C1032(3.95); C118(1.11)  LDD0843  [4]
 LDCM0246  AC128 HEK-293T C680(1.08); C673(1.01); C1032(1.17); C118(0.82)  LDD0844  [4]
 LDCM0247  AC129 HEK-293T C680(1.34); C673(1.67); C1032(1.71); C118(0.73)  LDD0845  [4]
 LDCM0249  AC130 HEK-293T C680(1.14); C673(1.42); C1032(1.57); C118(1.25)  LDD0847  [4]
 LDCM0250  AC131 HEK-293T C680(1.37); C673(1.20); C1032(1.00); C118(1.27)  LDD0848  [4]
 LDCM0251  AC132 HEK-293T C680(1.42); C673(1.37); C1032(1.21); C118(0.73)  LDD0849  [4]
 LDCM0252  AC133 HEK-293T C680(1.35); C673(2.64); C1032(1.61); C118(1.21)  LDD0850  [4]
 LDCM0253  AC134 HEK-293T C680(1.23); C673(1.62); C1032(1.26); C118(1.02)  LDD0851  [4]
 LDCM0254  AC135 HEK-293T C680(1.25); C673(1.48); C1032(1.62); C118(1.04)  LDD0852  [4]
 LDCM0255  AC136 HEK-293T C680(0.93); C673(1.33); C1032(1.95); C118(0.83)  LDD0853  [4]
 LDCM0256  AC137 HEK-293T C680(1.28); C673(2.76); C1032(1.97); C118(0.78)  LDD0854  [4]
 LDCM0257  AC138 HEK-293T C680(1.17); C673(3.19); C1032(2.30); C118(0.92)  LDD0855  [4]
 LDCM0258  AC139 HEK-293T C680(1.20); C673(2.37); C1032(1.92); C118(0.93)  LDD0856  [4]
 LDCM0259  AC14 HEK-293T C680(1.15); C673(1.12); C1032(1.21); C118(0.73)  LDD0857  [4]
 LDCM0260  AC140 HEK-293T C680(1.23); C673(1.90); C1032(1.56); C118(0.88)  LDD0858  [4]
 LDCM0261  AC141 HEK-293T C680(1.12); C673(3.31); C1032(2.17); C118(0.86)  LDD0859  [4]
 LDCM0262  AC142 HEK-293T C680(1.42); C673(2.05); C1032(1.74); C118(0.77)  LDD0860  [4]
 LDCM0263  AC143 HEK-293T C680(1.38); C673(1.03); C1032(1.12); C118(1.49)  LDD0861  [4]
 LDCM0264  AC144 HEK-293T C680(1.36); C673(1.09); C1032(1.43); C118(1.05)  LDD0862  [4]
 LDCM0265  AC145 HEK-293T C680(1.28); C673(1.25); C1032(1.47); C118(1.19)  LDD0863  [4]
 LDCM0266  AC146 HEK-293T C680(1.45); C673(3.89); C1032(1.51); C118(1.24)  LDD0864  [4]
 LDCM0267  AC147 HEK-293T C680(1.38); C673(2.91); C1032(1.57); C118(1.59)  LDD0865  [4]
 LDCM0268  AC148 HEK-293T C680(1.25); C673(2.03); C1032(1.24); C118(1.60)  LDD0866  [4]
 LDCM0269  AC149 HEK-293T C680(1.18); C673(0.91); C1032(1.08); C118(1.72)  LDD0867  [4]
 LDCM0270  AC15 HEK-293T C680(1.05); C673(1.52); C1032(2.18); C118(0.94)  LDD0868  [4]
 LDCM0271  AC150 HEK-293T C680(1.19); C673(2.08); C1032(1.28); C118(1.50)  LDD0869  [4]
 LDCM0272  AC151 HEK-293T C680(1.27); C673(2.00); C1032(1.41); C118(1.63)  LDD0870  [4]
 LDCM0273  AC152 HEK-293T C680(1.15); C673(1.42); C1032(1.11); C118(1.14)  LDD0871  [4]
 LDCM0274  AC153 HEK-293T C680(1.46); C673(2.46); C1032(1.29); C118(1.10)  LDD0872  [4]
 LDCM0621  AC154 HEK-293T C680(1.08); C673(1.33); C1032(1.27); C118(1.42)  LDD2162  [4]
 LDCM0622  AC155 HEK-293T C680(1.34); C673(1.48); C1032(1.15); C118(1.15)  LDD2163  [4]
 LDCM0623  AC156 HEK-293T C680(1.36); C673(2.68); C1032(1.62); C118(1.31)  LDD2164  [4]
 LDCM0624  AC157 HEK-293T C680(1.02); C673(3.28); C1032(1.96); C118(1.26)  LDD2165  [4]
 LDCM0276  AC17 HEK-293T C680(1.45); C673(1.45); C118(0.89); C124(1.14)  LDD0874  [4]
 LDCM0277  AC18 HEK-293T C680(1.75); C673(1.75); C118(0.95); C124(1.05)  LDD0875  [4]
 LDCM0278  AC19 HEK-293T C680(1.41); C673(1.41); C118(0.90); C124(1.05)  LDD0876  [4]
 LDCM0279  AC2 HEK-293T C680(1.26); C673(1.26); C1032(1.19); C124(1.20)  LDD0877  [4]
 LDCM0280  AC20 HEK-293T C680(1.28); C673(1.28); C118(0.93); C124(1.21)  LDD0878  [4]
 LDCM0281  AC21 HEK-293T C680(1.12); C673(1.12); C118(0.89); C124(1.10)  LDD0879  [4]
 LDCM0282  AC22 HEK-293T C680(1.10); C673(1.10); C118(0.83); C124(1.08)  LDD0880  [4]
 LDCM0283  AC23 HEK-293T C680(1.91); C673(1.91); C118(0.88); C124(1.28)  LDD0881  [4]
 LDCM0284  AC24 HEK-293T C680(1.36); C673(1.36); C118(0.84); C124(1.01)  LDD0882  [4]
 LDCM0285  AC25 HEK-293T C680(0.99); C673(0.91); C1032(1.08); C124(1.30)  LDD0883  [4]
 LDCM0286  AC26 HEK-293T C680(1.15); C673(0.85); C1032(1.12); C124(1.36)  LDD0884  [4]
 LDCM0287  AC27 HEK-293T C680(1.13); C673(1.05); C1032(1.24); C124(1.11)  LDD0885  [4]
 LDCM0288  AC28 HEK-293T C680(0.69); C673(0.89); C1032(1.95); C124(0.95)  LDD0886  [4]
 LDCM0289  AC29 HEK-293T C680(1.13); C673(1.05); C1032(1.21); C124(1.21)  LDD0887  [4]
 LDCM0290  AC3 HEK-293T C680(0.97); C673(0.97); C1032(1.09); C124(0.99)  LDD0888  [4]
 LDCM0291  AC30 HEK-293T C680(1.21); C673(0.96); C1032(1.18); C124(1.57)  LDD0889  [4]
 LDCM0292  AC31 HEK-293T C680(1.00); C673(0.88); C1032(0.99); C124(0.92)  LDD0890  [4]
 LDCM0293  AC32 HEK-293T C680(1.07); C673(1.00); C1032(1.26); C124(1.26)  LDD0891  [4]
 LDCM0294  AC33 HEK-293T C680(1.15); C673(0.99); C1032(1.43); C124(1.88)  LDD0892  [4]
 LDCM0295  AC34 HEK-293T C680(1.09); C673(0.98); C1032(1.17); C124(1.46)  LDD0893  [4]
 LDCM0296  AC35 HEK-293T C680(1.16); C673(1.05); C1032(1.02); C118(0.99)  LDD0894  [4]
 LDCM0297  AC36 HEK-293T C680(1.07); C673(1.11); C1032(1.05); C118(1.58)  LDD0895  [4]
 LDCM0298  AC37 HEK-293T C680(0.98); C673(1.20); C1032(1.12); C118(1.21)  LDD0896  [4]
 LDCM0299  AC38 HEK-293T C680(1.22); C673(1.22); C1032(1.19); C118(0.99)  LDD0897  [4]
 LDCM0300  AC39 HEK-293T C680(1.20); C673(1.20); C1032(1.40); C118(0.79)  LDD0898  [4]
 LDCM0301  AC4 HEK-293T C680(1.04); C673(1.04); C1032(1.11); C124(0.95)  LDD0899  [4]
 LDCM0302  AC40 HEK-293T C680(1.44); C673(1.25); C1032(1.41); C118(1.31)  LDD0900  [4]
 LDCM0303  AC41 HEK-293T C680(1.15); C673(1.13); C1032(1.51); C118(0.92)  LDD0901  [4]
 LDCM0304  AC42 HEK-293T C680(1.20); C673(1.23); C1032(1.44); C118(1.13)  LDD0902  [4]
 LDCM0305  AC43 HEK-293T C680(1.20); C673(1.19); C1032(1.37); C118(1.02)  LDD0903  [4]
 LDCM0306  AC44 HEK-293T C680(1.22); C673(1.28); C1032(1.77); C118(1.03)  LDD0904  [4]
 LDCM0307  AC45 HEK-293T C680(1.40); C673(1.41); C1032(1.60); C118(1.00)  LDD0905  [4]
 LDCM0308  AC46 HEK-293T C680(0.96); C673(1.05); C1032(1.40); C118(0.85)  LDD0906  [4]
 LDCM0309  AC47 HEK-293T C680(1.50); C673(1.04); C1032(1.69); C118(1.08)  LDD0907  [4]
 LDCM0310  AC48 HEK-293T C680(0.97); C673(1.00); C1032(1.90); C118(1.10)  LDD0908  [4]
 LDCM0311  AC49 HEK-293T C680(1.05); C673(1.06); C1032(1.33); C118(1.49)  LDD0909  [4]
 LDCM0312  AC5 HEK-293T C680(1.10); C673(1.10); C1032(1.22); C124(1.12)  LDD0910  [4]
 LDCM0313  AC50 HEK-293T C680(1.04); C673(1.14); C1032(2.08); C118(1.02)  LDD0911  [4]
 LDCM0314  AC51 HEK-293T C680(1.03); C673(1.09); C1032(2.02); C118(0.97)  LDD0912  [4]
 LDCM0315  AC52 HEK-293T C680(1.04); C673(1.17); C1032(1.56); C118(1.41)  LDD0913  [4]
 LDCM0316  AC53 HEK-293T C680(1.75); C673(1.82); C1032(1.61); C118(1.15)  LDD0914  [4]
 LDCM0317  AC54 HEK-293T C680(1.16); C673(1.18); C1032(2.25); C118(1.04)  LDD0915  [4]
 LDCM0318  AC55 HEK-293T C680(1.25); C673(1.45); C1032(1.72); C118(1.12)  LDD0916  [4]
 LDCM0319  AC56 HEK-293T C680(1.26); C673(1.01); C1032(1.11); C118(1.15)  LDD0917  [4]
 LDCM0320  AC57 HEK-293T C680(1.30); C673(1.41); C1032(0.61); C118(1.08)  LDD0918  [4]
 LDCM0321  AC58 HEK-293T C680(1.18); C673(1.07); C1032(0.38); C118(1.18)  LDD0919  [4]
 LDCM0322  AC59 HEK-293T C680(1.18); C673(1.13); C1032(0.39); C118(1.05)  LDD0920  [4]
 LDCM0323  AC6 HEK-293T C680(1.13); C673(0.98); C1032(0.68); C118(1.06)  LDD0921  [4]
 LDCM0324  AC60 HEK-293T C680(0.94); C673(0.98); C1032(1.19); C118(1.32)  LDD0922  [4]
 LDCM0325  AC61 HEK-293T C680(1.22); C673(1.20); C1032(0.92); C118(1.17)  LDD0923  [4]
 LDCM0326  AC62 HEK-293T C680(1.15); C673(1.07); C1032(0.62); C118(1.23)  LDD0924  [4]
 LDCM0327  AC63 HEK-293T C680(1.28); C673(1.43); C1032(0.75); C118(1.16)  LDD0925  [4]
 LDCM0328  AC64 HEK-293T C680(1.18); C673(1.31); C1032(0.59); C118(1.10)  LDD0926  [4]
 LDCM0329  AC65 HEK-293T C680(1.14); C673(1.16); C1032(0.61); C118(1.19)  LDD0927  [4]
 LDCM0330  AC66 HEK-293T C680(1.13); C673(1.10); C1032(0.58); C118(1.17)  LDD0928  [4]
 LDCM0331  AC67 HEK-293T C680(1.09); C673(1.05); C1032(0.48); C118(1.11)  LDD0929  [4]
 LDCM0332  AC68 HEK-293T C680(0.87); C673(0.87); C1032(1.43); C118(1.42)  LDD0930  [4]
 LDCM0333  AC69 HEK-293T C680(0.95); C673(0.95); C1032(1.41); C118(1.02)  LDD0931  [4]
 LDCM0334  AC7 HEK-293T C680(1.00); C673(0.95); C1032(1.09); C118(1.22)  LDD0932  [4]
 LDCM0335  AC70 HEK-293T C680(0.85); C673(0.85); C1032(1.77); C118(1.58)  LDD0933  [4]
 LDCM0336  AC71 HEK-293T C680(0.96); C673(0.96); C1032(1.04); C118(1.09)  LDD0934  [4]
 LDCM0337  AC72 HEK-293T C680(1.19); C673(1.19); C1032(1.70); C118(0.96)  LDD0935  [4]
 LDCM0338  AC73 HEK-293T C680(1.08); C673(1.08); C1032(1.90); C118(1.58)  LDD0936  [4]
 LDCM0339  AC74 HEK-293T C680(0.77); C673(0.77); C1032(1.38); C118(1.37)  LDD0937  [4]
 LDCM0340  AC75 HEK-293T C680(1.10); C673(1.10); C1032(2.02); C118(1.88)  LDD0938  [4]
 LDCM0341  AC76 HEK-293T C680(0.83); C673(0.83); C1032(1.13); C118(1.28)  LDD0939  [4]
 LDCM0342  AC77 HEK-293T C680(0.96); C673(0.96); C1032(1.54); C118(1.27)  LDD0940  [4]
 LDCM0343  AC78 HEK-293T C680(0.79); C673(0.79); C1032(2.44); C118(1.75)  LDD0941  [4]
 LDCM0344  AC79 HEK-293T C680(0.79); C673(0.79); C1032(0.92); C118(1.35)  LDD0942  [4]
 LDCM0345  AC8 HEK-293T C680(1.12); C673(1.15); C1032(1.40); C118(0.99)  LDD0943  [4]
 LDCM0346  AC80 HEK-293T C680(0.86); C673(0.86); C1032(2.01); C118(1.14)  LDD0944  [4]
 LDCM0347  AC81 HEK-293T C680(0.89); C673(0.89); C1032(1.47); C118(1.40)  LDD0945  [4]
 LDCM0348  AC82 HEK-293T C680(0.93); C673(0.93); C1032(2.15); C118(0.86)  LDD0946  [4]
 LDCM0349  AC83 HEK-293T C680(1.04); C673(1.05); C1032(1.01); C118(0.78)  LDD0947  [4]
 LDCM0350  AC84 HEK-293T C680(1.41); C673(1.45); C1032(1.42); C118(0.59)  LDD0948  [4]
 LDCM0351  AC85 HEK-293T C680(1.19); C673(1.35); C1032(1.26); C118(0.92)  LDD0949  [4]
 LDCM0352  AC86 HEK-293T C680(1.47); C673(1.31); C1032(1.40); C118(0.82)  LDD0950  [4]
 LDCM0353  AC87 HEK-293T C680(1.26); C673(1.19); C1032(1.30); C118(0.82)  LDD0951  [4]
 LDCM0354  AC88 HEK-293T C680(1.64); C673(1.79); C1032(1.35); C118(0.84)  LDD0952  [4]
 LDCM0355  AC89 HEK-293T C680(1.42); C673(2.01); C1032(2.19); C118(0.63)  LDD0953  [4]
 LDCM0357  AC90 HEK-293T C680(1.37); C673(1.70); C1032(1.85); C118(0.77)  LDD0955  [4]
 LDCM0358  AC91 HEK-293T C680(0.93); C673(1.19); C1032(1.37); C118(0.85)  LDD0956  [4]
 LDCM0359  AC92 HEK-293T C680(1.12); C673(1.18); C1032(1.37); C118(0.78)  LDD0957  [4]
 LDCM0360  AC93 HEK-293T C680(1.05); C673(1.48); C1032(1.29); C118(0.72)  LDD0958  [4]
 LDCM0361  AC94 HEK-293T C680(1.06); C673(1.82); C1032(1.44); C118(0.71)  LDD0959  [4]
 LDCM0362  AC95 HEK-293T C680(1.08); C673(1.41); C1032(1.38); C118(0.75)  LDD0960  [4]
 LDCM0363  AC96 HEK-293T C680(0.90); C673(1.15); C1032(1.30); C118(1.02)  LDD0961  [4]
 LDCM0364  AC97 HEK-293T C680(1.08); C673(1.55); C1032(1.93); C118(0.81)  LDD0962  [4]
 LDCM0365  AC98 HEK-293T C680(1.01); C673(1.06); C1032(1.07); C118(0.83)  LDD0963  [4]
 LDCM0366  AC99 HEK-293T C680(0.94); C673(0.93); C1032(1.25); C118(0.93)  LDD0964  [4]
 LDCM0248  AKOS034007472 HEK-293T C680(1.07); C673(1.00); C1032(0.87); C118(0.90)  LDD0846  [4]
 LDCM0356  AKOS034007680 HEK-293T C680(1.12); C673(1.49); C1032(1.34); C118(1.06)  LDD0954  [4]
 LDCM0275  AKOS034007705 HEK-293T C680(1.24); C673(1.43); C1032(1.38); C118(0.69)  LDD0873  [4]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C124(1.10); C673(1.09); C680(1.09); C118(0.92)  LDD0078  [4]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [10]
 LDCM0632  CL-Sc Hep-G2 C454(0.52)  LDD2227  [12]
 LDCM0367  CL1 HEK-293T C680(4.83); C673(4.83); C1032(1.36); C147(1.73)  LDD0965  [4]
 LDCM0368  CL10 HEK-293T C680(6.08); C673(6.08); C1032(2.67); C147(1.87)  LDD0966  [4]
 LDCM0369  CL100 HEK-293T C680(1.79); C673(1.79); C1032(1.61); C124(1.18)  LDD0967  [4]
 LDCM0370  CL101 HEK-293T C680(3.09); C673(2.22); C1032(1.19); C118(1.17)  LDD0968  [4]
 LDCM0371  CL102 HEK-293T C680(0.96); C673(2.00); C1032(1.61); C118(0.85)  LDD0969  [4]
 LDCM0372  CL103 HEK-293T C680(3.29); C673(1.28); C1032(1.15); C118(1.16)  LDD0970  [4]
 LDCM0373  CL104 HEK-293T C680(3.39); C673(2.72); C1032(1.46); C118(1.45)  LDD0971  [4]
 LDCM0374  CL105 HEK-293T C680(2.86); C673(2.86); C118(0.82); C124(0.96)  LDD0972  [4]
 LDCM0375  CL106 HEK-293T C680(2.27); C673(2.27); C118(0.83); C124(1.00)  LDD0973  [4]
 LDCM0376  CL107 HEK-293T C680(1.26); C673(1.26); C118(0.81); C124(0.98)  LDD0974  [4]
 LDCM0377  CL108 HEK-293T C680(1.50); C673(1.50); C118(1.06); C124(1.12)  LDD0975  [4]
 LDCM0378  CL109 HEK-293T C680(7.52); C673(7.52); C118(0.83); C124(1.02)  LDD0976  [4]
 LDCM0379  CL11 HEK-293T C680(1.94); C673(1.94); C1032(2.16); C147(1.30)  LDD0977  [4]
 LDCM0380  CL110 HEK-293T C680(7.96); C673(7.96); C118(0.89); C124(1.10)  LDD0978  [4]
 LDCM0381  CL111 HEK-293T C680(5.32); C673(5.32); C118(1.03); C124(1.08)  LDD0979  [4]
 LDCM0382  CL112 HEK-293T C680(4.18); C673(1.92); C1032(1.71); C124(1.25)  LDD0980  [4]
 LDCM0383  CL113 HEK-293T C680(1.13); C673(0.80); C1032(1.13); C124(1.17)  LDD0981  [4]
 LDCM0384  CL114 HEK-293T C680(1.42); C673(1.80); C1032(2.76); C124(2.11)  LDD0982  [4]
 LDCM0385  CL115 HEK-293T C680(3.30); C673(1.29); C1032(1.86); C124(1.24)  LDD0983  [4]
 LDCM0386  CL116 HEK-293T C680(2.87); C673(1.09); C1032(1.45); C124(1.75)  LDD0984  [4]
 LDCM0387  CL117 HEK-293T C680(1.70); C673(1.23); C1032(1.08); C118(0.92)  LDD0985  [4]
 LDCM0388  CL118 HEK-293T C680(1.10); C673(1.04); C1032(1.14); C118(1.17)  LDD0986  [4]
 LDCM0389  CL119 HEK-293T C680(1.15); C673(1.22); C1032(1.34); C118(1.21)  LDD0987  [4]
 LDCM0390  CL12 HEK-293T C680(2.41); C673(2.41); C1032(1.22); C147(0.88)  LDD0988  [4]
 LDCM0391  CL120 HEK-293T C680(1.20); C673(1.20); C1032(1.32); C118(0.99)  LDD0989  [4]
 LDCM0392  CL121 HEK-293T C680(2.11); C673(2.28); C1032(1.94); C118(1.54)  LDD0990  [4]
 LDCM0393  CL122 HEK-293T C680(2.46); C673(2.48); C1032(1.87); C118(0.99)  LDD0991  [4]
 LDCM0394  CL123 HEK-293T C680(2.66); C673(3.52); C1032(2.36); C118(0.87)  LDD0992  [4]
 LDCM0395  CL124 HEK-293T C680(2.45); C673(1.89); C1032(1.84); C118(1.24)  LDD0993  [4]
 LDCM0396  CL125 HEK-293T C680(1.27); C673(1.07); C1032(0.48); C118(0.97)  LDD0994  [4]
 LDCM0397  CL126 HEK-293T C680(2.30); C673(2.66); C1032(0.43); C118(1.05)  LDD0995  [4]
 LDCM0398  CL127 HEK-293T C680(1.38); C673(1.24); C1032(0.52); C118(1.10)  LDD0996  [4]
 LDCM0399  CL128 HEK-293T C680(1.42); C673(1.29); C1032(0.46); C118(1.23)  LDD0997  [4]
 LDCM0400  CL13 HEK-293T C680(1.72); C673(1.72); C1032(1.11); C147(0.94)  LDD0998  [4]
 LDCM0401  CL14 HEK-293T C680(3.39); C673(3.39); C1032(3.00); C147(1.26)  LDD0999  [4]
 LDCM0402  CL15 HEK-293T C680(12.60); C673(12.60); C1032(2.20); C147(1.24)  LDD1000  [4]
 LDCM0403  CL16 HEK-293T C680(2.19); C673(1.16); C1032(0.89); C118(1.12)  LDD1001  [4]
 LDCM0404  CL17 HEK-293T C680(4.06); C673(4.00); C1032(1.65); C118(1.30)  LDD1002  [4]
 LDCM0405  CL18 HEK-293T C680(2.31); C673(1.30); C1032(1.01); C118(1.45)  LDD1003  [4]
 LDCM0406  CL19 HEK-293T C680(2.78); C673(1.17); C1032(1.25); C118(0.98)  LDD1004  [4]
 LDCM0407  CL2 HEK-293T C680(2.38); C673(2.38); C1032(1.28); C147(1.01)  LDD1005  [4]
 LDCM0408  CL20 HEK-293T C680(1.27); C673(1.30); C1032(0.98); C118(1.00)  LDD1006  [4]
 LDCM0409  CL21 HEK-293T C680(3.51); C673(3.84); C1032(1.39); C118(1.42)  LDD1007  [4]
 LDCM0410  CL22 HEK-293T C680(3.61); C673(1.72); C1032(1.19); C118(1.02)  LDD1008  [4]
 LDCM0411  CL23 HEK-293T C680(1.16); C673(1.05); C1032(1.09); C118(1.41)  LDD1009  [4]
 LDCM0412  CL24 HEK-293T C680(1.28); C673(1.17); C1032(0.94); C118(1.57)  LDD1010  [4]
 LDCM0413  CL25 HEK-293T C680(8.55); C673(2.88); C1032(1.29); C118(1.49)  LDD1011  [4]
 LDCM0414  CL26 HEK-293T C680(1.65); C673(1.22); C1032(1.04); C118(1.04)  LDD1012  [4]
 LDCM0415  CL27 HEK-293T C680(4.35); C673(1.39); C1032(1.02); C118(1.38)  LDD1013  [4]
 LDCM0416  CL28 HEK-293T C680(4.70); C673(1.47); C1032(1.04); C118(1.54)  LDD1014  [4]
 LDCM0417  CL29 HEK-293T C680(4.45); C673(1.06); C1032(1.04); C118(1.21)  LDD1015  [4]
 LDCM0418  CL3 HEK-293T C680(1.66); C673(1.66); C1032(1.04); C147(1.44)  LDD1016  [4]
 LDCM0419  CL30 HEK-293T C680(3.55); C673(3.10); C1032(1.31); C118(1.11)  LDD1017  [4]
 LDCM0420  CL31 HEK-293T C680(2.95); C673(1.24); C1032(1.07); C118(1.14)  LDD1018  [4]
 LDCM0421  CL32 HEK-293T C680(3.49); C673(1.09); C1032(0.90); C118(1.04)  LDD1019  [4]
 LDCM0422  CL33 HEK-293T C680(3.34); C673(2.02); C1032(2.52); C118(1.28)  LDD1020  [4]
 LDCM0423  CL34 HEK-293T C680(3.39); C673(1.21); C1032(1.41); C118(0.96)  LDD1021  [4]
 LDCM0424  CL35 HEK-293T C680(3.06); C673(1.42); C1032(1.24); C118(1.08)  LDD1022  [4]
 LDCM0425  CL36 HEK-293T C680(4.14); C673(1.35); C1032(1.17); C118(1.03)  LDD1023  [4]
 LDCM0426  CL37 HEK-293T C680(3.51); C673(1.60); C1032(1.61); C118(0.84)  LDD1024  [4]
 LDCM0428  CL39 HEK-293T C680(4.03); C673(4.99); C1032(2.64); C118(1.03)  LDD1026  [4]
 LDCM0429  CL4 HEK-293T C680(2.57); C673(2.57); C1032(1.28); C147(1.07)  LDD1027  [4]
 LDCM0430  CL40 HEK-293T C680(1.14); C673(1.30); C1032(1.39); C118(0.86)  LDD1028  [4]
 LDCM0431  CL41 HEK-293T C680(2.64); C673(2.78); C1032(2.07); C118(1.03)  LDD1029  [4]
 LDCM0432  CL42 HEK-293T C680(3.23); C673(2.62); C1032(1.87); C118(0.91)  LDD1030  [4]
 LDCM0433  CL43 HEK-293T C680(1.79); C673(2.79); C1032(1.94); C118(0.93)  LDD1031  [4]
 LDCM0434  CL44 HEK-293T C680(2.88); C673(1.19); C1032(1.07); C118(1.05)  LDD1032  [4]
 LDCM0435  CL45 HEK-293T C680(4.54); C673(2.45); C1032(2.03); C118(1.07)  LDD1033  [4]
 LDCM0436  CL46 HEK-293T C680(2.83); C673(1.45); C1032(1.08); C118(0.96)  LDD1034  [4]
 LDCM0437  CL47 HEK-293T C680(2.03); C673(1.19); C1032(1.34); C118(1.24)  LDD1035  [4]
 LDCM0438  CL48 HEK-293T C680(1.75); C673(1.31); C1032(1.02); C118(1.14)  LDD1036  [4]
 LDCM0439  CL49 HEK-293T C680(2.33); C673(1.31); C1032(0.99); C118(1.14)  LDD1037  [4]
 LDCM0440  CL5 HEK-293T C680(1.27); C673(1.27); C1032(1.13); C147(1.16)  LDD1038  [4]
 LDCM0441  CL50 HEK-293T C680(3.11); C673(2.52); C1032(1.55); C118(0.95)  LDD1039  [4]
 LDCM0442  CL51 HEK-293T C680(3.18); C673(2.06); C1032(1.64); C118(1.01)  LDD1040  [4]
 LDCM0443  CL52 HEK-293T C680(2.49); C673(1.02); C1032(0.64); C118(0.96)  LDD1041  [4]
 LDCM0444  CL53 HEK-293T C680(2.81); C673(1.71); C1032(1.14); C118(1.21)  LDD1042  [4]
 LDCM0445  CL54 HEK-293T C680(3.40); C673(1.90); C1032(1.51); C118(1.02)  LDD1043  [4]
 LDCM0446  CL55 HEK-293T C680(1.35); C673(1.17); C1032(1.69); C118(1.39)  LDD1044  [4]
 LDCM0447  CL56 HEK-293T C680(1.56); C673(1.23); C1032(1.08); C118(1.33)  LDD1045  [4]
 LDCM0448  CL57 HEK-293T C680(2.96); C673(1.58); C1032(1.53); C118(1.10)  LDD1046  [4]
 LDCM0449  CL58 HEK-293T C680(2.07); C673(1.08); C1032(1.17); C118(0.94)  LDD1047  [4]
 LDCM0450  CL59 HEK-293T C680(1.99); C673(2.03); C1032(1.61); C118(0.96)  LDD1048  [4]
 LDCM0451  CL6 HEK-293T C680(6.05); C673(6.05); C1032(1.25); C147(1.20)  LDD1049  [4]
 LDCM0452  CL60 HEK-293T C680(3.29); C673(3.40); C1032(1.89); C118(0.79)  LDD1050  [4]
 LDCM0453  CL61 HEK-293T C680(0.98); C673(0.98); C1032(1.31); C118(1.01)  LDD1051  [4]
 LDCM0454  CL62 HEK-293T C680(1.67); C673(1.67); C1032(1.26); C118(0.94)  LDD1052  [4]
 LDCM0455  CL63 HEK-293T C680(1.37); C673(1.37); C1032(1.09); C118(1.13)  LDD1053  [4]
 LDCM0456  CL64 HEK-293T C680(6.30); C673(6.30); C1032(1.30); C118(1.53)  LDD1054  [4]
 LDCM0457  CL65 HEK-293T C680(1.11); C673(1.11); C1032(1.39); C118(0.90)  LDD1055  [4]
 LDCM0458  CL66 HEK-293T C680(2.29); C673(2.29); C1032(1.41); C118(1.12)  LDD1056  [4]
 LDCM0459  CL67 HEK-293T C680(1.24); C673(1.24); C1032(1.22); C118(0.87)  LDD1057  [4]
 LDCM0460  CL68 HEK-293T C680(1.92); C673(1.92); C1032(1.48); C118(0.76)  LDD1058  [4]
 LDCM0461  CL69 HEK-293T C680(1.80); C673(1.80); C1032(1.36); C118(0.94)  LDD1059  [4]
 LDCM0462  CL7 HEK-293T C680(0.98); C673(0.98); C1032(1.28); C147(1.42)  LDD1060  [4]
 LDCM0463  CL70 HEK-293T C680(1.06); C673(1.06); C1032(1.23); C118(1.00)  LDD1061  [4]
 LDCM0464  CL71 HEK-293T C680(3.91); C673(3.91); C1032(1.41); C118(0.98)  LDD1062  [4]
 LDCM0465  CL72 HEK-293T C680(1.10); C673(1.10); C1032(1.04); C118(0.91)  LDD1063  [4]
 LDCM0466  CL73 HEK-293T C680(4.26); C673(4.26); C1032(1.59); C118(0.97)  LDD1064  [4]
 LDCM0467  CL74 HEK-293T C680(2.39); C673(2.39); C1032(1.50); C118(1.02)  LDD1065  [4]
 LDCM0469  CL76 HEK-293T C680(1.24); C673(1.18); C1032(1.11); C118(0.86)  LDD1067  [4]
 LDCM0470  CL77 HEK-293T C680(7.49); C673(4.52); C1032(1.38); C118(1.16)  LDD1068  [4]
 LDCM0471  CL78 HEK-293T C680(1.08); C673(1.39); C1032(1.00); C118(0.79)  LDD1069  [4]
 LDCM0472  CL79 HEK-293T C680(1.35); C673(1.51); C1032(1.22); C118(1.00)  LDD1070  [4]
 LDCM0473  CL8 HEK-293T C680(1.02); C673(0.98); C1032(1.64); C147(1.10)  LDD1071  [4]
 LDCM0474  CL80 HEK-293T C680(1.06); C673(1.23); C1032(1.08); C118(0.91)  LDD1072  [4]
 LDCM0475  CL81 HEK-293T C680(1.22); C673(1.23); C1032(1.01); C118(1.08)  LDD1073  [4]
 LDCM0476  CL82 HEK-293T C680(1.00); C673(0.97); C1032(1.01); C118(1.30)  LDD1074  [4]
 LDCM0477  CL83 HEK-293T C680(1.27); C673(1.16); C1032(1.02); C118(0.97)  LDD1075  [4]
 LDCM0478  CL84 HEK-293T C680(2.75); C673(2.25); C1032(1.10); C118(0.82)  LDD1076  [4]
 LDCM0479  CL85 HEK-293T C680(1.34); C673(1.49); C1032(1.10); C118(0.90)  LDD1077  [4]
 LDCM0480  CL86 HEK-293T C680(1.85); C673(1.65); C1032(1.14); C118(0.89)  LDD1078  [4]
 LDCM0481  CL87 HEK-293T C680(2.69); C673(2.11); C1032(1.03); C118(0.79)  LDD1079  [4]
 LDCM0482  CL88 HEK-293T C680(2.06); C673(1.90); C1032(1.20); C118(0.93)  LDD1080  [4]
 LDCM0483  CL89 HEK-293T C680(1.22); C673(1.29); C1032(1.09); C118(0.85)  LDD1081  [4]
 LDCM0484  CL9 HEK-293T C680(0.96); C673(1.00); C1032(1.28); C147(1.04)  LDD1082  [4]
 LDCM0485  CL90 HEK-293T C680(10.90); C673(1.56); C1032(1.92); C118(1.11)  LDD1083  [4]
 LDCM0486  CL91 HEK-293T C680(1.51); C673(1.51); C1032(1.09); C124(0.96)  LDD1084  [4]
 LDCM0487  CL92 HEK-293T C680(2.26); C673(2.26); C1032(1.75); C124(0.96)  LDD1085  [4]
 LDCM0488  CL93 HEK-293T C680(2.14); C673(2.14); C1032(1.03); C124(0.98)  LDD1086  [4]
 LDCM0489  CL94 HEK-293T C680(1.81); C673(1.81); C1032(1.69); C124(1.59)  LDD1087  [4]
 LDCM0490  CL95 HEK-293T C680(12.10); C673(12.10); C1032(3.09); C124(1.68)  LDD1088  [4]
 LDCM0491  CL96 HEK-293T C680(2.89); C673(2.89); C1032(1.41); C124(1.04)  LDD1089  [4]
 LDCM0492  CL97 HEK-293T C680(4.74); C673(4.74); C1032(1.33); C124(1.01)  LDD1090  [4]
 LDCM0493  CL98 HEK-293T C680(2.25); C673(2.25); C1032(1.30); C124(1.03)  LDD1091  [4]
 LDCM0494  CL99 HEK-293T C680(1.78); C673(1.78); C1032(1.20); C124(1.04)  LDD1092  [4]
 LDCM0495  E2913 HEK-293T C454(0.94); C2808(0.85); C714(0.94); C2371(1.06)  LDD1698  [15]
 LDCM0468  Fragment33 HEK-293T C680(2.20); C673(2.20); C1032(1.65); C118(1.06)  LDD1066  [4]
 LDCM0427  Fragment51 HEK-293T C680(1.66); C673(1.17); C1032(1.26); C118(1.03)  LDD1025  [4]
 LDCM0022  KB02 HCT 116 C673(20.00); C680(20.00); C124(1.79); C118(2.91)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C673(17.47); C680(17.47); C124(20.00); C118(8.27)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C673(20.00); C680(20.00); C124(10.07); C118(2.72)  LDD0082  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C509(1.07)  LDD2127  [2]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C509(1.17)  LDD2146  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
GTPase HRas (HRAS) Ras family P01112
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Syndecan-2 (SDC2) Syndecan proteoglycan family P34741
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
14 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402