Details of the Target

General Information of Target

Target ID LDTP04119
Target Name Glycogenin-1 (GYG1)
Gene Name GYG1
Gene ID 2992
Synonyms
GYG; Glycogenin-1; GN-1; GN1; EC 2.4.1.186
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIM
VDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREEL
SAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIR
KHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNM
THPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAI
SHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ
Target Bioclass
Enzyme
Family
Glycosyltransferase 8 family, Glycogenin subfamily
Function
Glycogenin participates in the glycogen biosynthetic process along with glycogen synthase and glycogen branching enzyme. It self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase.
Uniprot ID
P46976
Ensemble ID
ENST00000296048.10
HGNC ID
HGNC:4699

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
IGROV1 SNV: p.V231F .
MFE319 SNV: p.E118G .
NUGC3 SNV: p.T53I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.87  LDD0402  [1]
Probe 1
 Probe Info  		Y332(18.70)  LDD3495  [2]
IA-alkyne
 Probe Info  		C89(0.37)  LDD2182  [3]
DBIA
 Probe Info  		C89(0.76)  LDD1109  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
AOyne
 Probe Info  		15.00  LDD0443  [6]
NAIA_5
 Probe Info  		N.A.  LDD2223  [7]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C087
 Probe Info  		9.99  LDD1779  [8]
C228
 Probe Info  		16.68  LDD1901  [8]
C280
 Probe Info  		10.13  LDD1950  [8]
C284
 Probe Info  		21.26  LDD1954  [8]
C343
 Probe Info  		11.63  LDD2005  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0230  AC113 PaTu 8988t C89(0.76)  LDD1109  [4]
 LDCM0231  AC114 PaTu 8988t C89(0.61)  LDD1110  [4]
 LDCM0232  AC115 PaTu 8988t C89(0.45)  LDD1111  [4]
 LDCM0233  AC116 PaTu 8988t C89(0.75)  LDD1112  [4]
 LDCM0234  AC117 PaTu 8988t C89(0.42)  LDD1113  [4]
 LDCM0235  AC118 PaTu 8988t C89(0.85)  LDD1114  [4]
 LDCM0236  AC119 PaTu 8988t C89(0.59)  LDD1115  [4]
 LDCM0238  AC120 PaTu 8988t C89(1.12)  LDD1117  [4]
 LDCM0239  AC121 PaTu 8988t C89(0.60)  LDD1118  [4]
 LDCM0240  AC122 PaTu 8988t C89(1.41)  LDD1119  [4]
 LDCM0241  AC123 PaTu 8988t C89(1.64)  LDD1120  [4]
 LDCM0242  AC124 PaTu 8988t C89(1.50)  LDD1121  [4]
 LDCM0243  AC125 PaTu 8988t C89(1.46)  LDD1122  [4]
 LDCM0244  AC126 PaTu 8988t C89(1.10)  LDD1123  [4]
 LDCM0245  AC127 PaTu 8988t C89(1.11)  LDD1124  [4]
 LDCM0246  AC128 PaTu 8988t C89(0.36)  LDD1125  [4]
 LDCM0247  AC129 PaTu 8988t C89(0.51)  LDD1126  [4]
 LDCM0249  AC130 PaTu 8988t C89(0.50)  LDD1128  [4]
 LDCM0250  AC131 PaTu 8988t C89(1.00)  LDD1129  [4]
 LDCM0251  AC132 PaTu 8988t C89(0.88)  LDD1130  [4]
 LDCM0252  AC133 PaTu 8988t C89(0.76)  LDD1131  [4]
 LDCM0253  AC134 PaTu 8988t C89(0.61)  LDD1132  [4]
 LDCM0254  AC135 PaTu 8988t C89(0.49)  LDD1133  [4]
 LDCM0255  AC136 PaTu 8988t C89(0.33)  LDD1134  [4]
 LDCM0256  AC137 PaTu 8988t C89(0.50)  LDD1135  [4]
 LDCM0257  AC138 PaTu 8988t C89(0.44)  LDD1136  [4]
 LDCM0258  AC139 PaTu 8988t C89(0.42)  LDD1137  [4]
 LDCM0260  AC140 PaTu 8988t C89(0.50)  LDD1139  [4]
 LDCM0261  AC141 PaTu 8988t C89(0.69)  LDD1140  [4]
 LDCM0262  AC142 PaTu 8988t C89(0.57)  LDD1141  [4]
 LDCM0263  AC143 PaTu 8988t C89(0.91)  LDD1142  [4]
 LDCM0264  AC144 PaTu 8988t C89(0.65)  LDD1143  [4]
 LDCM0265  AC145 PaTu 8988t C89(1.00)  LDD1144  [4]
 LDCM0266  AC146 PaTu 8988t C89(0.57)  LDD1145  [4]
 LDCM0267  AC147 PaTu 8988t C89(0.82)  LDD1146  [4]
 LDCM0268  AC148 PaTu 8988t C89(0.76)  LDD1147  [4]
 LDCM0269  AC149 PaTu 8988t C89(0.45)  LDD1148  [4]
 LDCM0271  AC150 PaTu 8988t C89(0.75)  LDD1150  [4]
 LDCM0272  AC151 PaTu 8988t C89(0.93)  LDD1151  [4]
 LDCM0273  AC152 PaTu 8988t C89(0.41)  LDD1152  [4]
 LDCM0274  AC153 PaTu 8988t C89(0.99)  LDD1153  [4]
 LDCM0621  AC154 PaTu 8988t C89(0.61)  LDD2166  [4]
 LDCM0622  AC155 PaTu 8988t C89(0.73)  LDD2167  [4]
 LDCM0623  AC156 PaTu 8988t C89(0.47)  LDD2168  [4]
 LDCM0624  AC157 PaTu 8988t C89(0.70)  LDD2169  [4]
 LDCM0156  Aniline NCI-H1299 11.52  LDD0403  [1]
 LDCM0367  CL1 PaTu 8988t C89(0.63)  LDD1246  [4]
 LDCM0368  CL10 PaTu 8988t C89(0.49)  LDD1247  [4]
 LDCM0379  CL11 PaTu 8988t C89(0.62)  LDD1258  [4]
 LDCM0390  CL12 PaTu 8988t C89(0.88)  LDD1269  [4]
 LDCM0400  CL13 PaTu 8988t C89(0.78)  LDD1279  [4]
 LDCM0401  CL14 PaTu 8988t C89(1.43)  LDD1280  [4]
 LDCM0402  CL15 PaTu 8988t C89(0.68)  LDD1281  [4]
 LDCM0407  CL2 PaTu 8988t C89(0.90)  LDD1286  [4]
 LDCM0418  CL3 PaTu 8988t C89(0.43)  LDD1297  [4]
 LDCM0429  CL4 PaTu 8988t C89(0.84)  LDD1308  [4]
 LDCM0440  CL5 PaTu 8988t C89(0.73)  LDD1319  [4]
 LDCM0451  CL6 PaTu 8988t C89(0.87)  LDD1330  [4]
 LDCM0462  CL7 PaTu 8988t C89(0.77)  LDD1341  [4]
 LDCM0473  CL8 PaTu 8988t C89(0.42)  LDD1352  [4]
 LDCM0484  CL9 PaTu 8988t C89(1.00)  LDD1363  [4]
 LDCM0625  F8 Ramos C89(0.68)  LDD2187  [3]
 LDCM0572  Fragment10 Ramos C89(0.67)  LDD2189  [3]
 LDCM0573  Fragment11 Ramos C89(0.54)  LDD2190  [3]
 LDCM0574  Fragment12 Ramos C89(0.60)  LDD2191  [3]
 LDCM0575  Fragment13 Ramos C89(1.51)  LDD2192  [3]
 LDCM0576  Fragment14 Ramos C89(0.57)  LDD2193  [3]
 LDCM0579  Fragment20 Ramos C89(0.56)  LDD2194  [3]
 LDCM0580  Fragment21 Ramos C89(0.83)  LDD2195  [3]
 LDCM0582  Fragment23 Ramos C89(0.68)  LDD2196  [3]
 LDCM0578  Fragment27 Ramos C89(2.05)  LDD2197  [3]
 LDCM0586  Fragment28 Ramos C89(0.95)  LDD2198  [3]
 LDCM0588  Fragment30 Ramos C89(1.14)  LDD2199  [3]
 LDCM0589  Fragment31 Ramos C89(1.25)  LDD2200  [3]
 LDCM0590  Fragment32 Ramos C89(0.57)  LDD2201  [3]
 LDCM0468  Fragment33 Ramos C89(0.94)  LDD2202  [3]
 LDCM0596  Fragment38 Ramos C89(2.63)  LDD2203  [3]
 LDCM0566  Fragment4 Ramos C89(0.47)  LDD2184  [3]
 LDCM0610  Fragment52 Ramos C89(2.93)  LDD2204  [3]
 LDCM0614  Fragment56 Ramos C89(1.50)  LDD2205  [3]
 LDCM0569  Fragment7 Ramos C89(0.45)  LDD2186  [3]
 LDCM0571  Fragment9 Ramos C89(0.55)  LDD2188  [3]
 LDCM0022  KB02 Ramos C89(0.37)  LDD2182  [3]
 LDCM0023  KB03 Ramos C89(0.61)  LDD2183  [3]
 LDCM0024  KB05 Ramos C89(0.30)  LDD2185  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glycogen [starch] synthase, muscle (GYS1) Glycosyltransferase 3 family P13807

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Uridine Diphosphate Glucose Small molecular drug DB01861
Uridine-5'-diphosphate Small molecular drug DB03435

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587