Details of the Target

General Information of Target

Target ID LDTP11001
Target Name Histone H2B type 1-L (H2BC13)
Gene Name H2BC13
Gene ID 8340
Synonyms
H2BFC; HIST1H2BL; Histone H2B type 1-L; Histone H2B.c; H2B/c
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MPEPVKSAPVPKKGSKKAINKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAM
GIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVT
KYTSSK
Target Bioclass
Other
Family
Histone H2B family
Subcellular location
Nucleus
Function
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Uniprot ID
Q99880
Ensemble ID
ENST00000377401.4
HGNC ID
HGNC:4748

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y122(20.00); Y84(16.42); Y41(6.07)  LDD0257  [1]
TH216
 Probe Info  		Y84(20.00); Y122(16.93)  LDD0259  [1]
STPyne
 Probe Info  		K6(7.19)  LDD0277  [2]
ONAyne
 Probe Info  		N.A.  LDD0273  [2]
HHS-482
 Probe Info  		Y84(1.47)  LDD0285  [3]
HHS-475
 Probe Info  		Y84(1.13)  LDD0264  [4]
HHS-465
 Probe Info  		Y84(2.95)  LDD2237  [5]
Acrolein
 Probe Info  		N.A.  LDD0223  [6]
CY-1
 Probe Info  		E114(0.00); E106(0.00); H110(0.00); K117(0.00)  LDD0246  [7]
NHS
 Probe Info  		K58(0.00); K47(0.00); K117(0.00); K6(0.00)  LDD0010  [8]
W1
 Probe Info  		E114(0.00); Y84(0.00); H50(0.00); H110(0.00)  LDD0236  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0116  HHS-0101 DM93 Y84(1.13)  LDD0264  [4]
 LDCM0117  HHS-0201 DM93 Y84(1.00)  LDD0265  [4]
 LDCM0118  HHS-0301 DM93 Y84(1.27)  LDD0266  [4]
 LDCM0119  HHS-0401 DM93 Y84(1.26)  LDD0267  [4]
 LDCM0120  HHS-0701 DM93 Y84(1.74)  LDD0268  [4]
 LDCM0123  JWB131 DM93 Y84(1.47)  LDD0285  [3]
 LDCM0124  JWB142 DM93 Y84(1.16)  LDD0286  [3]
 LDCM0125  JWB146 DM93 Y84(2.41)  LDD0287  [3]
 LDCM0126  JWB150 DM93 Y84(6.21)  LDD0288  [3]
 LDCM0127  JWB152 DM93 Y84(2.74)  LDD0289  [3]
 LDCM0128  JWB198 DM93 Y84(3.99)  LDD0290  [3]
 LDCM0129  JWB202 DM93 Y84(1.54)  LDD0291  [3]
 LDCM0130  JWB211 DM93 Y84(2.02)  LDD0292  [3]
 LDCM0109  NEM HeLa N.A.  LDD0223  [6]
 LDCM0110  W12 Hep-G2 H110(0.50); R87(0.59); N85(0.59); Q48(1.05)  LDD0237  [9]
 LDCM0111  W14 Hep-G2 H83(0.96); H50(1.14)  LDD0238  [9]
 LDCM0112  W16 Hep-G2 E106(0.86); K47(0.94); D52(0.97); Q48(0.97)  LDD0239  [9]
 LDCM0113  W17 Hep-G2 N85(0.55); S57(1.35); H50(1.38); Q48(1.41)  LDD0240  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-2 complex subunit mu (AP2M1) Adaptor complexes medium subunit family Q96CW1
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone H2A-Bbd type 2/3 (H2AB2; H2AB3) Histone H2A family P0C5Z0

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
5 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.