Details of the Target

General Information of Target

Target ID LDTP14615
Target Name Thymosin beta-15B (TMSB15B)
Gene Name TMSB15B
Gene ID 11013
Synonyms
Thymosin beta-15B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSDKPDLSEVEKFDRSKLKKTNTEEKNTLPSKETIQQEKECVQTS
Target Bioclass
Other
Family
Thymosin beta family
Subcellular location
Cytoplasm, cytoskeleton
Function Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. May be involved in cell migration.
Uniprot ID
P0CG35
Ensemble ID
ENST00000419165.5
HGNC ID
HGNC:28612

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
W1
 Probe Info  		E33(2.18)  LDD0237  [1]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0110  W12 Hep-G2 E33(2.18)  LDD0237  [1]

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004