Details of the Target

General Information of Target

Target ID LDTP02178
Target Name Fatty acid-binding protein, liver (FABP1)
Gene Name FABP1
Gene ID 2168
Synonyms
FABPL; Fatty acid-binding protein, liver; Fatty acid-binding protein 1; Liver-type fatty acid-binding protein; L-FABP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSFSGKYQLQSQENFEAFMKAIGLPEELIQKGKDIKGVSEIVQNGKHFKFTITAGSKVIQ
NEFTVGEECELETMTGEKVKTVVQLEGDNKLVTTFKNIKSVTELNGDIITNTMTLGDIVF
KRISKRI
Target Type
Successful
Target Bioclass
Other
Family
Calycin superfamily, Fatty-acid binding protein (FABP) family
Subcellular location
Cytoplasm
Function
Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes. Binds cholesterol. Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.
TTD ID
T73712
Uniprot ID
P07148
DrugMap ID
TTIV96N
Ensemble ID
ENST00000295834.8
HGNC ID
HGNC:3555
ChEMBL ID
CHEMBL5421

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]
W1
 Probe Info  		K31(5.11); Q30(5.14)  LDD0237  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0110  W12 Hep-G2 K31(5.11); Q30(5.14)  LDD0237  [2]
 LDCM0111  W14 Hep-G2 K31(4.87); K33(7.35)  LDD0238  [2]
 LDCM0112  W16 Hep-G2 K33(0.79); K31(0.79); Q30(0.79); N97(1.07)  LDD0239  [2]
 LDCM0113  W17 Hep-G2 Q30(6.53)  LDD0240  [2]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cholic Acid Small molecular drug DB02659
Fenofibric Acid Small molecular drug D0NF1U
Oleic Acid Small molecular drug DB04224
Investigative
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
1-anilinonaphthalene-8-sulfonic Acid Small molecular drug D0C7RS
Oleic Acid Small molecular drug D0A4EA
S-methylcysteine Small molecular drug DB02216
Withdrawn from market
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Indoprofen Small molecular drug D0Q5PL

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.