Details of the Target

General Information of Target

Target ID LDTP14645
Target Name Zinc finger protein 43 (ZNF43)
Gene Name ZNF43
Gene ID 7594
Synonyms
KOX27; ZNF39; ZNF39L1; Zinc finger protein 43; Zinc finger protein 39; Zinc finger protein HTF6; Zinc finger protein KOX27
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALPQGLLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLDISSKCMMKTFFS
TGQGNTEAFHTGTLQRQASHHIGDFCFQKIEKDIHGFQFQWKEDETNDHAAPMTEIKELT
GSTGQHDQRHAGNKHIKDQLGLSFHSHLPELHIFQPEGKIGNQVEKSINNASSVSTSQRI
CCRPKTHISNKYGNNSLHSSLLTQKRNVHMREKSFQCIESGKSFNCSSLLKKHQITHLEE
KQCKCDVYGKVFNQKRYLACHRRSHIDEKPYKCNECGKIFGHNTSLFLHKALHTADKPYE
CEECDKVFSRKSHLETHKIIYTGGKPYKCKVCDKAFTCNSYLAKHTIIHTGEKPYKCNEC
GKVFNRLSTLARHRRLHTGEKPYECEECEKVFSRKSHLERHKRIHTGEKPYKCKVCDKAF
AYNSYLAKHSIIHTGEKPYKCNECGKVFNQQSTLARHHRLHTAEKPYKCEECDKVFRCKS
HLERHRRIHTGEKPYKCKVCDKAFRSDSCLTEHQRVHTGEKPYMCNECGKVFSTKANLAC
HHKLHTAEKPYKCEECEKVFSRKSHMERHRRIHTGEKPYKCKVCDKAFRRDSHLAQHQRV
HTGEKPYKCNECGKTFRQTSSLIIHRRLHTGEKPYKCNECGKTFSQMSSLVYHHRLHSGE
KPYKCNECGKVFNQQAHLAQHQRVHTGEKPYKCNECGKTFSQMSNLVYHHRLHSGEKP
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
P17038
Ensemble ID
ENST00000354959.9
HGNC ID
HGNC:13109

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
BT549 SNV: p.K219N .
CCLP1 SNV: p.F6C .
HCT15 SNV: p.I23T .
HG3 SNV: p.T583S .
HGC27 SNV: p.I587S .
HS936T SNV: p.C260G .
HT115 SNV: p.G544D .
HUH7 SNV: p.N807D .
IGR1 SNV: p.H588Y .
Ishikawa (Heraklio) 02 ER SNV: p.H752Y .
LN18 SNV: p.K306E .
LS513 SNV: p.E479Ter .
MCC13 SNV: p.K331E .
MFE280 SNV: p.N39Y .
MFE319 SNV: p.C107R; p.K710R .
NCIH2172 SNV: p.E234D .
ONS76 SNV: p.H549R; p.K765E .
SAOS2 SNV: p.Y454H .
SHP77 SNV: p.K782N .
SW1116 SNV: p.S691L .
WM793 SNV: p.W325L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C736(18.38)  LDD1703  [1]
W1
 Probe Info  		H364(22.52)  LDD0237  [2]
HHS-465
 Probe Info  		K452(0.00); K455(0.00); Y454(0.00)  LDD2240  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 T cell C736(18.38)  LDD1703  [1]
 LDCM0110  W12 Hep-G2 H364(22.52)  LDD0237  [2]

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010