Details of the Target

General Information of Target

Target ID LDTP13544
Target Name Chromatin-remodeling ATPase INO80 (INO80)
Gene Name INO80
Gene ID 54617
Synonyms
INO80A; INOC1; KIAA1259; Chromatin-remodeling ATPase INO80; hINO80; EC 3.6.4.-; DNA helicase-related INO80 complex homolog 1; DNA helicase-related protein INO80; INO80 complex subunit A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKVHMHTKFCLICLLTFIFHHCNHCHEEHDHGPEALHRQHRGMTELEPSKFSKQAAENEK
KYYIEKLFERYGENGRLSFFGLEKLLTNLGLGERKVVEINHEDLGHDHVSHLDILAVQEG
KHFHSHNHQHSHNHLNSENQTVTSVSTKRNHKCDPEKETVEVSVKSDDKHMHDHNHRLRH
HHRLHHHLDHNNTHHFHNDSITPSERGEPSNEPSTETNKTQEQSDVKLPKGKRKKKGRKS
NENSEVITPGFPPNHDQGEQYEHNRVHKPDRVHNPGHSHVHLPERNGHDPGRGHQDLDPD
NEGELRHTRKREAPHVKNNAIISLRKDLNEDDHHHECLNVTQLLKYYGHGANSPISTDLF
TYLCPALLYQIDSRLCIEHFDKLLVEDINKDKNLVPEDEANIGASAWICGIISITVISLL
SLLGVILVPIINQGCFKFLLTFLVALAVGTMSGDALLHLLPHSQGGHDHSHQHAHGHGHS
HGHESNKFLEEYDAVLKGLVALGGIYLLFIIEHCIRMFKHYKQQRGKQKWFMKQNTEEST
IGRKLSDHKLNNTPDSDWLQLKPLAGTDDSVVSEDRLNETELTDLEGQQESPPKNYLCIE
EEKIIDHSHSDGLHTIHEHDLHAAAHNHHGENKTVLRKHNHQWHHKHSHHSHGPCHSGSD
LKETGIANIAWMVIMGDGIHNFSDGLAIGAAFSAGLTGGISTSIAVFCHELPHELGDFAV
LLKAGMTVKQAIVYNLLSAMMAYIGMLIGTAVGQYANNITLWIFAVTAGMFLYVALVDML
PEMLHGDGDNEEHGFCPVGQFILQNLGLLFGFAIMLVIALYEDKIVFDIQF
Target Bioclass
Enzyme
Family
SNF2/RAD54 helicase family
Subcellular location
Cytoplasm
Function
ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair. Binds DNA. As part of the INO80 complex, remodels chromatin by shifting nucleosomes. Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator. Involved in UV-damage excision DNA repair. The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Involved in DNA replication. Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle.
Uniprot ID
Q9ULG1
Ensemble ID
ENST00000648947.1
HGNC ID
HGNC:26956

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C887(6.23)  LDD0209  [1]
Acrolein
 Probe Info  		N.A.  LDD0222  [2]
W1
 Probe Info  		C673(14.73)  LDD0237  [3]
N1
 Probe Info  		N.A.  LDD0245  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [5]
NAIA_4
 Probe Info  		C13(0.00); C108(0.00); C1026(0.00)  LDD2226  [6]
NAIA_5
 Probe Info  		C108(0.00); C1049(0.00)  LDD2224  [6]
IPM
 Probe Info  		C108(0.00); C13(0.00)  LDD0147  [7]
TFBX
 Probe Info  		C1026(0.00); C13(0.00); C977(0.00); C887(0.00)  LDD0148  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C1001(0.96); C1011(0.96); C1026(1.23); C673(1.21)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C1001(1.32); C1011(1.32); C673(1.02); C887(0.82)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C1001(0.76); C1011(0.76); C1026(0.66); C673(1.00)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C1001(0.49); C1011(0.49); C1026(0.75); C673(1.03)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C1001(0.46); C1011(0.46); C1026(0.75); C673(0.87)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C1001(1.52); C1011(1.52); C1026(0.82); C673(0.98)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C1001(1.02); C1011(1.02); C1026(0.89); C673(0.94)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C1001(0.73); C1011(0.73); C1026(0.77); C673(0.97)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C1001(0.85); C1011(0.85); C1026(0.90); C673(1.01)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C1001(0.82); C1011(0.76); C1026(0.83); C673(1.12)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C1001(0.79); C1011(0.63); C1026(0.78); C673(1.10)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C1001(0.71); C1011(0.66); C1026(0.76); C673(0.90)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C1001(1.37); C1011(1.37); C673(1.06); C887(0.81)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C1001(0.84); C1011(0.68); C1026(0.93); C673(0.97)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C1001(0.88); C1011(0.59); C1026(0.77); C673(0.90)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C1001(0.63); C1011(0.70); C1026(0.75); C673(1.01)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C1026(0.90); C673(1.07); C887(1.09)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C1026(0.93); C673(1.13); C887(1.14)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C1026(0.99); C673(1.03); C887(1.01)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C1026(0.88); C673(1.14); C887(1.15)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C1026(0.98); C673(1.03); C887(1.00)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C1026(0.90); C673(1.05); C887(1.02)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C1026(0.89); C673(1.08); C887(1.80)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C1001(0.95); C1011(0.95); C673(0.98); C887(0.98)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C1026(0.85); C673(1.29); C887(1.77)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C1026(0.70); C673(1.11); C887(1.45)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C1026(0.86); C673(1.10); C887(1.70)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C1026(0.96); C673(0.98); C887(1.03)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C1026(1.06); C673(1.08); C887(1.46)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C1026(1.00); C673(1.07); C887(1.95)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C1026(0.97); C673(1.21); C887(1.20)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C1026(0.88); C673(1.13); C887(1.26)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C673(1.52); C887(1.85)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C673(1.65); C887(1.39)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C673(1.51); C887(1.16)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C673(1.36); C887(1.33)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C673(1.50); C887(0.99)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C673(1.43); C887(1.08)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C673(1.29); C887(1.21)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C673(1.40); C887(1.09)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C673(1.42); C887(0.93)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C673(1.35); C887(1.10)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C673(1.41); C887(1.10)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C673(1.45); C887(0.99)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C1001(1.07); C1011(1.07); C673(1.05); C887(1.24)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C673(1.61); C887(0.99)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C673(1.60); C887(0.95)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C673(1.41); C887(1.17)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C1026(1.14); C673(1.00); C887(0.87)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C1026(0.66); C887(0.88); C673(1.09)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C887(0.83); C1026(0.86); C673(1.04)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C1026(0.50); C673(1.07); C887(1.10)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C887(0.89); C1026(1.03); C673(1.14)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C1026(0.57); C887(0.94); C673(1.42)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C1026(0.56); C887(1.01); C673(1.18)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C673(1.00); C1001(1.14); C1011(1.14); C887(1.25)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C1026(0.68); C887(0.97); C673(1.11)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C1026(0.71); C887(0.80); C673(1.09)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C1026(0.67); C887(1.06); C673(1.21)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C1026(0.42); C887(1.27); C673(1.55)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C1026(0.64); C673(1.09); C887(0.88)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C1026(0.49); C673(1.11); C887(0.83)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C1026(0.53); C673(1.05); C887(1.16)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C1026(0.47); C673(1.01); C887(1.03)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C887(1.14); C673(1.19)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C673(0.96); C887(1.28)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C673(0.98); C887(1.32)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C1001(0.96); C1011(0.96); C673(1.06); C1026(1.07)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C887(1.18); C673(1.25)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C887(0.95); C673(1.29)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C887(1.01); C673(1.32)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C673(1.00); C887(1.18)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C887(1.14); C673(1.23)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C887(0.93); C673(1.21)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C887(0.66); C673(1.12)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C887(0.76); C673(1.02)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C887(0.74); C673(1.15)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C887(0.62); C673(1.10)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C1001(0.75); C1011(0.75); C1026(1.14); C673(1.20)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C887(0.59); C673(1.10)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C887(0.64); C673(1.22)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C887(0.53); C673(1.29)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C887(0.82); C673(1.12)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C887(0.84); C673(1.13)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C673(0.92); C887(1.37)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C673(0.88); C887(0.96)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C673(1.06); C887(1.45)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C887(1.01); C673(1.02)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C673(1.02); C887(1.02)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C1001(0.93); C1011(0.93); C673(1.20); C1026(1.29)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C673(1.03); C887(1.09)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C887(0.96); C673(0.97)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C673(1.05); C887(1.13)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C887(1.09); C673(1.09)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C673(1.07); C887(1.08)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C673(1.11); C887(1.30)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C1026(1.13); C673(1.19); C887(1.64)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C1026(1.16); C673(1.25); C887(1.45)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C673(1.16); C1026(1.35); C887(1.52)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C673(1.36); C887(1.38); C1026(1.39)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C1001(0.82); C1011(0.82); C673(1.24); C1026(1.28)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C1026(1.10); C673(1.20); C887(1.67)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C673(1.02); C1026(1.05); C887(1.43)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C1026(0.93); C887(0.96); C673(1.37)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C1026(1.00); C673(1.18); C887(1.60)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C673(1.21); C1026(1.22); C887(1.28)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C1026(1.16); C673(1.26); C887(1.31)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C887(1.48); C1026(1.55); C673(1.66)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C887(0.89); C673(1.18)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C887(0.90); C673(1.04)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C887(0.69); C673(1.16)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C887(0.93); C673(0.98); C1001(1.48); C1011(1.48)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C887(0.78); C673(1.21)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C887(0.64); C673(1.01)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C887(0.76); C673(1.35)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C887(0.71); C673(1.14)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C887(0.79); C673(1.43)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C887(0.79); C673(1.28)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C887(0.80); C673(1.28)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C887(0.75); C673(1.43)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C887(0.99); C673(1.13)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C887(0.95); C673(1.20)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C887(0.96); C673(1.01); C1001(1.05); C1011(1.05)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C887(0.78); C673(1.28)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C887(0.88); C673(1.40)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C887(0.93); C673(1.20)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C887(1.20); C673(1.45)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C887(1.26); C673(1.51)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C887(1.04); C673(1.65)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C887(0.95); C673(1.24)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C887(0.82); C673(1.23)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C887(1.01); C673(1.16)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C887(0.85); C673(1.30)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C673(1.03); C887(1.03); C1001(1.09); C1011(1.09)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C887(0.99); C673(1.23)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C887(0.99); C673(1.17)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C887(1.20); C673(1.73)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C887(0.44); C673(1.15)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C887(0.54); C673(1.34)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C887(0.48); C673(1.23)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C887(0.46); C673(1.06)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C887(0.51); C673(1.08)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C887(0.47); C673(1.16)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C887(0.50); C673(1.17)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C887(0.44); C673(1.13)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C887(0.54); C673(1.17)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C887(0.49); C673(1.31)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C887(0.51); C673(1.10)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C887(0.84); C673(1.40)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C887(0.43); C673(1.10)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C887(0.77); C673(1.31)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C887(0.41); C673(1.12)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C887(0.77); C1001(0.80); C1011(0.80); C1026(0.86)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C887(0.76); C1026(0.80); C1001(0.82); C1011(0.82)  LDD0683  [8]
 LDCM0248  AKOS034007472 HCT 116 C1001(0.93); C1011(0.93); C673(1.00); C887(1.02)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C887(0.90); C673(0.97); C1001(1.07); C1011(1.07)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C887(1.08); C673(1.14); C1001(1.68); C1011(1.68)  LDD0592  [8]
 LDCM0020  ARS-1620 HCC44 C1026(1.09); C13(1.04); C887(1.03)  LDD2171  [8]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0632  CL-Sc Hep-G2 C108(20.00)  LDD2227  [6]
 LDCM0367  CL1 HCT 116 C673(0.88); C1001(0.92); C1011(0.92); C887(0.98)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C887(0.81); C673(1.13); C1001(1.32); C1011(1.32)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C1001(1.00); C1011(1.00); C673(1.07); C1026(1.36)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C887(1.01); C673(1.02); C1001(1.48); C1011(1.48)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C673(0.91); C887(0.95); C1001(1.04); C1011(1.04)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C887(0.88); C673(0.88); C1001(0.97); C1011(0.97)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C673(0.92); C887(0.99); C1001(1.04); C1011(1.04)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C887(1.07); C673(1.11)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C673(1.28); C887(1.55)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C673(1.01); C887(1.21)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C887(1.18); C673(1.63)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C887(0.99); C673(1.04)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C887(0.88); C673(1.29); C1001(2.04); C1011(2.04)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C673(1.03); C887(1.13)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C673(1.12); C887(1.13)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C887(0.74); C673(1.10)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C887(0.66); C673(1.12)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C887(0.69); C673(1.12)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C887(0.59); C673(1.11)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C887(0.86); C673(1.13)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C887(1.22); C673(1.24)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C887(0.87); C673(0.96)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C673(1.00); C887(1.13)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C887(0.88); C673(1.19); C1001(2.09); C1011(2.09)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C673(0.99); C887(1.23)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C887(0.69); C1026(0.74); C673(0.81)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C887(1.05); C673(1.11); C1026(1.12)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C1026(1.01); C673(1.15); C887(1.35)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C1026(1.12); C887(1.24); C673(1.28)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C887(0.85); C673(1.07)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C887(0.62); C673(0.90)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C887(0.77); C673(1.06)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C887(0.87); C673(1.11)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C887(0.95); C673(1.10); C1001(1.42); C1011(1.42)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C887(0.95); C673(0.96); C1001(1.36); C1011(1.36)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C887(0.99); C673(1.05); C1001(1.65); C1011(1.65)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C673(0.88); C1001(0.91); C1011(0.91); C887(0.95)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C1001(0.78); C1011(0.78); C1026(0.79); C673(0.93)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C673(0.87); C1001(1.05); C1011(1.05); C1026(1.06)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C673(0.88); C1026(1.03); C1001(1.05); C1011(1.05)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C887(0.93); C1001(0.98); C1011(0.98); C673(0.99)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C1026(0.95); C673(0.96); C1001(0.96); C1011(0.96)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C1026(0.69); C1001(0.97); C1011(0.97); C887(1.05)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C673(1.29); C1001(1.33); C1011(1.33); C887(1.48)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C1026(0.82); C673(0.96); C887(1.17); C1001(1.54)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C1001(0.85); C1011(0.85); C887(1.02); C1026(1.02)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C1001(1.20); C1011(1.20); C1026(0.78); C673(0.98)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C1001(0.88); C1011(0.88); C1026(0.98); C673(0.91)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C1001(1.38); C1011(1.38); C1026(1.06); C673(1.03)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C1001(0.97); C1011(0.97); C1026(0.84); C673(0.97)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C1001(1.13); C1011(1.13); C1026(1.07); C673(0.98)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C1001(0.90); C1011(0.90); C673(0.98); C887(0.96)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C1001(1.07); C1011(1.07); C1026(1.09); C673(0.99)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C1001(1.15); C1011(1.15); C1026(0.74); C673(0.98)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C1001(0.89); C1011(0.89); C1026(1.07); C673(0.89)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C1001(1.20); C1011(1.20); C1026(0.82); C673(0.80)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C1001(2.28); C1011(2.28); C1026(0.89); C673(1.07)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C1001(1.33); C1011(1.33); C1026(0.85); C673(0.88)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C1001(1.46); C1011(1.46); C1026(0.86); C673(0.83)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C1001(1.99); C1011(1.99); C1026(1.01); C673(1.12)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C1001(2.46); C1011(2.46); C1026(0.75); C673(0.87)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C1001(1.04); C1011(1.04); C673(1.03); C887(0.85)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C1001(1.30); C1011(1.30); C1026(0.66); C673(0.91)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C1001(1.38); C1011(1.38); C1026(0.98); C673(0.79)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C1001(1.46); C1011(1.46); C1026(0.76); C673(0.82)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C1001(2.26); C1011(2.26); C1026(0.94); C673(0.96)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C1001(1.87); C1011(1.87); C1026(0.92); C673(1.18)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C1001(1.38); C1011(1.38); C1026(0.86); C673(1.09)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C1026(0.66); C673(0.91); C887(0.81)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C1026(0.94); C673(0.85); C887(0.98)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C1026(1.24); C673(0.85); C887(1.04)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C1026(0.85); C673(1.05); C887(0.75)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C1001(1.31); C1011(1.31); C673(1.10); C887(1.03)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C1026(0.92); C673(0.99); C887(0.80)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C1026(1.11); C673(0.93); C887(0.90)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C1026(1.16); C673(0.82); C887(0.77)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C1026(0.92); C673(0.75); C887(1.06)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C1026(0.81); C673(0.97); C887(0.95)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C1026(0.86); C673(0.87); C887(0.88)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C1026(1.00); C673(0.91); C887(1.09)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C1026(1.00); C673(0.87); C887(0.93)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C1026(0.90); C673(0.85); C887(1.01)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C1026(1.07); C673(1.04); C887(1.07)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C1001(1.70); C1011(1.70); C673(1.03); C887(0.98)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C1026(1.05); C673(1.00); C887(0.86)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C1001(0.89); C1011(0.89); C673(1.05); C887(1.01)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C1001(0.98); C1011(0.98); C673(1.05); C887(0.86)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C1001(0.97); C1011(0.97); C673(1.08); C887(0.85)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C1001(1.17); C1011(1.17); C673(1.12); C887(1.02)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C1001(0.88); C1011(0.88); C673(1.20); C887(1.01)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C1001(1.02); C1011(1.02); C673(1.27); C887(0.80)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C1001(1.02); C1011(1.02); C673(1.07); C887(1.13)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C1001(1.04); C1011(1.04); C673(1.09); C887(0.89)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C1001(0.93); C1011(0.93); C673(1.00); C887(0.89)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C1001(1.47); C1011(1.47); C673(1.20); C887(1.16)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C1001(0.96); C1011(0.96); C673(1.10); C887(0.85)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C1001(0.91); C1011(0.91); C673(1.02); C887(0.85)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C1001(0.81); C1011(0.81); C673(1.00); C887(0.87)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C1001(1.85); C1011(1.85); C673(0.95); C887(1.04)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C1001(1.26); C1011(1.26); C673(0.95); C887(1.02)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C1026(0.99); C887(1.97)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C1026(0.89); C887(1.12)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C1026(0.77); C887(0.83)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C1026(0.86); C887(1.06)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C1001(1.74); C1011(1.74); C673(1.02); C887(0.84)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C1026(1.27); C887(2.07)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C1026(0.83); C887(1.22)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C1026(1.06); C887(1.14)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C1026(0.86); C887(1.50)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C1026(1.10); C887(1.23)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C1026(0.87); C887(1.09)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C1026(0.86); C887(1.15)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C1026(0.85); C887(0.92)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C1026(1.02); C887(1.05)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C1026(1.34); C887(1.25)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C1001(1.42); C1011(1.42); C673(0.92); C887(0.82)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C1026(0.72); C887(0.98)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C1001(0.78); C1011(0.78); C1026(0.97); C673(1.08)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C1001(0.72); C1011(0.72); C1026(1.08); C673(1.04)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C1001(0.86); C1011(0.86); C1026(0.96); C673(0.95)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C1001(0.99); C1011(0.99); C1026(1.40); C673(1.05)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C1001(0.98); C1011(0.98); C1026(1.35); C673(1.01)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C1001(1.07); C1011(1.07); C1026(1.06); C673(1.03)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C1001(1.27); C1011(1.27); C1026(1.14); C673(1.10)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C1001(0.90); C1011(0.90); C1026(1.06); C673(1.10)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C1001(0.93); C1011(0.93); C1026(1.28); C673(1.20)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C13(1.11); C887(1.04); C816(1.05); C1049(1.16)  LDD1698  [9]
 LDCM0576  Fragment14 Ramos C13(1.05)  LDD2193  [10]
 LDCM0468  Fragment33 HCT 116 C1001(0.94); C1011(0.94); C673(1.07); C887(0.94)  LDD0785  [8]
 LDCM0566  Fragment4 Ramos C13(0.65)  LDD2184  [10]
 LDCM0427  Fragment51 HCT 116 C1001(1.31); C1011(1.31); C1026(0.52); C673(1.15)  LDD0744  [8]
 LDCM0569  Fragment7 Ramos C13(0.76)  LDD2186  [10]
 LDCM0022  KB02 HEK-293T C1026(1.04); C887(0.89); C1001(1.00)  LDD1492  [9]
 LDCM0023  KB03 Jurkat C887(6.23)  LDD0209  [1]
 LDCM0024  KB05 COLO792 C314(3.30); C816(2.32)  LDD3310  [11]
 LDCM0021  THZ1 HCT 116 C1026(1.09); C13(1.04); C887(1.03)  LDD2173  [8]
 LDCM0110  W12 Hep-G2 C673(14.73)  LDD0237  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcriptional repressor protein YY1 (YY1) YY transcription factor family P25490
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Actin-related protein 5 (ACTR5) Actin family Q9H9F9
DNA damage-binding protein 1 (DDB1) DDB1 family Q16531
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) . Q9H8W4

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840