Details of the Target

General Information of Target

Target ID LDTP04798
Target Name Coronin-7 (CORO7)
Gene Name CORO7
Gene ID 79585
Synonyms
Coronin-7; Crn7; 70 kDa WD repeat tumor rejection antigen homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNRFRVSKFRHTEARPPRRESWISDIRAGTAPSCRNHIKSSCSLIAFNSDRPGVLGIVPL
QGQGEDKRRVAHLGCHSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALPSAPGV
VLGPEDLPVEVLQFHPTSDGILVSAAGTTVKVWDAAKQQPLTELAAHGDLVQSAVWSRDG
ALVGTACKDKQLRIFDPRTKPRASQSTQAHENSRDSRLAWMGTWEHLVSTGFNQMREREV
KLWDTRFFSSALASLTLDTSLGCLVPLLDPDSGLLVLAGKGERQLYCYEVVPQQPALSPV
TQCVLESVLRGAALVPRQALAVMSCEVLRVLQLSDTAIVPIGYHVPRKAVEFHEDLFPDT
AGCVPATDPHSWWAGDNQQVQKVSLNPACRPHPSFTSCLVPPAEPLPDTAQPAVMETPVG
DADASEGFSSPPSSLTSPSTPSSLGPSLSSTSGIGTSPSLRSLQSLLGPSSKFRHAQGTV
LHRDSHITNLKGLNLTTPGESDGFCANKLRVAVPLLSSGGQVAVLELRKPGRLPDTALPT
LQNGAAVTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSL
RFHPLAANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGR
VRVYRPRSGPEPLQEGPGPKGGRGARIVWVCDGRCLLVSGFDSQSERQLLLYEAEALAGG
PLAVLGLDVAPSTLLPSYDPDTGLVLLTGKGDTRVFLYELLPESPFFLECNSFTSPDPHK
GLVLLPKTECDVREVELMRCLRLRQSSLEPVAFRLPRVRKEFFQDDVFPDTAVIWEPVLS
AEAWLQGANGQPWLLSLQPPDMSPVSQAPREAPARRAPSSAQYLEEKSDQQKKEELLNAM
VAKLGNREDPLPQDSFEGVDEDEWD
Target Bioclass
Other
Family
WD repeat coronin family
Subcellular location
Golgi apparatus membrane
Function
F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.
Uniprot ID
P57737
Ensemble ID
ENST00000251166.9
HGNC ID
HGNC:26161

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAMA1 SNV: p.Q477Ter DBIA    Probe Info 
COLO800 SNV: p.R804G DBIA    Probe Info 
HCT116 Deletion: p.V120WfsTer24 .
JURKAT Deletion: p.H779TfsTer19 Compound 10    Probe Info 
JURLMK1 SNV: p.G743S DBIA    Probe Info 
K562 SNV: p.D484N .
MDAMB453 SNV: p.S229F DBIA    Probe Info 
MEWO SNV: p.P554S DBIA    Probe Info 
MFE296 SNV: p.D90E DBIA    Probe Info 
NCIH1155 SNV: p.L252M DBIA    Probe Info 
NCIH358 SNV: p.E306Ter DBIA    Probe Info 
NUGC3 SNV: p.E921G DBIA    Probe Info 
OVK18 SNV: p.H482P DBIA    Probe Info 
SKMEL28 SNV: p.W22C DBIA    Probe Info 
TE4 SNV: p.E796Ter DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		9.72  LDD0402  [1]
BTD
 Probe Info  		C389(0.53)  LDD2091  [2]
DBIA
 Probe Info  		C34(235.67)  LDD0209  [3]
HHS-475
 Probe Info  		Y883(1.40)  LDD0264  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C34(0.00); C363(0.00); C695(0.00); C187(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		C187(0.00); C691(0.00); C505(0.00)  LDD0032  [6]
IPIAA_L
 Probe Info  		C770(0.00); C656(0.00)  LDD0031  [7]
Lodoacetamide azide
 Probe Info  		C187(0.00); C505(0.00); C691(0.00); C363(0.00)  LDD0037  [5]
NAIA_4
 Probe Info  		C75(0.00); C505(0.00); C656(0.00)  LDD2226  [8]
WYneN
 Probe Info  		N.A.  LDD0021  [9]
Compound 10
 Probe Info  		C187(0.00); C34(0.00); C42(0.00); C505(0.00)  LDD2216  [10]
Compound 11
 Probe Info  		C42(0.00); C505(0.00)  LDD2213  [10]
ENE
 Probe Info  		N.A.  LDD0006  [9]
IPM
 Probe Info  		N.A.  LDD0005  [9]
PF-06672131
 Probe Info  		N.A.  LDD0152  [11]
VSF
 Probe Info  		C187(0.00); C505(0.00)  LDD0007  [9]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [12]
W1
 Probe Info  		C505(0.00); C34(0.00); C389(0.00)  LDD0236  [13]
AOyne
 Probe Info  		8.60  LDD0443  [14]
NAIA_5
 Probe Info  		C187(0.00); C505(0.00); C656(0.00); C325(0.00)  LDD2223  [8]
HHS-465
 Probe Info  		N.A.  LDD2240  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C389(0.72); C34(0.89); C325(1.11)  LDD2117  [2]
 LDCM0025  4SU-RNA HEK-293T C34(2.60); C770(3.56)  LDD0371  [16]
 LDCM0214  AC1 HEK-293T C389(1.06); C691(0.88); C505(1.07); C42(1.17)  LDD1507  [17]
 LDCM0215  AC10 HEK-293T C389(0.91); C187(1.10); C691(1.02); C505(1.01)  LDD1508  [17]
 LDCM0226  AC11 HEK-293T C389(1.01); C187(1.05); C691(1.01); C505(1.02)  LDD1509  [17]
 LDCM0237  AC12 HEK-293T C389(0.94); C187(0.94); C691(0.99); C505(1.10)  LDD1510  [17]
 LDCM0259  AC14 HEK-293T C389(1.03); C691(1.01); C505(1.01); C42(0.92)  LDD1512  [17]
 LDCM0270  AC15 HEK-293T C389(0.92); C691(1.05); C505(1.07); C42(0.98)  LDD1513  [17]
 LDCM0276  AC17 HEK-293T C389(0.97); C691(1.02); C505(1.01); C42(1.11)  LDD1515  [17]
 LDCM0277  AC18 HEK-293T C389(0.95); C187(0.99); C691(0.94); C505(1.04)  LDD1516  [17]
 LDCM0278  AC19 HEK-293T C389(0.99); C187(1.11); C691(1.09); C505(1.01)  LDD1517  [17]
 LDCM0279  AC2 HEK-293T C389(0.94); C187(1.11); C691(1.04); C505(1.07)  LDD1518  [17]
 LDCM0280  AC20 HEK-293T C389(0.99); C187(1.01); C691(1.03); C505(0.97)  LDD1519  [17]
 LDCM0281  AC21 HEK-293T C389(0.92); C691(1.02); C505(0.98); C42(0.96)  LDD1520  [17]
 LDCM0282  AC22 HEK-293T C389(1.16); C691(1.00); C505(1.00); C42(1.00)  LDD1521  [17]
 LDCM0283  AC23 HEK-293T C389(1.00); C691(1.07); C505(1.04); C42(0.99)  LDD1522  [17]
 LDCM0284  AC24 HEK-293T C389(1.01); C691(1.00); C505(0.89); C42(0.89)  LDD1523  [17]
 LDCM0285  AC25 HEK-293T C389(1.00); C691(0.98); C505(1.01); C42(1.18)  LDD1524  [17]
 LDCM0286  AC26 HEK-293T C389(0.99); C187(1.10); C691(0.95); C505(1.03)  LDD1525  [17]
 LDCM0287  AC27 HEK-293T C389(0.97); C187(1.12); C691(0.95); C505(1.08)  LDD1526  [17]
 LDCM0288  AC28 HEK-293T C389(1.02); C187(0.99); C691(0.93); C505(0.98)  LDD1527  [17]
 LDCM0289  AC29 HEK-293T C389(0.93); C691(1.00); C505(0.98); C42(1.02)  LDD1528  [17]
 LDCM0290  AC3 HEK-293T C389(0.92); C187(0.95); C691(0.99); C505(1.08)  LDD1529  [17]
 LDCM0291  AC30 HEK-293T C389(1.08); C691(0.94); C505(1.08); C42(1.04)  LDD1530  [17]
 LDCM0292  AC31 HEK-293T C389(1.02); C691(1.03); C505(1.03); C42(0.92)  LDD1531  [17]
 LDCM0293  AC32 HEK-293T C389(1.00); C691(1.14); C505(0.92); C42(0.97)  LDD1532  [17]
 LDCM0294  AC33 HEK-293T C389(0.97); C691(0.92); C505(1.06); C42(1.09)  LDD1533  [17]
 LDCM0295  AC34 HEK-293T C389(0.96); C187(0.96); C691(1.06); C505(1.10)  LDD1534  [17]
 LDCM0296  AC35 HEK-293T C389(1.01); C187(1.10); C691(0.99); C505(1.04)  LDD1535  [17]
 LDCM0297  AC36 HEK-293T C389(0.99); C187(0.94); C691(0.95); C505(1.08)  LDD1536  [17]
 LDCM0298  AC37 HEK-293T C389(1.02); C691(1.05); C505(1.02); C42(0.97)  LDD1537  [17]
 LDCM0299  AC38 HEK-293T C389(1.07); C691(0.99); C505(1.01); C42(1.18)  LDD1538  [17]
 LDCM0300  AC39 HEK-293T C389(1.07); C691(1.11); C505(1.09); C42(0.93)  LDD1539  [17]
 LDCM0301  AC4 HEK-293T C389(1.00); C187(0.94); C691(0.93); C505(0.98)  LDD1540  [17]
 LDCM0302  AC40 HEK-293T C389(1.02); C691(1.09); C505(0.99); C42(0.97)  LDD1541  [17]
 LDCM0303  AC41 HEK-293T C389(1.01); C691(1.01); C505(1.04); C42(1.06)  LDD1542  [17]
 LDCM0304  AC42 HEK-293T C389(0.92); C187(1.07); C691(0.96); C505(1.17)  LDD1543  [17]
 LDCM0305  AC43 HEK-293T C389(0.98); C187(1.11); C691(1.04); C505(1.03)  LDD1544  [17]
 LDCM0306  AC44 HEK-293T C389(0.97); C187(0.91); C691(1.02); C505(1.01)  LDD1545  [17]
 LDCM0307  AC45 HEK-293T C389(0.90); C691(0.97); C505(1.09); C42(1.05)  LDD1546  [17]
 LDCM0308  AC46 HEK-293T C389(1.12); C691(1.02); C505(1.08); C42(1.00)  LDD1547  [17]
 LDCM0309  AC47 HEK-293T C389(0.97); C691(1.09); C505(1.13); C42(0.96)  LDD1548  [17]
 LDCM0310  AC48 HEK-293T C389(1.04); C691(1.02); C505(0.91); C42(0.98)  LDD1549  [17]
 LDCM0311  AC49 HEK-293T C389(0.94); C691(0.87); C505(1.03); C42(1.18)  LDD1550  [17]
 LDCM0312  AC5 HEK-293T C389(0.95); C691(0.98); C505(1.09); C42(1.09)  LDD1551  [17]
 LDCM0313  AC50 HEK-293T C389(1.00); C187(1.04); C691(0.95); C505(1.10)  LDD1552  [17]
 LDCM0314  AC51 HEK-293T C389(0.97); C187(1.04); C691(1.07); C505(1.04)  LDD1553  [17]
 LDCM0315  AC52 HEK-293T C389(0.99); C187(0.94); C691(0.93); C505(1.02)  LDD1554  [17]
 LDCM0316  AC53 HEK-293T C389(0.98); C691(1.05); C505(1.05); C42(0.99)  LDD1555  [17]
 LDCM0317  AC54 HEK-293T C389(1.05); C691(1.14); C505(1.12); C42(1.00)  LDD1556  [17]
 LDCM0318  AC55 HEK-293T C389(0.96); C691(1.01); C505(1.01); C42(0.91)  LDD1557  [17]
 LDCM0319  AC56 HEK-293T C389(1.03); C691(1.00); C505(0.99); C42(0.88)  LDD1558  [17]
 LDCM0320  AC57 HEK-293T C389(0.93); C691(1.01); C505(1.08); C42(1.07)  LDD1559  [17]
 LDCM0321  AC58 HEK-293T C389(0.90); C187(1.05); C691(0.99); C505(1.12)  LDD1560  [17]
 LDCM0322  AC59 HEK-293T C389(1.00); C187(1.09); C691(1.00); C505(1.08)  LDD1561  [17]
 LDCM0323  AC6 HEK-293T C389(1.04); C691(1.06); C505(1.02); C42(1.04)  LDD1562  [17]
 LDCM0324  AC60 HEK-293T C389(0.97); C187(0.89); C691(0.97); C505(1.06)  LDD1563  [17]
 LDCM0325  AC61 HEK-293T C389(0.91); C691(1.02); C505(1.00); C42(0.99)  LDD1564  [17]
 LDCM0326  AC62 HEK-293T C389(1.03); C691(1.01); C505(1.06); C42(1.01)  LDD1565  [17]
 LDCM0327  AC63 HEK-293T C389(0.98); C691(1.02); C505(1.03); C42(1.04)  LDD1566  [17]
 LDCM0328  AC64 HEK-293T C389(1.00); C691(1.07); C505(0.96); C42(1.00)  LDD1567  [17]
 LDCM0334  AC7 HEK-293T C389(1.01); C691(1.10); C505(1.10); C42(1.05)  LDD1568  [17]
 LDCM0345  AC8 HEK-293T C389(1.00); C691(1.14); C505(0.95); C42(1.14)  LDD1569  [17]
 LDCM0248  AKOS034007472 HEK-293T C389(1.00); C691(1.08); C505(1.04); C42(1.00)  LDD1511  [17]
 LDCM0356  AKOS034007680 HEK-293T C389(0.97); C691(0.98); C505(1.05); C42(1.05)  LDD1570  [17]
 LDCM0275  AKOS034007705 HEK-293T C389(0.97); C691(1.02); C505(0.91); C42(0.84)  LDD1514  [17]
 LDCM0498  BS-3668 MDA-MB-231 C389(0.53)  LDD2091  [2]
 LDCM0632  CL-Sc Hep-G2 C187(20.00)  LDD2227  [8]
 LDCM0367  CL1 HEK-293T C389(0.91); C187(1.06); C691(1.01); C505(1.10)  LDD1571  [17]
 LDCM0368  CL10 HEK-293T C389(1.27); C691(1.18); C505(1.25); C42(0.93)  LDD1572  [17]
 LDCM0369  CL100 HEK-293T C389(0.96); C187(1.02); C691(1.00); C505(1.01)  LDD1573  [17]
 LDCM0370  CL101 HEK-293T C389(0.98); C187(1.00); C691(0.93); C505(1.05)  LDD1574  [17]
 LDCM0371  CL102 HEK-293T C389(0.34); C691(1.08); C505(1.09); C42(1.06)  LDD1575  [17]
 LDCM0372  CL103 HEK-293T C389(1.01); C691(0.95); C505(0.99); C770(1.03)  LDD1576  [17]
 LDCM0373  CL104 HEK-293T C389(0.94); C187(0.98); C691(0.97); C505(1.00)  LDD1577  [17]
 LDCM0374  CL105 HEK-293T C389(1.07); C187(1.07); C691(1.00); C505(0.99)  LDD1578  [17]
 LDCM0375  CL106 HEK-293T C389(1.02); C691(1.02); C505(0.99); C42(1.07)  LDD1579  [17]
 LDCM0376  CL107 HEK-293T C389(0.94); C691(0.95); C505(0.98); C770(1.07)  LDD1580  [17]
 LDCM0377  CL108 HEK-293T C389(1.02); C187(1.10); C691(1.02); C505(1.05)  LDD1581  [17]
 LDCM0378  CL109 HEK-293T C389(0.96); C187(0.98); C691(1.00); C505(1.05)  LDD1582  [17]
 LDCM0379  CL11 HEK-293T C389(1.27); C691(1.12); C505(1.18); C42(0.92)  LDD1583  [17]
 LDCM0380  CL110 HEK-293T C389(0.96); C691(1.05); C505(1.05); C42(1.05)  LDD1584  [17]
 LDCM0381  CL111 HEK-293T C389(0.92); C691(0.93); C505(1.02); C770(1.13)  LDD1585  [17]
 LDCM0382  CL112 HEK-293T C389(0.89); C187(0.94); C691(0.96); C505(1.00)  LDD1586  [17]
 LDCM0383  CL113 HEK-293T C389(0.96); C187(0.90); C691(1.00); C505(1.05)  LDD1587  [17]
 LDCM0384  CL114 HEK-293T C389(0.94); C691(1.06); C505(1.02); C42(1.04)  LDD1588  [17]
 LDCM0385  CL115 HEK-293T C389(0.99); C691(0.94); C505(0.92); C770(1.11)  LDD1589  [17]
 LDCM0386  CL116 HEK-293T C389(0.96); C187(0.90); C691(1.01); C505(1.11)  LDD1590  [17]
 LDCM0387  CL117 HEK-293T C389(0.98); C187(0.95); C691(0.94); C505(1.06)  LDD1591  [17]
 LDCM0388  CL118 HEK-293T C389(1.02); C691(0.98); C505(1.12); C42(0.94)  LDD1592  [17]
 LDCM0389  CL119 HEK-293T C389(0.98); C691(0.94); C505(0.93); C770(1.07)  LDD1593  [17]
 LDCM0390  CL12 HEK-293T C389(1.26); C691(1.01); C505(0.93); C42(1.07)  LDD1594  [17]
 LDCM0391  CL120 HEK-293T C389(0.96); C187(0.93); C691(0.98); C505(0.94)  LDD1595  [17]
 LDCM0392  CL121 HEK-293T C389(0.98); C187(1.01); C691(0.95); C505(1.06)  LDD1596  [17]
 LDCM0393  CL122 HEK-293T C389(0.93); C691(0.93); C505(1.00); C42(0.96)  LDD1597  [17]
 LDCM0394  CL123 HEK-293T C389(0.96); C691(1.00); C505(0.94); C770(1.10)  LDD1598  [17]
 LDCM0395  CL124 HEK-293T C389(1.00); C187(0.96); C691(0.92); C505(1.00)  LDD1599  [17]
 LDCM0396  CL125 HEK-293T C389(0.97); C187(0.91); C691(1.02); C505(1.13)  LDD1600  [17]
 LDCM0397  CL126 HEK-293T C389(0.97); C691(0.95); C505(1.03); C42(1.18)  LDD1601  [17]
 LDCM0398  CL127 HEK-293T C389(1.02); C691(1.02); C505(1.01); C770(0.95)  LDD1602  [17]
 LDCM0399  CL128 HEK-293T C389(0.99); C187(0.87); C691(1.02); C505(0.95)  LDD1603  [17]
 LDCM0400  CL13 HEK-293T C389(0.91); C187(1.01); C691(0.90); C505(1.13)  LDD1604  [17]
 LDCM0401  CL14 HEK-293T C389(0.88); C691(0.96); C505(1.11); C42(1.10)  LDD1605  [17]
 LDCM0402  CL15 HEK-293T C389(0.87); C691(0.96); C505(1.06); C770(1.07)  LDD1606  [17]
 LDCM0403  CL16 HEK-293T C389(1.03); C187(1.03); C691(1.04); C505(0.92)  LDD1607  [17]
 LDCM0404  CL17 HEK-293T C389(0.85); C691(0.95); C505(1.06); C42(1.07)  LDD1608  [17]
 LDCM0405  CL18 HEK-293T C389(0.94); C187(1.15); C691(0.97); C505(1.09)  LDD1609  [17]
 LDCM0406  CL19 HEK-293T C389(0.96); C187(1.07); C691(1.00); C505(1.11)  LDD1610  [17]
 LDCM0407  CL2 HEK-293T C389(0.89); C691(0.97); C505(1.08); C42(0.94)  LDD1611  [17]
 LDCM0408  CL20 HEK-293T C389(1.22); C187(0.89); C691(1.04); C505(1.02)  LDD1612  [17]
 LDCM0409  CL21 HEK-293T C389(1.13); C691(0.96); C505(1.07); C42(1.13)  LDD1613  [17]
 LDCM0410  CL22 HEK-293T C389(1.61); C691(1.16); C505(1.07); C42(0.84)  LDD1614  [17]
 LDCM0411  CL23 HEK-293T C389(1.51); C691(1.10); C505(1.04); C42(0.90)  LDD1615  [17]
 LDCM0412  CL24 HEK-293T C389(1.27); C691(1.07); C505(1.12); C42(0.97)  LDD1616  [17]
 LDCM0413  CL25 HEK-293T C389(1.06); C187(0.80); C691(0.92); C505(1.11)  LDD1617  [17]
 LDCM0414  CL26 HEK-293T C389(0.98); C691(0.97); C505(1.09); C42(1.03)  LDD1618  [17]
 LDCM0415  CL27 HEK-293T C389(0.95); C691(0.91); C505(0.95); C770(1.03)  LDD1619  [17]
 LDCM0416  CL28 HEK-293T C389(0.97); C187(0.98); C691(0.92); C505(1.09)  LDD1620  [17]
 LDCM0417  CL29 HEK-293T C389(1.05); C691(0.91); C505(1.01); C42(0.98)  LDD1621  [17]
 LDCM0418  CL3 HEK-293T C389(0.92); C691(0.99); C505(1.04); C770(1.11)  LDD1622  [17]
 LDCM0419  CL30 HEK-293T C389(1.01); C187(1.02); C691(1.01); C505(0.99)  LDD1623  [17]
 LDCM0420  CL31 HEK-293T C389(1.11); C187(1.07); C691(0.98); C505(1.06)  LDD1624  [17]
 LDCM0421  CL32 HEK-293T C389(1.09); C187(1.12); C691(1.02); C505(1.09)  LDD1625  [17]
 LDCM0422  CL33 HEK-293T C389(1.15); C691(1.09); C505(1.21); C42(0.93)  LDD1626  [17]
 LDCM0423  CL34 HEK-293T C389(1.23); C691(1.09); C505(1.07); C42(0.85)  LDD1627  [17]
 LDCM0424  CL35 HEK-293T C389(1.40); C691(1.15); C505(1.15); C42(0.86)  LDD1628  [17]
 LDCM0425  CL36 HEK-293T C389(1.14); C691(1.06); C505(1.09); C42(0.95)  LDD1629  [17]
 LDCM0426  CL37 HEK-293T C389(1.00); C187(0.96); C691(0.91); C505(0.97)  LDD1630  [17]
 LDCM0428  CL39 HEK-293T C389(0.93); C691(0.97); C505(1.05); C770(1.04)  LDD1632  [17]
 LDCM0429  CL4 HEK-293T C389(1.01); C187(1.00); C691(1.04); C505(0.99)  LDD1633  [17]
 LDCM0430  CL40 HEK-293T C389(1.00); C187(0.95); C691(0.99); C505(1.06)  LDD1634  [17]
 LDCM0431  CL41 HEK-293T C389(1.02); C691(0.93); C505(1.05); C42(0.98)  LDD1635  [17]
 LDCM0432  CL42 HEK-293T C389(0.98); C187(1.09); C691(1.00); C505(1.02)  LDD1636  [17]
 LDCM0433  CL43 HEK-293T C389(1.14); C187(1.12); C691(1.02); C505(1.02)  LDD1637  [17]
 LDCM0434  CL44 HEK-293T C389(1.08); C187(1.09); C691(1.00); C505(1.03)  LDD1638  [17]
 LDCM0435  CL45 HEK-293T C389(1.13); C691(1.03); C505(1.16); C42(0.86)  LDD1639  [17]
 LDCM0436  CL46 HEK-293T C389(1.27); C691(1.03); C505(1.08); C42(0.94)  LDD1640  [17]
 LDCM0437  CL47 HEK-293T C389(1.36); C691(1.13); C505(1.14); C42(0.87)  LDD1641  [17]
 LDCM0438  CL48 HEK-293T C389(1.19); C691(1.03); C505(1.10); C42(1.14)  LDD1642  [17]
 LDCM0439  CL49 HEK-293T C389(0.90); C187(0.93); C691(0.93); C505(1.10)  LDD1643  [17]
 LDCM0440  CL5 HEK-293T C389(0.93); C691(0.89); C505(0.99); C42(0.95)  LDD1644  [17]
 LDCM0441  CL50 HEK-293T C389(0.98); C691(1.04); C505(1.12); C42(1.10)  LDD1645  [17]
 LDCM0443  CL52 HEK-293T C389(1.05); C187(1.04); C691(0.94); C505(1.08)  LDD1646  [17]
 LDCM0444  CL53 HEK-293T C389(0.90); C691(0.92); C505(1.01); C42(1.11)  LDD1647  [17]
 LDCM0445  CL54 HEK-293T C389(0.88); C187(1.07); C691(1.01); C505(1.19)  LDD1648  [17]
 LDCM0446  CL55 HEK-293T C389(1.06); C187(1.08); C691(0.97); C505(1.03)  LDD1649  [17]
 LDCM0447  CL56 HEK-293T C389(1.12); C187(1.09); C691(1.08); C505(1.08)  LDD1650  [17]
 LDCM0448  CL57 HEK-293T C389(1.08); C691(0.99); C505(1.20); C42(1.04)  LDD1651  [17]
 LDCM0449  CL58 HEK-293T C389(1.37); C691(1.17); C505(1.20); C42(0.85)  LDD1652  [17]
 LDCM0450  CL59 HEK-293T C389(1.28); C691(1.09); C505(1.08); C42(0.91)  LDD1653  [17]
 LDCM0451  CL6 HEK-293T C389(0.96); C187(1.11); C691(1.02); C505(1.22)  LDD1654  [17]
 LDCM0452  CL60 HEK-293T C389(1.30); C691(1.04); C505(0.98); C42(0.91)  LDD1655  [17]
 LDCM0453  CL61 HEK-293T C389(0.95); C187(0.77); C691(0.95); C505(0.97)  LDD1656  [17]
 LDCM0454  CL62 HEK-293T C389(0.93); C691(0.98); C505(1.06); C42(0.96)  LDD1657  [17]
 LDCM0455  CL63 HEK-293T C389(0.96); C691(0.98); C505(1.05); C770(1.04)  LDD1658  [17]
 LDCM0456  CL64 HEK-293T C389(0.93); C187(0.95); C691(1.02); C505(1.05)  LDD1659  [17]
 LDCM0457  CL65 HEK-293T C389(1.05); C691(0.99); C505(1.06); C42(1.05)  LDD1660  [17]
 LDCM0458  CL66 HEK-293T C389(0.94); C187(1.07); C691(1.02); C505(1.06)  LDD1661  [17]
 LDCM0459  CL67 HEK-293T C389(1.02); C187(1.08); C691(1.04); C505(0.97)  LDD1662  [17]
 LDCM0460  CL68 HEK-293T C389(1.08); C187(1.04); C691(1.03); C505(1.06)  LDD1663  [17]
 LDCM0461  CL69 HEK-293T C389(1.03); C691(0.98); C505(1.18); C42(0.92)  LDD1664  [17]
 LDCM0462  CL7 HEK-293T C389(0.98); C187(1.00); C691(0.92); C505(1.06)  LDD1665  [17]
 LDCM0463  CL70 HEK-293T C389(1.32); C691(1.23); C505(1.15); C42(0.91)  LDD1666  [17]
 LDCM0464  CL71 HEK-293T C389(1.19); C691(1.05); C505(1.12); C42(0.84)  LDD1667  [17]
 LDCM0465  CL72 HEK-293T C389(1.14); C691(1.04); C505(0.96); C42(0.88)  LDD1668  [17]
 LDCM0466  CL73 HEK-293T C389(0.88); C187(0.83); C691(0.98); C505(1.06)  LDD1669  [17]
 LDCM0467  CL74 HEK-293T C389(0.90); C691(1.04); C505(1.01); C42(1.00)  LDD1670  [17]
 LDCM0469  CL76 HEK-293T C389(0.93); C187(0.91); C691(0.95); C505(0.97)  LDD1672  [17]
 LDCM0470  CL77 HEK-293T C389(0.86); C691(1.01); C505(1.16); C42(1.11)  LDD1673  [17]
 LDCM0471  CL78 HEK-293T C389(0.99); C187(1.05); C691(1.06); C505(1.07)  LDD1674  [17]
 LDCM0472  CL79 HEK-293T C389(1.02); C187(1.09); C691(1.02); C505(1.06)  LDD1675  [17]
 LDCM0473  CL8 HEK-293T C389(0.82); C187(0.91); C691(1.28); C505(1.26)  LDD1676  [17]
 LDCM0474  CL80 HEK-293T C389(1.09); C187(1.01); C691(0.99); C505(0.95)  LDD1677  [17]
 LDCM0475  CL81 HEK-293T C389(1.05); C691(0.97); C505(1.09); C42(0.90)  LDD1678  [17]
 LDCM0476  CL82 HEK-293T C389(1.35); C691(1.03); C505(1.03); C42(1.02)  LDD1679  [17]
 LDCM0477  CL83 HEK-293T C389(1.27); C691(1.13); C505(1.20); C42(0.89)  LDD1680  [17]
 LDCM0478  CL84 HEK-293T C389(1.09); C691(1.04); C505(1.08); C42(0.92)  LDD1681  [17]
 LDCM0479  CL85 HEK-293T C389(0.91); C187(0.83); C691(0.94); C505(1.09)  LDD1682  [17]
 LDCM0480  CL86 HEK-293T C389(0.92); C691(0.94); C505(1.06); C42(1.06)  LDD1683  [17]
 LDCM0481  CL87 HEK-293T C389(0.91); C691(1.01); C505(0.90); C770(1.00)  LDD1684  [17]
 LDCM0482  CL88 HEK-293T C389(0.95); C187(1.01); C691(1.01); C505(1.10)  LDD1685  [17]
 LDCM0483  CL89 HEK-293T C389(1.09); C691(0.95); C505(1.01); C42(1.04)  LDD1686  [17]
 LDCM0484  CL9 HEK-293T C389(1.08); C691(0.95); C505(1.07); C42(0.86)  LDD1687  [17]
 LDCM0485  CL90 HEK-293T C389(0.73); C187(1.40); C691(1.00); C505(1.26)  LDD1688  [17]
 LDCM0486  CL91 HEK-293T C389(1.06); C187(1.12); C691(0.99); C505(1.10)  LDD1689  [17]
 LDCM0487  CL92 HEK-293T C389(0.91); C187(0.86); C691(0.96); C505(0.98)  LDD1690  [17]
 LDCM0488  CL93 HEK-293T C389(0.93); C691(1.00); C505(1.15); C42(0.93)  LDD1691  [17]
 LDCM0489  CL94 HEK-293T C389(1.16); C691(1.06); C505(1.20); C42(0.87)  LDD1692  [17]
 LDCM0490  CL95 HEK-293T C389(0.98); C691(1.10); C505(1.34); C42(1.07)  LDD1693  [17]
 LDCM0491  CL96 HEK-293T C389(0.97); C691(1.11); C505(1.13); C42(1.08)  LDD1694  [17]
 LDCM0492  CL97 HEK-293T C389(0.94); C187(0.94); C691(0.98); C505(1.07)  LDD1695  [17]
 LDCM0493  CL98 HEK-293T C389(0.96); C691(0.98); C505(1.02); C42(1.14)  LDD1696  [17]
 LDCM0494  CL99 HEK-293T C389(0.97); C691(0.90); C505(0.97); C770(0.97)  LDD1697  [17]
 LDCM0495  E2913 HEK-293T C389(0.95); C691(0.97); C505(0.98); C770(0.92)  LDD1698  [17]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C34(0.98); C389(0.83)  LDD1702  [2]
 LDCM0625  F8 Ramos C34(1.49); C505(1.25)  LDD2187  [18]
 LDCM0572  Fragment10 Ramos C34(2.31); C505(0.67)  LDD2189  [18]
 LDCM0573  Fragment11 Ramos C34(0.27); C505(3.17)  LDD2190  [18]
 LDCM0574  Fragment12 Ramos C34(0.91); C505(0.84)  LDD2191  [18]
 LDCM0575  Fragment13 Ramos C34(0.99)  LDD2192  [18]
 LDCM0576  Fragment14 Ramos C34(0.80); C505(1.54)  LDD2193  [18]
 LDCM0579  Fragment20 Ramos C34(1.00); C505(0.69)  LDD2194  [18]
 LDCM0580  Fragment21 Ramos C34(1.01); C505(1.19)  LDD2195  [18]
 LDCM0582  Fragment23 Ramos C34(0.88); C505(0.40)  LDD2196  [18]
 LDCM0578  Fragment27 Ramos C34(1.04); C505(0.95)  LDD2197  [18]
 LDCM0586  Fragment28 Ramos C34(0.81); C505(1.08)  LDD2198  [18]
 LDCM0588  Fragment30 Ramos C34(1.39); C505(1.06)  LDD2199  [18]
 LDCM0589  Fragment31 Ramos C34(0.85)  LDD2200  [18]
 LDCM0590  Fragment32 Ramos C34(9.01); C505(0.79)  LDD2201  [18]
 LDCM0468  Fragment33 HEK-293T C389(1.03); C691(1.05); C505(1.04); C770(1.06)  LDD1671  [17]
 LDCM0596  Fragment38 Ramos C34(0.86); C505(0.56)  LDD2203  [18]
 LDCM0566  Fragment4 Ramos C34(0.91); C505(0.66)  LDD2184  [18]
 LDCM0427  Fragment51 HEK-293T C389(0.97); C691(0.91); C505(0.98); C42(1.01)  LDD1631  [17]
 LDCM0610  Fragment52 Ramos C34(1.61)  LDD2204  [18]
 LDCM0614  Fragment56 Ramos C34(1.55); C505(1.28)  LDD2205  [18]
 LDCM0569  Fragment7 Ramos C34(0.89); C505(0.91)  LDD2186  [18]
 LDCM0571  Fragment9 Ramos C34(1.96); C505(0.67)  LDD2188  [18]
 LDCM0116  HHS-0101 DM93 Y883(1.40)  LDD0264  [4]
 LDCM0117  HHS-0201 DM93 Y883(1.83)  LDD0265  [4]
 LDCM0118  HHS-0301 DM93 Y883(1.24)  LDD0266  [4]
 LDCM0119  HHS-0401 DM93 Y883(0.81)  LDD0267  [4]
 LDCM0120  HHS-0701 DM93 Y883(1.29)  LDD0268  [4]
 LDCM0022  KB02 HEK-293T C34(0.96); C389(0.97); C691(0.80); C363(0.98)  LDD1492  [17]
 LDCM0023  KB03 Jurkat C34(235.67)  LDD0209  [3]
 LDCM0024  KB05 G361 C34(2.55); C187(3.68); C691(1.99)  LDD3311  [19]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C389(1.14)  LDD2093  [2]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C389(0.86); C325(1.19)  LDD2099  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C389(0.78); C790(1.95)  LDD2107  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C389(0.87); C34(0.97)  LDD2111  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C389(0.57); C34(0.53)  LDD2125  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C389(0.97)  LDD2127  [2]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C34(0.64)  LDD2134  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C34(0.94)  LDD2137  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C389(0.68)  LDD2140  [2]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C389(2.08); C187(0.11)  LDD2144  [2]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C389(0.78)  LDD2146  [2]
 LDCM0110  W12 Hep-G2 C34(14.82)  LDD0237  [13]
 LDCM0111  W14 Hep-G2 C34(11.82)  LDD0238  [13]
 LDCM0112  W16 Hep-G2 C34(1.15)  LDD0239  [13]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
4 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
11 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
12 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
13 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
16 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
19 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840