Details of the Target

General Information of Target

Target ID LDTP03484
Target Name Lysine-specific demethylase 5A (KDM5A)
Gene Name KDM5A
Gene ID 5927
Synonyms
JARID1A; RBBP2; RBP2; Lysine-specific demethylase 5A; EC 1.14.11.67; Histone demethylase JARID1A; Jumonji/ARID domain-containing protein 1A; Retinoblastoma-binding protein 2; RBBP-2; [histone H3]-trimethyl-L-lysine(4) demethylase 5A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGVGPGGYAAEFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPP
FACEVKSFRFTPRVQRLNELEAMTRVRLDFLDQLAKFWELQGSTLKIPVVERKILDLYAL
SKIVASKGGFEMVTKEKKWSKVGSRLGYLPGKGTGSLLKSHYERILYPYELFQSGVSLMG
VQMPNLDLKEKVEPEVLSTDTQTSPEPGTRMNILPKRTRRVKTQSESGDVSRNTELKKLQ
IFGAGPKVVGLAMGTKDKEDEVTRRRKVTNRSDAFNMQMRQRKGTLSVNFVDLYVCMFCG
RGNNEDKLLLCDGCDDSYHTFCLIPPLPDVPKGDWRCPKCVAEECSKPREAFGFEQAVRE
YTLQSFGEMADNFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGS
GFPVKDGRRKILPEEEEYALSGWNLNNMPVLEQSVLAHINVDISGMKVPWLYVGMCFSSF
CWHIEDHWSYSINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQPDLLHQLVTIM
NPNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAEAVNFCTADWLPIGRQCVN
HYRRLRRHCVFSHEELIFKMAADPECLDVGLAAMVCKELTLMTEEETRLRESVVQMGVLM
SEEEVFELVPDDERQCSACRTTCFLSALTCSCNPERLVCLYHPTDLCPCPMQKKCLRYRY
PLEDLPSLLYGVKVRAQSYDTWVSRVTEALSANFNHKKDLIELRVMLEDAEDRKYPENDL
FRKLRDAVKEAETCASVAQLLLSKKQKHRQSPDSGRTRTKLTVEELKAFVQQLFSLPCVI
SQARQVKNLLDDVEEFHERAQEAMMDETPDSSKLQMLIDMGSSLYVELPELPRLKQELQQ
ARWLDEVRLTLSDPQQVTLDVMKKLIDSGVGLAPHHAVEKAMAELQELLTVSERWEEKAK
VCLQARPRHSVASLESIVNEAKNIPAFLPNVLSLKEALQKAREWTAKVEAIQSGSNYAYL
EQLESLSAKGRPIPVRLEALPQVESQVAAARAWRERTGRTFLKKNSSHTLLQVLSPRTDI
GVYGSGKNRRKKVKELIEKEKEKDLDLEPLSDLEEGLEETRDTAMVVAVFKEREQKEIEA
MHSLRAANLAKMTMVDRIEEVKFCICRKTASGFMLQCELCKDWFHNSCVPLPKSSSQKKG
SSWQAKEVKFLCPLCMRSRRPRLETILSLLVSLQKLPVRLPEGEALQCLTERAMSWQDRA
RQALATDELSSALAKLSVLSQRMVEQAAREKTEKIISAELQKAAANPDLQGHLPSFQQSA
FNRVVSSVSSSPRQTMDYDDEETDSDEDIRETYGYDMKDTASVKSSSSLEPNLFCDEEIP
IKSEEVVTHMWTAPSFCAEHAYSSASKSCSQGSSTPRKQPRKSPLVPRSLEPPVLELSPG
AKAQLEELMMVGDLLEVSLDETQHIWRILQATHPPSEDRFLHIMEDDSMEEKPLKVKGKD
SSEKKRKRKLEKVEQLFGEGKQKSKELKKMDKPRKKKLKLGADKSKELNKLAKKLAKEEE
RKKKKEKAAAAKVELVKESTEKKREKKVLDIPSKYDWSGAEESDDENAVCAAQNCQRPCK
DKVDWVQCDGGCDEWFHQVCVGVSPEMAENEDYICINCAKKQGPVSPGPAPPPSFIMSYK
LPMEDLKETS
Target Type
Patented-recorded
Target Bioclass
Enzyme
Family
JARID1 histone demethylase family
Subcellular location
Nucleus, nucleolus
Function
Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif. May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1. Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells.
TTD ID
T28052
Uniprot ID
P29375
DrugMap ID
TTIG67W
Ensemble ID
ENST00000399788.7
HGNC ID
HGNC:9886
ChEMBL ID
CHEMBL2424504

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.P593L DBIA    Probe Info 
AN3CA SNV: p.V653A DBIA    Probe Info 
COLO792 SNV: p.P1667L DBIA    Probe Info 
HCT116 Deletion: p.G1200DfsTer9 DBIA    Probe Info 
HT SNV: p.S156P .
HT115 SNV: p.R164I; p.R1350Ter DBIA    Probe Info 
LNCaP clone FGC Deletion: p.G1200DfsTer9
SNV: p.C636R		 DBIA    Probe Info 
MCC26 SNV: p.S677L DBIA    Probe Info 
MEWO SNV: p.A1304P DBIA    Probe Info 
MFE319 Deletion: p.G1200DfsTer9 DBIA    Probe Info 
MOLT4 SNV: p.V1126A; p.K1562N .
NALM6 SNV: p.R1051W DBIA    Probe Info 
NB1 SNV: p.R606M .
NCIH358 SNV: p.Q1262H DBIA    Probe Info 
OVK18 Deletion: p.G1200DfsTer9 DBIA    Probe Info 
TOV21G Deletion: p.D759IfsTer2 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
AHL-Pu-1
 Probe Info  		C1397(2.07)  LDD0168  [2]
DBIA
 Probe Info  		C1610(1.03); C1615(1.03); C1619(1.03); C683(0.84)  LDD0078  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]
NAIA_4
 Probe Info  		N.A.  LDD2226  [5]
NAIA_5
 Probe Info  		N.A.  LDD2224  [5]
Compound 10
 Probe Info  		N.A.  LDD2216  [6]
Compound 11
 Probe Info  		N.A.  LDD2213  [6]
IPM
 Probe Info  		N.A.  LDD0147  [7]
TFBX
 Probe Info  		C794(0.00); C1409(0.00)  LDD0148  [7]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C270
 Probe Info  		16.80  LDD1940  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C1397(2.07)  LDD0168  [2]
 LDCM0026  4SU-RNA+native RNA DM93 C1409(3.05); C1397(6.63)  LDD0171  [2]
 LDCM0214  AC1 HCT 116 C1212(0.93); C1215(0.93); C683(1.14); C692(1.14)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C1212(1.16); C1215(1.16); C683(0.75); C690(0.75)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C1212(0.75); C1215(0.78); C683(1.02); C692(1.02)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C1212(0.78); C1215(0.80); C683(1.07); C692(1.07)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C1212(0.81); C1215(0.84); C683(0.98); C692(0.98)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C1212(0.73); C1215(0.79); C683(1.18); C692(1.18)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C1212(0.79); C1215(0.87); C683(0.98); C692(0.98)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C1212(0.70); C1215(0.76); C683(1.19); C692(1.19)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C1212(0.67); C1215(0.72); C683(1.06); C692(1.06)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C1212(0.72); C1215(0.81); C683(1.07); C692(1.07)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C1212(0.76); C1215(0.63); C683(0.73); C692(0.73)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C1212(0.88); C1215(0.74); C683(0.79); C692(0.79)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C1212(1.21); C1215(1.21); C683(1.16); C690(1.16)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C1212(0.89); C1215(0.78); C683(0.93); C692(0.93)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C1212(0.85); C1215(0.77); C683(0.94); C692(0.94)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C1212(0.72); C1215(0.72); C683(0.98); C692(0.98)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C1212(1.01); C1215(1.01); C683(0.93); C690(0.93)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C1212(1.03); C1215(1.03); C683(0.92); C690(0.97)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C1212(1.08); C1215(1.09); C683(0.94); C690(1.07)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C1212(1.10); C1215(1.07); C683(0.98); C690(0.92)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C1212(0.99); C1215(0.96); C683(0.82); C690(0.90)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C1212(1.01); C1215(1.01); C683(0.84); C690(0.97)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C1212(0.92); C1215(0.94); C683(0.72); C690(0.94)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C1212(1.09); C1215(1.09); C683(0.87); C690(0.87)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C1212(1.15); C1215(1.16); C683(0.85); C690(0.81)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C1212(0.96); C1215(0.98); C683(0.71); C690(0.83)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C1212(0.99); C1215(1.00); C683(0.90); C690(1.09)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C1212(1.14); C1215(1.12); C683(0.75); C690(0.84)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C1212(1.08); C1215(1.07); C683(0.75); C690(0.77)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C1212(0.95); C1215(0.97); C683(0.86); C690(0.92)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C1212(0.94); C1215(0.93); C683(0.92); C690(1.08)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C1212(0.95); C1215(0.94); C683(0.79); C690(0.79)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C1212(1.24); C1215(1.24)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C1212(1.06); C1215(1.06)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C1212(1.04); C1215(1.04)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C1212(1.08); C1215(1.08)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C1212(0.96); C1215(0.96)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C1212(1.20); C1215(1.20)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C1212(1.18); C1215(1.18)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C1212(1.20); C1215(1.20)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C1212(1.23); C1215(1.23)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C1212(1.07); C1215(1.07)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C1212(1.42); C1215(1.42)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C1212(1.01); C1215(1.01)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C1212(1.28); C1215(1.28); C683(0.98); C690(0.98)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C1212(1.09); C1215(1.09)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C1212(1.15); C1215(1.15)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C1212(1.06); C1215(1.06)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C683(0.96); C690(0.96); C692(0.98); C1212(1.06)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C692(0.70); C683(0.76); C690(0.76); C1212(1.11)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C683(1.02); C690(1.02); C692(1.03); C1212(1.18)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C683(0.98); C690(0.98); C692(1.05); C1212(1.22)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C683(0.94); C690(0.94); C692(0.97); C1212(1.21)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C692(0.82); C683(0.91); C690(0.91); C1212(1.71)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C683(0.93); C690(0.93); C692(1.03); C1212(1.25)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C683(1.08); C690(1.08); C692(1.08); C1212(1.12)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C692(0.76); C683(0.96); C690(0.96); C1212(1.16)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C692(0.88); C683(0.92); C690(0.92); C1212(1.02)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C683(1.04); C690(1.04); C692(1.16); C1212(1.48)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C692(0.76); C683(0.77); C690(0.77); C1212(1.48)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C1212(1.26); C1215(1.26); C683(0.86); C690(0.86)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C1212(1.02); C1215(1.02); C683(0.88); C690(0.88)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C1212(1.05); C1215(1.05); C683(0.88); C690(0.88)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C1212(1.27); C1215(1.27); C683(0.81); C690(0.81)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C1212(0.89); C1215(0.89)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C1212(1.17); C1215(1.17)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C1212(0.91); C1215(0.91)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C1212(0.92); C1215(0.92); C683(1.05); C692(1.05)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C1212(1.11); C1215(1.11)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C1212(1.12); C1215(1.12)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C1212(1.12); C1215(1.12)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C1212(0.91); C1215(0.91)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C1212(1.00); C1215(1.00)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C692(0.68); C683(0.73); C690(0.73); C1212(0.93)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C692(0.74); C683(0.84); C690(0.84); C1212(0.98)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C692(0.90); C683(0.95); C690(0.95); C1212(1.00)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C692(0.92); C683(0.94); C690(0.94); C1212(0.94)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C692(0.77); C1212(0.87); C1215(0.87); C683(0.98)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C1212(0.93); C1215(0.93); C683(1.10); C692(1.10)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C692(0.78); C683(0.87); C690(0.87); C1212(1.08)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C692(0.87); C683(1.00); C690(1.00); C1212(1.07)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C692(0.82); C683(0.97); C690(0.97); C1212(1.08)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C692(0.91); C683(0.94); C690(0.94); C1212(1.04)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C692(0.78); C683(0.80); C690(0.80); C1212(0.86)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C1212(1.25); C1215(1.25)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C1212(1.13); C1215(1.13)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C1212(0.95); C1215(0.95)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C1212(1.09); C1215(1.09)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C1212(0.96); C1215(0.96)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C1212(1.06); C1215(1.06); C683(1.21); C692(1.21)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C1212(1.17); C1215(1.17)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C1212(1.11); C1215(1.11)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C1212(1.39); C1215(1.39)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C1212(1.15); C1215(1.15)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C1212(1.24); C1215(1.24)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C1212(1.22); C1215(1.22)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C1212(1.08); C1215(1.08)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C1212(1.05); C1215(1.05)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C1212(0.86); C1215(0.86)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C1212(1.16); C1215(1.16)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C1212(1.10); C1215(1.10); C683(1.45); C692(1.45)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C1212(1.31); C1215(1.31)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C1212(1.10); C1215(1.10)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C1212(1.14); C1215(1.14)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C1212(1.24); C1215(1.24)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C1212(1.28); C1215(1.28)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C1212(1.23); C1215(1.23)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C1212(1.48); C1215(1.48)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C1212(1.08); C1215(1.08); C683(1.36); C692(1.36)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C1212(1.20); C1215(1.20); C683(1.37); C692(1.37)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C1212(0.92); C1215(0.92); C683(1.56); C692(1.56)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C683(0.90); C690(0.90); C692(0.90); C1212(1.16)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C683(1.02); C692(1.02); C1212(1.04); C1215(1.04)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C1212(0.93); C1215(0.93); C683(1.34); C692(1.34)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C1212(1.07); C1215(1.07); C683(1.45); C692(1.45)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C1212(0.84); C1215(0.84); C683(1.40); C692(1.40)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C1212(0.91); C1215(0.91); C683(1.33); C692(1.33)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C1212(0.95); C1215(0.95); C683(1.28); C692(1.28)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C1212(0.96); C1215(0.96); C683(1.24); C692(1.24)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C1212(0.97); C1215(0.97); C683(1.45); C692(1.45)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C1212(1.13); C1215(1.13); C683(2.25); C690(2.25)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C1212(1.25); C1215(1.25); C683(1.64); C690(1.64)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C1212(1.08); C1215(1.08); C683(1.13); C690(1.13)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C1212(0.95); C1215(0.95); C683(2.29); C690(2.29)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C1212(1.01); C1215(1.01); C683(1.79); C690(1.79)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C1212(1.01); C1215(1.01); C683(1.58); C690(1.58)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C1212(1.23); C1215(1.23); C683(1.60); C690(1.60)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C683(1.37); C690(1.37); C692(1.37); C1212(1.44)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C1212(1.36); C1215(1.36); C683(1.89); C690(1.89)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C1212(1.16); C1215(1.16); C683(2.22); C690(2.22)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C1212(1.17); C1215(1.17); C683(1.72); C690(1.72)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C1212(0.98); C1215(0.98); C683(1.26); C690(1.26)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C1212(0.97); C1215(0.97); C683(1.65); C690(1.65)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C683(0.60); C690(0.60); C692(0.60); C1212(1.06)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C1212(1.16); C1215(1.16); C683(2.13); C690(2.13)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C1212(1.30); C1215(1.30); C683(1.42); C690(1.42)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C1212(1.43); C1215(1.43); C683(1.58); C690(1.58)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C1212(1.04); C1215(1.04)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C1212(1.13); C1215(1.13)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C1212(1.03); C1215(1.03)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C1212(0.86); C1215(0.86)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C1212(0.89); C1215(0.89)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C1212(0.93); C1215(0.93)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C1212(0.98); C1215(0.98)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C1212(0.79); C1215(0.79)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C1212(1.08); C1215(1.08)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C1212(0.99); C1215(0.99)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C1212(0.94); C1215(0.94)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C1212(0.96); C1215(0.96)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C1212(0.94); C1215(0.94)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C1212(1.21); C1215(1.21)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C1212(0.94); C1215(0.94)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C1212(0.84); C1215(0.94); C683(1.36); C692(1.36)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C1215(0.72); C1212(0.72); C683(1.11); C692(1.11)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C1212(1.04); C1215(1.04); C683(0.82); C690(0.82)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C1212(1.04); C1215(1.04); C683(1.37); C690(1.37)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C683(1.09); C690(1.09); C692(1.09); C1212(1.30)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C1610(1.03); C1615(1.03); C1619(1.03); C683(0.84)  LDD0078  [3]
 LDCM0367  CL1 HCT 116 C1212(0.96); C1215(0.96); C692(1.11)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C1212(1.02); C1215(1.02); C692(1.02)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C1212(0.89); C1215(0.89); C683(1.14); C692(1.14)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C683(1.15); C690(1.15); C692(1.15); C1212(1.31)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C683(0.83); C690(0.83); C692(0.83); C1212(1.25)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C683(1.01); C690(1.01); C692(1.01); C1212(1.17)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C683(0.93); C690(0.93); C692(0.93); C1212(1.12)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C1212(0.98); C1215(0.98)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C1212(1.07); C1215(1.07)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C1212(0.99); C1215(0.99)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C1212(0.99); C1215(0.99)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C1212(1.05); C1215(1.05)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C1212(0.88); C1215(0.88); C692(1.02)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C1212(0.99); C1215(0.99)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C1212(0.85); C1215(0.85)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C692(0.70); C683(0.79); C690(0.79); C1212(1.12)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C683(0.94); C690(0.94); C692(0.99); C1212(1.08)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C692(0.80); C683(0.94); C690(0.94); C1212(1.03)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C692(0.72); C683(0.90); C690(0.90); C1212(0.94)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C692(0.69); C683(0.87); C690(0.87); C1212(0.91)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C1212(1.39); C1215(1.39)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C1212(1.11); C1215(1.11)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C1212(1.04); C1215(1.04)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C692(0.76); C1212(0.97); C1215(0.97)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C1212(0.87); C1215(0.87)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C1212(1.19); C1215(1.19)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C1212(1.18); C1215(1.18)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C1212(1.54); C1215(1.54)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C1212(1.17); C1215(1.17)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C1212(0.77); C1215(0.77); C683(0.79); C692(0.79)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C683(0.77); C692(0.77); C1212(1.10); C1215(1.10)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C683(0.89); C692(0.89); C1212(0.98); C1215(0.98)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C1212(0.92); C1215(0.92); C683(0.99); C692(0.99)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C692(1.04); C1212(1.07); C1215(1.07)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C692(0.92); C1212(0.94); C1215(0.94)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C692(1.13); C1212(1.48); C1215(1.48)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C1212(0.54); C1215(0.54); C683(0.97); C690(0.97)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C683(0.85); C690(0.85); C692(0.85); C1212(1.14)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C683(0.82); C690(0.82); C692(0.82); C1212(0.84)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C1212(0.94); C1215(0.94); C683(1.31); C690(1.31)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C692(0.77); C1212(1.05); C1215(1.05)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C1212(0.88); C1215(0.88); C683(1.52); C690(1.52)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C1212(0.95); C1215(0.95); C683(1.15); C690(1.15)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C683(0.94); C690(0.94); C692(0.94); C1212(1.25)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C1212(0.97); C1215(0.97); C683(1.02); C690(1.02)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C683(0.74); C690(0.74); C692(0.74); C1212(0.79)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C1212(0.84); C1215(0.84); C683(0.91); C690(0.91)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C1212(0.90); C1215(0.90); C683(1.32); C690(1.32)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C1212(0.91); C1215(0.91); C683(0.88); C690(0.88)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C1212(0.71); C1215(0.71); C683(1.13); C690(1.13)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C1212(0.79); C1215(0.79); C683(0.83); C690(0.83)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C1212(0.87); C1215(0.87); C692(0.90)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C1212(0.85); C1215(0.85); C683(1.00); C690(1.00)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C1212(0.97); C1215(0.97)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C683(0.96); C690(0.96); C692(0.96)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C683(0.74); C690(0.74); C692(0.74)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C683(1.17); C690(1.17); C692(1.17)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C683(1.17); C690(1.17); C692(1.17)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C683(0.66); C690(0.66); C692(0.66)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C683(1.06); C690(1.06); C692(1.06)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C683(0.96); C690(0.96); C692(0.96)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C1212(1.00); C1215(1.00); C692(0.97)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C683(0.84); C690(0.84); C692(0.84)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C683(1.14); C690(1.14); C692(1.14)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C683(0.89); C690(0.89); C692(0.89)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C683(0.85); C690(0.85); C692(0.85)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C683(0.81); C690(0.81); C692(0.81)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C683(0.75); C690(0.75); C692(0.75)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C1212(0.91); C1215(0.91)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C1212(1.06); C1215(1.06)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C1212(1.01); C1215(1.01)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C1212(1.05); C1215(1.05)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C1212(1.01); C1215(1.01); C692(0.93)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C1212(1.05); C1215(1.05)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C1212(1.00); C1215(1.00)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C1212(0.95); C1215(0.95)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C1212(1.22); C1215(1.22)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C1212(1.08); C1215(1.08)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C1212(1.03); C1215(1.03)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C1212(1.15); C1215(1.15)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C1212(1.27); C1215(1.27)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C1212(1.02); C1215(1.02)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C1212(1.04); C1215(1.04)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C1212(0.96); C1215(0.96); C692(0.78)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C1212(0.99); C1215(0.99)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C1212(0.97); C1215(0.97)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C1212(0.85); C1215(0.85)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C1212(0.91); C1215(0.91)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C1212(1.00); C1215(1.00)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C1212(0.96); C1215(0.96)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C1212(1.12); C1215(1.12)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C1212(1.21); C1215(1.21)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C1212(1.23); C1215(1.23)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C1212(1.19); C1215(1.19)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C1212(0.87); C1215(0.87); C692(0.77)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C1212(1.07); C1215(1.07)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C1212(1.04); C1215(1.04)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C1212(1.07); C1215(1.07)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C1212(1.03); C1215(1.03)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C1212(1.23); C1215(1.23)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C1212(1.03); C1215(1.03); C683(1.33); C690(1.26)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C1212(1.02); C1215(1.02); C683(1.16); C690(0.77)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C1212(0.96); C1215(0.96); C683(1.00); C690(0.67)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C1212(1.05); C1215(1.05); C683(1.41); C690(0.99)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C1212(1.18); C1215(1.18); C692(1.03)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C1212(1.19); C1215(1.19); C683(1.27); C690(1.16)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C1212(0.97); C1215(0.97); C683(1.50); C690(1.35)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C1212(1.12); C1215(1.12); C683(1.45); C690(0.98)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C1212(1.16); C1215(1.16); C683(1.75); C690(1.47)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C1212(1.14); C1215(1.14); C683(1.51); C690(1.26)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C1212(0.89); C1215(0.89); C683(1.44); C690(1.20)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C1212(1.04); C1215(1.04); C683(1.30); C690(1.01)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C1212(0.95); C1215(0.95); C683(1.31); C690(0.84)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C1212(0.95); C1215(0.95); C683(1.00); C690(0.78)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C1212(1.41); C1215(1.41); C683(1.70); C690(1.21)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C1212(0.98); C1215(0.98); C692(1.47)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C1212(1.04); C1215(1.04); C683(1.34); C690(0.96)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C1212(0.87); C1215(0.87); C683(1.72); C692(1.72)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C1212(0.97); C1215(0.97); C683(1.26); C692(1.26)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C1212(1.02); C1215(1.02); C683(1.29); C692(1.29)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C1212(1.00); C1215(1.00); C683(1.55); C692(1.55)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C1212(0.94); C1215(0.94); C683(1.36); C692(1.36)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C1212(0.87); C1215(0.87); C683(0.88); C692(0.88)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C1212(1.01); C1215(1.01); C683(0.86); C692(0.86)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C1212(1.03); C1215(1.03); C683(0.85); C692(0.85)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C1212(0.94); C1215(0.94); C683(1.11); C692(1.11)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C1375(0.91); C838(1.74); C1409(1.15); C1248(0.99)  LDD1698  [9]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C962(2.53); C1409(1.34)  LDD1702  [10]
 LDCM0468  Fragment33 HCT 116 C1212(1.20); C1215(1.20)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C683(0.84); C690(0.84); C692(0.84)  LDD0744  [3]
 LDCM0022  KB02 HCT 116 C626(2.07); C636(2.07); C1212(3.60); C1215(3.60)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C626(4.53); C636(4.53); C1212(5.92); C1215(5.92)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C626(2.74); C636(2.74); C1212(2.39); C1215(2.39)  LDD0082  [3]
 LDCM0021  THZ1 HCT 116 C683(1.14); C690(1.14); C692(1.14)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Retinoblastoma-associated protein (RB1) Retinoblastoma protein (RB) family P06400

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pbit Small molecular drug D0IQ7Y
Patented
Click To Hide/Show 20 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
1190312-92-5 Small molecular drug D0ZJ0Z
6ep Small molecular drug D00SUC
Akos020330481 Small molecular drug D0NG8M
Akos020330656 Small molecular drug D0HT9Q
Bdbm50158703 Small molecular drug D0GH8J
Bdbm50158755 Small molecular drug D0K4LW
Bdbm50158791 Small molecular drug D05CCY
Bdbm50158794 Small molecular drug D0G8QR
Bdbm50158803 Small molecular drug D01WHH
Ncgc00381656-01 Small molecular drug D0PQ5P
Us10022354, Example 151 Small molecular drug D03POM
Us10022354, Example 152 Small molecular drug D0T8YT
Us10022354, Example 5 Small molecular drug D0NM3B
Us10040779, Example 1 Small molecular drug D0VZ5E
Us10040779, Example 4 Small molecular drug D06TKT
Us10174026, Example 2 Small molecular drug D0R2GT
Us10174026, Example 99 Small molecular drug D0N9JZ
Us9611221, Example 9 Small molecular drug D09CWB
Us9714230, 12 Small molecular drug D03TKM
Us9714230, 46 Small molecular drug D0F3TL

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761