Details of the Target

General Information of Target

Target ID LDTP13716
Target Name Exocyst complex component 7 (EXOC7)
Gene Name EXOC7
Gene ID 23265
Synonyms
EXO70; KIAA1067; Exocyst complex component 7; Exocyst complex component Exo70
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKKIFSKKGESPLGSFARRQRSSAGGGGEPGEGAYSQPGYHVRDRDLGKIHKAASAGNVA
KVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKA
VQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDL
TPLLLAVSGKKQQMVEFLIKKKANVNAVDKLESSHQLISEYKEERIPKHSSQNSNSVDES
SEDSLSRLSGKPGVDDSWPTSDDEDLNFDTKNVPKPSLAKLMTASQQSRKNLEATYGTVR
TGNRTLFEDRDSDSQDEVVVESLPTTSIKVQCFSHPTYQSPDLLPKPSHKSLANPGLMKE
EPTKPGIAKKENGIDIIESAPLEQTNNDNLTYVDEVHKNNRSDMMSALGLGQEEDIESPW
DSESISENFPQKYVDPLAGAADGKEKNIGNEQAEDVFYIPSCMSGSRNFKMAKLEDTRNV
GMPVAHMESPERYLHLKPTIEMKDSVPNKAGGMKDVQTSKAAEHDLEVASEEEQEREGSE
NNQPQVEEERKKHRNNEMEVSANIHDGATDDAEDDDDDDGLIQKRKSGETDHQQFPRKEN
KEYASSGPALQMKEVKSTEKEKRTSKESVNSPVFGKASLLTGGLLQVDDDSSLSEIDEDE
GRPTKKTSNEKNKVKNQIQSMDDVDDLTQSSETASEDCELPHSSYKNFMLLIEQLGMECK
DSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQ
KVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTL
EMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSEN
SHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTI
KQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDR
DQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEF
HHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQ
SENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISEC
NHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLK
KKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLL
NANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENG
EFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTV
QKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLF
LQAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYL
EELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLTTRPVMEPPCVGNLNNSLD
LNRKLIPRENLVISTSNPRASNNSMENYLSKMQQELEKNITRELKEAAAELESGSIASPL
GSTDESNLNQDLVWKASREYVQVLKKNYMI
Target Bioclass
Transporter and channel
Family
EXO70 family
Subcellular location
Cytoplasm, cytosol
Function
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion. It is required for neuron survival and plays an essential role in cortical development.
Uniprot ID
Q9UPT5
Ensemble ID
ENST00000332065.9
HGNC ID
HGNC:23214

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.R229S; p.L352M .
MOLT4 SNV: p.R155C IA-alkyne    Probe Info 
NCIH358 SNV: p.Q74E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K140(10.00); K590(2.28); K643(5.26); K65(6.07)  LDD0277  [2]
ONAyne
 Probe Info  		K65(10.00)  LDD0275  [2]
Probe 1
 Probe Info  		Y629(23.94); Y718(14.14)  LDD3495  [3]
DA-P3
 Probe Info  		5.23  LDD0183  [4]
AHL-Pu-1
 Probe Info  		C83(3.76)  LDD0168  [5]
DBIA
 Probe Info  		C550(0.85); C667(0.66)  LDD0532  [6]
ATP probe
 Probe Info  		N.A.  LDD0199  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C367(0.00); C550(0.00); C667(0.00); C83(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C667(0.00); C550(0.00); C83(0.00)  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		C667(0.00); C550(0.00); C83(0.00)  LDD0037  [8]
NAIA_4
 Probe Info  		N.A.  LDD2226  [9]
WYneO
 Probe Info  		N.A.  LDD0022  [10]
IPM
 Probe Info  		N.A.  LDD0147  [11]
PF-06672131
 Probe Info  		N.A.  LDD0152  [12]
SF
 Probe Info  		N.A.  LDD0028  [13]
TFBX
 Probe Info  		C83(0.00); C550(0.00); C667(0.00)  LDD0148  [11]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [14]
W1
 Probe Info  		N.A.  LDD0236  [15]
AOyne
 Probe Info  		14.90  LDD0443  [16]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C106
 Probe Info  		20.97  LDD1793  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C83(3.76)  LDD0168  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C83(6.43)  LDD0169  [5]
 LDCM0214  AC1 HEK-293T C550(0.90)  LDD0812  [6]
 LDCM0215  AC10 HCT 116 C550(0.85); C667(0.66)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C667(0.48)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C667(0.57)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C667(0.53)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C667(0.43)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C667(0.42)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C667(0.49)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C667(0.55)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C667(0.52)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C667(0.63)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C667(0.61)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C550(0.92); C667(0.66)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C667(0.54)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C667(0.60)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C667(0.47)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C667(1.08)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C667(0.79)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C667(0.78)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C667(1.01)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C667(0.82)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C667(0.86)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C667(0.80)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C550(0.99); C667(0.75)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C667(0.91)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C667(0.73)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C667(0.94)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C667(0.79)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C667(0.93)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C667(0.91)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C667(0.81)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C667(0.95)  LDD0562  [6]
 LDCM0246  AC128 HEK-293T C550(1.03)  LDD0844  [6]
 LDCM0247  AC129 HEK-293T C550(0.99)  LDD0845  [6]
 LDCM0249  AC130 HEK-293T C550(1.05)  LDD0847  [6]
 LDCM0250  AC131 HEK-293T C550(1.00)  LDD0848  [6]
 LDCM0251  AC132 HEK-293T C550(1.16)  LDD0849  [6]
 LDCM0252  AC133 HEK-293T C550(1.14)  LDD0850  [6]
 LDCM0253  AC134 HEK-293T C550(1.09)  LDD0851  [6]
 LDCM0254  AC135 HEK-293T C550(1.01)  LDD0852  [6]
 LDCM0255  AC136 HEK-293T C550(1.00)  LDD0853  [6]
 LDCM0256  AC137 HEK-293T C550(0.96)  LDD0854  [6]
 LDCM0257  AC138 HEK-293T C550(0.82)  LDD0855  [6]
 LDCM0258  AC139 HEK-293T C550(0.81)  LDD0856  [6]
 LDCM0259  AC14 HCT 116 C550(1.02); C667(0.71)  LDD0576  [6]
 LDCM0260  AC140 HEK-293T C550(1.11)  LDD0858  [6]
 LDCM0261  AC141 HEK-293T C550(0.87)  LDD0859  [6]
 LDCM0262  AC142 HEK-293T C550(1.05)  LDD0860  [6]
 LDCM0263  AC143 HEK-293T C550(0.69)  LDD0861  [6]
 LDCM0264  AC144 HEK-293T C550(0.79)  LDD0862  [6]
 LDCM0265  AC145 HEK-293T C550(0.86)  LDD0863  [6]
 LDCM0266  AC146 HEK-293T C550(0.76)  LDD0864  [6]
 LDCM0267  AC147 HEK-293T C550(0.70)  LDD0865  [6]
 LDCM0268  AC148 HEK-293T C550(0.86)  LDD0866  [6]
 LDCM0269  AC149 HEK-293T C550(0.95)  LDD0867  [6]
 LDCM0270  AC15 HCT 116 C667(0.64); C550(1.03)  LDD0587  [6]
 LDCM0271  AC150 HEK-293T C550(0.88)  LDD0869  [6]
 LDCM0272  AC151 HEK-293T C550(0.79)  LDD0870  [6]
 LDCM0273  AC152 HEK-293T C550(0.88)  LDD0871  [6]
 LDCM0274  AC153 HEK-293T C550(0.87)  LDD0872  [6]
 LDCM0621  AC154 HEK-293T C550(0.88)  LDD2162  [6]
 LDCM0622  AC155 HEK-293T C550(0.83)  LDD2163  [6]
 LDCM0623  AC156 HEK-293T C550(0.71)  LDD2164  [6]
 LDCM0624  AC157 HEK-293T C550(0.46)  LDD2165  [6]
 LDCM0276  AC17 HCT 116 C667(0.69)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C667(0.55)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C667(0.68)  LDD0595  [6]
 LDCM0279  AC2 HEK-293T C550(1.03)  LDD0877  [6]
 LDCM0280  AC20 HCT 116 C667(0.70)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C667(0.67)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C667(0.81)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C667(0.67)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C667(0.90)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C667(0.80); C550(0.86)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C667(0.62); C550(0.78)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C667(0.58); C550(0.78)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C667(0.53); C550(0.80)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C667(0.58); C550(0.84)  LDD0606  [6]
 LDCM0290  AC3 HEK-293T C550(1.17)  LDD0888  [6]
 LDCM0291  AC30 HCT 116 C667(0.57); C550(0.86)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C667(0.64); C550(0.79)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C667(0.47); C550(0.76)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C667(0.51); C550(0.76)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C667(0.51); C550(0.84)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C667(0.97); C550(1.15)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C550(0.86); C667(1.03)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C550(0.88); C667(1.09)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C550(1.01); C667(1.02)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C550(0.96); C667(0.99)  LDD0617  [6]
 LDCM0301  AC4 HEK-293T C550(1.08)  LDD0899  [6]
 LDCM0302  AC40 HCT 116 C550(0.92); C667(0.98)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C550(0.90); C667(1.02)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C550(0.89); C667(1.02)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C550(0.90); C667(0.96)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C550(0.87); C667(1.06)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C550(0.87); C667(0.99)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C667(0.99)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C667(0.99)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C667(1.14)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C667(1.09)  LDD0628  [6]
 LDCM0312  AC5 HEK-293T C550(1.09)  LDD0910  [6]
 LDCM0313  AC50 HCT 116 C667(1.08)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C667(1.30)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C667(1.05)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C667(1.01)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C667(0.98)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C667(1.06)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C667(1.11)  LDD0636  [6]
 LDCM0320  AC57 HEK-293T C550(0.94)  LDD0918  [6]
 LDCM0321  AC58 HEK-293T C550(1.06)  LDD0919  [6]
 LDCM0322  AC59 HEK-293T C550(0.98)  LDD0920  [6]
 LDCM0323  AC6 HCT 116 C667(0.63); C550(0.90)  LDD0640  [6]
 LDCM0324  AC60 HEK-293T C550(0.77)  LDD0922  [6]
 LDCM0325  AC61 HEK-293T C550(1.05)  LDD0923  [6]
 LDCM0326  AC62 HEK-293T C550(1.02)  LDD0924  [6]
 LDCM0327  AC63 HEK-293T C550(0.96)  LDD0925  [6]
 LDCM0328  AC64 HEK-293T C550(1.04)  LDD0926  [6]
 LDCM0329  AC65 HEK-293T C550(0.98)  LDD0927  [6]
 LDCM0330  AC66 HEK-293T C550(0.97)  LDD0928  [6]
 LDCM0331  AC67 HEK-293T C550(1.00)  LDD0929  [6]
 LDCM0332  AC68 HEK-293T C550(0.96)  LDD0930  [6]
 LDCM0333  AC69 HEK-293T C550(0.97)  LDD0931  [6]
 LDCM0334  AC7 HCT 116 C667(0.74); C550(0.94)  LDD0651  [6]
 LDCM0335  AC70 HEK-293T C550(0.95)  LDD0933  [6]
 LDCM0336  AC71 HEK-293T C550(0.94)  LDD0934  [6]
 LDCM0337  AC72 HEK-293T C550(1.01)  LDD0935  [6]
 LDCM0338  AC73 HEK-293T C550(0.95)  LDD0936  [6]
 LDCM0339  AC74 HEK-293T C550(1.04)  LDD0937  [6]
 LDCM0340  AC75 HEK-293T C550(0.96)  LDD0938  [6]
 LDCM0341  AC76 HEK-293T C550(0.95)  LDD0939  [6]
 LDCM0342  AC77 HEK-293T C550(0.93)  LDD0940  [6]
 LDCM0343  AC78 HEK-293T C550(0.82)  LDD0941  [6]
 LDCM0344  AC79 HEK-293T C550(0.98)  LDD0942  [6]
 LDCM0345  AC8 HCT 116 C667(0.67); C550(0.89)  LDD0662  [6]
 LDCM0346  AC80 HEK-293T C550(0.90)  LDD0944  [6]
 LDCM0347  AC81 HEK-293T C550(1.15)  LDD0945  [6]
 LDCM0348  AC82 HEK-293T C550(0.91)  LDD0946  [6]
 LDCM0349  AC83 HCT 116 C667(0.59); C550(0.93)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C667(0.64); C550(0.93)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C667(0.72); C550(0.84)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C667(0.75); C550(1.05)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C667(0.95); C550(1.07)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C667(0.79); C550(1.02)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C667(0.69); C550(1.00)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C550(0.93); C667(1.29)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C667(0.60); C550(0.92)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C667(0.61); C550(0.96)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C667(0.72); C550(0.95)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C667(0.70); C550(0.79)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C667(0.78); C550(0.82)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C667(0.70); C550(0.82)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C667(0.62); C550(0.79)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C667(0.50)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C667(0.59)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C550(0.97); C667(0.92)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C667(0.71); C550(0.95)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C667(0.63); C550(0.87)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C550(0.95)  LDD2171  [6]
 LDCM0632  CL-Sc Hep-G2 C83(0.97)  LDD2227  [9]
 LDCM0367  CL1 HEK-293T C550(1.05)  LDD0965  [6]
 LDCM0368  CL10 HEK-293T C550(1.14)  LDD0966  [6]
 LDCM0369  CL100 HEK-293T C550(1.16)  LDD0967  [6]
 LDCM0370  CL101 HCT 116 C667(0.62); C550(0.84)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C667(0.75); C550(0.93)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C667(0.75); C550(0.92)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C667(0.79); C550(0.95)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C667(0.56)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C667(0.52)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C667(0.55)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C667(0.51)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C667(0.57)  LDD0695  [6]
 LDCM0379  CL11 HEK-293T C550(1.29)  LDD0977  [6]
 LDCM0380  CL110 HCT 116 C667(0.52)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C667(0.58)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C667(0.84); C550(0.96)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C667(0.45); C550(0.73)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C667(0.66); C550(0.75)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C667(0.58); C550(0.81)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C667(0.69); C550(0.82)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C667(1.01); C550(1.08)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C550(0.89); C667(1.00)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C550(0.90); C667(0.98)  LDD0706  [6]
 LDCM0390  CL12 HEK-293T C550(1.21)  LDD0988  [6]
 LDCM0391  CL120 HCT 116 C550(0.86); C667(0.94)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C667(1.19)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C667(1.09)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C667(0.95)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C667(0.96)  LDD0712  [6]
 LDCM0396  CL125 HEK-293T C550(0.98)  LDD0994  [6]
 LDCM0397  CL126 HEK-293T C550(1.05)  LDD0995  [6]
 LDCM0398  CL127 HEK-293T C550(1.04)  LDD0996  [6]
 LDCM0399  CL128 HEK-293T C550(1.01)  LDD0997  [6]
 LDCM0400  CL13 HEK-293T C550(1.26)  LDD0998  [6]
 LDCM0401  CL14 HEK-293T C550(1.27)  LDD0999  [6]
 LDCM0402  CL15 HEK-293T C550(1.34)  LDD1000  [6]
 LDCM0403  CL16 HCT 116 C550(0.84)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C550(0.75)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C550(0.78)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C550(0.78)  LDD0723  [6]
 LDCM0407  CL2 HEK-293T C550(1.31)  LDD1005  [6]
 LDCM0408  CL20 HCT 116 C550(0.73)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C550(0.85)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C550(1.12)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C550(0.75)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C550(0.77)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C550(0.68)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C550(0.69)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C550(0.76)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C550(0.79)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C550(0.83)  LDD0734  [6]
 LDCM0418  CL3 HEK-293T C550(1.35)  LDD1016  [6]
 LDCM0419  CL30 HCT 116 C550(0.83)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C550(1.01)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C550(0.95)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C550(0.81)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C550(0.90)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C550(0.93)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C550(0.83)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C550(0.93)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C550(1.00)  LDD0745  [6]
 LDCM0429  CL4 HEK-293T C550(1.26)  LDD1027  [6]
 LDCM0430  CL40 HCT 116 C550(0.71)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C550(0.99)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C550(0.97)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C550(0.92)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C550(0.98)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C550(0.84)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C550(0.89)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C550(0.93)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C550(1.00)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C550(1.03)  LDD0756  [6]
 LDCM0440  CL5 HEK-293T C550(1.42)  LDD1038  [6]
 LDCM0441  CL50 HCT 116 C550(0.98)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C550(0.94)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C550(0.94)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C550(1.09)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C550(1.00)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C550(1.11)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C550(1.02)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C550(0.96)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C550(1.01)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C550(1.09)  LDD0767  [6]
 LDCM0451  CL6 HEK-293T C550(1.22)  LDD1049  [6]
 LDCM0452  CL60 HCT 116 C550(0.98)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C550(0.88)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C550(0.97)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C550(0.90)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C550(0.97)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C550(1.00)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C550(0.95)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C550(0.93)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C550(1.00)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C550(0.89)  LDD0778  [6]
 LDCM0462  CL7 HEK-293T C550(1.35)  LDD1060  [6]
 LDCM0463  CL70 HCT 116 C550(1.06)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C550(0.95)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C550(0.95)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C550(0.88)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C550(0.94)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C550(0.87)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C550(1.32)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C550(0.81)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C550(0.81)  LDD0789  [6]
 LDCM0473  CL8 HEK-293T C550(1.06)  LDD1071  [6]
 LDCM0474  CL80 HCT 116 C550(0.88)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C550(0.83)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C550(0.90)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C550(0.80)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C550(0.99)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C550(0.80)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C550(1.19)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C550(1.03)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C550(0.90)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C550(1.10)  LDD0800  [6]
 LDCM0484  CL9 HEK-293T C550(1.12)  LDD1082  [6]
 LDCM0485  CL90 HCT 116 C550(0.76)  LDD0802  [6]
 LDCM0486  CL91 HEK-293T C550(1.03)  LDD1084  [6]
 LDCM0487  CL92 HEK-293T C550(1.14)  LDD1085  [6]
 LDCM0488  CL93 HEK-293T C550(1.03)  LDD1086  [6]
 LDCM0489  CL94 HEK-293T C550(1.04)  LDD1087  [6]
 LDCM0490  CL95 HEK-293T C550(1.07)  LDD1088  [6]
 LDCM0491  CL96 HEK-293T C550(1.12)  LDD1089  [6]
 LDCM0492  CL97 HEK-293T C550(1.14)  LDD1090  [6]
 LDCM0493  CL98 HEK-293T C550(1.03)  LDD1091  [6]
 LDCM0494  CL99 HEK-293T C550(1.09)  LDD1092  [6]
 LDCM0495  E2913 HEK-293T C83(0.84); C550(0.89)  LDD1698  [18]
 LDCM0031  Epigallocatechin gallate HEK-293T 5.23  LDD0183  [4]
 LDCM0468  Fragment33 HCT 116 C550(0.86)  LDD0785  [6]
 LDCM0427  Fragment51 HCT 116 C550(0.99)  LDD0744  [6]
 LDCM0022  KB02 HEK-293T C667(0.98); C83(0.84); C550(0.99)  LDD1492  [18]
 LDCM0023  KB03 HEK-293T C667(0.99); C83(0.89); C550(0.90)  LDD1497  [18]
 LDCM0024  KB05 SKMEL24 C667(3.26)  LDD3323  [19]
 LDCM0021  THZ1 HCT 116 C550(0.95)  LDD2173  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lysine-specific histone demethylase 1A (KDM1A) Flavin monoamine oxidase family O60341
Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D (SSC5D) . A1L4H1
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
SNARE-associated protein Snapin (SNAPIN) SNAPIN family O95295
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mesogenin-1 (MSGN1) . A6NI15
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (SMARCE1) . Q969G3
Other
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
KxDL motif-containing protein 1 (KXD1) KXD1 family Q9BQD3
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (ARFGEF2) . Q9Y6D5
Cancer/testis antigen 55 (CT55) . Q8WUE5
F-box only protein 28 (FBXO28) . Q9NVF7
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964
Intraflagellar transport protein 20 homolog (IFT20) . Q8IY31
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) . Q9H8W4
Protein YAE1 homolog (YAE1) . Q9NRH1
Suppressor APC domain-containing protein 2 (SAPCD2) . Q86UD0

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
13 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
14 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
15 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840