Details of the Target

General Information of Target

Target ID LDTP08682
Target Name Ankyrin repeat domain-containing protein 13A (ANKRD13A)
Gene Name ANKRD13A
Gene ID 88455
Synonyms
ANKRD13; Ankyrin repeat domain-containing protein 13A; Protein KE03
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSACDAGDHYPLHLLVWKNDYRQLEKELQGQNVEAVDPRGRTLLHLAVSLGHLESARVL
LRHKADVTKENRQGWTVLHEAVSTGDPEMVYTVLQHRDYHNTSMALEGVPELLQKILEAP
DFYVQMKWEFTSWVPLVSRICPNDVCRIWKSGAKLRVDITLLGFENMSWIRGRRSFIFKG
EDNWAELMEVNHDDKVVTTERFDLSQEMERLTLDLMKPKSREVERRLTSPVINTSLDTKN
IAFERTKSGFWGWRTDKAEVVNGYEAKVYTVNNVNVITKIRTEHLTEEEKKRYKADRNPL
ESLLGTVEHQFGAQGDLTTECATANNPTAITPDEYFNEEFDLKDRDIGRPKELTIRTQKF
KAMLWMCEEFPLSLVEQVIPIIDLMARTSAHFARLRDFIKLEFPPGFPVKIEIPLFHVLN
ARITFGNVNGCSTAEESVSQNVEGTQADSASHITNFEVDQSVFEIPESYYVQDNGRNVHL
QDEDYEIMQFAIQQSLLESSRSQELSGPASNGGISQTNTYDAQYERAIQESLLTSTEGLC
PSALSETSRFDNDLQLAMELSAKELEEWELRLQEEEAELQQVLQLSLTDK
Target Bioclass
Other
Subcellular location
Cell membrane
Function
Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.
Uniprot ID
Q8IZ07
Ensemble ID
ENST00000261739.9
HGNC ID
HGNC:21268

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y520(10,614.18)  LDD3495  [1]
AHL-Pu-1
 Probe Info  		C540(5.45)  LDD0168  [2]
DBIA
 Probe Info  		C141(0.98); C146(0.98)  LDD0531  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]
NAIA_5
 Probe Info  		N.A.  LDD2224  [5]
IPM
 Probe Info  		N.A.  LDD2156  [6]
VSF
 Probe Info  		N.A.  LDD0007  [7]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C106
 Probe Info  		16.56  LDD1793  [8]
C390
 Probe Info  		36.25  LDD2049  [8]
FFF probe11
 Probe Info  		20.00  LDD0471  [9]
FFF probe13
 Probe Info  		20.00  LDD0475  [9]
FFF probe14
 Probe Info  		20.00  LDD0477  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C540(5.45)  LDD0168  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C540(3.14)  LDD0169  [2]
 LDCM0214  AC1 HCT 116 C141(0.98); C146(0.98)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C141(1.08); C146(1.08)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C141(1.35); C146(1.35)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C141(0.91); C146(0.91)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C141(0.65); C146(0.65)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C141(0.86); C146(0.86)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C141(1.36); C146(1.36)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C141(1.55); C146(1.55)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C141(1.09); C146(1.09)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C141(0.90); C146(0.90)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C141(0.95); C146(0.95)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C141(0.59); C146(0.59)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C141(1.28); C146(1.28)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C141(1.03); C146(1.03)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C141(1.15); C146(1.15)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C141(1.30); C146(1.30)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C141(0.90); C146(0.90)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C141(0.93); C146(0.83)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C141(0.76); C146(0.72)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C141(0.88); C146(0.88)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C141(0.91); C146(0.95)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C141(0.94); C146(0.91)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C141(0.93); C146(0.96)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C141(1.27); C146(1.27)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C141(0.98); C146(0.96)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C141(1.07); C146(0.99)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C141(1.07); C146(0.98)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C141(1.19); C146(1.07)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C141(1.10); C146(1.00)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C141(0.92); C146(0.84)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C141(1.09); C146(0.96)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C141(1.02); C146(0.99)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C141(1.27); C146(1.27)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C141(1.31); C146(1.31)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C141(1.33); C146(1.33)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C141(1.29); C146(1.29)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C141(1.38); C146(1.38)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C141(1.47); C146(1.47)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C141(1.28); C146(1.28)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C141(1.56); C146(1.56)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C141(1.25); C146(1.25)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C141(1.29); C146(1.29)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C141(1.22); C146(1.22)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C141(1.18); C146(1.18)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C141(0.92); C146(0.92)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C141(1.39); C146(1.39)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C141(1.25); C146(1.25)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C141(1.27); C146(1.27)  LDD0579  [3]
 LDCM0263  AC143 HEK-293T C141(0.96); C146(0.96)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C141(0.99); C146(0.99)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C141(0.90); C146(0.90)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C141(0.93); C146(0.93)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C141(1.61); C146(1.61)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C141(1.14); C146(1.14)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C141(1.24); C146(1.24)  LDD0867  [3]
 LDCM0270  AC15 HCT 116 C141(0.97); C146(0.97)  LDD0587  [3]
 LDCM0271  AC150 HEK-293T C141(1.04); C146(1.04)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C141(0.88); C146(0.88)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C141(1.06); C146(1.06)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C141(1.19); C146(1.19)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C141(1.29); C146(1.29)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C141(1.02); C146(1.02)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C141(1.03); C146(1.03)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C141(1.53); C146(1.53)  LDD2165  [3]
 LDCM0276  AC17 HCT 116 C141(1.19); C146(1.19)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C141(1.11); C146(1.11)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C141(0.98); C146(0.98)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C141(1.12); C146(1.12)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C141(0.96); C146(0.96)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C141(1.36); C146(1.36)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C141(1.34); C146(1.34)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C141(1.48); C146(1.48)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C141(1.37); C146(1.37)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C141(0.93)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C141(1.19)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C141(1.29)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C141(1.11)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C141(0.96)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C141(0.97); C146(0.97)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C141(1.12)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C141(0.98)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C141(1.06)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C141(0.78)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C141(1.11)  LDD0612  [3]
 LDCM0296  AC35 HEK-293T C141(0.86); C146(0.86)  LDD0894  [3]
 LDCM0297  AC36 HEK-293T C141(1.27); C146(1.27)  LDD0895  [3]
 LDCM0298  AC37 HEK-293T C141(1.40); C146(1.40)  LDD0896  [3]
 LDCM0299  AC38 HEK-293T C141(1.18); C146(1.18)  LDD0897  [3]
 LDCM0300  AC39 HEK-293T C141(0.89); C146(0.89)  LDD0898  [3]
 LDCM0301  AC4 HCT 116 C141(1.18); C146(1.18)  LDD0618  [3]
 LDCM0302  AC40 HEK-293T C141(1.59); C146(1.59)  LDD0900  [3]
 LDCM0303  AC41 HEK-293T C141(1.46); C146(1.46)  LDD0901  [3]
 LDCM0304  AC42 HEK-293T C141(1.16); C146(1.16)  LDD0902  [3]
 LDCM0305  AC43 HEK-293T C141(1.02); C146(1.02)  LDD0903  [3]
 LDCM0306  AC44 HEK-293T C141(1.09); C146(1.09)  LDD0904  [3]
 LDCM0307  AC45 HEK-293T C141(1.06); C146(1.06)  LDD0905  [3]
 LDCM0308  AC46 HCT 116 C141(0.83); C146(0.83)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C141(0.91); C146(0.91)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C141(0.83); C146(0.83)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C141(0.81); C146(0.81)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C141(1.16); C146(1.16)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C141(0.89); C146(0.89)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C141(0.85); C146(0.85)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C141(0.85); C146(0.85)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C141(1.13); C146(1.13)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C141(0.86); C146(0.86)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C141(1.39); C146(1.39)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C141(1.15); C146(1.15)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C141(0.77); C146(0.77)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C141(0.72); C146(0.72)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C141(0.75); C146(0.75)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C141(0.90); C146(0.90)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C141(0.66); C146(0.66)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C141(0.70); C146(0.70)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C141(0.66); C146(0.66)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C141(0.70); C146(0.70)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C141(0.68); C146(0.68)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C141(0.76); C146(0.76)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C141(0.82); C146(0.82)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C141(0.73); C146(0.73)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C141(0.92); C146(0.92)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C141(0.81); C146(0.81)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C141(1.11); C146(1.11)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C141(0.96); C146(0.96)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C141(1.11); C146(1.11)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C141(1.11); C146(1.11)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C141(0.88); C146(0.88)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C141(1.04); C146(1.04)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C141(1.07); C146(1.07)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C141(0.95); C146(0.95)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C141(0.89); C146(0.89)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C141(1.00); C146(1.00)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C141(1.04); C146(1.04)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C141(0.97); C146(0.97)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C141(0.99); C146(0.99)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C141(1.02); C146(1.02)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C141(0.96); C146(0.96)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C141(1.90); C146(1.90)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C141(2.14); C146(2.14)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C141(1.99); C146(1.99)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C141(1.59); C146(1.59)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C141(1.79); C146(1.79)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C141(1.90); C146(1.90)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C141(2.12); C146(2.12)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C141(1.84); C146(1.84)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C141(1.93); C146(1.93)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C141(1.96); C146(1.96)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C141(1.82); C146(1.82)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C141(2.63); C146(2.63)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C141(1.82); C146(1.82)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C141(1.89); C146(1.89)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C141(1.97); C146(1.97)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C141(1.07); C146(1.07)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C141(1.51); C146(1.51)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C141(1.10); C146(1.10)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C141(1.25); C146(1.25)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C141(0.90); C146(0.90)  LDD0592  [3]
 LDCM0632  CL-Sc Hep-G2 C5(0.40)  LDD2227  [5]
 LDCM0367  CL1 HCT 116 C141(1.04); C146(1.04)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C141(1.05); C146(1.05)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C141(0.92); C146(0.92)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C141(1.02); C146(1.02)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C141(1.20); C146(1.20)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C141(1.40); C146(1.40)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C141(1.21); C146(1.21)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C141(1.35); C146(1.35)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C141(1.19); C146(1.19)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C141(0.86); C146(0.86)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C141(1.24); C146(1.24)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C141(1.05); C146(1.05)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C141(1.44); C146(1.44)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C141(1.16); C146(1.16)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C141(1.10); C146(1.10)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C141(1.00)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C141(1.12)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C141(1.36)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C141(1.22)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C141(0.82)  LDD0703  [3]
 LDCM0387  CL117 HEK-293T C141(1.57); C146(1.57)  LDD0985  [3]
 LDCM0388  CL118 HEK-293T C141(1.76); C146(1.76)  LDD0986  [3]
 LDCM0389  CL119 HEK-293T C141(1.20); C146(1.20)  LDD0987  [3]
 LDCM0390  CL12 HCT 116 C141(1.05); C146(1.05)  LDD0707  [3]
 LDCM0391  CL120 HEK-293T C141(1.31); C146(1.31)  LDD0989  [3]
 LDCM0392  CL121 HCT 116 C141(0.89); C146(0.89)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C141(0.84); C146(0.84)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C141(0.93); C146(0.93)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C141(0.90); C146(0.90)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C141(0.88); C146(0.88)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C141(0.86); C146(0.86)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C141(0.88); C146(0.88)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C141(0.80); C146(0.80)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C141(1.08); C146(1.08)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C141(1.06); C146(1.06)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C141(1.08); C146(1.08)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C141(1.18); C146(1.19)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C146(0.89); C141(1.10)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C146(0.47); C141(0.71)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C146(0.53); C141(0.66)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C141(0.92); C146(0.92)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C146(0.58); C141(0.78)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C146(0.59); C141(0.81)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C146(0.66); C141(0.83)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C141(1.34); C146(1.49)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C146(0.55); C141(0.90)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C141(0.92); C146(0.68)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C141(0.82); C146(0.78)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C141(1.03); C146(0.78)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C141(0.98); C146(0.69)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C141(0.77); C146(0.52)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C141(0.94); C146(0.94)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C141(0.72); C146(0.62)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C141(0.65); C146(0.65)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C141(0.58); C146(0.58)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C141(0.71); C146(0.71)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C141(0.72); C146(0.72)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C141(0.82); C146(0.82)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C141(0.72); C146(0.72)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C141(0.82); C146(0.82)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C141(0.66); C146(0.66)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C141(1.01); C146(1.01)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C141(0.65); C146(0.65)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C141(0.72); C146(0.72)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C141(0.71); C146(0.71)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C141(0.61); C146(0.61)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C141(0.73); C146(0.73)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C141(0.75); C146(0.75)  LDD0752  [3]
 LDCM0436  CL46 HEK-293T C141(0.98); C146(0.93)  LDD1034  [3]
 LDCM0437  CL47 HEK-293T C141(1.12); C146(1.10)  LDD1035  [3]
 LDCM0438  CL48 HEK-293T C141(1.13); C146(0.98)  LDD1036  [3]
 LDCM0439  CL49 HEK-293T C141(0.92); C146(0.86)  LDD1037  [3]
 LDCM0440  CL5 HCT 116 C141(1.16); C146(1.16)  LDD0757  [3]
 LDCM0441  CL50 HEK-293T C141(1.05); C146(1.01)  LDD1039  [3]
 LDCM0442  CL51 HEK-293T C141(1.06); C146(0.93)  LDD1040  [3]
 LDCM0443  CL52 HEK-293T C141(0.80); C146(0.78)  LDD1041  [3]
 LDCM0444  CL53 HEK-293T C141(1.15); C146(1.05)  LDD1042  [3]
 LDCM0445  CL54 HEK-293T C141(0.96); C146(0.89)  LDD1043  [3]
 LDCM0446  CL55 HEK-293T C141(1.07); C146(0.92)  LDD1044  [3]
 LDCM0447  CL56 HEK-293T C141(1.20); C146(1.02)  LDD1045  [3]
 LDCM0448  CL57 HEK-293T C141(1.09); C146(0.88)  LDD1046  [3]
 LDCM0449  CL58 HEK-293T C141(0.95); C146(0.99)  LDD1047  [3]
 LDCM0450  CL59 HEK-293T C141(1.12); C146(0.90)  LDD1048  [3]
 LDCM0451  CL6 HCT 116 C141(1.06); C146(1.06)  LDD0768  [3]
 LDCM0452  CL60 HEK-293T C141(1.00); C146(0.85)  LDD1050  [3]
 LDCM0453  CL61 PaTu 8988t C141(0.69)  LDD1332  [3]
 LDCM0454  CL62 PaTu 8988t C141(0.70)  LDD1333  [3]
 LDCM0455  CL63 PaTu 8988t C141(0.51)  LDD1334  [3]
 LDCM0456  CL64 PaTu 8988t C141(1.16)  LDD1335  [3]
 LDCM0457  CL65 PaTu 8988t C141(0.68)  LDD1336  [3]
 LDCM0458  CL66 PaTu 8988t C141(0.72)  LDD1337  [3]
 LDCM0459  CL67 PaTu 8988t C141(0.90)  LDD1338  [3]
 LDCM0460  CL68 PaTu 8988t C141(1.26)  LDD1339  [3]
 LDCM0461  CL69 PaTu 8988t C141(0.73)  LDD1340  [3]
 LDCM0462  CL7 HCT 116 C141(1.02); C146(1.02)  LDD0779  [3]
 LDCM0463  CL70 PaTu 8988t C141(0.61)  LDD1342  [3]
 LDCM0464  CL71 PaTu 8988t C141(0.86)  LDD1343  [3]
 LDCM0465  CL72 PaTu 8988t C141(0.76)  LDD1344  [3]
 LDCM0466  CL73 PaTu 8988t C141(0.66)  LDD1345  [3]
 LDCM0467  CL74 PaTu 8988t C141(0.54)  LDD1346  [3]
 LDCM0469  CL76 PaTu 8988t C146(0.59); C141(0.66)  LDD1348  [3]
 LDCM0470  CL77 PaTu 8988t C146(0.90); C141(0.80)  LDD1349  [3]
 LDCM0471  CL78 PaTu 8988t C146(1.36); C141(1.08)  LDD1350  [3]
 LDCM0472  CL79 PaTu 8988t C146(0.70); C141(0.86)  LDD1351  [3]
 LDCM0473  CL8 HCT 116 C141(1.37); C146(1.37)  LDD0790  [3]
 LDCM0474  CL80 PaTu 8988t C146(0.55); C141(0.69)  LDD1353  [3]
 LDCM0475  CL81 PaTu 8988t C146(0.72); C141(0.76)  LDD1354  [3]
 LDCM0476  CL82 PaTu 8988t C146(0.82); C141(0.78)  LDD1355  [3]
 LDCM0477  CL83 PaTu 8988t C146(0.76); C141(0.74)  LDD1356  [3]
 LDCM0478  CL84 PaTu 8988t C146(0.62); C141(0.76)  LDD1357  [3]
 LDCM0479  CL85 PaTu 8988t C146(1.16); C141(1.10)  LDD1358  [3]
 LDCM0480  CL86 PaTu 8988t C146(0.68); C141(0.77)  LDD1359  [3]
 LDCM0481  CL87 PaTu 8988t C146(0.87); C141(0.95)  LDD1360  [3]
 LDCM0482  CL88 PaTu 8988t C146(1.01); C141(0.90)  LDD1361  [3]
 LDCM0483  CL89 PaTu 8988t C146(0.73); C141(0.67)  LDD1362  [3]
 LDCM0484  CL9 HCT 116 C141(0.95); C146(0.95)  LDD0801  [3]
 LDCM0485  CL90 PaTu 8988t C146(0.81); C141(0.76)  LDD1364  [3]
 LDCM0486  CL91 HCT 116 C141(0.99); C146(0.99)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C141(1.05); C146(1.05)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C141(1.10); C146(1.10)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C141(0.94); C146(0.94)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C141(1.18); C146(1.18)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C141(1.13); C146(1.13)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C141(1.08); C146(1.08)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C141(1.00); C146(1.00)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C141(0.98); C146(0.98)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C540(0.92); C141(1.01)  LDD1698  [10]
 LDCM0625  F8 Ramos C540(1.76)  LDD2187  [11]
 LDCM0572  Fragment10 Ramos C540(1.97)  LDD2189  [11]
 LDCM0573  Fragment11 Ramos C540(1.38)  LDD2190  [11]
 LDCM0574  Fragment12 Ramos C540(1.78)  LDD2191  [11]
 LDCM0575  Fragment13 Ramos C540(1.22)  LDD2192  [11]
 LDCM0576  Fragment14 Ramos C540(0.96)  LDD2193  [11]
 LDCM0579  Fragment20 Ramos C540(1.74)  LDD2194  [11]
 LDCM0580  Fragment21 Ramos C540(1.16)  LDD2195  [11]
 LDCM0582  Fragment23 Ramos C540(1.47)  LDD2196  [11]
 LDCM0578  Fragment27 Ramos C540(1.27)  LDD2197  [11]
 LDCM0586  Fragment28 Ramos C540(0.98)  LDD2198  [11]
 LDCM0588  Fragment30 Ramos C540(1.27)  LDD2199  [11]
 LDCM0589  Fragment31 Ramos C540(0.98)  LDD2200  [11]
 LDCM0590  Fragment32 Ramos C540(1.88)  LDD2201  [11]
 LDCM0468  Fragment33 PaTu 8988t C141(0.59)  LDD1347  [3]
 LDCM0596  Fragment38 Ramos C540(0.77)  LDD2203  [11]
 LDCM0566  Fragment4 Ramos C540(1.04)  LDD2184  [11]
 LDCM0427  Fragment51 HCT 116 C141(0.85); C146(0.85)  LDD0744  [3]
 LDCM0610  Fragment52 Ramos C540(0.97)  LDD2204  [11]
 LDCM0614  Fragment56 Ramos C540(1.00)  LDD2205  [11]
 LDCM0569  Fragment7 Ramos C540(1.16)  LDD2186  [11]
 LDCM0571  Fragment9 Ramos C540(1.69)  LDD2188  [11]
 LDCM0022  KB02 HEK-293T C540(1.00); C141(0.93)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C540(1.17); C141(0.92)  LDD1497  [10]
 LDCM0024  KB05 MEL167 C540(2.21)  LDD3316  [12]

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840