Details of the Target

General Information of Target

Target ID LDTP08203
Target Name E3 ubiquitin-protein ligase synoviolin (SYVN1)
Gene Name SYVN1
Gene ID 84447
Synonyms
HRD1; KIAA1810; E3 ubiquitin-protein ligase synoviolin; EC 2.3.2.27; RING-type E3 ubiquitin transferase synoviolin; Synovial apoptosis inhibitor 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFRTAVMMAASLALTGAVVAHAYYLKHQFYPTVVYLTKSSPSMAVLYIQAFVLVFLLGKV
MGKVFFGQLRAAEMEHLLERSWYAVTETCLAFTVFRDDFSPRFVALFTLLLFLKCFHWLA
EDRVDFMERSPNISWLFHCRIVSLMFLLGILDFLFVSHAYHSILTRGASVQLVFGFEYAI
LMTMVLTIFIKYVLHSVDLQSENPWDNKAVYMLYTELFTGFIKVLLYMAFMTIMIKVHTF
PLFAIRPMYLAMRQFKKAVTDAIMSRRAIRNMNTLYPDATPEELQAMDNVCIICREEMVT
GAKRLPCNHIFHTSCLRSWFQRQQTCPTCRMDVLRASLPAQSPPPPEPADQGPPPAPHPP
PLLPQPPNFPQGLLPPFPPGMFPLWPPMGPFPPVPPPPSSGEAVAPPSTSAAALSRPSGA
ATTTAAGTSATAASATASGPGSGSAPEAGPAPGFPFPPPWMGMPLPPPFAFPPMPVPPAG
FAGLTPEELRALEGHERQHLEARLQSLRNIHTLLDAAMLQINQYLTVLASLGPPRPATSV
NSTEETATTVVAAASSTSIPSSEATTPTPGASPPAPEMERPPAPESVGTEEMPEDGEPDA
AELRRRRLQKLESPVAH
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
HRD1 family
Subcellular location
Endoplasmic reticulum membrane
Function
E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis. Mediates the ubiquitination and subsequent degradation of cytoplasmic NFE2L1. During the early stage of B cell development, required for degradation of the pre-B cell receptor (pre-BCR) complex, hence supporting further differentiation into mature B cells.
TTD ID
T01441
Uniprot ID
Q86TM6
DrugMap ID
TT8XKYM
Ensemble ID
ENST00000294256.12
HGNC ID
HGNC:20738

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
SNGM SNV: p.R129C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K303(3.47); K610(10.00)  LDD0277  [1]
IPM
 Probe Info  		C139(0.00); C326(0.00); C329(0.00)  LDD0241  [2]
BTD
 Probe Info  		C326(1.20)  LDD2152  [3]
IA-alkyne
 Probe Info  		C139(0.67)  LDD2182  [4]
Acrolein
 Probe Info  		N.A.  LDD0227  [5]
DBIA
 Probe Info  		C326(2.42); C329(2.42)  LDD0078  [6]
W1
 Probe Info  		C326(0.00); C329(0.00)  LDD0236  [2]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C106
 Probe Info  		20.11  LDD1793  [7]
C348
 Probe Info  		10.41  LDD2009  [7]
C349
 Probe Info  		12.21  LDD2010  [7]
C350
 Probe Info  		37.53  LDD2011  [7]
STS-1
 Probe Info  		N.A.  LDD0137  [8]
VE-P
 Probe Info  		N.A.  LDD0396  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C326(1.20)  LDD2152  [3]
 LDCM0214  AC1 HCT 116 C326(0.49); C329(0.49)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C326(1.02); C329(1.02)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C326(0.75); C329(0.75)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C326(0.80); C329(0.80)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C326(0.91); C329(0.91)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C326(0.67); C329(0.67)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C326(0.93); C329(0.93)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C326(0.82); C329(0.82)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C326(0.58); C329(0.58)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C326(0.64); C329(0.64)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C326(0.63); C329(0.63)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C326(0.86); C329(0.86)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C326(1.14); C329(1.14)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C326(0.64); C329(0.64)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C326(0.73); C329(0.73)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C326(0.67); C329(0.67)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C139(1.21); C329(1.27)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C139(1.59); C329(1.32)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C139(1.61); C329(1.21)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C139(1.19); C329(1.06)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C139(1.19); C329(1.42)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C139(1.23); C329(1.52)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C139(0.99); C329(1.78)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C326(1.20); C329(1.20)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C139(1.25); C329(1.25)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C139(0.93); C329(1.77)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C139(1.78); C329(1.46)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C139(1.14); C329(1.50)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C139(1.08); C329(1.15)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C139(1.60); C329(1.00)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C139(1.51); C329(1.56)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C139(0.95); C329(1.21)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C139(1.23); C326(1.04); C329(1.04)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C139(1.74); C326(0.68); C329(0.68)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C139(0.94); C326(1.00); C329(1.00)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C139(0.87); C326(0.88); C329(0.88)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C139(0.90); C326(1.16); C329(1.16)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C139(1.04); C326(0.86); C329(0.86)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C139(1.33); C326(0.95); C329(0.95)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C139(1.17); C326(0.87); C329(0.87)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C139(1.34); C326(0.72); C329(0.72)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C139(1.19); C326(0.99); C329(0.99)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C139(1.30); C326(0.89); C329(0.89)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C139(1.07); C326(0.85); C329(0.85)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C326(0.99); C329(0.99)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C139(1.07); C326(0.76); C329(0.76)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C139(0.95); C326(1.04); C329(1.04)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C139(1.14); C326(0.98); C329(0.98)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C326(0.84); C329(0.84)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C326(0.81); C329(0.81)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C326(1.17); C329(1.17)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C326(0.94); C329(0.94)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C326(1.50); C329(1.50)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C326(1.49); C329(1.49)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C326(1.27); C329(1.27)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C326(0.99); C329(0.99)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C326(1.00); C329(1.00)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C326(0.66); C329(0.66)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C326(0.60); C329(0.60)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C326(1.07); C329(1.07)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C326(0.69); C329(0.69)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C326(0.57); C329(0.57)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C326(0.68); C329(0.68)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C326(0.59); C329(0.59)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C326(1.03); C329(1.03)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C326(0.92); C329(0.92)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C326(1.01); C329(1.01)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C326(0.61); C329(0.61)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C326(0.89); C329(0.89)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C326(0.96); C329(0.96)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C326(0.96); C329(0.96)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C326(0.87); C329(0.87)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C326(1.01); C329(1.01)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C326(0.71); C329(0.71)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C326(0.76); C329(0.76)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C326(0.60); C329(0.60)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C326(0.63); C329(0.63)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C326(0.79); C329(0.79)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C326(0.78); C329(0.78)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C326(0.62); C329(0.62)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C326(0.58); C329(0.58)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C326(0.60); C329(0.60)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C326(0.63); C329(0.63)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C326(0.58); C329(0.58)  LDD0612  [6]
 LDCM0297  AC36 HEK-293T C326(1.04)  LDD1536  [10]
 LDCM0299  AC38 HEK-293T C329(0.89)  LDD1538  [10]
 LDCM0300  AC39 HEK-293T C329(1.04)  LDD1539  [10]
 LDCM0301  AC4 HCT 116 C326(0.66); C329(0.66)  LDD0618  [6]
 LDCM0302  AC40 HEK-293T C329(1.10)  LDD1541  [10]
 LDCM0303  AC41 HEK-293T C329(1.02)  LDD1542  [10]
 LDCM0304  AC42 HEK-293T C329(0.94)  LDD1543  [10]
 LDCM0306  AC44 HEK-293T C326(0.95)  LDD1545  [10]
 LDCM0308  AC46 HCT 116 C326(1.45); C329(1.45)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C326(1.84); C329(1.84)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C326(1.11); C329(1.11)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C326(1.23); C329(1.23)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C326(0.49); C329(0.49)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C326(0.73); C329(0.73)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C326(1.13); C329(1.13)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C326(1.29); C329(1.29)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C326(1.43); C329(1.43)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C326(0.90); C329(0.90)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C326(1.12); C329(1.12)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C326(0.96); C329(0.96)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C326(0.87); C329(0.87)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C326(0.79); C329(0.79)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C326(0.88); C329(0.88)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C326(0.95); C329(0.95)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C326(0.85); C329(0.85)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C326(0.84); C329(0.84)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C326(1.06); C329(1.06)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C326(0.87); C329(0.87)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C326(0.99); C329(0.99)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C326(0.82); C329(0.82)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C326(0.84); C329(0.84)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C326(0.73); C329(0.73)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C139(1.05); C326(1.07); C329(1.46)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C139(0.97); C326(1.02); C329(1.16)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C326(1.17); C329(1.17)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C139(0.79); C326(1.02); C329(1.26)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C326(0.90); C139(1.16); C329(1.20)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C326(0.94); C139(1.24); C329(1.36)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C326(1.01); C329(1.26); C139(1.28)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C326(0.91); C139(1.34); C329(1.71)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C326(0.86); C329(1.18); C139(1.46)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C326(0.98); C139(1.08); C329(1.46)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C326(0.79); C139(1.18); C329(1.19)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C326(0.90); C139(1.03); C329(1.07)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C326(0.80); C139(1.15); C329(1.19)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C326(1.04); C329(1.04)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C326(1.03); C139(1.40); C329(1.99)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C326(0.83); C139(1.02); C329(1.65)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C326(0.73); C139(1.19); C329(1.31)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C326(0.79); C139(1.10); C329(1.12)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C326(0.72); C329(0.99); C139(1.20)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C326(0.71); C139(0.84); C329(0.99)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C326(0.79); C139(0.82); C329(0.88)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C326(0.83); C329(1.02); C139(1.06)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C139(0.85); C326(0.97); C329(1.15)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C326(0.85); C329(0.95); C139(1.09)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C326(0.84); C329(1.02); C139(1.04)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C326(0.98); C139(1.05); C329(1.28)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C326(0.79); C139(1.02); C329(1.06)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C139(0.75); C326(0.85); C329(0.97)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C326(0.64); C329(0.88); C139(0.94)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C326(0.74); C139(0.89); C329(0.93)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C326(0.67); C329(0.87); C139(0.88)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C326(0.87); C139(0.95); C329(1.16)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C326(0.81); C329(0.81)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C326(0.71); C329(0.71)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C326(1.24); C329(1.24)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C326(1.12); C329(1.12)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C326(1.01); C329(1.01)  LDD0592  [6]
 LDCM0020  ARS-1620 HCC44 C326(2.42); C329(2.42)  LDD0078  [6]
 LDCM0367  CL1 HCT 116 C326(1.36); C329(1.36)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C326(1.22); C329(1.22)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C326(0.52); C329(0.52)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C326(1.26); C329(1.26)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C326(1.02); C329(1.02)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C326(1.54); C329(1.54)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C326(1.21); C329(1.21)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C326(0.93); C329(0.93)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C326(0.88); C329(0.88)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C326(0.91); C329(0.91)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C326(0.98); C329(0.98)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C326(0.96); C329(0.96)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C326(1.49); C329(1.49)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C326(0.95); C329(0.95)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C326(0.86); C329(0.86)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C326(0.83); C329(0.83)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C326(0.64); C329(0.64)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C326(0.70); C329(0.70)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C326(0.57); C329(0.57)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C326(0.56); C329(0.56)  LDD0703  [6]
 LDCM0387  CL117 HEK-293T C329(0.94)  LDD1591  [10]
 LDCM0388  CL118 HEK-293T C329(0.82)  LDD1592  [10]
 LDCM0389  CL119 HEK-293T C329(1.54)  LDD1593  [10]
 LDCM0390  CL12 HCT 116 C326(1.47); C329(1.47)  LDD0707  [6]
 LDCM0391  CL120 HEK-293T C329(1.07)  LDD1595  [10]
 LDCM0392  CL121 HCT 116 C326(1.10); C329(1.10)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C326(1.20); C329(1.20)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C326(0.75); C329(0.75)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C326(1.18); C329(1.18)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C326(0.99); C329(0.99)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C326(1.08); C329(1.08)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C326(0.99); C329(0.99)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C326(0.90); C329(0.90)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C326(1.25); C329(1.25)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C326(1.26); C329(1.26)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C326(1.38); C329(1.38)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C326(1.34); C329(1.34)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C326(1.07); C329(1.07)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C326(1.22); C329(1.22)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C326(1.21); C329(1.21)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C326(1.51); C329(1.51)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C326(1.32); C329(1.32)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C326(1.29); C329(1.29)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C326(1.68); C329(1.68)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C326(1.40); C329(1.40)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C326(1.34); C329(1.34)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C326(1.44); C329(1.44)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C326(1.34); C329(1.34)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C326(1.34); C329(1.34)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C326(1.29); C329(1.29)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C326(1.31); C329(1.31)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C326(1.55); C329(1.55)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C326(1.45); C329(1.45)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C326(0.79); C329(0.79)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C326(0.79); C329(0.79)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C326(0.77); C329(0.77)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C326(0.74); C329(0.74)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C326(0.75); C329(0.75)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C326(0.90); C329(0.90)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C326(0.77); C329(0.77)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C326(0.89); C329(0.89)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C326(1.27); C329(1.27)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C326(0.80); C329(0.80)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C326(1.08); C329(1.08)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C326(0.80); C329(0.80)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C326(0.81); C329(0.81)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C326(0.71); C329(0.71)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C326(0.82); C329(0.82)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C326(1.16); C329(1.16)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C326(1.23); C329(1.23)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C326(1.12); C329(1.12)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C326(1.48); C329(1.48)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C326(1.51); C329(1.51)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C326(1.18); C329(1.18)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C326(1.28); C329(1.28)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C326(1.17); C329(1.17)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C326(0.84); C329(0.84)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C326(1.08); C329(1.08)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C326(1.20); C329(1.20)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C326(1.10); C329(1.10)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C326(1.42); C329(1.42)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C326(1.24); C329(1.24)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C326(1.35); C329(1.35)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C326(1.24); C329(1.24)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C326(1.36); C329(1.36)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C326(1.24); C329(1.24)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C326(0.97); C329(0.97)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C326(0.86); C329(0.86)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C326(0.92); C329(0.92)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C326(0.89); C329(0.89)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C326(0.98); C329(0.98)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C326(0.97); C329(0.97)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C326(1.05); C329(1.05)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C326(0.93); C329(0.93)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C326(1.37); C329(1.37)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C326(0.84); C329(0.84)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C326(0.93); C329(0.93)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C326(0.96); C329(0.96)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C326(1.03); C329(1.03)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C326(1.03); C329(1.03)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C326(0.94); C329(0.94)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C326(0.87); C329(0.87)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C326(0.97); C329(0.97)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C326(0.95); C329(0.95)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C326(1.17); C329(1.17)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C326(0.95); C329(0.95)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C326(0.84); C329(0.84)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C326(0.92); C329(0.92)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C326(0.85); C329(0.85)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C326(1.03); C329(1.03)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C326(0.79); C329(0.79)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C326(0.87); C329(0.87)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C326(0.84); C329(0.84)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C326(0.88); C329(0.88)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C326(1.02); C329(1.02)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C326(1.30); C329(1.30)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C326(0.91); C329(0.91)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C326(0.80); C329(0.80)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C326(0.40); C329(0.40)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C326(0.54); C329(0.54)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C326(1.00); C329(1.00)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C326(0.55); C329(0.55)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C326(0.77); C329(0.77)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C326(0.64); C329(0.64)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C326(0.73); C329(0.73)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C326(0.59); C329(0.59)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C329(1.17)  LDD1698  [10]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C329(2.29)  LDD1702  [3]
 LDCM0625  F8 Ramos C139(1.00)  LDD2187  [4]
 LDCM0572  Fragment10 Ramos C139(0.48)  LDD2189  [4]
 LDCM0573  Fragment11 Ramos C139(1.13)  LDD2190  [4]
 LDCM0574  Fragment12 Ramos C139(0.45)  LDD2191  [4]
 LDCM0575  Fragment13 Ramos C139(0.53)  LDD2192  [4]
 LDCM0576  Fragment14 Ramos C139(1.27)  LDD2193  [4]
 LDCM0579  Fragment20 Ramos C139(0.67)  LDD2194  [4]
 LDCM0580  Fragment21 Ramos C139(0.60)  LDD2195  [4]
 LDCM0582  Fragment23 Ramos C139(1.29)  LDD2196  [4]
 LDCM0578  Fragment27 Ramos C139(0.87)  LDD2197  [4]
 LDCM0586  Fragment28 Ramos C139(1.78)  LDD2198  [4]
 LDCM0588  Fragment30 Ramos C139(0.75)  LDD2199  [4]
 LDCM0589  Fragment31 Ramos C139(0.43)  LDD2200  [4]
 LDCM0590  Fragment32 Ramos C139(0.37)  LDD2201  [4]
 LDCM0468  Fragment33 HCT 116 C326(0.96); C329(0.96)  LDD0785  [6]
 LDCM0596  Fragment38 Ramos C139(1.30)  LDD2203  [4]
 LDCM0566  Fragment4 Ramos C139(0.92)  LDD2184  [4]
 LDCM0427  Fragment51 HCT 116 C326(1.07); C329(1.07)  LDD0744  [6]
 LDCM0610  Fragment52 Ramos C139(1.02)  LDD2204  [4]
 LDCM0614  Fragment56 Ramos C139(0.66)  LDD2205  [4]
 LDCM0569  Fragment7 Ramos C139(0.63)  LDD2186  [4]
 LDCM0571  Fragment9 Ramos C139(0.59)  LDD2188  [4]
 LDCM0022  KB02 HEK-293T C307(1.02); C329(0.83); C326(0.97)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C307(1.19); C329(0.78); C326(1.06)  LDD1497  [10]
 LDCM0024  KB05 HEK-293T C307(1.08); C329(0.72); C326(1.07)  LDD1502  [10]
 LDCM0109  NEM HeLa N.A.  LDD0227  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin carboxyl-terminal hydrolase 15 (USP15) Peptidase C19 family Q9Y4E8
Ubiquitin-conjugating enzyme E2 J1 (UBE2J1) Ubiquitin-conjugating enzyme family Q9Y385
Transporter and channel
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Erlin-1 (ERLIN1) Band 7/mec-2 family O75477
Erlin-2 (ERLIN2) Band 7/mec-2 family O94905
Cellular tumor antigen p53 (TP53) P53 family P04637
Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1) Ser/Thr protein kinase family O75460
Protein sel-1 homolog 1 (SEL1L) Sel-1 family Q9UBV2
Protein FAM8A1 (FAM8A1) . Q9UBU6

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
8 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
9 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402