Details of the Target

General Information of Target

Target ID LDTP02879
Target Name Zinc finger protein 24 (ZNF24)
Gene Name ZNF24
Gene ID 7572
Synonyms
KOX17; ZNF191; ZSCAN3; Zinc finger protein 24; Retinoic acid suppression protein A; RSG-A; Zinc finger and SCAN domain-containing protein 3; Zinc finger protein 191; Zinc finger protein KOX17
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSAQSVEEDSILIIPTPDEEEKILRVKLEEDPDGEEGSSIPWNHLPDPEIFRQRFRQFGY
QDSPGPREAVSQLRELCRLWLRPETHTKEQILELVVLEQFVAILPKELQTWVRDHHPENG
EEAVTVLEDLESELDDPGQPVSLRRRKREVLVEDMVSQEEAQGLPSSELDAVENQLKWAS
WELHSLRHCDDDGRTENGALAPKQELPSALESHEVPGTLNMGVPQIFKYGETCFPKGRFE
RKRNPSRKKQHICDECGKHFSQGSALILHQRIHSGEKPYGCVECGKAFSRSSILVQHQRV
HTGEKPYKCLECGKAFSQNSGLINHQRIHTGEKPYECVQCGKSYSQSSNLFRHQRRHNAE
KLLNVVKV
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function
Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence. Has transcription repressor activity in vitro.
Uniprot ID
P17028
Ensemble ID
ENST00000261332.11
HGNC ID
HGNC:13032

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MFE319 SNV: p.G222S .
RKO SNV: p.Q204H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.05  LDD0402  [1]
TH211
 Probe Info  		Y279(12.31)  LDD0257  [2]
AHL-Pu-1
 Probe Info  		C233(2.41)  LDD0169  [3]
DBIA
 Probe Info  		C233(2.26); C253(1.76); C256(1.76)  LDD0080  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
TFBX
 Probe Info  		N.A.  LDD0027  [7]
IPM
 Probe Info  		N.A.  LDD0005  [8]
VSF
 Probe Info  		N.A.  LDD0007  [8]
Phosphinate-6
 Probe Info  		C337(0.00); C340(0.00); C281(0.00); C233(0.00)  LDD0018  [9]
AOyne
 Probe Info  		15.00  LDD0443  [10]
NAIA_5
 Probe Info  		N.A.  LDD2223  [6]
HHS-482
 Probe Info  		Y307(1.28)  LDD2239  [11]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C106
 Probe Info  		16.56  LDD1793  [12]
FFF probe11
 Probe Info  		20.00  LDD0471  [13]
FFF probe2
 Probe Info  		14.59  LDD0463  [13]
FFF probe4
 Probe Info  		20.00  LDD0466  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C233(2.41)  LDD0169  [3]
 LDCM0214  AC1 HCT 116 C189(0.73); C233(0.79); C340(1.03)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C189(0.90); C233(0.75)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C233(1.12)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C233(1.10)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C233(1.03)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C233(1.25)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C233(1.02)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C233(1.21)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C233(1.34)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C233(1.26)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C233(1.07)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C233(0.85)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C189(1.03); C233(0.79)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C233(1.04)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C233(1.07)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C233(1.11)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C189(0.90); C233(0.88); C337(0.82); C340(0.82)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C189(1.03); C233(0.85); C337(0.74); C340(0.74)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C189(0.88); C233(0.91); C337(0.79); C340(0.79)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C189(0.98); C233(0.86); C337(0.71); C340(0.71)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C189(0.88); C233(0.77); C337(0.71); C340(0.71)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C189(0.86); C233(0.83); C337(0.58); C340(0.58)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C189(0.96); C233(0.97); C337(0.70); C340(0.70)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C189(0.83); C233(0.66)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C189(0.93); C233(0.91); C337(0.69); C340(0.69)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C189(0.78); C233(0.79); C337(0.79); C340(0.79)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C189(1.08); C233(0.80); C337(0.70); C340(0.70)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C189(1.30); C233(0.84); C337(0.64); C340(0.64)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C189(0.83); C233(0.78); C337(0.71); C340(0.71)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C189(1.02); C233(0.79); C337(0.73); C340(0.73)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C189(0.92); C233(0.84); C337(0.76); C340(0.76)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C189(0.88); C233(0.79); C337(0.65); C340(0.65)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C233(0.45)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C233(0.49)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C233(0.52)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C233(0.48)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C233(0.59)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C233(0.52)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C233(0.59)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C233(0.58)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C233(0.62)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C233(0.61)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C233(0.73)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C233(0.60)  LDD0575  [4]
 LDCM0259  AC14 HCT 116 C189(0.86); C233(0.71)  LDD0576  [4]
 LDCM0260  AC140 HCT 116 C233(0.65)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C233(0.67)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C233(0.55)  LDD0579  [4]
 LDCM0263  AC143 HCT 116 C233(1.14)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C233(0.89)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C233(1.07)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C233(1.33)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C233(1.18)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C233(1.53)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C233(1.19)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C189(0.79); C233(0.86)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C233(0.96)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C233(1.14)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C233(1.02)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C233(1.60)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C233(1.21)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C233(1.21)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C233(1.01)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C233(1.13)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C233(1.06)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C233(1.44)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C233(1.05)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C233(0.91); C189(1.01); C340(1.20)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C233(1.03)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C233(1.60)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C233(1.29)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C233(0.88)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C233(0.97)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C233(0.89); C189(1.45)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C233(0.99); C189(1.61)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C233(0.99); C189(1.75)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C233(0.93); C189(1.56)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C233(0.93); C189(1.58)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C233(0.78); C189(0.97); C340(1.15)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C233(0.78); C189(1.77)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C233(1.01); C189(1.42)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C233(1.05); C189(1.48)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C233(0.95); C189(1.90)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C233(1.20); C189(2.00)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C233(0.77); C189(1.15)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C189(0.69); C233(0.96)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C189(0.97); C233(0.98)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C189(0.87); C233(0.98)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C189(0.77); C233(0.92)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C233(0.61); C189(0.91); C340(1.23)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C233(0.91); C189(0.96)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C189(0.82); C233(1.37)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C189(0.71); C233(1.31)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C189(0.74); C233(1.22)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C189(0.98); C233(1.27)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C189(0.83); C233(1.23)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C189(1.03); C233(1.20)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C233(1.02); C189(1.10)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C233(1.14); C189(1.28)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C189(1.25); C233(1.34)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C233(0.69); C189(0.80); C340(1.02)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C233(1.10); C189(1.34)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C233(0.91); C189(0.96)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C189(0.92); C233(1.11)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C189(1.12); C233(1.21)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C189(0.92); C233(1.12)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C233(1.23); C189(1.69)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C233(1.68); C189(1.97)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C233(0.81)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C233(0.85)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C233(0.75)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C233(0.76); C189(0.92)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C233(0.68)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C233(1.03)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C233(0.75)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C233(0.54)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C233(0.67)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C233(1.02)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C233(0.96)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C233(0.86)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C253(0.84); C256(0.84); C233(1.52)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C253(1.07); C256(1.07); C233(1.57)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C233(0.71); C189(0.79)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C253(0.63); C256(0.63); C233(2.35)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C253(0.96); C256(0.96); C233(1.98)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C253(0.75); C256(0.75); C233(1.66)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C253(0.60); C256(0.60); C233(2.37)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C253(0.73); C256(0.73); C233(1.41)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C253(0.57); C256(0.57); C233(1.74)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C253(0.76); C256(0.76); C233(1.70)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C253(0.94); C256(0.94); C233(1.24)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C253(1.06); C256(1.06); C233(2.59)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C253(0.77); C256(0.77); C233(1.92)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C233(0.75); C189(0.81)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C253(0.73); C256(0.73); C233(1.23)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C253(0.97); C256(0.97); C233(1.33)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C253(0.51); C256(0.51); C233(1.15)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C233(1.40); C189(1.45)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C189(1.14); C233(1.19)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C189(0.94); C233(1.25)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C233(1.25); C189(1.30)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C189(1.22); C233(1.40)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C233(1.10); C189(1.13)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C233(1.00); C189(1.25)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C189(1.35); C233(1.41)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C233(0.90); C189(1.03)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C233(1.07); C189(1.22)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C233(1.03); C189(1.05)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C189(0.72); C233(0.84)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C233(0.90); C189(1.31)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C189(0.69); C233(1.06)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C233(0.91); C189(1.28)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C233(1.49)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C233(1.08)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C189(1.05); C233(0.72)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C233(0.74); C189(1.00)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C233(0.98); C189(1.04)  LDD0592  [4]
 LDCM0020  ARS-1620 HCC44 C233(1.17)  LDD2171  [4]
 LDCM0632  CL-Sc Hep-G2 C189(0.86)  LDD2227  [6]
 LDCM0367  CL1 HCT 116 C189(1.05); C233(1.12)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C189(1.32); C233(1.42)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C233(0.86); C189(1.02); C340(1.32)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C233(0.74); C189(0.84)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C233(0.59); C189(0.80)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C233(0.73); C189(0.79)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C189(0.70); C233(0.73)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C233(0.93)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C233(1.22)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C233(1.04)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C233(1.04)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C233(1.16)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C233(1.38); C189(1.78)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C233(1.35)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C233(1.01)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C233(0.96); C189(1.03)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C233(0.91); C189(1.31)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C233(0.98); C189(1.63)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C233(1.14); C189(1.63)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C233(0.78); C189(1.67)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C233(0.92); C189(1.51)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C189(0.89); C233(0.90)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C189(0.87); C233(1.10)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C233(1.29); C189(1.60)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C233(1.10); C189(1.75)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C233(1.03); C189(1.05)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C233(0.91); C189(1.06)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C189(1.04); C233(1.10)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C189(1.15); C233(1.38)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C233(0.88)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C233(0.95)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C233(0.89)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C233(0.87)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C233(1.23); C189(1.24)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C233(1.16); C189(1.22)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C233(1.16); C189(1.46)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C253(1.05); C256(1.05); C233(1.09); C337(1.19)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C233(0.90); C337(0.98); C340(0.98); C253(1.12)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C337(0.92); C340(0.92); C233(0.93); C189(1.40)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C233(0.80); C337(0.90); C340(0.90); C253(1.13)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C189(1.00); C233(1.02)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C253(0.98); C256(0.98); C233(1.01); C337(1.07)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C233(0.75); C337(0.79); C340(0.79); C253(1.20)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C253(0.83); C256(0.83); C233(0.85); C189(0.89)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C253(0.92); C256(0.92); C233(1.04); C189(1.15)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C189(1.29); C233(0.97); C253(0.93); C256(0.93)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C189(1.06); C233(0.87); C253(0.86); C256(0.86)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C189(1.18); C233(0.92); C253(1.09); C256(1.09)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C189(1.30); C233(0.90); C253(0.98); C256(0.98)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C189(1.57); C233(1.09); C253(1.19); C256(1.19)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C189(1.24); C233(0.86); C253(1.00); C256(1.00)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C189(1.08); C233(1.25)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C189(1.11); C233(0.92); C253(1.29); C256(1.29)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C189(1.03); C233(0.95)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C189(0.96); C233(1.18)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C189(1.34); C233(1.22)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C189(1.35); C233(1.15)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C189(0.98); C233(1.28)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C189(1.11); C233(0.95)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C189(0.89); C233(1.19)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C189(1.20); C233(1.11)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C189(1.24); C233(1.09)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C189(1.06); C233(1.09)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C189(0.99); C233(1.06)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C189(1.07); C233(1.24)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C189(1.06); C233(1.19)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C189(1.03); C233(1.24)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C189(0.97); C233(1.34)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C189(0.93); C233(1.05); C337(1.01); C340(1.01)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C189(0.84); C233(1.09); C337(0.95); C340(0.95)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C189(0.75); C233(1.09); C337(0.99); C340(0.99)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C189(0.98); C233(1.09); C337(1.07); C340(1.07)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C189(1.31); C233(1.03)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C189(0.75); C233(1.26); C337(0.92); C340(0.92)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C189(0.88); C233(0.96); C337(1.06); C340(1.06)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C189(0.90); C233(1.33); C337(1.06); C340(1.06)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C189(0.75); C233(1.16); C337(0.90); C340(0.90)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C189(0.72); C233(0.89); C337(0.83); C340(0.83)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C189(0.78); C233(1.19); C337(1.06); C340(1.06)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C189(0.69); C233(1.45); C337(0.87); C340(0.87)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C189(0.63); C233(1.34); C337(0.86); C340(0.86)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C189(0.90); C233(1.03); C337(1.02); C340(1.02)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C189(0.82); C233(1.19); C337(1.02); C340(1.02)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C189(1.38); C233(1.23)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C189(0.73); C233(1.16); C337(1.11); C340(1.11)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C189(1.26); C233(1.44); C253(1.04); C256(1.04)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C189(1.30); C233(1.31); C253(0.89); C256(0.89)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C189(1.35); C233(1.32); C253(0.81); C256(0.81)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C189(1.17); C233(1.53); C253(0.74); C256(0.74)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C189(1.12); C233(1.20); C253(1.14); C256(1.14)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C189(1.36); C233(1.51); C253(0.57); C256(0.57)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C189(1.30); C233(1.15); C253(0.74); C256(0.74)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C189(1.30); C233(1.12); C253(0.82); C256(0.82)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C189(1.49); C233(1.40); C253(1.02); C256(1.02)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C189(1.50); C233(1.18)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C189(1.43); C233(1.64); C253(1.06); C256(1.06)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C189(1.01); C233(1.57); C253(0.87); C256(0.87)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C189(1.28); C233(1.31); C253(1.11); C256(1.11)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C189(0.99); C233(1.32); C253(0.82); C256(0.82)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C189(1.28); C233(1.36); C253(0.70); C256(0.70)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C189(1.10); C253(0.81); C256(0.81)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C189(2.20); C253(1.03); C256(1.03)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C189(2.10); C253(1.13); C256(1.13)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C189(1.78); C253(1.13); C256(1.13)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C189(1.52); C233(1.51)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C189(1.88); C253(1.30); C256(1.30)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C189(1.36); C253(1.08); C256(1.08)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C189(2.49); C253(1.03); C256(1.03)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C189(2.05); C253(0.76); C256(0.76)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C189(2.20); C253(0.97); C256(0.97)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C189(1.22); C253(0.77); C256(0.77)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C189(1.13); C253(0.83); C256(0.83)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C189(1.22); C253(0.75); C256(0.75)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C189(1.41); C253(0.89); C256(0.89)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C189(2.78); C253(1.04); C256(1.04)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C189(1.14); C233(1.24)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C189(1.91); C253(0.75); C256(0.75)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C189(0.94); C233(0.63); C340(0.98)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C189(0.86); C233(0.63); C340(0.93)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C189(0.85); C233(0.59); C340(0.95)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C189(0.92); C233(0.69); C340(1.26)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C189(0.92); C233(0.89); C340(0.97)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C189(0.98); C233(0.64); C340(1.07)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C189(1.06); C233(0.74); C340(1.29)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C189(0.96); C233(1.12); C340(1.01)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C189(1.01); C233(0.71); C340(1.07)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C189(1.00); C281(1.03)  LDD1698  [14]
 LDCM0573  Fragment11 Ramos C189(20.00)  LDD2190  [15]
 LDCM0576  Fragment14 Ramos C189(1.29)  LDD2193  [15]
 LDCM0586  Fragment28 Ramos C189(0.71)  LDD2198  [15]
 LDCM0468  Fragment33 HCT 116 C189(1.17); C233(1.71); C253(0.76); C256(0.76)  LDD0785  [4]
 LDCM0566  Fragment4 Ramos C189(0.88)  LDD2184  [15]
 LDCM0427  Fragment51 HCT 116 C189(0.80); C233(1.33)  LDD0744  [4]
 LDCM0569  Fragment7 Ramos C189(1.49)  LDD2186  [15]
 LDCM0022  KB02 HCT 116 C233(2.26); C253(1.76); C256(1.76)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C233(1.44); C253(1.88); C256(1.88)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C233(1.84); C253(1.62); C256(1.62)  LDD0082  [4]
 LDCM0021  THZ1 HCT 116 C233(1.17)  LDD2173  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable ATP-dependent RNA helicase DDX6 (DDX6) DEAD box helicase family P26196
E3 ubiquitin-protein ligase DZIP3 (DZIP3) . Q86Y13
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apolipoprotein E (APOE) Apolipoprotein A1/A4/E family P02649
Amyloid-beta precursor protein (APP) APP family P05067
Transcription factor
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and SCAN domain-containing protein 12 (ZSCAN12) Krueppel C2H2-type zinc-finger protein family O43309
Zinc finger and SCAN domain-containing protein 16 (ZSCAN16) Krueppel C2H2-type zinc-finger protein family Q9H4T2
Zinc finger and SCAN domain-containing protein 21 (ZSCAN21) Krueppel C2H2-type zinc-finger protein family Q9Y5A6
Zinc finger and SCAN domain-containing protein 22 (ZSCAN22) Krueppel C2H2-type zinc-finger protein family P10073
Zinc finger and SCAN domain-containing protein 23 (ZSCAN23) Krueppel C2H2-type zinc-finger protein family Q3MJ62
Zinc finger and SCAN domain-containing protein 32 (ZSCAN32) Krueppel C2H2-type zinc-finger protein family Q9NX65
Zinc finger protein 165 (ZNF165) Krueppel C2H2-type zinc-finger protein family P49910
Zinc finger protein 232 (ZNF232) Krueppel C2H2-type zinc-finger protein family Q9UNY5
Zinc finger protein 24 (ZNF24) Krueppel C2H2-type zinc-finger protein family P17028
Zinc finger protein 446 (ZNF446) Krueppel C2H2-type zinc-finger protein family Q9NWS9
Zinc finger protein 620 (ZNF620) Krueppel C2H2-type zinc-finger protein family Q6ZNG0
Zinc finger protein with KRAB and SCAN domains 4 (ZKSCAN4) Krueppel C2H2-type zinc-finger protein family Q969J2
Other
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid beta precursor like protein 1 (APLP1) APP family P51693
Microtubule-associated proteins 1A/1B light chain 3C (MAP1LC3C) ATG8 family Q9BXW4
Probable splicing factor YJU2B (YJU2B) CWC16 family P13994
Protein FAM161A (FAM161A) FAM161 family Q3B820
U4/U6 small nuclear ribonucleoprotein Prp31 (PRPF31) PRP31 family Q8WWY3
TRPM8 channel-associated factor 1 (TCAF1) TCAF family Q9Y4C2
PiggyBac transposable element-derived protein 1 (PGBD1) . Q96JS3
Rhombotin-1 (LMO1) . P25800
Rhombotin-2 (LMO2) . P25791
SCAN domain-containing protein 1 (SCAND1) . P57086

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578