Details of the Target

General Information of Target

Target ID LDTP13689
Target Name Conserved oligomeric Golgi complex subunit 5 (COG5)
Gene Name COG5
Gene ID 10466
Synonyms
GOLTC1; GTC90; Conserved oligomeric Golgi complex subunit 5; COG complex subunit 5; 13S Golgi transport complex 90 kDa subunit; GTC-90; Component of oligomeric Golgi complex 5; Golgi transport complex 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLPAPAAPRWPPLLLLLLLLLPLARGAPARPAAGGQASELVVPTRLPGSAGELALHLSAF
GKGFVLRLAPDDSFLAPEFKIERLGGSGRATGGERGLRGCFFSGTVNGEPESLAAVSLCR
GLSGSFLLDGEEFTIQPQGAGGSLAQPHRLQRWGPAGARPLPRGPEWEVETGEGQRQERG
DHQEDSEEESQEEEAEGASEPPPPLGATSRTKRFVSEARFVETLLVADASMAAFYGADLQ
NHILTLMSVAARIYKHPSIKNSINLMVVKVLIVEDEKWGPEVSDNGGLTLRNFCNWQRRF
NQPSDRHPEHYDTAILLTRQNFCGQEGLCDTLGVADIGTICDPNKSCSVIEDEGLQAAHT
LAHELGHVLSMPHDDSKPCTRLFGPMGKHHVMAPLFVHLNQTLPWSPCSAMYLTELLDGG
HGDCLLDAPAAALPLPTGLPGRMALYQLDQQCRQIFGPDFRHCPNTSAQDVCAQLWCHTD
GAEPLCHTKNGSLPWADGTPCGPGHLCSEGSCLPEEEVERPKPVADGGWAPWGPWGECSR
TCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEECPPDGKSFREQQCEKYNAYNY
TDMDGNLLQWVPKYAGVSPRDRCKLFCRARGRSEFKVFEAKVIDGTLCGPETLAICVRGQ
CVKAGCDHVVDSPRKLDKCGVCGGKGNSCRKVSGSLTPTNYGYNDIVTIPAGATNIDVKQ
RSHPGVQNDGNYLALKTADGQYLLNGNLAISAIEQDILVKGTILKYSGSIATLERLQSFR
PLPEPLTVQLLTVPGEVFPPKVKYTFFVPNDVDFSMQSSKERATTNIIQPLLHAQWVLGD
WSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQLCPL
Target Bioclass
Other
Family
COG5 family
Subcellular location
Cytoplasm, cytosol
Function Required for normal Golgi function.
Uniprot ID
Q9UP83
Ensemble ID
ENST00000297135.9
HGNC ID
HGNC:14857

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.12  LDD0402  [1]
STPyne
 Probe Info  		K151(0.99)  LDD0277  [2]
Probe 1
 Probe Info  		Y156(17.08); Y485(7.37)  LDD3495  [3]
AHL-Pu-1
 Probe Info  		C64(3.39)  LDD0168  [4]
DBIA
 Probe Info  		C664(10.79)  LDD0209  [5]
HHS-475
 Probe Info  		Y342(0.94)  LDD0264  [6]
HHS-465
 Probe Info  		Y342(8.84)  LDD2237  [7]
Acrolein
 Probe Info  		C173(0.00); H781(0.00)  LDD0221  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C716(0.00); C173(0.00); C345(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C345(0.00); C173(0.00)  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		C716(0.00); C345(0.00); C173(0.00)  LDD0037  [9]
IPM
 Probe Info  		N.A.  LDD0005  [10]
TFBX
 Probe Info  		N.A.  LDD0148  [11]
1c-yne
 Probe Info  		N.A.  LDD0228  [12]
W1
 Probe Info  		N.A.  LDD0236  [13]
AOyne
 Probe Info  		12.50  LDD0443  [14]
NAIA_5
 Probe Info  		C716(0.00); C345(0.00)  LDD2223  [15]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C106
 Probe Info  		16.22  LDD1793  [16]
VE-P
 Probe Info  		N.A.  LDD0396  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C64(3.39)  LDD0168  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C64(3.03)  LDD0169  [4]
 LDCM0214  AC1 HEK-293T C345(1.01); C366(0.91); C716(1.09); C284(0.90)  LDD1507  [18]
 LDCM0215  AC10 HEK-293T C345(1.05); C366(0.95); C716(1.06); C284(0.96)  LDD1508  [18]
 LDCM0226  AC11 HEK-293T C345(1.07); C366(1.01); C716(1.04); C284(0.98)  LDD1509  [18]
 LDCM0237  AC12 HEK-293T C345(1.04); C366(0.96); C716(0.97); C284(1.08)  LDD1510  [18]
 LDCM0259  AC14 HEK-293T C345(0.94); C366(1.00); C716(1.04); C284(0.98)  LDD1512  [18]
 LDCM0270  AC15 HEK-293T C345(1.03); C366(0.96); C716(0.82); C284(1.05)  LDD1513  [18]
 LDCM0276  AC17 HEK-293T C345(1.00); C366(0.93); C716(1.00); C284(0.87)  LDD1515  [18]
 LDCM0277  AC18 HEK-293T C345(1.06); C366(0.89); C716(0.93); C284(0.96)  LDD1516  [18]
 LDCM0278  AC19 HEK-293T C345(0.91); C366(0.89); C716(0.91); C284(0.85)  LDD1517  [18]
 LDCM0279  AC2 HEK-293T C345(1.14); C366(0.93); C716(1.03); C284(0.98)  LDD1518  [18]
 LDCM0280  AC20 HEK-293T C345(0.92); C366(0.92); C716(0.97); C284(1.13)  LDD1519  [18]
 LDCM0281  AC21 HEK-293T C345(0.96); C366(1.01); C716(0.90); C284(1.05)  LDD1520  [18]
 LDCM0282  AC22 HEK-293T C345(0.93); C366(0.96); C716(1.01); C284(0.94)  LDD1521  [18]
 LDCM0283  AC23 HEK-293T C345(1.04); C366(0.90); C716(0.83); C284(1.03)  LDD1522  [18]
 LDCM0284  AC24 HEK-293T C345(1.03); C366(0.87); C716(0.77); C284(1.02)  LDD1523  [18]
 LDCM0285  AC25 HEK-293T C345(0.95); C366(0.90); C716(1.03); C284(0.95)  LDD1524  [18]
 LDCM0286  AC26 HEK-293T C345(0.99); C366(1.00); C716(0.98); C284(0.88)  LDD1525  [18]
 LDCM0287  AC27 HEK-293T C345(0.96); C366(0.95); C716(1.02); C284(0.93)  LDD1526  [18]
 LDCM0288  AC28 HEK-293T C345(1.00); C366(0.98); C716(1.00); C284(1.01)  LDD1527  [18]
 LDCM0289  AC29 HEK-293T C345(0.98); C366(1.01); C716(0.90); C284(1.09)  LDD1528  [18]
 LDCM0290  AC3 HEK-293T C345(1.00); C366(1.03); C716(1.11); C284(1.01)  LDD1529  [18]
 LDCM0291  AC30 HEK-293T C345(0.95); C366(0.94); C716(1.01); C284(0.95)  LDD1530  [18]
 LDCM0292  AC31 HEK-293T C345(1.05); C366(0.94); C716(0.84); C284(1.00)  LDD1531  [18]
 LDCM0293  AC32 HEK-293T C345(0.98); C366(0.92); C716(0.94); C284(1.06)  LDD1532  [18]
 LDCM0294  AC33 HEK-293T C345(1.00); C366(0.92); C716(1.06); C284(0.84)  LDD1533  [18]
 LDCM0295  AC34 HEK-293T C345(1.02); C366(0.97); C716(1.01); C284(0.91)  LDD1534  [18]
 LDCM0296  AC35 HEK-293T C345(1.07); C366(0.97); C716(0.92); C284(0.97)  LDD1535  [18]
 LDCM0297  AC36 HEK-293T C345(1.01); C366(0.90); C716(1.01); C284(1.32)  LDD1536  [18]
 LDCM0298  AC37 HEK-293T C345(0.99); C366(0.99); C716(1.00); C284(1.13)  LDD1537  [18]
 LDCM0299  AC38 HEK-293T C345(1.04); C366(0.95); C716(1.00); C284(0.88)  LDD1538  [18]
 LDCM0300  AC39 HEK-293T C345(1.00); C366(0.89); C716(1.01); C284(1.02)  LDD1539  [18]
 LDCM0301  AC4 HEK-293T C345(0.98); C366(0.95); C716(0.97); C284(1.33)  LDD1540  [18]
 LDCM0302  AC40 HEK-293T C345(0.98); C366(0.96); C716(0.95); C284(0.99)  LDD1541  [18]
 LDCM0303  AC41 HEK-293T C345(0.96); C366(0.93); C716(1.07); C284(0.94)  LDD1542  [18]
 LDCM0304  AC42 HEK-293T C345(1.00); C366(0.96); C716(1.27); C284(0.95)  LDD1543  [18]
 LDCM0305  AC43 HEK-293T C345(0.98); C366(1.02); C716(0.94); C284(1.02)  LDD1544  [18]
 LDCM0306  AC44 HEK-293T C345(0.94); C366(0.97); C716(0.99); C284(1.12)  LDD1545  [18]
 LDCM0307  AC45 HEK-293T C345(0.95); C366(0.95); C716(0.98); C284(1.15)  LDD1546  [18]
 LDCM0308  AC46 HEK-293T C345(0.99); C366(0.88); C716(1.09); C284(1.00)  LDD1547  [18]
 LDCM0309  AC47 HEK-293T C345(0.96); C366(0.96); C716(1.06); C284(1.00)  LDD1548  [18]
 LDCM0310  AC48 HEK-293T C345(1.00); C366(0.85); C716(0.76); C284(1.08)  LDD1549  [18]
 LDCM0311  AC49 HEK-293T C345(0.93); C366(0.93); C716(1.09); C284(0.97)  LDD1550  [18]
 LDCM0312  AC5 HEK-293T C345(1.00); C366(0.95); C716(1.00); C284(0.90)  LDD1551  [18]
 LDCM0313  AC50 HEK-293T C345(1.06); C366(0.95); C716(1.02); C284(0.92)  LDD1552  [18]
 LDCM0314  AC51 HEK-293T C345(1.03); C366(0.97); C716(1.05); C284(1.04)  LDD1553  [18]
 LDCM0315  AC52 HEK-293T C345(1.00); C366(0.97); C716(0.97); C284(1.22)  LDD1554  [18]
 LDCM0316  AC53 HEK-293T C345(1.05); C366(0.92); C716(0.89); C284(1.08)  LDD1555  [18]
 LDCM0317  AC54 HEK-293T C345(0.99); C366(0.89); C716(1.02); C284(0.98)  LDD1556  [18]
 LDCM0318  AC55 HEK-293T C345(1.02); C366(0.90); C716(0.87); C284(0.98)  LDD1557  [18]
 LDCM0319  AC56 HEK-293T C345(0.97); C366(0.89); C716(0.94); C284(0.97)  LDD1558  [18]
 LDCM0320  AC57 HEK-293T C345(0.97); C366(0.97); C716(1.07); C284(0.91)  LDD1559  [18]
 LDCM0321  AC58 HEK-293T C345(1.01); C366(0.96); C716(0.97); C284(1.00)  LDD1560  [18]
 LDCM0322  AC59 HEK-293T C345(1.03); C366(0.97); C716(1.06); C284(1.06)  LDD1561  [18]
 LDCM0323  AC6 HEK-293T C345(0.96); C366(0.96); C716(1.14); C284(0.99)  LDD1562  [18]
 LDCM0324  AC60 HEK-293T C345(1.02); C366(0.96); C716(1.03); C284(0.95)  LDD1563  [18]
 LDCM0325  AC61 HEK-293T C345(0.94); C366(1.00); C716(1.00); C284(1.11)  LDD1564  [18]
 LDCM0326  AC62 HEK-293T C345(0.99); C366(0.97); C716(1.02); C284(0.88)  LDD1565  [18]
 LDCM0327  AC63 HEK-293T C345(0.98); C366(1.03); C716(1.00); C284(1.03)  LDD1566  [18]
 LDCM0328  AC64 HEK-293T C345(0.97); C366(0.83); C716(1.14); C284(1.13)  LDD1567  [18]
 LDCM0334  AC7 HEK-293T C345(1.04); C366(0.90); C716(0.86); C284(1.07)  LDD1568  [18]
 LDCM0345  AC8 HEK-293T C345(0.98); C366(0.85); C716(0.84); C284(1.08)  LDD1569  [18]
 LDCM0248  AKOS034007472 HEK-293T C345(1.05); C366(1.02); C716(0.92); C284(1.08)  LDD1511  [18]
 LDCM0356  AKOS034007680 HEK-293T C345(1.01); C366(0.96); C716(1.15); C284(0.94)  LDD1570  [18]
 LDCM0275  AKOS034007705 HEK-293T C345(0.98); C366(0.92); C716(0.85); C284(0.99)  LDD1514  [18]
 LDCM0108  Chloroacetamide HeLa C173(0.00); H781(0.00)  LDD0222  [8]
 LDCM0632  CL-Sc Hep-G2 C345(0.27)  LDD2227  [15]
 LDCM0367  CL1 HEK-293T C345(1.03); C366(4.03); C716(1.02); C284(1.02)  LDD1571  [18]
 LDCM0368  CL10 HEK-293T C345(0.97); C366(2.74); C716(1.26); C284(1.25)  LDD1572  [18]
 LDCM0369  CL100 HEK-293T C345(0.96); C366(1.76); C716(1.41); C284(0.89)  LDD1573  [18]
 LDCM0370  CL101 HEK-293T C345(1.03); C366(1.22); C716(1.05); C284(1.03)  LDD1574  [18]
 LDCM0371  CL102 HEK-293T C345(0.93); C366(3.92); C716(1.02); C284(0.86)  LDD1575  [18]
 LDCM0372  CL103 HEK-293T C345(0.96); C366(1.07); C716(0.96); C284(0.97)  LDD1576  [18]
 LDCM0373  CL104 HEK-293T C345(0.97); C366(1.43); C716(1.09); C284(1.03)  LDD1577  [18]
 LDCM0374  CL105 HEK-293T C345(0.93); C366(1.70); C716(1.03); C284(1.07)  LDD1578  [18]
 LDCM0375  CL106 HEK-293T C345(1.02); C366(2.48); C716(1.13); C284(0.87)  LDD1579  [18]
 LDCM0376  CL107 HEK-293T C345(0.90); C366(0.93); C716(0.89); C284(1.01)  LDD1580  [18]
 LDCM0377  CL108 HEK-293T C345(0.95); C366(1.00); C716(0.97); C284(0.99)  LDD1581  [18]
 LDCM0378  CL109 HEK-293T C345(0.99); C366(2.51); C716(0.93); C284(1.00)  LDD1582  [18]
 LDCM0379  CL11 HEK-293T C345(1.03); C366(2.44); C716(1.04); C284(1.18)  LDD1583  [18]
 LDCM0380  CL110 HEK-293T C345(1.02); C366(4.56); C716(1.04); C284(0.88)  LDD1584  [18]
 LDCM0381  CL111 HEK-293T C345(0.93); C366(2.04); C716(1.02); C284(0.94)  LDD1585  [18]
 LDCM0382  CL112 HEK-293T C345(0.89); C366(1.61); C716(1.14); C284(1.00)  LDD1586  [18]
 LDCM0383  CL113 HEK-293T C345(0.99); C366(0.88); C716(0.97); C284(1.07)  LDD1587  [18]
 LDCM0384  CL114 HEK-293T C345(0.95); C366(5.12); C716(1.06); C284(0.87)  LDD1588  [18]
 LDCM0385  CL115 HEK-293T C345(0.93); C366(1.02); C716(1.06); C284(0.94)  LDD1589  [18]
 LDCM0386  CL116 HEK-293T C345(0.99); C366(0.89); C716(1.04); C284(1.01)  LDD1590  [18]
 LDCM0387  CL117 HEK-293T C345(1.00); C366(0.98); C716(1.11); C284(1.09)  LDD1591  [18]
 LDCM0388  CL118 HEK-293T C345(1.02); C366(0.94); C716(1.05); C284(1.02)  LDD1592  [18]
 LDCM0389  CL119 HEK-293T C345(0.98); C366(0.96); C716(1.00); C284(1.12)  LDD1593  [18]
 LDCM0390  CL12 HEK-293T C345(1.02); C366(1.75); C716(0.72); C284(1.13)  LDD1594  [18]
 LDCM0391  CL120 HEK-293T C345(0.98); C366(0.91); C716(1.10); C284(0.99)  LDD1595  [18]
 LDCM0392  CL121 HEK-293T C345(1.05); C366(1.14); C716(0.92); C284(0.97)  LDD1596  [18]
 LDCM0393  CL122 HEK-293T C345(0.97); C366(1.95); C716(0.99); C284(0.85)  LDD1597  [18]
 LDCM0394  CL123 HEK-293T C345(0.99); C366(3.01); C716(1.05); C284(0.90)  LDD1598  [18]
 LDCM0395  CL124 HEK-293T C345(0.95); C366(2.13); C716(1.24); C284(0.95)  LDD1599  [18]
 LDCM0396  CL125 HEK-293T C345(1.06); C366(0.92); C716(1.00); C284(1.09)  LDD1600  [18]
 LDCM0397  CL126 HEK-293T C345(0.95); C366(1.71); C716(1.16); C284(0.94)  LDD1601  [18]
 LDCM0398  CL127 HEK-293T C345(0.98); C366(1.10); C716(0.96); C284(0.95)  LDD1602  [18]
 LDCM0399  CL128 HEK-293T C345(0.97); C366(0.89); C716(1.43); C284(1.04)  LDD1603  [18]
 LDCM0400  CL13 HEK-293T C345(1.04); C366(1.19); C716(0.90); C284(1.10)  LDD1604  [18]
 LDCM0401  CL14 HEK-293T C345(1.05); C366(1.21); C716(0.87); C284(1.00)  LDD1605  [18]
 LDCM0402  CL15 HEK-293T C345(1.09); C366(2.96); C716(1.03); C284(0.93)  LDD1606  [18]
 LDCM0403  CL16 HEK-293T C345(0.95); C366(1.04); C716(0.81); C284(1.14)  LDD1607  [18]
 LDCM0404  CL17 HEK-293T C345(1.01); C366(3.46); C716(1.13); C284(0.90)  LDD1608  [18]
 LDCM0405  CL18 HEK-293T C345(1.08); C366(1.06); C716(0.80); C284(1.07)  LDD1609  [18]
 LDCM0406  CL19 HEK-293T C345(1.09); C366(1.16); C716(0.81); C284(1.08)  LDD1610  [18]
 LDCM0407  CL2 HEK-293T C345(1.07); C366(1.19); C716(1.03); C284(0.96)  LDD1611  [18]
 LDCM0408  CL20 HEK-293T C345(1.03); C366(1.11); C716(0.85); C284(1.12)  LDD1612  [18]
 LDCM0409  CL21 HEK-293T C345(1.04); C366(4.60); C716(0.96); C284(1.02)  LDD1613  [18]
 LDCM0410  CL22 HEK-293T C345(1.02); C366(1.32); C716(0.86); C284(0.94)  LDD1614  [18]
 LDCM0411  CL23 HEK-293T C345(1.02); C366(1.15); C716(1.09); C284(1.08)  LDD1615  [18]
 LDCM0412  CL24 HEK-293T C345(1.04); C366(1.22); C716(0.52); C284(1.17)  LDD1616  [18]
 LDCM0413  CL25 HEK-293T C345(1.00); C366(3.13); C716(1.28); C284(1.13)  LDD1617  [18]
 LDCM0414  CL26 HEK-293T C345(1.01); C366(1.00); C716(0.90); C284(0.99)  LDD1618  [18]
 LDCM0415  CL27 HEK-293T C345(0.95); C366(0.96); C716(0.91); C284(1.01)  LDD1619  [18]
 LDCM0416  CL28 HEK-293T C345(0.90); C366(1.78); C716(1.01); C284(1.03)  LDD1620  [18]
 LDCM0417  CL29 HEK-293T C345(1.10); C366(0.98); C716(1.00); C284(1.11)  LDD1621  [18]
 LDCM0418  CL3 HEK-293T C345(0.94); C366(1.51); C716(0.96); C284(0.95)  LDD1622  [18]
 LDCM0419  CL30 HEK-293T C345(1.11); C366(0.95); C716(0.83); C284(1.09)  LDD1623  [18]
 LDCM0420  CL31 HEK-293T C345(1.02); C366(1.48); C716(0.90); C284(1.04)  LDD1624  [18]
 LDCM0421  CL32 HEK-293T C345(0.95); C366(1.22); C716(0.81); C284(1.39)  LDD1625  [18]
 LDCM0422  CL33 HEK-293T C345(1.05); C366(4.60); C716(0.96); C284(1.08)  LDD1626  [18]
 LDCM0423  CL34 HEK-293T C345(1.04); C366(2.41); C716(0.87); C284(1.15)  LDD1627  [18]
 LDCM0424  CL35 HEK-293T C345(1.01); C366(1.17); C716(0.83); C284(1.11)  LDD1628  [18]
 LDCM0425  CL36 HEK-293T C345(0.95); C366(1.95); C716(0.63); C284(1.18)  LDD1629  [18]
 LDCM0426  CL37 HEK-293T C345(1.05); C366(1.87); C716(0.91); C284(1.02)  LDD1630  [18]
 LDCM0428  CL39 HEK-293T C345(0.93); C366(1.84); C716(0.94); C284(0.95)  LDD1632  [18]
 LDCM0429  CL4 HEK-293T C345(1.00); C366(2.40); C716(1.23); C284(0.99)  LDD1633  [18]
 LDCM0430  CL40 HEK-293T C345(1.03); C366(0.91); C716(1.00); C284(1.15)  LDD1634  [18]
 LDCM0431  CL41 HEK-293T C345(0.97); C366(2.26); C716(1.02); C284(1.00)  LDD1635  [18]
 LDCM0432  CL42 HEK-293T C345(1.10); C366(0.95); C716(0.77); C284(1.07)  LDD1636  [18]
 LDCM0433  CL43 HEK-293T C345(1.04); C366(1.45); C716(0.73); C284(1.09)  LDD1637  [18]
 LDCM0434  CL44 HEK-293T C345(0.95); C366(1.01); C716(0.89); C284(1.63)  LDD1638  [18]
 LDCM0435  CL45 HEK-293T C345(0.92); C366(3.36); C716(0.78); C284(0.99)  LDD1639  [18]
 LDCM0436  CL46 HEK-293T C345(1.00); C366(1.45); C716(0.75); C284(0.96)  LDD1640  [18]
 LDCM0437  CL47 HEK-293T C345(1.01); C366(1.22); C716(0.96); C284(1.16)  LDD1641  [18]
 LDCM0438  CL48 HEK-293T C345(1.05); C366(1.46); C716(0.53); C284(1.07)  LDD1642  [18]
 LDCM0439  CL49 HEK-293T C345(1.10); C366(1.16); C716(0.88); C284(1.19)  LDD1643  [18]
 LDCM0440  CL5 HEK-293T C345(1.05); C366(1.11); C716(1.03); C284(0.93)  LDD1644  [18]
 LDCM0441  CL50 HEK-293T C345(1.00); C366(2.85); C716(0.98); C284(0.88)  LDD1645  [18]
 LDCM0443  CL52 HEK-293T C345(0.94); C366(1.02); C716(1.12); C284(1.05)  LDD1646  [18]
 LDCM0444  CL53 HEK-293T C345(1.02); C366(4.45); C716(1.04); C284(0.95)  LDD1647  [18]
 LDCM0445  CL54 HEK-293T C345(1.14); C366(3.43); C716(1.53); C284(1.06)  LDD1648  [18]
 LDCM0446  CL55 HEK-293T C345(1.04); C366(1.22); C716(0.87); C284(1.00)  LDD1649  [18]
 LDCM0447  CL56 HEK-293T C345(0.97); C366(1.11); C716(0.89); C284(1.29)  LDD1650  [18]
 LDCM0448  CL57 HEK-293T C345(0.97); C366(3.50); C716(0.89); C284(0.96)  LDD1651  [18]
 LDCM0449  CL58 HEK-293T C345(0.98); C366(2.03); C716(0.99); C284(0.92)  LDD1652  [18]
 LDCM0450  CL59 HEK-293T C345(0.94); C366(1.29); C716(0.93); C284(1.16)  LDD1653  [18]
 LDCM0451  CL6 HEK-293T C345(1.05); C366(3.45); C716(1.08); C284(0.93)  LDD1654  [18]
 LDCM0452  CL60 HEK-293T C345(1.00); C366(1.85); C716(0.80); C284(1.03)  LDD1655  [18]
 LDCM0453  CL61 HEK-293T C345(1.11); C366(0.86); C716(0.91); C284(1.13)  LDD1656  [18]
 LDCM0454  CL62 HEK-293T C345(1.08); C366(0.96); C716(0.96); C284(1.00)  LDD1657  [18]
 LDCM0455  CL63 HEK-293T C345(1.01); C366(0.92); C716(0.87); C284(1.04)  LDD1658  [18]
 LDCM0456  CL64 HEK-293T C345(0.96); C366(3.40); C716(1.34); C284(0.96)  LDD1659  [18]
 LDCM0457  CL65 HEK-293T C345(1.03); C366(0.90); C716(0.96); C284(1.03)  LDD1660  [18]
 LDCM0458  CL66 HEK-293T C345(0.99); C366(1.39); C716(0.86); C284(0.98)  LDD1661  [18]
 LDCM0459  CL67 HEK-293T C345(1.08); C366(1.05); C716(0.84); C284(1.00)  LDD1662  [18]
 LDCM0460  CL68 HEK-293T C345(1.01); C366(1.65); C716(0.54); C284(1.15)  LDD1663  [18]
 LDCM0461  CL69 HEK-293T C345(1.14); C366(2.90); C716(0.77); C284(1.13)  LDD1664  [18]
 LDCM0462  CL7 HEK-293T C345(1.07); C366(1.70); C716(0.90); C284(1.06)  LDD1665  [18]
 LDCM0463  CL70 HEK-293T C345(0.97); C366(1.17); C716(0.84); C284(0.94)  LDD1666  [18]
 LDCM0464  CL71 HEK-293T C345(0.99); C366(1.51); C716(0.92); C284(1.02)  LDD1667  [18]
 LDCM0465  CL72 HEK-293T C345(0.95); C366(1.01); C716(0.75); C284(1.07)  LDD1668  [18]
 LDCM0466  CL73 HEK-293T C345(1.04); C366(2.76); C716(0.91); C284(1.04)  LDD1669  [18]
 LDCM0467  CL74 HEK-293T C345(1.03); C366(0.98); C716(1.04); C284(1.01)  LDD1670  [18]
 LDCM0469  CL76 HEK-293T C345(0.99); C366(0.93); C716(1.22); C284(0.93)  LDD1672  [18]
 LDCM0470  CL77 HEK-293T C345(1.01); C366(3.46); C716(0.69); C284(0.90)  LDD1673  [18]
 LDCM0471  CL78 HEK-293T C345(1.06); C366(0.93); C716(0.98); C284(1.02)  LDD1674  [18]
 LDCM0472  CL79 HEK-293T C345(1.07); C366(1.13); C716(0.87); C284(1.05)  LDD1675  [18]
 LDCM0473  CL8 HEK-293T C345(2.74); C366(2.32); C716(1.09); C284(1.04)  LDD1676  [18]
 LDCM0474  CL80 HEK-293T C345(1.06); C366(0.99); C716(0.89); C284(1.21)  LDD1677  [18]
 LDCM0475  CL81 HEK-293T C345(1.04); C366(1.22); C716(0.76); C284(1.17)  LDD1678  [18]
 LDCM0476  CL82 HEK-293T C345(0.94); C366(1.13); C716(0.79); C284(0.97)  LDD1679  [18]
 LDCM0477  CL83 HEK-293T C345(1.05); C366(1.69); C716(0.95); C284(1.08)  LDD1680  [18]
 LDCM0478  CL84 HEK-293T C345(1.02); C366(4.48); C716(0.84); C284(1.06)  LDD1681  [18]
 LDCM0479  CL85 HEK-293T C345(1.02); C366(0.80); C716(1.06); C284(1.03)  LDD1682  [18]
 LDCM0480  CL86 HEK-293T C345(1.10); C366(1.24); C716(1.11); C284(0.98)  LDD1683  [18]
 LDCM0481  CL87 HEK-293T C345(0.96); C366(1.34); C716(0.91); C284(0.97)  LDD1684  [18]
 LDCM0482  CL88 HEK-293T C345(1.07); C366(0.94); C716(1.22); C284(1.04)  LDD1685  [18]
 LDCM0483  CL89 HEK-293T C345(0.99); C366(1.02); C716(1.24); C284(1.01)  LDD1686  [18]
 LDCM0484  CL9 HEK-293T C345(0.95); C366(2.20); C716(0.84); C284(1.23)  LDD1687  [18]
 LDCM0485  CL90 HEK-293T C345(1.18); C366(3.93); C716(1.66); C284(0.77)  LDD1688  [18]
 LDCM0486  CL91 HEK-293T C345(1.13); C366(1.18); C716(0.97); C284(1.08)  LDD1689  [18]
 LDCM0487  CL92 HEK-293T C345(0.96); C366(2.13); C716(0.93); C284(1.28)  LDD1690  [18]
 LDCM0488  CL93 HEK-293T C345(1.03); C366(4.56); C716(0.84); C284(1.09)  LDD1691  [18]
 LDCM0489  CL94 HEK-293T C345(0.95); C366(1.27); C716(0.87); C284(0.99)  LDD1692  [18]
 LDCM0490  CL95 HEK-293T C345(1.05); C366(3.42); C716(1.38); C284(0.94)  LDD1693  [18]
 LDCM0491  CL96 HEK-293T C345(1.03); C366(4.11); C716(1.01); C284(1.01)  LDD1694  [18]
 LDCM0492  CL97 HEK-293T C345(1.00); C366(3.03); C716(0.95); C284(1.00)  LDD1695  [18]
 LDCM0493  CL98 HEK-293T C345(1.01); C366(2.13); C716(1.22); C284(0.94)  LDD1696  [18]
 LDCM0494  CL99 HEK-293T C345(0.95); C366(1.15); C716(1.08); C284(0.94)  LDD1697  [18]
 LDCM0495  E2913 HEK-293T C345(0.92); C366(1.00); C716(0.92); C284(0.92)  LDD1698  [18]
 LDCM0625  F8 Ramos C173(1.25)  LDD2187  [19]
 LDCM0572  Fragment10 Ramos C173(1.11)  LDD2189  [19]
 LDCM0574  Fragment12 Ramos C173(1.38)  LDD2191  [19]
 LDCM0575  Fragment13 Ramos C173(0.91)  LDD2192  [19]
 LDCM0579  Fragment20 Ramos C173(1.52)  LDD2194  [19]
 LDCM0580  Fragment21 Ramos C173(1.25)  LDD2195  [19]
 LDCM0582  Fragment23 Ramos C173(1.30)  LDD2196  [19]
 LDCM0578  Fragment27 Ramos C173(0.90)  LDD2197  [19]
 LDCM0586  Fragment28 Ramos C173(0.94)  LDD2198  [19]
 LDCM0588  Fragment30 Ramos C173(1.15)  LDD2199  [19]
 LDCM0589  Fragment31 Ramos C173(1.42)  LDD2200  [19]
 LDCM0590  Fragment32 Ramos C173(1.02)  LDD2201  [19]
 LDCM0468  Fragment33 HEK-293T C345(0.94); C366(1.36); C716(1.07); C284(0.97)  LDD1671  [18]
 LDCM0596  Fragment38 Ramos C173(1.06)  LDD2203  [19]
 LDCM0566  Fragment4 Ramos C173(1.25)  LDD2184  [19]
 LDCM0427  Fragment51 HEK-293T C345(1.04); C366(1.02); C716(0.89); C284(1.06)  LDD1631  [18]
 LDCM0610  Fragment52 Ramos C173(1.17)  LDD2204  [19]
 LDCM0614  Fragment56 Ramos C173(1.13)  LDD2205  [19]
 LDCM0569  Fragment7 Ramos C173(1.11)  LDD2186  [19]
 LDCM0571  Fragment9 Ramos C173(1.42)  LDD2188  [19]
 LDCM0116  HHS-0101 DM93 Y342(0.94)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y342(1.12)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y342(0.72)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y342(1.30)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y342(1.23)  LDD0268  [6]
 LDCM0107  IAA HeLa C173(0.00); H781(0.00)  LDD0221  [8]
 LDCM0022  KB02 HEK-293T C345(1.01); C173(0.84); C64(0.90); C284(0.88)  LDD1492  [18]
 LDCM0023  KB03 Jurkat C664(10.79)  LDD0209  [5]
 LDCM0024  KB05 COLO792 C173(2.39)  LDD3310  [20]
 LDCM0109  NEM HeLa N.A.  LDD0223  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Conserved oligomeric Golgi complex subunit 4 (COG4) COG4 family Q9H9E3
Conserved oligomeric Golgi complex subunit 7 (COG7) COG7 family P83436

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
13 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
17 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
20 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840