Details of the Target

General Information of Target

Target ID LDTP01914
Target Name Putative HLA class I histocompatibility antigen, alpha chain H (HLA-H)
Gene Name HLA-H
Synonyms
HLAH; Putative HLA class I histocompatibility antigen, alpha chain H; HLA-12.4; HLA-AR; MHC class I antigen H
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVLMAPRTLLLLLSGALALTQTWARSHSMRYFYTTMSRPGAGEPRFISVGYVDDTQFVRF
DSDDASPREEPRAPWMEREGPKYWDRNTQICKAQAQTERENLRIALRYYNQSEGGSHTMQ
VMYGCDVGPDGPFLRGYEQHAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAARRAEQR
RVYLEGEFVEWLRRYLENGKETLQRADPPKTHMTHHPISDHEATLRCWALGFYPAEITLT
WQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWEP
SSQPTVPIVGIVAGLVLLVAVVTGAVVAAVMWRKKSSDRKGGSYSQAASSNSAQGSDVSL
TA
Target Bioclass
Other
Family
MHC class I family
Subcellular location
Cell membrane
Function Involved in the presentation of foreign antigens to the immune system.
Uniprot ID
P01893
HGNC ID
HGNC:4965

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
P3
 Probe Info  		10.00  LDD0450  [2]
P8
 Probe Info  		10.00  LDD0451  [2]
IPM
 Probe Info  		N.A.  LDD0241  [3]
OPA-S-S-alkyne
 Probe Info  		K200(1.46); K210(2.51)  LDD3494  [4]
DBIA
 Probe Info  		C283(2.03)  LDD3310  [5]
YY4-yne
 Probe Info  		4.02  LDD0400  [6]
DA-P3
 Probe Info  		5.98  LDD0179  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0167  [8]
NAIA_4
 Probe Info  		N.A.  LDD2226  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0156  Aniline NCI-H1299 13.14  LDD0403  [1]
 LDCM0027  Dopamine HEK-293T 5.98  LDD0179  [7]
 LDCM0022  KB02 A2058 C283(1.75)  LDD2253  [5]
 LDCM0023  KB03 A2058 C283(2.00)  LDD2670  [5]
 LDCM0024  KB05 COLO792 C283(2.03)  LDD3310  [5]
 LDCM0030  Luteolin HEK-293T 4.90  LDD0182  [7]
 LDCM0154  YY4 T cell 4.02  LDD0400  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock cognate 71 kDa protein (HSPA8) Heat shock protein 70 family P11142

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex. Angew Chem Int Ed Engl. 2020 Mar 2;59(10):3896-3899. doi: 10.1002/anie.201914391. Epub 2020 Feb 11.
7 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264