Details of the Target

General Information of Target

Target ID LDTP09851
Target Name Protein TFG (TFG)
Gene Name TFG
Gene ID 10342
Synonyms
Protein TFG; TRK-fused gene protein
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSLVAYASSDESEPDEAEPEPEEEEAVAPTSGPALGGLFASLPAPKGPALLPPPPQMLAP
AFPPPLLLPPPTGDPRLQPPPPLPFGLGGFPPPPGVSPAEAAGVGEGLGLGLPSPRGPGL
NLPPPIGGAGPPLGLPKPKKRKEPVKIAAPELHKGDSDSEEDEPTKKKTILQGSSEGTGL
SALLPQPKNLTVKETNRLLLPHAFSRKPSDGSPDTKPSRLASKTKTSSLAPVVGTTTTTP
SPSAIKAAAKSAALQVTKQITQEEDDSDEEVAPENFFSLPEKAEPPGVEPYPYPIPTVPE
ELPPGTEPEPAFQDDAANAPLEFKMAAGSSGAPWMPKPGDDYSYNQFSTYGDANAAGAYY
QDYYSGGYYPAQDPALVPPQEIAPDASFIDDEAFKRLQGKRNRGREEINFVEIKGDDQLS
GAQQWMTKSLTEEKTMKSFSKKKGEQPTGQQRRKHQITYLIHQAKERELELKNTWSENKL
SRRQTQAKYGF
Target Bioclass
Other
Subcellular location
Endoplasmic reticulum
Function
Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.
Uniprot ID
Q92734
Ensemble ID
ENST00000240851.9
HGNC ID
HGNC:11758

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CHL1 SNV: p.P199L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.75  LDD0402  [1]
P8
 Probe Info  		10.00  LDD0451  [2]
ONAyne
 Probe Info  		K103(0.19)  LDD0274  [3]
STPyne
 Probe Info  		K103(4.23); K47(2.00)  LDD0277  [3]
AZ-9
 Probe Info  		E53(1.00)  LDD2208  [4]
Probe 1
 Probe Info  		Y33(6.60)  LDD3495  [5]
HHS-482
 Probe Info  		Y392(1.32)  LDD0285  [6]
HHS-475
 Probe Info  		Y392(0.91)  LDD0264  [7]
HHS-465
 Probe Info  		Y392(8.15)  LDD2237  [8]
DBIA
 Probe Info  		C80(0.94)  LDD0828  [9]
5E-2FA
 Probe Info  		N.A.  LDD2235  [10]
ATP probe
 Probe Info  		K103(0.00); K147(0.00)  LDD0199  [11]
1d-yne
 Probe Info  		N.A.  LDD0358  [12]
IA-alkyne
 Probe Info  		N.A.  LDD0149  [13]
SF
 Probe Info  		Y392(0.00); Y399(0.00)  LDD0028  [14]
1c-yne
 Probe Info  		N.A.  LDD0228  [12]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C191
 Probe Info  		11.31  LDD1868  [15]
FFF probe11
 Probe Info  		5.64  LDD0471  [16]
FFF probe13
 Probe Info  		20.00  LDD0475  [16]
FFF probe14
 Probe Info  		20.00  LDD0477  [16]
FFF probe2
 Probe Info  		20.00  LDD0463  [16]
JN0003
 Probe Info  		20.00  LDD0469  [16]
STS-1
 Probe Info  		N.A.  LDD0137  [17]
Kambe_26
 Probe Info  		2.01  LDD0134  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C80(0.76)  LDD1093  [9]
 LDCM0215  AC10 HEK-293T C80(1.04)  LDD1508  [19]
 LDCM0216  AC100 PaTu 8988t C80(0.97)  LDD1095  [9]
 LDCM0217  AC101 PaTu 8988t C80(1.04)  LDD1096  [9]
 LDCM0218  AC102 PaTu 8988t C80(0.84)  LDD1097  [9]
 LDCM0219  AC103 PaTu 8988t C80(1.13)  LDD1098  [9]
 LDCM0220  AC104 PaTu 8988t C80(0.96)  LDD1099  [9]
 LDCM0221  AC105 PaTu 8988t C80(0.90)  LDD1100  [9]
 LDCM0222  AC106 PaTu 8988t C80(0.90)  LDD1101  [9]
 LDCM0223  AC107 PaTu 8988t C80(1.05)  LDD1102  [9]
 LDCM0224  AC108 PaTu 8988t C80(0.98)  LDD1103  [9]
 LDCM0225  AC109 PaTu 8988t C80(1.05)  LDD1104  [9]
 LDCM0226  AC11 HEK-293T C80(0.97)  LDD1509  [19]
 LDCM0227  AC110 PaTu 8988t C80(0.96)  LDD1106  [9]
 LDCM0228  AC111 PaTu 8988t C80(0.91)  LDD1107  [9]
 LDCM0229  AC112 PaTu 8988t C80(0.78)  LDD1108  [9]
 LDCM0230  AC113 HEK-293T C80(0.94)  LDD0828  [9]
 LDCM0231  AC114 HEK-293T C80(0.91)  LDD0829  [9]
 LDCM0232  AC115 HEK-293T C80(1.05)  LDD0830  [9]
 LDCM0233  AC116 HEK-293T C80(1.01)  LDD0831  [9]
 LDCM0234  AC117 HEK-293T C80(1.08)  LDD0832  [9]
 LDCM0235  AC118 HEK-293T C80(1.01)  LDD0833  [9]
 LDCM0236  AC119 HEK-293T C80(0.90)  LDD0834  [9]
 LDCM0237  AC12 HEK-293T C80(0.99)  LDD1510  [19]
 LDCM0238  AC120 HEK-293T C80(1.31)  LDD0836  [9]
 LDCM0239  AC121 HEK-293T C80(0.83)  LDD0837  [9]
 LDCM0240  AC122 HEK-293T C80(1.09)  LDD0838  [9]
 LDCM0241  AC123 HEK-293T C80(1.24)  LDD0839  [9]
 LDCM0242  AC124 HEK-293T C80(1.21)  LDD0840  [9]
 LDCM0243  AC125 HEK-293T C80(1.05)  LDD0841  [9]
 LDCM0244  AC126 HEK-293T C80(1.17)  LDD0842  [9]
 LDCM0245  AC127 HEK-293T C80(0.75)  LDD0843  [9]
 LDCM0246  AC128 HEK-293T C80(1.19)  LDD0844  [9]
 LDCM0247  AC129 HEK-293T C80(1.75)  LDD0845  [9]
 LDCM0249  AC130 HEK-293T C80(2.02)  LDD0847  [9]
 LDCM0250  AC131 HEK-293T C80(1.23)  LDD0848  [9]
 LDCM0251  AC132 HEK-293T C80(1.43)  LDD0849  [9]
 LDCM0252  AC133 HEK-293T C80(1.83)  LDD0850  [9]
 LDCM0253  AC134 HEK-293T C80(2.55)  LDD0851  [9]
 LDCM0254  AC135 HEK-293T C80(1.10)  LDD0852  [9]
 LDCM0255  AC136 HEK-293T C80(1.75)  LDD0853  [9]
 LDCM0256  AC137 HEK-293T C80(1.69)  LDD0854  [9]
 LDCM0257  AC138 HEK-293T C80(1.88)  LDD0855  [9]
 LDCM0258  AC139 HEK-293T C80(1.44)  LDD0856  [9]
 LDCM0259  AC14 HEK-293T C80(1.05)  LDD1512  [19]
 LDCM0260  AC140 HEK-293T C80(2.09)  LDD0858  [9]
 LDCM0261  AC141 HEK-293T C80(1.36)  LDD0859  [9]
 LDCM0262  AC142 HEK-293T C80(1.36)  LDD0860  [9]
 LDCM0263  AC143 HEK-293T C80(1.19)  LDD0861  [9]
 LDCM0264  AC144 HEK-293T C80(1.11)  LDD0862  [9]
 LDCM0265  AC145 HEK-293T C80(1.40)  LDD0863  [9]
 LDCM0266  AC146 HEK-293T C80(1.29)  LDD0864  [9]
 LDCM0267  AC147 HEK-293T C80(1.08)  LDD0865  [9]
 LDCM0268  AC148 HEK-293T C80(1.20)  LDD0866  [9]
 LDCM0269  AC149 HEK-293T C80(1.21)  LDD0867  [9]
 LDCM0270  AC15 HEK-293T C80(1.07)  LDD1513  [19]
 LDCM0271  AC150 HEK-293T C80(1.12)  LDD0869  [9]
 LDCM0272  AC151 HEK-293T C80(1.07)  LDD0870  [9]
 LDCM0273  AC152 HEK-293T C80(0.84)  LDD0871  [9]
 LDCM0274  AC153 HEK-293T C80(1.18)  LDD0872  [9]
 LDCM0621  AC154 HEK-293T C80(0.99)  LDD2162  [9]
 LDCM0622  AC155 HEK-293T C80(1.05)  LDD2163  [9]
 LDCM0623  AC156 HEK-293T C80(1.16)  LDD2164  [9]
 LDCM0624  AC157 HEK-293T C80(0.88)  LDD2165  [9]
 LDCM0276  AC17 HEK-293T C80(1.76)  LDD0874  [9]
 LDCM0277  AC18 HEK-293T C80(0.87)  LDD0875  [9]
 LDCM0278  AC19 HEK-293T C80(1.35)  LDD0876  [9]
 LDCM0279  AC2 PaTu 8988t C80(0.73)  LDD1158  [9]
 LDCM0280  AC20 HEK-293T C80(0.62)  LDD0878  [9]
 LDCM0281  AC21 HEK-293T C80(0.20)  LDD0879  [9]
 LDCM0282  AC22 HEK-293T C80(0.91)  LDD0880  [9]
 LDCM0283  AC23 HEK-293T C80(2.13)  LDD0881  [9]
 LDCM0284  AC24 HEK-293T C80(1.44)  LDD0882  [9]
 LDCM0285  AC25 HEK-293T C80(0.73)  LDD0883  [9]
 LDCM0286  AC26 HEK-293T C80(1.02)  LDD0884  [9]
 LDCM0287  AC27 HEK-293T C80(1.13)  LDD0885  [9]
 LDCM0288  AC28 HEK-293T C80(0.65)  LDD0886  [9]
 LDCM0289  AC29 HEK-293T C80(1.05)  LDD0887  [9]
 LDCM0290  AC3 PaTu 8988t C80(0.73)  LDD1169  [9]
 LDCM0291  AC30 HEK-293T C80(0.96)  LDD0889  [9]
 LDCM0292  AC31 HEK-293T C80(1.02)  LDD0890  [9]
 LDCM0293  AC32 HEK-293T C80(1.10)  LDD0891  [9]
 LDCM0294  AC33 HEK-293T C80(1.18)  LDD0892  [9]
 LDCM0295  AC34 HEK-293T C80(1.40)  LDD0893  [9]
 LDCM0296  AC35 PaTu 8988t C80(1.11)  LDD1175  [9]
 LDCM0297  AC36 PaTu 8988t C80(1.07)  LDD1176  [9]
 LDCM0298  AC37 PaTu 8988t C80(0.96)  LDD1177  [9]
 LDCM0299  AC38 PaTu 8988t C80(1.04)  LDD1178  [9]
 LDCM0300  AC39 PaTu 8988t C80(1.07)  LDD1179  [9]
 LDCM0301  AC4 PaTu 8988t C80(0.69)  LDD1180  [9]
 LDCM0302  AC40 PaTu 8988t C80(1.12)  LDD1181  [9]
 LDCM0303  AC41 PaTu 8988t C80(1.00)  LDD1182  [9]
 LDCM0304  AC42 PaTu 8988t C80(0.84)  LDD1183  [9]
 LDCM0305  AC43 PaTu 8988t C80(0.96)  LDD1184  [9]
 LDCM0306  AC44 PaTu 8988t C80(1.12)  LDD1185  [9]
 LDCM0307  AC45 PaTu 8988t C80(1.06)  LDD1186  [9]
 LDCM0308  AC46 PaTu 8988t C80(0.54)  LDD1187  [9]
 LDCM0309  AC47 PaTu 8988t C80(0.91)  LDD1188  [9]
 LDCM0310  AC48 PaTu 8988t C80(0.77)  LDD1189  [9]
 LDCM0311  AC49 PaTu 8988t C80(0.53)  LDD1190  [9]
 LDCM0312  AC5 PaTu 8988t C80(0.76)  LDD1191  [9]
 LDCM0313  AC50 PaTu 8988t C80(0.72)  LDD1192  [9]
 LDCM0314  AC51 PaTu 8988t C80(0.79)  LDD1193  [9]
 LDCM0315  AC52 PaTu 8988t C80(0.85)  LDD1194  [9]
 LDCM0316  AC53 PaTu 8988t C80(1.25)  LDD1195  [9]
 LDCM0317  AC54 PaTu 8988t C80(1.05)  LDD1196  [9]
 LDCM0318  AC55 PaTu 8988t C80(0.62)  LDD1197  [9]
 LDCM0319  AC56 PaTu 8988t C80(0.86)  LDD1198  [9]
 LDCM0320  AC57 HEK-293T C80(0.98)  LDD1559  [19]
 LDCM0321  AC58 HEK-293T C80(0.96)  LDD1560  [19]
 LDCM0322  AC59 HEK-293T C80(0.95)  LDD1561  [19]
 LDCM0323  AC6 HEK-293T C80(1.02)  LDD1562  [19]
 LDCM0324  AC60 HEK-293T C80(0.99)  LDD1563  [19]
 LDCM0325  AC61 HEK-293T C80(1.03)  LDD1564  [19]
 LDCM0326  AC62 HEK-293T C80(0.98)  LDD1565  [19]
 LDCM0327  AC63 HEK-293T C80(1.05)  LDD1566  [19]
 LDCM0328  AC64 HEK-293T C80(0.98)  LDD1567  [19]
 LDCM0332  AC68 PaTu 8988t C80(1.32)  LDD1211  [9]
 LDCM0333  AC69 PaTu 8988t C80(1.01)  LDD1212  [9]
 LDCM0334  AC7 HEK-293T C80(1.05)  LDD1568  [19]
 LDCM0335  AC70 PaTu 8988t C80(1.01)  LDD1214  [9]
 LDCM0336  AC71 PaTu 8988t C80(1.09)  LDD1215  [9]
 LDCM0337  AC72 PaTu 8988t C80(0.91)  LDD1216  [9]
 LDCM0338  AC73 PaTu 8988t C80(1.13)  LDD1217  [9]
 LDCM0339  AC74 PaTu 8988t C80(0.96)  LDD1218  [9]
 LDCM0340  AC75 PaTu 8988t C80(1.15)  LDD1219  [9]
 LDCM0341  AC76 PaTu 8988t C80(1.09)  LDD1220  [9]
 LDCM0342  AC77 PaTu 8988t C80(1.22)  LDD1221  [9]
 LDCM0343  AC78 PaTu 8988t C80(0.94)  LDD1222  [9]
 LDCM0344  AC79 PaTu 8988t C80(1.03)  LDD1223  [9]
 LDCM0345  AC8 HEK-293T C80(0.99)  LDD1569  [19]
 LDCM0346  AC80 PaTu 8988t C80(0.91)  LDD1225  [9]
 LDCM0347  AC81 PaTu 8988t C80(0.99)  LDD1226  [9]
 LDCM0348  AC82 PaTu 8988t C80(1.05)  LDD1227  [9]
 LDCM0349  AC83 PaTu 8988t C80(0.84)  LDD1228  [9]
 LDCM0350  AC84 PaTu 8988t C80(0.97)  LDD1229  [9]
 LDCM0351  AC85 PaTu 8988t C80(0.95)  LDD1230  [9]
 LDCM0352  AC86 PaTu 8988t C80(0.95)  LDD1231  [9]
 LDCM0353  AC87 PaTu 8988t C80(0.77)  LDD1232  [9]
 LDCM0354  AC88 PaTu 8988t C80(0.85)  LDD1233  [9]
 LDCM0355  AC89 PaTu 8988t C80(0.96)  LDD1234  [9]
 LDCM0357  AC90 PaTu 8988t C80(0.95)  LDD1236  [9]
 LDCM0358  AC91 PaTu 8988t C80(0.88)  LDD1237  [9]
 LDCM0359  AC92 PaTu 8988t C80(1.08)  LDD1238  [9]
 LDCM0360  AC93 PaTu 8988t C80(0.89)  LDD1239  [9]
 LDCM0361  AC94 PaTu 8988t C80(0.80)  LDD1240  [9]
 LDCM0362  AC95 PaTu 8988t C80(0.96)  LDD1241  [9]
 LDCM0363  AC96 PaTu 8988t C80(0.80)  LDD1242  [9]
 LDCM0364  AC97 PaTu 8988t C80(0.76)  LDD1243  [9]
 LDCM0365  AC98 PaTu 8988t C80(0.99)  LDD1244  [9]
 LDCM0366  AC99 PaTu 8988t C80(0.97)  LDD1245  [9]
 LDCM0248  AKOS034007472 HEK-293T C80(1.09)  LDD1511  [19]
 LDCM0356  AKOS034007680 HEK-293T C80(0.98)  LDD1570  [19]
 LDCM0275  AKOS034007705 HEK-293T C80(1.00)  LDD1514  [19]
 LDCM0156  Aniline NCI-H1299 12.07  LDD0403  [1]
 LDCM0630  CCW28-3 231MFP C80(1.04)  LDD2214  [20]
 LDCM0367  CL1 HEK-293T C80(1.16)  LDD1571  [19]
 LDCM0368  CL10 HEK-293T C80(0.97)  LDD1572  [19]
 LDCM0369  CL100 PaTu 8988t C80(0.66)  LDD1248  [9]
 LDCM0370  CL101 HEK-293T C80(0.96)  LDD1574  [19]
 LDCM0371  CL102 HEK-293T C80(1.00)  LDD1575  [19]
 LDCM0372  CL103 HEK-293T C80(0.97)  LDD1576  [19]
 LDCM0373  CL104 HEK-293T C80(1.01)  LDD1577  [19]
 LDCM0374  CL105 HEK-293T C80(0.69)  LDD0972  [9]
 LDCM0375  CL106 HEK-293T C80(1.10)  LDD0973  [9]
 LDCM0376  CL107 HEK-293T C80(1.05)  LDD0974  [9]
 LDCM0377  CL108 HEK-293T C80(1.49)  LDD0975  [9]
 LDCM0378  CL109 HEK-293T C80(1.00)  LDD0976  [9]
 LDCM0379  CL11 HEK-293T C80(1.08)  LDD1583  [19]
 LDCM0380  CL110 HEK-293T C80(0.51)  LDD0978  [9]
 LDCM0381  CL111 HEK-293T C80(1.35)  LDD0979  [9]
 LDCM0382  CL112 HEK-293T C80(0.77)  LDD0980  [9]
 LDCM0383  CL113 HEK-293T C80(1.15)  LDD0981  [9]
 LDCM0384  CL114 HEK-293T C80(0.97)  LDD0982  [9]
 LDCM0385  CL115 HEK-293T C80(1.38)  LDD0983  [9]
 LDCM0386  CL116 HEK-293T C80(1.02)  LDD0984  [9]
 LDCM0387  CL117 PaTu 8988t C80(0.87)  LDD1266  [9]
 LDCM0388  CL118 PaTu 8988t C80(1.02)  LDD1267  [9]
 LDCM0389  CL119 PaTu 8988t C80(1.05)  LDD1268  [9]
 LDCM0390  CL12 HEK-293T C80(1.03)  LDD1594  [19]
 LDCM0391  CL120 PaTu 8988t C80(1.03)  LDD1270  [9]
 LDCM0392  CL121 PaTu 8988t C80(0.97)  LDD1271  [9]
 LDCM0393  CL122 PaTu 8988t C80(0.96)  LDD1272  [9]
 LDCM0394  CL123 PaTu 8988t C80(0.84)  LDD1273  [9]
 LDCM0395  CL124 PaTu 8988t C80(0.68)  LDD1274  [9]
 LDCM0396  CL125 HEK-293T C80(1.16)  LDD1600  [19]
 LDCM0397  CL126 HEK-293T C80(1.03)  LDD1601  [19]
 LDCM0398  CL127 HEK-293T C80(0.91)  LDD1602  [19]
 LDCM0399  CL128 HEK-293T C80(0.97)  LDD1603  [19]
 LDCM0400  CL13 HEK-293T C80(1.09)  LDD1604  [19]
 LDCM0401  CL14 HEK-293T C80(1.13)  LDD1605  [19]
 LDCM0402  CL15 HEK-293T C80(0.92)  LDD1606  [19]
 LDCM0403  CL16 PaTu 8988t C80(0.84)  LDD1282  [9]
 LDCM0404  CL17 PaTu 8988t C80(0.99)  LDD1283  [9]
 LDCM0405  CL18 PaTu 8988t C80(0.92)  LDD1284  [9]
 LDCM0406  CL19 PaTu 8988t C80(0.80)  LDD1285  [9]
 LDCM0407  CL2 HEK-293T C80(1.08)  LDD1611  [19]
 LDCM0408  CL20 PaTu 8988t C80(0.98)  LDD1287  [9]
 LDCM0409  CL21 PaTu 8988t C80(1.01)  LDD1288  [9]
 LDCM0410  CL22 PaTu 8988t C80(1.22)  LDD1289  [9]
 LDCM0411  CL23 PaTu 8988t C80(0.78)  LDD1290  [9]
 LDCM0412  CL24 PaTu 8988t C80(0.77)  LDD1291  [9]
 LDCM0413  CL25 PaTu 8988t C80(0.93)  LDD1292  [9]
 LDCM0414  CL26 PaTu 8988t C80(0.68)  LDD1293  [9]
 LDCM0415  CL27 PaTu 8988t C80(0.68)  LDD1294  [9]
 LDCM0416  CL28 PaTu 8988t C80(1.48)  LDD1295  [9]
 LDCM0417  CL29 PaTu 8988t C80(0.72)  LDD1296  [9]
 LDCM0418  CL3 HEK-293T C80(1.05)  LDD1622  [19]
 LDCM0419  CL30 PaTu 8988t C80(0.88)  LDD1298  [9]
 LDCM0420  CL31 HEK-293T C80(0.60)  LDD1018  [9]
 LDCM0421  CL32 HEK-293T C80(0.98)  LDD1019  [9]
 LDCM0422  CL33 HEK-293T C80(1.05)  LDD1020  [9]
 LDCM0423  CL34 HEK-293T C80(0.58)  LDD1021  [9]
 LDCM0424  CL35 HEK-293T C80(1.26)  LDD1022  [9]
 LDCM0425  CL36 HEK-293T C80(1.08)  LDD1023  [9]
 LDCM0426  CL37 HEK-293T C80(0.86)  LDD1024  [9]
 LDCM0428  CL39 HEK-293T C80(0.73)  LDD1026  [9]
 LDCM0429  CL4 HEK-293T C80(1.04)  LDD1633  [19]
 LDCM0430  CL40 HEK-293T C80(1.06)  LDD1028  [9]
 LDCM0431  CL41 HEK-293T C80(0.52)  LDD1029  [9]
 LDCM0432  CL42 HEK-293T C80(1.00)  LDD1030  [9]
 LDCM0433  CL43 HEK-293T C80(0.89)  LDD1031  [9]
 LDCM0434  CL44 HEK-293T C80(0.95)  LDD1032  [9]
 LDCM0435  CL45 HEK-293T C80(0.92)  LDD1033  [9]
 LDCM0436  CL46 HEK-293T C80(1.06)  LDD1640  [19]
 LDCM0437  CL47 HEK-293T C80(1.14)  LDD1641  [19]
 LDCM0438  CL48 HEK-293T C80(1.07)  LDD1642  [19]
 LDCM0439  CL49 HEK-293T C80(1.11)  LDD1643  [19]
 LDCM0440  CL5 HEK-293T C80(1.05)  LDD1644  [19]
 LDCM0441  CL50 HEK-293T C80(0.99)  LDD1645  [19]
 LDCM0443  CL52 HEK-293T C80(1.11)  LDD1646  [19]
 LDCM0444  CL53 HEK-293T C80(0.86)  LDD1647  [19]
 LDCM0445  CL54 HEK-293T C80(0.89)  LDD1648  [19]
 LDCM0446  CL55 HEK-293T C80(0.99)  LDD1649  [19]
 LDCM0447  CL56 HEK-293T C80(0.98)  LDD1650  [19]
 LDCM0448  CL57 HEK-293T C80(0.94)  LDD1651  [19]
 LDCM0449  CL58 HEK-293T C80(1.12)  LDD1652  [19]
 LDCM0450  CL59 HEK-293T C80(1.14)  LDD1653  [19]
 LDCM0451  CL6 HEK-293T C80(0.94)  LDD1654  [19]
 LDCM0452  CL60 HEK-293T C80(1.08)  LDD1655  [19]
 LDCM0453  CL61 PaTu 8988t C80(0.67)  LDD1332  [9]
 LDCM0454  CL62 PaTu 8988t C80(0.72)  LDD1333  [9]
 LDCM0455  CL63 PaTu 8988t C80(1.00)  LDD1334  [9]
 LDCM0456  CL64 PaTu 8988t C80(1.01)  LDD1335  [9]
 LDCM0457  CL65 PaTu 8988t C80(0.63)  LDD1336  [9]
 LDCM0458  CL66 PaTu 8988t C80(1.39)  LDD1337  [9]
 LDCM0459  CL67 PaTu 8988t C80(0.70)  LDD1338  [9]
 LDCM0460  CL68 PaTu 8988t C80(0.76)  LDD1339  [9]
 LDCM0461  CL69 PaTu 8988t C80(1.31)  LDD1340  [9]
 LDCM0462  CL7 HEK-293T C80(1.02)  LDD1665  [19]
 LDCM0463  CL70 PaTu 8988t C80(0.68)  LDD1342  [9]
 LDCM0464  CL71 PaTu 8988t C80(0.59)  LDD1343  [9]
 LDCM0465  CL72 PaTu 8988t C80(1.66)  LDD1344  [9]
 LDCM0466  CL73 PaTu 8988t C80(0.73)  LDD1345  [9]
 LDCM0467  CL74 PaTu 8988t C80(1.09)  LDD1346  [9]
 LDCM0469  CL76 HEK-293T C80(0.99)  LDD1672  [19]
 LDCM0470  CL77 HEK-293T C80(0.92)  LDD1673  [19]
 LDCM0471  CL78 HEK-293T C80(1.01)  LDD1674  [19]
 LDCM0472  CL79 HEK-293T C80(1.04)  LDD1675  [19]
 LDCM0473  CL8 HEK-293T C80(0.76)  LDD1676  [19]
 LDCM0474  CL80 HEK-293T C80(1.03)  LDD1677  [19]
 LDCM0475  CL81 HEK-293T C80(1.02)  LDD1678  [19]
 LDCM0476  CL82 HEK-293T C80(1.04)  LDD1679  [19]
 LDCM0477  CL83 HEK-293T C80(1.09)  LDD1680  [19]
 LDCM0478  CL84 HEK-293T C80(0.98)  LDD1681  [19]
 LDCM0479  CL85 HEK-293T C80(1.14)  LDD1682  [19]
 LDCM0480  CL86 HEK-293T C80(1.15)  LDD1683  [19]
 LDCM0481  CL87 HEK-293T C80(0.97)  LDD1684  [19]
 LDCM0482  CL88 HEK-293T C80(1.01)  LDD1685  [19]
 LDCM0483  CL89 HEK-293T C80(1.09)  LDD1686  [19]
 LDCM0484  CL9 HEK-293T C80(1.03)  LDD1687  [19]
 LDCM0485  CL90 HEK-293T C80(0.76)  LDD1688  [19]
 LDCM0486  CL91 PaTu 8988t C80(0.70)  LDD1365  [9]
 LDCM0487  CL92 PaTu 8988t C80(0.67)  LDD1366  [9]
 LDCM0488  CL93 PaTu 8988t C80(0.70)  LDD1367  [9]
 LDCM0489  CL94 PaTu 8988t C80(0.73)  LDD1368  [9]
 LDCM0490  CL95 PaTu 8988t C80(0.76)  LDD1369  [9]
 LDCM0491  CL96 PaTu 8988t C80(0.66)  LDD1370  [9]
 LDCM0492  CL97 PaTu 8988t C80(0.76)  LDD1371  [9]
 LDCM0493  CL98 PaTu 8988t C80(0.91)  LDD1372  [9]
 LDCM0494  CL99 PaTu 8988t C80(0.69)  LDD1373  [9]
 LDCM0495  E2913 HEK-293T C80(1.03)  LDD1698  [19]
 LDCM0468  Fragment33 PaTu 8988t C80(0.77)  LDD1347  [9]
 LDCM0427  Fragment51 HEK-293T C80(0.84)  LDD1025  [9]
 LDCM0116  HHS-0101 DM93 Y392(0.91)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y392(0.87)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y392(1.04)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y392(1.58)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y392(5.07)  LDD0268  [7]
 LDCM0123  JWB131 DM93 Y392(1.32)  LDD0285  [6]
 LDCM0124  JWB142 DM93 Y392(0.86)  LDD0286  [6]
 LDCM0125  JWB146 DM93 Y392(1.47)  LDD0287  [6]
 LDCM0126  JWB150 DM93 Y392(4.14)  LDD0288  [6]
 LDCM0127  JWB152 DM93 Y392(2.19)  LDD0289  [6]
 LDCM0128  JWB198 DM93 Y392(1.67)  LDD0290  [6]
 LDCM0129  JWB202 DM93 Y392(0.83)  LDD0291  [6]
 LDCM0130  JWB211 DM93 Y392(1.28)  LDD0292  [6]
 LDCM0078  kambe_cp70 PC-3 2.01  LDD0134  [18]
 LDCM0022  KB02 HEK-293T C80(1.03)  LDD1492  [19]
 LDCM0023  KB03 HEK-293T C80(1.00)  LDD1497  [19]
 LDCM0024  KB05 HEK-293T C80(0.93)  LDD1502  [19]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Maspardin (SPG21) AB hydrolase superfamily Q9NZD8
Integrator complex subunit 11 (INTS11) RNA-metabolizing metallo-beta-lactamase-like family Q5TA45
Glutamine-dependent NAD(+) synthetase (NADSYN1) NAD synthetase family Q6IA69
Group 10 secretory phospholipase A2 (PLA2G10) Phospholipase A2 family O15496
Phospholipid scramblase 1 (PLSCR1) Phospholipid scramblase family O15162
E3 ubiquitin-protein ligase RNF4 (RNF4) . P78317
Methyltransferase-like protein 27 (METTL27) . Q8N6F8
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Annexin A11 (ANXA11) Annexin family P50995
Huntingtin (HTT) Huntingtin family P42858
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cone-rod homeobox protein (CRX) Paired homeobox family O43186
POU domain class 2-associating factor 1 (POU2AF1) POU2AF family Q16633
Forkhead box protein H1 (FOXH1) . O75593
T-box transcription factor TBX19 (TBX19) . O60806
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Oxoeicosanoid receptor 1 (OXER1) G-protein coupled receptor 1 family Q8TDS5
Other
Click To Hide/Show 30 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
BPI fold-containing family A member 1 (BPIFA1) Plunc family Q9NP55
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997
Protein INCA1 (INCA1) INCA family Q0VD86
Mediator of RNA polymerase II transcription subunit 25 (MED25) Mediator complex subunit 25 family Q71SY5
MAPK-interacting and spindle-stabilizing protein-like (MAPK1IP1L) MISS family Q8NDC0
Keratin-associated protein 26-1 (KRTAP26-1) PMG family Q6PEX3
Prefoldin subunit 5 (PFDN5) Prefoldin subunit alpha family Q99471
Proline-rich protein 20D (PRR20D) PRR20 family P86480
Protein boule-like (BOLL) RRM DAZ family Q8N9W6
RNA-binding protein EWS (EWSR1) RRM TET family Q01844
Protein transport protein Sec24A (SEC24A) SEC23/SEC24 family O95486
Splicing factor 3A subunit 2 (SF3A2) SF3A2 family Q15428
Splicing factor 3B subunit 4 (SF3B4) SF3B4 family Q15427
Vacuolar protein sorting-associated protein 37C (VPS37C) VPS37 family A5D8V6
Centrosomal protein of 55 kDa (CEP55) . Q53EZ4
Cleavage stimulation factor subunit 2 (CSTF2) . P33240
DAZ-associated protein 2 (DAZAP2) . Q15038
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964
Heterogeneous nuclear ribonucleoprotein F (HNRNPF) . P52597
Leukocyte receptor cluster member 8 (LENG8) . Q96PV6
Melanoma-associated antigen D1 (MAGED1) . Q9Y5V3
Peflin (PEF1) . Q9UBV8
Protein SPMIP9 (SPMIP9) . Q96LM6
Protein TFG (TFG) . Q92734
Puratrophin-1 (PLEKHG4) . Q58EX7
Putative protein MSS51 homolog, mitochondrial (MSS51) . Q4VC12
Rho guanine nucleotide exchange factor 16 (ARHGEF16) . Q5VV41
RNA-binding protein with multiple splicing (RBPMS) . Q93062
Saitohin (STH) . Q8IWL8
Ubiquitin-associated protein 2 (UBAP2) . Q5T6F2

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
13 Sequence-Based Prediction of Cysteine Reactivity Using Machine Learning. Biochemistry. 2018 Jan 30;57(4):451-460. doi: 10.1021/acs.biochem.7b00897. Epub 2017 Oct 26.
14 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
15 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
16 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
17 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
18 Mapping the protein interaction landscape for fully functionalized small-molecule probes in human cells. J Am Chem Soc. 2014 Jul 30;136(30):10777-82. doi: 10.1021/ja505517t. Epub 2014 Jul 21.
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
20 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.