Details of the Target

General Information of Target

Target ID LDTP01296
Target Name Protein XRP2 (RP2)
Gene Name RP2
Gene ID 6102
Synonyms
Protein XRP2
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MGCFFSKRRKADKESRPENEEERPKQYSWDQREKVDPKDYMFSGLKDETVGRLPGTVAGQ
QFLIQDCENCNIYIFDHSATVTIDDCTNCIIFLGPVKGSVFFRNCRDCKCTLACQQFRVR
DCRKLEVFLCCATQPIIESSSNIKFGCFQWYYPELAFQFKDAGLSIFNNTWSNIHDFTPV
SGELNWSLLPEDAVVQDYVPIPTTEELKAVRVSTEANRSIVPISRGQRQKSSDESCLVVL
FAGDYTIANARKLIDEMVGKGFFLVQTKEVSMKAEDAQRVFREKAPDFLPLLNKGPVIAL
EFNGDGAVEVCQLIVNEIFNGTKMFVSESKETASGDVDSFYNFADIQMGI
Target Bioclass
Other
Family
TBCC family
Subcellular location
Cell membrane
Function
Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Involved in localization of proteins, such as NPHP3, to the cilium membrane by inducing hydrolysis of GTP ARL3, leading to the release of UNC119 (or UNC119B). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. Acts as a guanine nucleotide dissociation inhibitor towards ADP-ribosylation factor-like proteins.
Uniprot ID
O75695
Ensemble ID
ENST00000218340.4
HGNC ID
HGNC:10274

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TG42
 Probe Info  		4.15  LDD0326  [1]
m-APA
 Probe Info  		11.54  LDD0403  [2]
DBIA
 Probe Info  		C110(0.61); C114(0.61)  LDD0533  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
AOyne
 Probe Info  		9.20  LDD0443  [5]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C378
 Probe Info  		6.50  LDD2037  [6]
VE-P
 Probe Info  		N.A.  LDD0396  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C114(1.18)  LDD0812  [3]
 LDCM0215  AC10 HEK-293T C110(0.86); C114(0.86); C147(1.22)  LDD0813  [3]
 LDCM0216  AC100 HCT 116 C110(0.61); C114(0.61)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C110(0.60); C114(0.60)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C110(0.51); C114(0.51)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C110(0.53); C114(0.53)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C110(0.38); C114(0.38)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C110(0.54); C114(0.54)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C110(0.64); C114(0.64)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C110(0.56); C114(0.49)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C110(0.61); C114(0.55)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C110(0.48); C114(0.57)  LDD0542  [3]
 LDCM0226  AC11 HEK-293T C110(0.84); C114(0.84); C147(1.09)  LDD0824  [3]
 LDCM0227  AC110 HCT 116 C110(0.43); C114(0.51)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C110(0.38); C114(0.51)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C110(0.41); C114(0.48)  LDD0546  [3]
 LDCM0230  AC113 PaTu 8988t C147(1.96)  LDD1109  [3]
 LDCM0231  AC114 PaTu 8988t C147(0.78)  LDD1110  [3]
 LDCM0232  AC115 PaTu 8988t C147(1.84)  LDD1111  [3]
 LDCM0233  AC116 PaTu 8988t C147(1.55)  LDD1112  [3]
 LDCM0234  AC117 PaTu 8988t C147(1.90)  LDD1113  [3]
 LDCM0235  AC118 PaTu 8988t C147(0.99)  LDD1114  [3]
 LDCM0236  AC119 PaTu 8988t C147(1.17)  LDD1115  [3]
 LDCM0237  AC12 HEK-293T C110(0.80); C114(0.80); C147(1.04)  LDD0835  [3]
 LDCM0238  AC120 PaTu 8988t C147(1.03)  LDD1117  [3]
 LDCM0239  AC121 PaTu 8988t C147(1.08)  LDD1118  [3]
 LDCM0240  AC122 PaTu 8988t C147(0.86)  LDD1119  [3]
 LDCM0241  AC123 PaTu 8988t C147(1.25)  LDD1120  [3]
 LDCM0242  AC124 PaTu 8988t C147(0.89)  LDD1121  [3]
 LDCM0243  AC125 PaTu 8988t C147(0.99)  LDD1122  [3]
 LDCM0244  AC126 PaTu 8988t C147(1.15)  LDD1123  [3]
 LDCM0245  AC127 PaTu 8988t C147(0.83)  LDD1124  [3]
 LDCM0246  AC128 HEK-293T C110(0.90); C114(0.90)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C110(0.69); C114(0.69)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C110(0.65); C114(0.65)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C110(0.75); C114(0.75)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C110(0.79); C114(0.79)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C110(0.69); C114(0.69)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C110(0.64); C114(0.64)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C110(0.86); C114(0.86)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C110(0.88); C114(0.88)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C110(0.82); C114(0.82)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C110(0.82); C114(0.82)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C110(0.72); C114(0.72)  LDD0856  [3]
 LDCM0259  AC14 HEK-293T C110(0.65); C114(0.65); C147(1.99)  LDD0857  [3]
 LDCM0260  AC140 HEK-293T C110(0.96); C114(0.96)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C110(0.83); C114(0.83)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C110(0.79); C114(0.79)  LDD0860  [3]
 LDCM0263  AC143 HEK-293T C147(1.22)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C147(2.04)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C147(2.17)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C147(1.98)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C147(1.65)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C147(2.76)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C147(0.83)  LDD0867  [3]
 LDCM0270  AC15 HEK-293T C110(0.78); C114(0.78); C147(2.19)  LDD0868  [3]
 LDCM0271  AC150 HEK-293T C147(1.31)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C147(1.24)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C147(1.15)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C147(1.56)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C147(1.12)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C147(1.71)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C147(2.04)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C147(3.01)  LDD2165  [3]
 LDCM0276  AC17 HEK-293T C114(1.21); C147(1.63)  LDD0874  [3]
 LDCM0277  AC18 HEK-293T C114(1.12); C147(1.11)  LDD0875  [3]
 LDCM0278  AC19 HEK-293T C114(1.14); C147(1.00)  LDD0876  [3]
 LDCM0279  AC2 HEK-293T C114(1.21)  LDD0877  [3]
 LDCM0280  AC20 HEK-293T C114(1.37); C147(1.38)  LDD0878  [3]
 LDCM0281  AC21 HEK-293T C114(1.46); C147(1.43)  LDD0879  [3]
 LDCM0282  AC22 HEK-293T C114(1.53); C147(1.34)  LDD0880  [3]
 LDCM0283  AC23 HEK-293T C114(1.42); C147(1.74)  LDD0881  [3]
 LDCM0284  AC24 HEK-293T C114(1.04); C147(1.15)  LDD0882  [3]
 LDCM0285  AC25 HEK-293T C114(1.11)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C114(1.11)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C114(1.00)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C114(0.80)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C114(1.07)  LDD0887  [3]
 LDCM0290  AC3 HEK-293T C114(1.01)  LDD0888  [3]
 LDCM0291  AC30 HEK-293T C114(0.93)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C114(0.87)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C114(1.05)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C114(1.19)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C114(0.97)  LDD0893  [3]
 LDCM0296  AC35 HCT 116 C114(0.92); C110(1.09)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C114(1.13); C110(1.58)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C114(0.96); C110(1.08)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C114(0.96); C110(1.39)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C114(1.09); C110(1.21)  LDD0617  [3]
 LDCM0301  AC4 HEK-293T C114(1.11)  LDD0899  [3]
 LDCM0302  AC40 HCT 116 C114(1.24); C110(1.30)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C114(0.90); C110(1.38)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C114(1.18); C110(1.58)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C114(0.95); C110(0.98)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C110(1.26); C114(1.27)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C114(1.08); C110(1.10)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C110(0.84); C114(0.84)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C110(0.75); C114(0.75)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C110(0.67); C114(0.67)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C110(0.42); C114(0.42)  LDD0628  [3]
 LDCM0312  AC5 HEK-293T C114(1.01)  LDD0910  [3]
 LDCM0313  AC50 HCT 116 C110(0.58); C114(0.58)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C110(1.01); C114(1.01)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C110(1.21); C114(1.21)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C110(0.52); C114(0.52)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C110(0.46); C114(0.46)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C110(0.50); C114(0.50)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C110(0.35); C114(0.35)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C110(0.55); C114(0.64)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C110(0.65); C114(0.79)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C110(0.69); C114(0.96)  LDD0639  [3]
 LDCM0323  AC6 HEK-293T C110(0.93); C114(0.93); C147(0.81)  LDD0921  [3]
 LDCM0324  AC60 HCT 116 C110(0.44); C114(0.53)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C110(0.60); C114(0.71)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C110(0.68); C114(0.85)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C110(0.62); C114(0.84)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C110(0.53); C114(0.61)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C110(0.76); C114(0.87)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C110(0.88); C114(0.94)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C110(0.37); C114(0.49)  LDD0648  [3]
 LDCM0332  AC68 HEK-293T C110(0.79)  LDD0930  [3]
 LDCM0333  AC69 HEK-293T C110(0.72)  LDD0931  [3]
 LDCM0334  AC7 HEK-293T C110(0.85); C114(0.85); C147(1.03)  LDD0932  [3]
 LDCM0335  AC70 HEK-293T C110(0.67)  LDD0933  [3]
 LDCM0336  AC71 HEK-293T C110(0.77)  LDD0934  [3]
 LDCM0337  AC72 HEK-293T C110(0.72)  LDD0935  [3]
 LDCM0338  AC73 HEK-293T C110(0.87)  LDD0936  [3]
 LDCM0339  AC74 HEK-293T C110(0.68)  LDD0937  [3]
 LDCM0340  AC75 HEK-293T C110(0.61)  LDD0938  [3]
 LDCM0341  AC76 HEK-293T C110(0.73)  LDD0939  [3]
 LDCM0342  AC77 HEK-293T C110(0.79)  LDD0940  [3]
 LDCM0343  AC78 HEK-293T C110(0.79)  LDD0941  [3]
 LDCM0344  AC79 HEK-293T C110(0.69)  LDD0942  [3]
 LDCM0345  AC8 HEK-293T C110(0.94); C114(0.94); C147(1.26)  LDD0943  [3]
 LDCM0346  AC80 HEK-293T C110(0.74)  LDD0944  [3]
 LDCM0347  AC81 HEK-293T C110(0.69)  LDD0945  [3]
 LDCM0348  AC82 HEK-293T C110(0.92)  LDD0946  [3]
 LDCM0349  AC83 HEK-293T C147(0.83)  LDD0947  [3]
 LDCM0350  AC84 HEK-293T C147(1.21)  LDD0948  [3]
 LDCM0351  AC85 HEK-293T C147(1.05)  LDD0949  [3]
 LDCM0352  AC86 HEK-293T C147(1.00)  LDD0950  [3]
 LDCM0353  AC87 HEK-293T C147(1.24)  LDD0951  [3]
 LDCM0354  AC88 HEK-293T C147(1.30)  LDD0952  [3]
 LDCM0355  AC89 HEK-293T C147(1.39)  LDD0953  [3]
 LDCM0357  AC90 HEK-293T C147(1.17)  LDD0955  [3]
 LDCM0358  AC91 HEK-293T C147(1.24)  LDD0956  [3]
 LDCM0359  AC92 HEK-293T C147(1.26)  LDD0957  [3]
 LDCM0360  AC93 HEK-293T C147(1.31)  LDD0958  [3]
 LDCM0361  AC94 HEK-293T C147(1.55)  LDD0959  [3]
 LDCM0362  AC95 HEK-293T C147(1.26)  LDD0960  [3]
 LDCM0363  AC96 HEK-293T C147(1.16)  LDD0961  [3]
 LDCM0364  AC97 HEK-293T C147(2.57)  LDD0962  [3]
 LDCM0365  AC98 HCT 116 C110(0.15); C114(0.15)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C110(0.59); C114(0.59)  LDD0683  [3]
 LDCM0248  AKOS034007472 HEK-293T C110(0.74); C114(0.74); C147(1.20)  LDD0846  [3]
 LDCM0356  AKOS034007680 HEK-293T C110(0.78); C114(0.78); C147(1.57)  LDD0954  [3]
 LDCM0275  AKOS034007705 HEK-293T C110(0.67); C114(0.67); C147(1.21)  LDD0873  [3]
 LDCM0156  Aniline NCI-H1299 11.54  LDD0403  [2]
 LDCM0367  CL1 HCT 116 C110(1.05)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C110(1.03)  LDD0685  [3]
 LDCM0369  CL100 HEK-293T C114(1.40)  LDD0967  [3]
 LDCM0370  CL101 HEK-293T C110(0.68); C114(0.68); C147(1.76)  LDD0968  [3]
 LDCM0371  CL102 HEK-293T C110(0.64); C114(0.64); C147(1.29)  LDD0969  [3]
 LDCM0372  CL103 HEK-293T C110(0.81); C114(0.81); C147(1.14)  LDD0970  [3]
 LDCM0373  CL104 HEK-293T C110(0.95); C114(0.95); C147(1.20)  LDD0971  [3]
 LDCM0374  CL105 HEK-293T C114(1.19); C147(1.15)  LDD0972  [3]
 LDCM0375  CL106 HEK-293T C114(1.10); C147(1.34)  LDD0973  [3]
 LDCM0376  CL107 HEK-293T C114(1.03); C147(0.98)  LDD0974  [3]
 LDCM0377  CL108 HEK-293T C114(1.05); C147(1.18)  LDD0975  [3]
 LDCM0378  CL109 HEK-293T C114(0.91); C147(1.04)  LDD0976  [3]
 LDCM0379  CL11 HCT 116 C110(0.74)  LDD0696  [3]
 LDCM0380  CL110 HEK-293T C114(1.08); C147(1.30)  LDD0978  [3]
 LDCM0381  CL111 HEK-293T C114(0.90); C147(1.00)  LDD0979  [3]
 LDCM0382  CL112 HEK-293T C114(1.24)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C114(0.98)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C114(1.67)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C114(1.42)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C114(1.51)  LDD0984  [3]
 LDCM0387  CL117 HCT 116 C114(0.55); C110(0.60)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C114(1.07); C110(1.31)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C114(1.08); C110(1.12)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C110(0.97)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C114(0.94); C110(1.39)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C110(0.51); C114(0.51)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C110(0.73); C114(0.73)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C110(0.72); C114(0.72)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C110(0.52); C114(0.52)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C110(0.92); C114(0.94)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C110(0.63); C114(0.75)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C110(0.70); C114(0.77)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C110(0.61); C114(0.76)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C110(0.93)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C110(1.17)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C110(0.77)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C110(1.21)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C110(1.26)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C110(0.92)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C110(1.03)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C110(1.21)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C110(1.42)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C110(0.66)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C110(0.53)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C110(1.09)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C110(0.82)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C110(0.97)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C110(1.02)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C110(0.95)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C110(0.89)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C110(1.00)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C110(1.51)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C110(0.89)  LDD0736  [3]
 LDCM0420  CL31 HEK-293T C147(0.97)  LDD1018  [3]
 LDCM0421  CL32 HEK-293T C147(1.06)  LDD1019  [3]
 LDCM0422  CL33 HEK-293T C147(1.38)  LDD1020  [3]
 LDCM0423  CL34 HEK-293T C147(1.08)  LDD1021  [3]
 LDCM0424  CL35 HEK-293T C147(0.98)  LDD1022  [3]
 LDCM0425  CL36 HEK-293T C147(1.16)  LDD1023  [3]
 LDCM0426  CL37 HEK-293T C147(1.15)  LDD1024  [3]
 LDCM0428  CL39 HEK-293T C147(2.40)  LDD1026  [3]
 LDCM0429  CL4 HCT 116 C110(0.80)  LDD0746  [3]
 LDCM0430  CL40 HEK-293T C147(1.54)  LDD1028  [3]
 LDCM0431  CL41 HEK-293T C147(1.99)  LDD1029  [3]
 LDCM0432  CL42 HEK-293T C147(2.41)  LDD1030  [3]
 LDCM0433  CL43 HEK-293T C147(2.74)  LDD1031  [3]
 LDCM0434  CL44 HEK-293T C147(1.11)  LDD1032  [3]
 LDCM0435  CL45 HEK-293T C147(1.88)  LDD1033  [3]
 LDCM0436  CL46 HEK-293T C114(1.45); C147(0.91)  LDD1034  [3]
 LDCM0437  CL47 HEK-293T C114(1.06); C147(1.01)  LDD1035  [3]
 LDCM0438  CL48 HEK-293T C114(1.50); C147(0.82)  LDD1036  [3]
 LDCM0439  CL49 HEK-293T C114(1.17); C147(1.36)  LDD1037  [3]
 LDCM0440  CL5 HCT 116 C110(1.12)  LDD0757  [3]
 LDCM0441  CL50 HEK-293T C114(1.52); C147(1.44)  LDD1039  [3]
 LDCM0442  CL51 HEK-293T C114(1.19); C147(1.15)  LDD1040  [3]
 LDCM0443  CL52 HEK-293T C114(0.78); C147(0.76)  LDD1041  [3]
 LDCM0444  CL53 HEK-293T C114(1.12); C147(1.45)  LDD1042  [3]
 LDCM0445  CL54 HEK-293T C114(1.10); C147(1.21)  LDD1043  [3]
 LDCM0446  CL55 HEK-293T C114(1.43); C147(1.42)  LDD1044  [3]
 LDCM0447  CL56 HEK-293T C114(1.25); C147(1.07)  LDD1045  [3]
 LDCM0448  CL57 HEK-293T C114(1.49); C147(1.55)  LDD1046  [3]
 LDCM0449  CL58 HEK-293T C114(1.06); C147(1.07)  LDD1047  [3]
 LDCM0450  CL59 HEK-293T C114(1.38); C147(1.22)  LDD1048  [3]
 LDCM0451  CL6 HCT 116 C110(0.93)  LDD0768  [3]
 LDCM0452  CL60 HEK-293T C114(1.33); C147(2.06)  LDD1050  [3]
 LDCM0453  CL61 HEK-293T C114(0.94); C147(0.65)  LDD1051  [3]
 LDCM0454  CL62 HEK-293T C114(1.00); C147(0.78)  LDD1052  [3]
 LDCM0455  CL63 HEK-293T C114(1.14); C147(0.88)  LDD1053  [3]
 LDCM0456  CL64 HEK-293T C114(1.03); C147(1.06)  LDD1054  [3]
 LDCM0457  CL65 HEK-293T C114(1.15); C147(0.87)  LDD1055  [3]
 LDCM0458  CL66 HEK-293T C114(0.94); C147(0.96)  LDD1056  [3]
 LDCM0459  CL67 HEK-293T C114(0.79); C147(1.04)  LDD1057  [3]
 LDCM0460  CL68 HEK-293T C114(1.00); C147(1.22)  LDD1058  [3]
 LDCM0461  CL69 HEK-293T C114(0.81); C147(0.77)  LDD1059  [3]
 LDCM0462  CL7 HCT 116 C110(0.83)  LDD0779  [3]
 LDCM0463  CL70 HEK-293T C114(0.75); C147(1.06)  LDD1061  [3]
 LDCM0464  CL71 HEK-293T C114(0.95); C147(0.94)  LDD1062  [3]
 LDCM0465  CL72 HEK-293T C114(0.96); C147(0.79)  LDD1063  [3]
 LDCM0466  CL73 HEK-293T C114(1.07); C147(1.76)  LDD1064  [3]
 LDCM0467  CL74 HEK-293T C114(1.41); C147(2.04)  LDD1065  [3]
 LDCM0469  CL76 PaTu 8988t C110(0.50); C114(1.02); C147(0.44)  LDD1348  [3]
 LDCM0470  CL77 PaTu 8988t C110(0.48); C114(0.75); C147(0.63)  LDD1349  [3]
 LDCM0471  CL78 PaTu 8988t C110(0.46); C114(0.90); C147(0.57)  LDD1350  [3]
 LDCM0472  CL79 PaTu 8988t C110(1.18); C114(1.24); C147(0.65)  LDD1351  [3]
 LDCM0473  CL8 HCT 116 C110(0.72)  LDD0790  [3]
 LDCM0474  CL80 PaTu 8988t C110(0.32); C114(1.10); C147(0.36)  LDD1353  [3]
 LDCM0475  CL81 PaTu 8988t C110(0.66); C114(1.18); C147(0.51)  LDD1354  [3]
 LDCM0476  CL82 PaTu 8988t C110(0.43); C114(1.82); C147(0.46)  LDD1355  [3]
 LDCM0477  CL83 PaTu 8988t C110(0.57); C114(0.92); C147(0.47)  LDD1356  [3]
 LDCM0478  CL84 PaTu 8988t C110(0.41); C114(0.81); C147(0.38)  LDD1357  [3]
 LDCM0479  CL85 PaTu 8988t C110(0.61); C114(0.98); C147(0.82)  LDD1358  [3]
 LDCM0480  CL86 PaTu 8988t C110(0.34); C114(0.71); C147(0.38)  LDD1359  [3]
 LDCM0481  CL87 PaTu 8988t C110(0.28); C114(0.67); C147(0.35)  LDD1360  [3]
 LDCM0482  CL88 PaTu 8988t C110(0.39); C114(0.93); C147(0.36)  LDD1361  [3]
 LDCM0483  CL89 PaTu 8988t C110(0.39); C114(0.74); C147(0.38)  LDD1362  [3]
 LDCM0484  CL9 HCT 116 C110(1.09)  LDD0801  [3]
 LDCM0485  CL90 PaTu 8988t C110(0.40); C114(0.74); C147(0.46)  LDD1364  [3]
 LDCM0486  CL91 HEK-293T C114(1.26)  LDD1084  [3]
 LDCM0487  CL92 HEK-293T C114(0.85)  LDD1085  [3]
 LDCM0488  CL93 HEK-293T C114(1.04)  LDD1086  [3]
 LDCM0489  CL94 HEK-293T C114(1.80)  LDD1087  [3]
 LDCM0490  CL95 HEK-293T C114(1.74)  LDD1088  [3]
 LDCM0491  CL96 HEK-293T C114(1.04)  LDD1089  [3]
 LDCM0492  CL97 HEK-293T C114(1.09)  LDD1090  [3]
 LDCM0493  CL98 HEK-293T C114(1.35)  LDD1091  [3]
 LDCM0494  CL99 HEK-293T C114(1.27)  LDD1092  [3]
 LDCM0495  E2913 HEK-293T C147(1.28); C130(0.93)  LDD1698  [8]
 LDCM0468  Fragment33 HEK-293T C114(1.51); C147(1.81)  LDD1066  [3]
 LDCM0427  Fragment51 HEK-293T C147(1.35)  LDD1025  [3]
 LDCM0022  KB02 HEK-293T C147(1.08); C131(1.10); C130(1.12)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C147(1.00); C131(1.04); C130(1.02)  LDD1497  [8]
 LDCM0024  KB05 MKN45 C147(1.87)  LDD3332  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Xaa-Arg dipeptidase (PM20D2) Peptidase M20A family Q8IYS1

References

1 Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d.
Mass spectrometry data entry: PXD010277
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
6 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
7 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840